Cytotoxicity and lipase inhibition of essential oils from amazon annonaceae species
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/56616 |
Resumo: | Fundação de Amparo à Pesquisa do Estado do Amazonas (FAPEAM). Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). |
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Barros, André de LimaLima, Emilly J. S. P. deFaria, Jéssica V.Acho, Leonard R. D.Lima, Emerson S.Bezerra, Daniel P.Soares, Elzalina R.Lima, Bruna R. deCosta, Emmanoel V.Pinheiro, Maria Lúcia B.Bataglion, Giovana A.Silva, Felipe M. A. daCardozo, Nállaret M. DávilaGonçalves, José F. C.Koolen, Hector H. F.2023-01-25T18:08:48Z2023-01-25T18:08:48Z2022BARROS, André de Lima et al. Cytotoxicity and lipase inhibition of essential oils from amazon annonaceae species. Chemistry, v. 4, p. 1-18, 20222624-8549https://www.arca.fiocruz.br/handle/icict/5661610.3390/chemistry4040081Fundação de Amparo à Pesquisa do Estado do Amazonas (FAPEAM). Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES).Universidade do Estado do Amazonas. Escola Superior de Ciências da Saúde. Grupo de Pesquisas em Metabolômica e Espectrometria de Massas. Manaus, AM, Brasil.Universidade do Estado do Amazonas. Escola Superior de Ciências da Saúde. Grupo de Pesquisas em Metabolômica e Espectrometria de Massas. Manaus, AM, Brasil.Universidade do Estado do Amazonas. Escola Superior de Ciências da Saúde. Grupo de Pesquisas em Metabolômica e Espectrometria de Massas. Manaus, AM, Brasil / Universidade do Estado do Amazonas. Centro de Estudos Superiores de Tefé. Tefé, AM, Brasil.Universidade Federal do Amazonas. Faculdade de Farmácia. Manaus, AM, Brasil.Universidade Federal do Amazonas. Faculdade de Farmácia. Manaus, AM, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Universidade do Estado do Amazonas. Centro de Estudos Superiores de Tefé. Tefé, AM, Brasil.Universidade Federal do Amazonas. Departamento de Química. Manaus, AM, Brasil / Universidade Federal do Amazonas. Centro de Apoio Multidisciplinar. Manaus, AM, Brasil.Universidade Federal do Amazonas. Departamento de Química. Manaus, AM, Brasil.Universidade Federal do Amazonas. Departamento de Química. Manaus, AM, Brasil.Universidade Federal do Amazonas. Departamento de Química. Manaus, AM, Brasil.Universidade Federal do Amazonas. Departamento de Química. Manaus, AM, Brasil / Universidade Federal do Amazonas. Centro de Apoio Multidisciplinar. Manaus, AM, Brasil.Instituto de Investigaciones de la Amazonía Peruana. Iquitos, Peru.Instituto Nacional de Pesquisas da Amazônia. Laboratório de Fisiologia e Bioquímica Vegetal. Manaus, AM, Brasil.Universidade do Estado do Amazonas. Escola Superior de Ciências da Saúde. Grupo de Pesquisas em Metabolômica e Espectrometria de Massas. Manaus, AM, Brasil.Essential oils from Amazonian species are gaining increasing interest worldwide due to their medicinal and cosmetic applications; however, the relation among the chemical constituents and their biological properties are not well explored. Therefore, the present research aims to obtain an understanding of the bioactivity of chemical compounds in the essential oils of plants from the Annonaceae family (Bocageopsis pleiosperma, Onychopetalum amazonicum, Unonopsis duckei, U. floribunda, U. rufescens, U. stipitata, U. guatterioides, Duguetia flagellaris and Xylopia benthamii). By means of gas chromatography coupled to mass spectrometry, in vitro cytotoxic and anti-lipase assays, principal component analysis and molecular docking, it was possible to establish the main compounds that may be responsible for the cytotoxic effect of O. amazonicum and B. pleiosperma. Moreover, the anti-lipase potential of D. flagellaris was also established, as well as its composition related to the activity. Thus, by the employed strategy, allo-aromadendrene, cryptomerione, δ-cadinene and β-bisabolene were suggested as plausible cytotoxic agents against cancer cell lines, and dehydroaromadendrene, spathulenol and elemol, against lipase. The present study provides significant information on the chemical profile and bioactivity studies of Amazon Annonaceae aromatic plantsengMDPIAnnonaceaeÓleos essenciaisBocageopsisOnychopetalumLipaseCâncerAnnonaceaeEssential oilsBocageopsisOnychopetalumLipaseCancerAnnonaceaeÓleos VoláteisLipaseNeoplasiasCytotoxicity and lipase inhibition of essential oils from amazon annonaceae speciesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALBarros,A.L. Cytotoxicity and Lipase Inhibition...2022.pdfBarros,A.L. Cytotoxicity and Lipase Inhibition...2022.pdfapplication/pdf1596134https://www.arca.fiocruz.br/bitstream/icict/56616/2/Barros%2cA.L.%20Cytotoxicity%20and%20Lipase%20Inhibition...2022.pdfdff352ab9853129a0822a9c64b3313d3MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/56616/1/license.txt5a560609d32a3863062d77ff32785d58MD51icict/566162023-03-15 14:32:50.518oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:32:50Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.en_US.fl_str_mv |
Cytotoxicity and lipase inhibition of essential oils from amazon annonaceae species |
| title |
Cytotoxicity and lipase inhibition of essential oils from amazon annonaceae species |
| spellingShingle |
Cytotoxicity and lipase inhibition of essential oils from amazon annonaceae species Barros, André de Lima Annonaceae Óleos essenciais Bocageopsis Onychopetalum Lipase Câncer Annonaceae Essential oils Bocageopsis Onychopetalum Lipase Cancer Annonaceae Óleos Voláteis Lipase Neoplasias |
| title_short |
Cytotoxicity and lipase inhibition of essential oils from amazon annonaceae species |
| title_full |
Cytotoxicity and lipase inhibition of essential oils from amazon annonaceae species |
| title_fullStr |
Cytotoxicity and lipase inhibition of essential oils from amazon annonaceae species |
| title_full_unstemmed |
Cytotoxicity and lipase inhibition of essential oils from amazon annonaceae species |
| title_sort |
Cytotoxicity and lipase inhibition of essential oils from amazon annonaceae species |
| author |
Barros, André de Lima |
| author_facet |
Barros, André de Lima Lima, Emilly J. S. P. de Faria, Jéssica V. Acho, Leonard R. D. Lima, Emerson S. Bezerra, Daniel P. Soares, Elzalina R. Lima, Bruna R. de Costa, Emmanoel V. Pinheiro, Maria Lúcia B. Bataglion, Giovana A. Silva, Felipe M. A. da Cardozo, Nállaret M. Dávila Gonçalves, José F. C. Koolen, Hector H. F. |
| author_role |
author |
| author2 |
Lima, Emilly J. S. P. de Faria, Jéssica V. Acho, Leonard R. D. Lima, Emerson S. Bezerra, Daniel P. Soares, Elzalina R. Lima, Bruna R. de Costa, Emmanoel V. Pinheiro, Maria Lúcia B. Bataglion, Giovana A. Silva, Felipe M. A. da Cardozo, Nállaret M. Dávila Gonçalves, José F. C. Koolen, Hector H. F. |
| author2_role |
author author author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Barros, André de Lima Lima, Emilly J. S. P. de Faria, Jéssica V. Acho, Leonard R. D. Lima, Emerson S. Bezerra, Daniel P. Soares, Elzalina R. Lima, Bruna R. de Costa, Emmanoel V. Pinheiro, Maria Lúcia B. Bataglion, Giovana A. Silva, Felipe M. A. da Cardozo, Nállaret M. Dávila Gonçalves, José F. C. Koolen, Hector H. F. |
| dc.subject.other.en_US.fl_str_mv |
Annonaceae Óleos essenciais Bocageopsis Onychopetalum Lipase Câncer |
| topic |
Annonaceae Óleos essenciais Bocageopsis Onychopetalum Lipase Câncer Annonaceae Essential oils Bocageopsis Onychopetalum Lipase Cancer Annonaceae Óleos Voláteis Lipase Neoplasias |
| dc.subject.en.en_US.fl_str_mv |
Annonaceae Essential oils Bocageopsis Onychopetalum Lipase Cancer |
| dc.subject.decs.en_US.fl_str_mv |
Annonaceae Óleos Voláteis Lipase Neoplasias |
| description |
Fundação de Amparo à Pesquisa do Estado do Amazonas (FAPEAM). Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES). |
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2022 |
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2022 |
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2023-01-25T18:08:48Z |
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2023-01-25T18:08:48Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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BARROS, André de Lima et al. Cytotoxicity and lipase inhibition of essential oils from amazon annonaceae species. Chemistry, v. 4, p. 1-18, 2022 |
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https://www.arca.fiocruz.br/handle/icict/56616 |
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2624-8549 |
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10.3390/chemistry4040081 |
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BARROS, André de Lima et al. Cytotoxicity and lipase inhibition of essential oils from amazon annonaceae species. Chemistry, v. 4, p. 1-18, 2022 2624-8549 10.3390/chemistry4040081 |
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MDPI |
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