In silico and in vitro arboviral MHC class I-restricted-epitope signatures reveal immunodominance and poor overlapping patterns

Ribeiro, Ágata Lopes; Araujo, Franklin Pereira; Oliveira, Patrícia de Melo; Teixeira, Lorena de Almeida; Ferreira, Geovane Marques; Lourenço, Alice Aparecida; Dias, Laura Cardoso Corrêa; Teixeira, Caio Wilker; Retes, Henrique Morais; Lopes, Élisson Nogueira; Versiani, Alice Freitas; Stancioli, Edel Figueiredo Barbosa; Fonseca, Flávio Guimarães da; Martins Filho, Olindo Assis; Tsuji, Moriya; Pascoal, Vanessa Peruhype Magalhães; Reis, Jordana Grazziela Alves Coelho-dos

In silico and in vitro arboviral MHC class I-restricted-epitope signatures reveal immunodominance and poor overlapping patterns

Detalhes bibliográficos
Autor(a) principal:	Ribeiro, Ágata Lopes
Data de Publicação:	2022
Outros Autores:	Araujo, Franklin Pereira, Oliveira, Patrícia de Melo, Teixeira, Lorena de Almeida, Ferreira, Geovane Marques, Lourenço, Alice Aparecida, Dias, Laura Cardoso Corrêa, Teixeira, Caio Wilker, Retes, Henrique Morais, Lopes, Élisson Nogueira, Versiani, Alice Freitas, Stancioli, Edel Figueiredo Barbosa, Fonseca, Flávio Guimarães da, Martins Filho, Olindo Assis, Tsuji, Moriya, Pascoal, Vanessa Peruhype Magalhães, Reis, Jordana Grazziela Alves Coelho-dos
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/56522
Resumo:	Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Laboratório de Virologia Básica e Aplicada. Belo Horizonte, MG, Brazil/Fundação Oswaldo Cruz. Instituto René Rachou. Grupo Integrado de Pesquisas em Biomarcadores. Belo Horizonte, MG, Brazil

Metadados do item

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network_name_str	Repositório Institucional da FIOCRUZ (ARCA)
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spelling	Ribeiro, Ágata LopesAraujo, Franklin PereiraOliveira, Patrícia de MeloTeixeira, Lorena de AlmeidaFerreira, Geovane MarquesLourenço, Alice AparecidaDias, Laura Cardoso CorrêaTeixeira, Caio WilkerRetes, Henrique MoraisLopes, Élisson NogueiraVersiani, Alice FreitasStancioli, Edel Figueiredo BarbosaFonseca, Flávio Guimarães daMartins Filho, Olindo AssisTsuji, MoriyaPascoal, Vanessa Peruhype MagalhãesReis, Jordana Grazziela Alves Coelho-dos2023-01-19T16:28:43Z2023-01-19T16:28:43Z2022RIBEIRO, Ágata Lopes et al. In silico and in vitro arboviral MHC class I-restricted-epitope signatures reveal immunodominance and poor overlapping patterns. Front Immunol., v. 13, 1035515, 2022. doi: 10.3389/fimmu.2022.1035515.1664-3224https://www.arca.fiocruz.br/handle/icict/56522engFrontiers Research FoundationIn silico and in vitro arboviral MHC class I-restricted-epitope signatures reveal immunodominance and poor overlapping patternsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Laboratório de Virologia Básica e Aplicada. Belo Horizonte, MG, Brazil/Fundação Oswaldo Cruz. Instituto René Rachou. Grupo Integrado de Pesquisas em Biomarcadores. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Laboratório de Virologia Básica e Aplicada. Belo Horizonte, MG, Brazil/Fundação Oswaldo Cruz. Instituto René Rachou. Grupo Integrado de Pesquisas em Biomarcadores. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Laboratório de Virologia Básica e Aplicada. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Laboratório de Virologia Básica e Aplicada. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Laboratório de Virologia Básica e Aplicada. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Laboratório de Virologia Básica e Aplicada. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Laboratório de Virologia Básica e Aplicada. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Laboratório de Virologia Básica e Aplicada. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Laboratório de Virologia Básica e Aplicada. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Instituto de Ciências Biológicas. Departamento de Genética. Laboratorio de Genética Celular e Molecular. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Laboratório de Virologia Básica e Aplicada. Belo Horizonte, MG, Brazil/ Department of Pathology da University of Texas Medical Branch. Galveston, TX, United StatesUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Laboratório de Virologia Básica e Aplicada. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Laboratório de Virologia Básica e Aplicada. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Instituto René Rachou. Grupo Integrado de Pesquisas em Biomarcadores. Belo Horizonte, MG, BrazilAaron Diamond AIDS Research Center. Irving Medical School. Columbia University. New York City, NY, United StatesFundação Oswaldo Cruz. Instituto René Rachou. Grupo Integrado de Pesquisas em Biomarcadores. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Laboratório de Virologia Básica e Aplicada. Belo Horizonte, MG, Brazil/Fundação Oswaldo Cruz. Instituto René Rachou. Grupo Integrado de Pesquisas em Biomarcadores. Belo Horizonte, MG, BrazilIntroduction: The present work sought to identify MHC-I-restricted peptide signatures for arbovirus using in silico and in vitro peptide microarray tools. Methods: First, an in-silico analysis of immunogenic epitopes restricted to four of the most prevalent human MHC class-I was performed by identification of MHC affinity score. For that, more than 10,000 peptide sequences from 5 Arbovirus and 8 different viral serotypes, namely Zika (ZIKV), Dengue (DENV serotypes 1-4), Chikungunya (CHIKV), Mayaro (MAYV) and Oropouche (OROV) viruses, in addition to YFV were analyzed. Haplotype HLA-A02.01 was the dominant human MHC for all arboviruses. Over one thousand HLA-A2 immunogenic peptides were employed to build a comprehensive identity matrix. Intending to assess HLAA02:01 reactivity of peptides in vitro, a peptide microarray was designed and generated using a dimeric protein containing HLA-A02:01. Results: The comprehensive identity matrix allowed the identification of only three overlapping peptides between two or more flavivirus sequences, suggesting poor overlapping of virus-specific immunogenic peptides amongst arborviruses. Global analysis of the fluorescence intensity for peptide-HLA-A02:01 binding indicated a dose-dependent effect in the array. Considering all assessed arboviruses, the number of DENV-derived peptides with HLA-A02:01 reactivity was the highest. Furthermore, a lower number of YFV-17DD overlapping peptides presented reactivity when compared to non-overlapping peptides. In addition, the assessment of HLA-A02:01-reactive peptides across virus polyproteins highlighted non-structural proteins as "hot-spots". Data analysis supported these findings showing the presence of major hydrophobic sites in the final segment of non-structural protein 1 throughout 2a (Ns2a) and in nonstructural proteins 2b (Ns2b), 4a (Ns4a) and 4b (Ns4b). Discussion: To our knowledge, these results provide the most comprehensive and detailed snapshot of the immunodominant peptide signature for arbovirus with MHC-class I restriction, which may bring insight into the design of future virus-specific vaccines to arboviruses and for vaccination protocols in highly endemic areas.CD8+T cell responseHLA-A2-restricted peptidesMHC-I peptidesarbovirusimmunoinformaticsoverlapping peptidesinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALIn silico and in vitro arboviral MHC class I-restricted-epitope.pdfIn silico and in vitro arboviral MHC class I-restricted-epitope.pdfapplication/pdf12536086https://www.arca.fiocruz.br/bitstream/icict/56522/2/In%20silico%20and%20in%20vitro%20arboviral%20MHC%20class%20I-restricted-epitope.pdfb6d9fede278d3c23ee8aa1e0dc0b11deMD52LICENSElicense.txtlicense.txttext/plain; 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dc.title.en_US.fl_str_mv	In silico and in vitro arboviral MHC class I-restricted-epitope signatures reveal immunodominance and poor overlapping patterns
title	In silico and in vitro arboviral MHC class I-restricted-epitope signatures reveal immunodominance and poor overlapping patterns
spellingShingle	In silico and in vitro arboviral MHC class I-restricted-epitope signatures reveal immunodominance and poor overlapping patterns Ribeiro, Ágata Lopes CD8+T cell response HLA-A2-restricted peptides MHC-I peptides arbovirus immunoinformatics overlapping peptides
title_short	In silico and in vitro arboviral MHC class I-restricted-epitope signatures reveal immunodominance and poor overlapping patterns
title_full	In silico and in vitro arboviral MHC class I-restricted-epitope signatures reveal immunodominance and poor overlapping patterns
title_fullStr	In silico and in vitro arboviral MHC class I-restricted-epitope signatures reveal immunodominance and poor overlapping patterns
title_full_unstemmed	In silico and in vitro arboviral MHC class I-restricted-epitope signatures reveal immunodominance and poor overlapping patterns
title_sort	In silico and in vitro arboviral MHC class I-restricted-epitope signatures reveal immunodominance and poor overlapping patterns
author	Ribeiro, Ágata Lopes
author_facet	Ribeiro, Ágata Lopes Araujo, Franklin Pereira Oliveira, Patrícia de Melo Teixeira, Lorena de Almeida Ferreira, Geovane Marques Lourenço, Alice Aparecida Dias, Laura Cardoso Corrêa Teixeira, Caio Wilker Retes, Henrique Morais Lopes, Élisson Nogueira Versiani, Alice Freitas Stancioli, Edel Figueiredo Barbosa Fonseca, Flávio Guimarães da Martins Filho, Olindo Assis Tsuji, Moriya Pascoal, Vanessa Peruhype Magalhães Reis, Jordana Grazziela Alves Coelho-dos
author_role	author
author2	Araujo, Franklin Pereira Oliveira, Patrícia de Melo Teixeira, Lorena de Almeida Ferreira, Geovane Marques Lourenço, Alice Aparecida Dias, Laura Cardoso Corrêa Teixeira, Caio Wilker Retes, Henrique Morais Lopes, Élisson Nogueira Versiani, Alice Freitas Stancioli, Edel Figueiredo Barbosa Fonseca, Flávio Guimarães da Martins Filho, Olindo Assis Tsuji, Moriya Pascoal, Vanessa Peruhype Magalhães Reis, Jordana Grazziela Alves Coelho-dos
author2_role	author author author author author author author author author author author author author author author author
dc.contributor.author.fl_str_mv	Ribeiro, Ágata Lopes Araujo, Franklin Pereira Oliveira, Patrícia de Melo Teixeira, Lorena de Almeida Ferreira, Geovane Marques Lourenço, Alice Aparecida Dias, Laura Cardoso Corrêa Teixeira, Caio Wilker Retes, Henrique Morais Lopes, Élisson Nogueira Versiani, Alice Freitas Stancioli, Edel Figueiredo Barbosa Fonseca, Flávio Guimarães da Martins Filho, Olindo Assis Tsuji, Moriya Pascoal, Vanessa Peruhype Magalhães Reis, Jordana Grazziela Alves Coelho-dos
dc.subject.en.en_US.fl_str_mv	CD8+T cell response HLA-A2-restricted peptides MHC-I peptides arbovirus immunoinformatics overlapping peptides
topic	CD8+T cell response HLA-A2-restricted peptides MHC-I peptides arbovirus immunoinformatics overlapping peptides
description	Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Departamento de Microbiologia. Laboratório de Virologia Básica e Aplicada. Belo Horizonte, MG, Brazil/Fundação Oswaldo Cruz. Instituto René Rachou. Grupo Integrado de Pesquisas em Biomarcadores. Belo Horizonte, MG, Brazil
publishDate	2022
dc.date.issued.fl_str_mv	2022
dc.date.accessioned.fl_str_mv	2023-01-19T16:28:43Z
dc.date.available.fl_str_mv	2023-01-19T16:28:43Z
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	RIBEIRO, Ágata Lopes et al. In silico and in vitro arboviral MHC class I-restricted-epitope signatures reveal immunodominance and poor overlapping patterns. Front Immunol., v. 13, 1035515, 2022. doi: 10.3389/fimmu.2022.1035515.
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/56522
dc.identifier.issn.en_US.fl_str_mv	1664-3224
identifier_str_mv	RIBEIRO, Ágata Lopes et al. In silico and in vitro arboviral MHC class I-restricted-epitope signatures reveal immunodominance and poor overlapping patterns. Front Immunol., v. 13, 1035515, 2022. doi: 10.3389/fimmu.2022.1035515. 1664-3224
url	https://www.arca.fiocruz.br/handle/icict/56522
dc.language.iso.fl_str_mv	eng
language	eng
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	Frontiers Research Foundation
publisher.none.fl_str_mv	Frontiers Research Foundation
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
instname_str	Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str	FIOCRUZ
institution	FIOCRUZ
reponame_str	Repositório Institucional da FIOCRUZ (ARCA)
collection	Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv	https://www.arca.fiocruz.br/bitstream/icict/56522/2/In%20silico%20and%20in%20vitro%20arboviral%20MHC%20class%20I-restricted-epitope.pdf https://www.arca.fiocruz.br/bitstream/icict/56522/1/license.txt
bitstream.checksum.fl_str_mv	b6d9fede278d3c23ee8aa1e0dc0b11de 5a560609d32a3863062d77ff32785d58
bitstream.checksumAlgorithm.fl_str_mv	MD5 MD5
repository.name.fl_str_mv	Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv	repositorio.arca@fiocruz.br
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In silico and in vitro arboviral MHC class I-restricted-epitope signatures reveal immunodominance and poor overlapping patterns

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