Continuous increase of cardiovascular diseases, diabetes, and non-HIV related cancers as causes of death in HIV-infected individuals in Brazil: an analysis of nationwide data

Detalhes bibliográficos
Autor(a) principal: Paula, Adelzon Assis de
Data de Publicação: 2014
Outros Autores: Schechter, Mauro, Tuboi, Suely Hiromi, José Claudio, Faulhaber, Luz, Paula Mendes, Santos, Valdiléa Gonçalves Veloso dos, Moreira, Ronaldo Ismério, Grinsztejn, Beatriz, Harrison, Lee H., Pacheco, Antonio Guilherme Fonseca
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/10733
Resumo: FAPERJ, CNPq, Capes, GlaxoSmithKline
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spelling Paula, Adelzon Assis deSchechter, MauroTuboi, Suely HiromiJosé Claudio, FaulhaberLuz, Paula MendesSantos, Valdiléa Gonçalves Veloso dosMoreira, Ronaldo IsmérioGrinsztejn, BeatrizHarrison, Lee H.Pacheco, Antonio Guilherme Fonseca2015-06-08T15:56:26Z2015-06-08T15:56:26Z2014PAULA, Adelzon Assis de et al. Continuous increase of cardiovascular diseases, diabetes, and non-HIV related cancers as causes of death in HIV-infected individuals in Brazil: an analysis of nationwide data. Plos One, v. 9, n. 4, p. 1-5, Apr. 2014.1932-6203https://www.arca.fiocruz.br/handle/icict/1073310.1371/journal.pone.00946361932-6203FAPERJ, CNPq, Capes, GlaxoSmithKlineFundação Oswaldo Cruz. Presidência. Programa de Computação Científica. Rio de Janeiro, RJ, Brasil.Universidade Federal do Rio de Janeiro. Hospital Escola São Francisco de Assis. Projeto Praça Onze. Rio de Janeiro, RJ, Brasil.GlaxoSmithKline. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Instituto de Matemática e Estatística. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em DST e AIDS. Rio de Janeiro, RJ, Brasil.University of Pittsburgh. Graduate School of Public Health and School of Medicine. Infectious Diseases Epidemiology Research Unit. Pittsburgh, PA, USA.Fundação Oswaldo Cruz. Presidência. Programa de Computação Científica. Rio de Janeiro, RJ, Brasil.Introduction: After antiretroviral therapy (ART) became available, there was a decline in the number of deaths in persons infected with HIV. Thereafter, there was a decrease in the proportion of deaths attributed to opportunistic infections and an increase in the proportion of deaths attributed to chronic comorbidities. Herein we extend previous observations from a nationwide survey on temporal trends in causes of death in HIV-infected patients in Brazil. Methods: We describe temporal trends in causes of death among adults who had HIV/AIDS listed in the death certificate to those who did not. All death certificates issued in Brazil from 1999 to 2011 and listed in the national mortality database were included. Generalized linear mixed-effects logistic models were used to study temporal trends in proportions. Results: In the HIV-infected population, there was an annual adjusted average increase of 6.0%, 12.0%, 4.0% and 4.1% for cancer, external causes, cardiovascular diseases (CVD) and diabetes mellitus (DM), respectively, compared to 3.0%, 4.0%, 1.0% and 3.9%, in the non-HIV group. For tuberculosis (TB), there was an adjusted average increase of 0.3%/year and a decrease of 3.0%/year in the HIV and the non-HIV groups, respectively. Compared to 1999, the odds ratio (OR) for cancer, external causes, CVD, DM, or TB in the HIV group were, respectively, 2.31, 4.17, 1.76, 2.27 and 1.02, while for the non-HIV group, the corresponding OR were 1.31, 1.63, 1.14, 1.62 and 0.67. Interactions between year as a continuous or categorical variable and HIV were significant (p,0.001) for all conditions, except for DM when year was considered as a continuous variable (p = 0.76). Conclusions: Non HIV-related co-morbidities continue to increase more rapidly as causes of death among HIV-infected individuals than in those without HIV infection, highlighting the need for targeting prevention measures and surveillance for chronic diseases among those patients.engPublic Library of ScienceContinuous increase of cardiovascular diseases, diabetes, and non-HIV related cancers as causes of death in HIV-infected individuals in Brazil: an analysis of nationwide datainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleHIVAntiretroviral therapyAIDS-related opportunistic infectionsBrazil/ethnologyHighly activeHIVTerapia antirretroviral de alta atividadeInfecções oportunistas relacionadas com a AIDSBrasil/etnologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82352https://www.arca.fiocruz.br/bitstream/icict/10733/1/license.txtafbdf7d7a9bcf771a1cc7edf5f618413MD51ORIGINALContinuous increase of cardiovascular diseases, diabetes, and non-HIV related cancers as causes of death in HIV-infected individuals in Brazil An analysis of nationwide data.pdfContinuous increase of cardiovascular diseases, diabetes, and non-HIV related cancers as causes of death in HIV-infected individuals in Brazil An analysis of nationwide data.pdfapplication/pdf230011https://www.arca.fiocruz.br/bitstream/icict/10733/2/Continuous%20increase%20of%20cardiovascular%20diseases%2c%20diabetes%2c%20and%20non-HIV%20related%20cancers%20as%20causes%20of%20death%20in%20HIV-infected%20individuals%20in%20Brazil%20An%20analysis%20of%20nationwide%20data.pdf38db3e3f10c0e4bc919491116c33a7e8MD52TEXTContinuous increase of cardiovascular diseases, diabetes, and non-HIV related cancers as causes of death in HIV-infected individuals in Brazil An analysis of nationwide data.pdf.txtContinuous increase of cardiovascular diseases, diabetes, and non-HIV related cancers as causes of death in HIV-infected individuals in Brazil An analysis of nationwide data.pdf.txtExtracted texttext/plain22185https://www.arca.fiocruz.br/bitstream/icict/10733/3/Continuous%20increase%20of%20cardiovascular%20diseases%2c%20diabetes%2c%20and%20non-HIV%20related%20cancers%20as%20causes%20of%20death%20in%20HIV-infected%20individuals%20in%20Brazil%20An%20analysis%20of%20nationwide%20data.pdf.txt91ed5e5f3f3e91af5700cca0d12bfb1dMD53icict/107332023-06-15 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dc.title.pt_BR.fl_str_mv Continuous increase of cardiovascular diseases, diabetes, and non-HIV related cancers as causes of death in HIV-infected individuals in Brazil: an analysis of nationwide data
title Continuous increase of cardiovascular diseases, diabetes, and non-HIV related cancers as causes of death in HIV-infected individuals in Brazil: an analysis of nationwide data
spellingShingle Continuous increase of cardiovascular diseases, diabetes, and non-HIV related cancers as causes of death in HIV-infected individuals in Brazil: an analysis of nationwide data
Paula, Adelzon Assis de
HIV
Antiretroviral therapy
AIDS-related opportunistic infections
Brazil/ethnology
Highly active
HIV
Terapia antirretroviral de alta atividade
Infecções oportunistas relacionadas com a AIDS
Brasil/etnologia
title_short Continuous increase of cardiovascular diseases, diabetes, and non-HIV related cancers as causes of death in HIV-infected individuals in Brazil: an analysis of nationwide data
title_full Continuous increase of cardiovascular diseases, diabetes, and non-HIV related cancers as causes of death in HIV-infected individuals in Brazil: an analysis of nationwide data
title_fullStr Continuous increase of cardiovascular diseases, diabetes, and non-HIV related cancers as causes of death in HIV-infected individuals in Brazil: an analysis of nationwide data
title_full_unstemmed Continuous increase of cardiovascular diseases, diabetes, and non-HIV related cancers as causes of death in HIV-infected individuals in Brazil: an analysis of nationwide data
title_sort Continuous increase of cardiovascular diseases, diabetes, and non-HIV related cancers as causes of death in HIV-infected individuals in Brazil: an analysis of nationwide data
author Paula, Adelzon Assis de
author_facet Paula, Adelzon Assis de
Schechter, Mauro
Tuboi, Suely Hiromi
José Claudio, Faulhaber
Luz, Paula Mendes
Santos, Valdiléa Gonçalves Veloso dos
Moreira, Ronaldo Ismério
Grinsztejn, Beatriz
Harrison, Lee H.
Pacheco, Antonio Guilherme Fonseca
author_role author
author2 Schechter, Mauro
Tuboi, Suely Hiromi
José Claudio, Faulhaber
Luz, Paula Mendes
Santos, Valdiléa Gonçalves Veloso dos
Moreira, Ronaldo Ismério
Grinsztejn, Beatriz
Harrison, Lee H.
Pacheco, Antonio Guilherme Fonseca
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Paula, Adelzon Assis de
Schechter, Mauro
Tuboi, Suely Hiromi
José Claudio, Faulhaber
Luz, Paula Mendes
Santos, Valdiléa Gonçalves Veloso dos
Moreira, Ronaldo Ismério
Grinsztejn, Beatriz
Harrison, Lee H.
Pacheco, Antonio Guilherme Fonseca
dc.subject.en.pt_BR.fl_str_mv HIV
Antiretroviral therapy
AIDS-related opportunistic infections
Brazil/ethnology
Highly active
topic HIV
Antiretroviral therapy
AIDS-related opportunistic infections
Brazil/ethnology
Highly active
HIV
Terapia antirretroviral de alta atividade
Infecções oportunistas relacionadas com a AIDS
Brasil/etnologia
dc.subject.decs.pt_BR.fl_str_mv HIV
Terapia antirretroviral de alta atividade
Infecções oportunistas relacionadas com a AIDS
Brasil/etnologia
description FAPERJ, CNPq, Capes, GlaxoSmithKline
publishDate 2014
dc.date.issued.fl_str_mv 2014
dc.date.accessioned.fl_str_mv 2015-06-08T15:56:26Z
dc.date.available.fl_str_mv 2015-06-08T15:56:26Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv PAULA, Adelzon Assis de et al. Continuous increase of cardiovascular diseases, diabetes, and non-HIV related cancers as causes of death in HIV-infected individuals in Brazil: an analysis of nationwide data. Plos One, v. 9, n. 4, p. 1-5, Apr. 2014.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/10733
dc.identifier.issn.none.fl_str_mv 1932-6203
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pone.0094636
dc.identifier.eissn.none.fl_str_mv 1932-6203
identifier_str_mv PAULA, Adelzon Assis de et al. Continuous increase of cardiovascular diseases, diabetes, and non-HIV related cancers as causes of death in HIV-infected individuals in Brazil: an analysis of nationwide data. Plos One, v. 9, n. 4, p. 1-5, Apr. 2014.
1932-6203
10.1371/journal.pone.0094636
url https://www.arca.fiocruz.br/handle/icict/10733
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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instacron_str FIOCRUZ
institution FIOCRUZ
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collection Repositório Institucional da FIOCRUZ (ARCA)
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