Proteome of the Triatomine Digestive Tract: From Catalytic to Immune Pathways; Focusing on Annexin Expression

Detalhes bibliográficos
Autor(a) principal: Gumiel, Marcia
Data de Publicação: 2020
Outros Autores: Mattos, Debora Passos de, Vieira, Cecília Sthal, Moraes, Caroline Silva, Moreira, Carlos José de Carvalho, Gonzalez, Marcelo Salabert, Ferreira, Andre Teixeira, Waghabi, Mariana, Azambuja, Patricia, Carels, Nicolas
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/44864
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica e Fisiologia de Insetos. Rio de Janeiro, RJ, Brasil / Universidad Privada Franz Tamayo. Research Department. La Paz, Bolivia.
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spelling Gumiel, MarciaMattos, Debora Passos deVieira, Cecília SthalMoraes, Caroline SilvaMoreira, Carlos José de CarvalhoGonzalez, Marcelo SalabertFerreira, Andre TeixeiraWaghabi, MarianaAzambuja, PatriciaCarels, Nicolas2020-12-14T14:39:05Z2020-12-14T14:39:05Z2020GUMIEL, Marcia et al. Proteome of the Triatomine Digestive Tract: From Catalytic to Immune Pathways; Focusing on Annexin Expression. Frontiers in Molecular Biosciences, v. 7, Article 589435, p. 1-23, Dec. 2020.2296-889Xhttps://www.arca.fiocruz.br/handle/icict/4486410.3389/fmolb.2020.589435engFrontiers MediaProteomaTrato digestivoTriatomíneosVias catalíticas às imunológicasExpressão de anexinaProteomeTriatomine Digestive TractCatalytic to Immune PathwaysAnnexin ExpressionProteome of the Triatomine Digestive Tract: From Catalytic to Immune Pathways; Focusing on Annexin Expressioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica e Fisiologia de Insetos. Rio de Janeiro, RJ, Brasil / Universidad Privada Franz Tamayo. Research Department. La Paz, Bolivia.Universidade Federal Fluminense. Departamento de Biologia Geral. Laboratório de Biologia de Insetos. Niterói, RJ, Brasil / Universidade Federal Fluminense. Instituto de Biologia. Programa de Pós-Graduação em Ciências e Biotecnologia. Niterói, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica e Fisiologia de Insetos. Rio de Janeiro, RJ, Brasil / Instituto Nacional de Entomologia Molecular. Departamento de Entomologia Molecular. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica e Fisiologia de Insetos. Rio de Janeiro, RJ, Brasil .Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Doenças Parasitárias. Rio de Janeiro, RJ, Brasil.Universidade Federal Fluminense. Departamento de Biologia Geral. Laboratório de Biologia de Insetos. Niterói, RJ, Brasil / Universidade Federal Fluminense. Instituto de Biologia. Programa de Pós-Graduação em Ciências e Biotecnologia. Niterói, RJ, Brasil / Instituto Nacional de Entomologia Molecular. Departamento de Entomologia Molecular. Rio de Janeiro, RJ. Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Tpxicologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Laboratório de Genômica Funcional e Bioinformática. Rio de Janeiro, RJ, Brasil..Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica e Fisiologia de Insetos. Rio de Janeiro, RJ, Brasil / Universidade Federal Fluminense. Departamento de Biologia Geral. Laboratório de Biologia de Insetos. Niterói, RJ, Brasil / Universidade Federal Fluminense. Instituto de Biologia. Programa de Pós-Graduação em Ciências e Biotecnologia. Niterói, RJ, Brasil / Departamento de Entomologia Molecular, Instituto Nacional de Entomologia Molecular. Rio de Janeiro, Brasil.Fundação Oswaldo Cruz. Centro de Desenvolvimento Tecnológico em Saúde. Instituto Nacional de Ciência e Tecnologia em Inovação em Doenças Negligenciadas. Laboratório de Modelagem de Sistemas Biológicos. Rio de Janeiro, RJ, Brasil,.Rhodnius prolixus, Panstrongylus megistus, Triatoma infestans, and Dipetalogaster maxima are all triatomines and potential vectors of the protozoan Trypanosoma cruzi responsible for human Chagas’ disease. Considering that the T. cruzi’s cycle occurs inside the triatomine digestive tract (TDT), the analysis of the TDT protein profile is an essential step to understand TDT physiology during T. cruzi infection. To characterize the protein profile of TDT of D. maxima, P. megistus, R. prolixus, and T. infestans, a shotgun liquid chromatography-tandem mass spectrometry (LC-MS/MS) approach was applied in this report. Most proteins were found to be closely related to metabolic pathways such as gluconeogenesis/glycolysis, citrate cycle, fatty acid metabolism, oxidative phosphorylation, but also to the immune system. We annotated this new proteome contribution gathering it with those previously published in accordance with Gene Ontology and KEGG. Enzymes were classified in terms of class, acceptor, and function, while the proteins from the immune system were annotated by reference to the pathways of humoral response, cell cycle regulation, Toll, IMD, JNK, Jak-STAT, and MAPK, as available from the Insect Innate Immunity Database (IIID). These pathways were further subclassified in recognition, signaling, response, coagulation, melanization and none. Finally, phylogenetic affinities and gene expression of annexins were investigated for understanding their role in the protection and homeostasis of intestinal epithelial cells against the inflammation.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/44864/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALCeciliaVieira_PatriciaAzambuja_etal_IOC_2020.pdfCeciliaVieira_PatriciaAzambuja_etal_IOC_2020.pdfapplication/pdf3145567https://www.arca.fiocruz.br/bitstream/icict/44864/2/CeciliaVieira_PatriciaAzambuja_etal_IOC_2020.pdf571cf150cdf2a59933e498e8bec0724bMD52TEXTCeciliaVieira_PatriciaAzambuja_etal_IOC_2020.pdf.txtCeciliaVieira_PatriciaAzambuja_etal_IOC_2020.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Proteome of the Triatomine Digestive Tract: From Catalytic to Immune Pathways; Focusing on Annexin Expression
title Proteome of the Triatomine Digestive Tract: From Catalytic to Immune Pathways; Focusing on Annexin Expression
spellingShingle Proteome of the Triatomine Digestive Tract: From Catalytic to Immune Pathways; Focusing on Annexin Expression
Gumiel, Marcia
Proteoma
Trato digestivo
Triatomíneos
Vias catalíticas às imunológicas
Expressão de anexina
Proteome
Triatomine Digestive Tract
Catalytic to Immune Pathways
Annexin Expression
title_short Proteome of the Triatomine Digestive Tract: From Catalytic to Immune Pathways; Focusing on Annexin Expression
title_full Proteome of the Triatomine Digestive Tract: From Catalytic to Immune Pathways; Focusing on Annexin Expression
title_fullStr Proteome of the Triatomine Digestive Tract: From Catalytic to Immune Pathways; Focusing on Annexin Expression
title_full_unstemmed Proteome of the Triatomine Digestive Tract: From Catalytic to Immune Pathways; Focusing on Annexin Expression
title_sort Proteome of the Triatomine Digestive Tract: From Catalytic to Immune Pathways; Focusing on Annexin Expression
author Gumiel, Marcia
author_facet Gumiel, Marcia
Mattos, Debora Passos de
Vieira, Cecília Sthal
Moraes, Caroline Silva
Moreira, Carlos José de Carvalho
Gonzalez, Marcelo Salabert
Ferreira, Andre Teixeira
Waghabi, Mariana
Azambuja, Patricia
Carels, Nicolas
author_role author
author2 Mattos, Debora Passos de
Vieira, Cecília Sthal
Moraes, Caroline Silva
Moreira, Carlos José de Carvalho
Gonzalez, Marcelo Salabert
Ferreira, Andre Teixeira
Waghabi, Mariana
Azambuja, Patricia
Carels, Nicolas
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Gumiel, Marcia
Mattos, Debora Passos de
Vieira, Cecília Sthal
Moraes, Caroline Silva
Moreira, Carlos José de Carvalho
Gonzalez, Marcelo Salabert
Ferreira, Andre Teixeira
Waghabi, Mariana
Azambuja, Patricia
Carels, Nicolas
dc.subject.other.pt_BR.fl_str_mv Proteoma
Trato digestivo
Triatomíneos
Vias catalíticas às imunológicas
Expressão de anexina
topic Proteoma
Trato digestivo
Triatomíneos
Vias catalíticas às imunológicas
Expressão de anexina
Proteome
Triatomine Digestive Tract
Catalytic to Immune Pathways
Annexin Expression
dc.subject.en.pt_BR.fl_str_mv Proteome
Triatomine Digestive Tract
Catalytic to Immune Pathways
Annexin Expression
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica e Fisiologia de Insetos. Rio de Janeiro, RJ, Brasil / Universidad Privada Franz Tamayo. Research Department. La Paz, Bolivia.
publishDate 2020
dc.date.accessioned.fl_str_mv 2020-12-14T14:39:05Z
dc.date.available.fl_str_mv 2020-12-14T14:39:05Z
dc.date.issued.fl_str_mv 2020
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv GUMIEL, Marcia et al. Proteome of the Triatomine Digestive Tract: From Catalytic to Immune Pathways; Focusing on Annexin Expression. Frontiers in Molecular Biosciences, v. 7, Article 589435, p. 1-23, Dec. 2020.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/44864
dc.identifier.issn.pt_BR.fl_str_mv 2296-889X
dc.identifier.doi.none.fl_str_mv 10.3389/fmolb.2020.589435
identifier_str_mv GUMIEL, Marcia et al. Proteome of the Triatomine Digestive Tract: From Catalytic to Immune Pathways; Focusing on Annexin Expression. Frontiers in Molecular Biosciences, v. 7, Article 589435, p. 1-23, Dec. 2020.
2296-889X
10.3389/fmolb.2020.589435
url https://www.arca.fiocruz.br/handle/icict/44864
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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https://www.arca.fiocruz.br/bitstream/icict/44864/2/CeciliaVieira_PatriciaAzambuja_etal_IOC_2020.pdf
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