Lung granulomas from Mycobacterium tuberculosis/HIV-1 co-infected patients display decreased in situ TNF production.

Detalhes bibliográficos
Autor(a) principal: Noronha, Almério Libório Lopes de
Data de Publicação: 2008
Outros Autores: Bafica, Andre Luiz Barbosa, Nogueira, Lucas L, Barral, Aldina Maria Prado, Barral Netto, Manoel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/7402
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil
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spelling Noronha, Almério Libório Lopes deBafica, Andre Luiz BarbosaNogueira, Lucas LBarral, Aldina Maria PradoBarral Netto, Manoel2014-03-13T14:01:44Z2014-03-13T14:01:44Z2008NORONHA, A. L. L. de Lung granulomas from Mycobacterium tuberculosis/HIV-1 co-infected patients display decreased in situ TNF production. Pathology, Research and Practice, v. 204, p. 155–161, 2008.0344-033810.1016/j.prp.2007.10.008https://www.arca.fiocruz.br/handle/icict/7402engElsevierLung granulomas from Mycobacterium tuberculosis/HIV-1 co-infected patients display decreased in situ TNF production.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, BrasilFederal University of Santa Catarina. Division of Immunology, Microbiology and Parasitology Departament. Florianópolis, SC, BRasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, BrasilTuberculosis/HIV-1 co-infection is responsible for thousands of deaths each year, and previous studies have reported that co-infected individuals display major morphological alterations in tissue granulomas. The purpose of this study was to evaluate immunohistopathological characteristics in lung tissues from pulmonary TB/HIV-1-co-infected individuals. Following autopsy, tuberculosis-positive HIV-1-negative cases displayed granulomas with normal architecture, mainly composed of a mononuclear infiltrate with typical epithelioid, as well as giant cells, and exhibiting caseous necrosis. In contrast, lesions from the TB/HIV-1-co-infected group showed extensive necrosis, poorly formed granulomas, and a marked presence of polymorphonuclear cells. More importantly, TNF staining was greatly reduced in the TB/HIV-1-co-infected individuals. Our data suggest that HIV-1 infection alters the organization of pulmonary granulomas by modulating TNF and, possibly, cell trafficking, leading to an impaired anti-tuberculosis response.Mycobacterium tuberculosisAutopsyGranulomaHIVTNFGranuloma do Sistema Respiratório/imunologiaInfecções por HIV/complicaçõesPulmão/imunologiaTuberculose Pulmonar/complicaçõesFator de Necrose Tumoral alfa/biossínteseInfecções Oportunistas Relacionadas com a AIDS/imunologiaInfecções Oportunistas Relacionadas com a AIDS/patologiaGranuloma do Sistema Respiratório/microbiologiaGranuloma do Sistema Respiratório/patologiaInfecções Oportunistas Relacionadas com a AIDS/imunologiaInfecções por HIV/patologiaHIV-IHumanosPulmão/microbiologiaPulmão/patologiaMycobacterium tuberculosisTuberculose Pulmonar/imunologiaTuberculose Pulmonar/patologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALNoronha A Lung gramulomas....pdfNoronha A Lung gramulomas....pdfapplication/pdf1241291https://www.arca.fiocruz.br/bitstream/icict/7402/1/Noronha%20A%20Lung%20gramulomas....pdf0c8fb78284e08bfc7c166f805429a8b1MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7402/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTNoronha A Lung gramulomas....pdf.txtNoronha A Lung gramulomas....pdf.txtExtracted texttext/plain25185https://www.arca.fiocruz.br/bitstream/icict/7402/5/Noronha%20A%20Lung%20gramulomas....pdf.txt5a86affabe5ef52606485ecae9400762MD55THUMBNAILNoronha A Lung gramulomas....pdf.jpgNoronha A Lung gramulomas....pdf.jpgGenerated Thumbnailimage/jpeg2181https://www.arca.fiocruz.br/bitstream/icict/7402/4/Noronha%20A%20Lung%20gramulomas....pdf.jpg4ee94ee66e44cadf5d0e25a3a154a9a7MD54icict/74022023-03-15 14:33:26.144oai:www.arca.fiocruz.br:icict/7402TElDRU7Dh0EgREUgRElTVFJJQlVJw4fDg08gTsODTy1FWENMVVNJVkEKCkFvIGNvbmNvcmRhciBlIGFjZWl0YXIgZXN0YSBsaWNlbsOnYSB2b2PDqiAoYXV0b3Igb3UgZGV0ZW50b3IgZG9zIGRpcmVpdG9zIGF1dG9yYWlzKToKCmEpIERlY2xhcmEgcXVlIGNvbmhlY2UgYSBwb2zDrXRpY2EgZGUgY29weXJpZ2h0IGRhIGVkaXRvcmEgZG8gc2V1IGRvY3VtZW50by4KCmIpIERlY2xhcmEgcXVlIGNvbmhlY2UgZSBhY2VpdGEgYXMgRGlyZXRyaXplcyBwYXJhIG8gUmVwb3NpdMOzcmlvIEluc3RpdHVjaW9uYWwgZGEgRnVuZGHDp8OjbyBPc3dhbGRvIENydXogKEZJT0NSVVopLgoKYykgQ29uY2VkZSDDoCBGSU9DUlVaIG8gZGlyZWl0byBuw6NvLWV4Y2x1c2l2byBkZSBhcnF1aXZhciwgcmVwcm9kdXppciwgY29udmVydGVyIChjb21vIGRlZmluaWRvIGEgc2VndWlyKSwgY29tdW5pY2FyCiAKZS9vdSBkaXN0cmlidWlyIG5vIFJlcG9zaXTDs3JpbyBkYSBGSU9DUlVaLCBvIGRvY3VtZW50byBlbnRyZWd1ZSAoaW5jbHVpbmRvIG8gcmVzdW1vL2Fic3RyYWN0KSBlbSBmb3JtYXRvIGRpZ2l0YWwgb3UgCgpwb3IgcXVhbHF1ZXIgb3V0cm8gbWVpby4KCmQpIERlY2xhcmEgcXVlIGF1dG9yaXphIGEgRklPQ1JVWiBhIGFycXVpdmFyIG1haXMgZGUgdW1hIGPDs3BpYSBkZXN0ZSBkb2N1bWVudG8gZSBjb252ZXJ0w6otbG8sIHNlbSBhbHRlcmFyIG8gc2V1IGNvbnRlw7pkbywgCgpwYXJhIHF1YWxxdWVyIGZvcm1hdG8gZGUgYXJxdWl2bywgbWVpbyBvdSBzdXBvcnRlLCBwYXJhIGVmZWl0b3MgZGUgc2VndXJhbsOnYSwgcHJlc2VydmHDp8OjbyAoYmFja3VwKSBlIGFjZXNzby4KCmUpIERlY2xhcmEgcXVlIG8gZG9jdW1lbnRvIHN1Ym1ldGlkbyDDqSBvIHNldSB0cmFiYWxobyBvcmlnaW5hbCwgZSBxdWUgZGV0w6ltIG8gZGlyZWl0byBkZSBjb25jZWRlciBhIHRlcmNlaXJvcyBvcyBkaXJlaXRvcyAKCmNvbnRpZG9zIG5lc3RhIGxpY2Vuw6dhLiBEZWNsYXJhIHRhbWLDqW0gcXVlIGEgZW50cmVnYSBkbyBkb2N1bWVudG8gbsOjbyBpbmZyaW5nZSBvcyBkaXJlaXRvcyBkZSBxdWFscXVlciBvdXRyYSBwZXNzb2Egb3UgZW50aWRhZGUuCgpmKSBEZWNsYXJhIHF1ZSwgbm8gY2FzbyBkbyBkb2N1bWVudG8gc3VibWV0aWRvIGNvbnRlciBtYXRlcmlhbCBkbyBxdWFsIG7Do28gZGV0w6ltIG9zIGRpcmVpdG9zIGRlIGF1dG9yLCBvYnRldmUgYSBhdXRvcml6YcOnw6NvIAoKaXJyZXN0cml0YSBkbyByZXNwZWN0aXZvIGRldGVudG9yIGRlc3NlcyBkaXJlaXRvcywgcGFyYSBjZWRlciBhIEZJT0NSVVogb3MgZGlyZWl0b3MgcmVxdWVyaWRvcyBwb3IgZXN0YSBMaWNlbsOnYSBlIGF1dG9yaXphciBhIAoKdXRpbGl6w6EtbG9zIGxlZ2FsbWVudGUuIERlY2xhcmEgdGFtYsOpbSBxdWUgZXNzZSBtYXRlcmlhbCBjdWpvcyBkaXJlaXRvcyBzw6NvIGRlIHRlcmNlaXJvcyBlc3TDoSBjbGFyYW1lbnRlIGlkZW50aWZpY2FkbyBlIHJlY29uaGVjaWRvIAoKbm8gdGV4dG8gb3UgY29udGXDumRvIGRvIGRvY3VtZW50byBlbnRyZWd1ZS4KCmcpIFNFIE8gRE9DVU1FTlRPIEVOVFJFR1VFIMOJIEJBU0VBRE8gRU0gVFJBQkFMSE8gRklOQU5DSUFETyBPVSBBUE9JQURPIFBPUiBPVVRSQSBJTlNUSVRVScOHw4NPIFFVRSBOw4NPIEEgRklPQ1JVWiwgREVDTEFSQSBRVUUgQ1VNUFJJVSAKClFVQUlTUVVFUiBPQlJJR0HDh8OVRVMgRVhJR0lEQVMgUEVMTyBSRVNQRUNUSVZPIENPTlRSQVRPIE9VIEFDT1JETy4gQSBGSU9DUlVaIGlkZW50aWZpY2Fyw6EgY2xhcmFtZW50ZSBvKHMpIG5vbWUocykgZG8ocykgYXV0b3IoZXMpIGRvcyAKCmRpcmVpdG9zIGRvIGRvY3VtZW50byBlbnRyZWd1ZSBlIG7Do28gZmFyw6EgcXVhbHF1ZXIgYWx0ZXJhw6fDo28sIHBhcmEgYWzDqW0gZG8gcHJldmlzdG8gbmEgYWzDrW5lYSBjKS4KRepositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:26Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Lung granulomas from Mycobacterium tuberculosis/HIV-1 co-infected patients display decreased in situ TNF production.
title Lung granulomas from Mycobacterium tuberculosis/HIV-1 co-infected patients display decreased in situ TNF production.
spellingShingle Lung granulomas from Mycobacterium tuberculosis/HIV-1 co-infected patients display decreased in situ TNF production.
Noronha, Almério Libório Lopes de
Mycobacterium tuberculosis
Autopsy
Granuloma
HIV
TNF
Granuloma do Sistema Respiratório/imunologia
Infecções por HIV/complicações
Pulmão/imunologia
Tuberculose Pulmonar/complicações
Fator de Necrose Tumoral alfa/biossíntese
Infecções Oportunistas Relacionadas com a AIDS/imunologia
Infecções Oportunistas Relacionadas com a AIDS/patologia
Granuloma do Sistema Respiratório/microbiologia
Granuloma do Sistema Respiratório/patologia
Infecções Oportunistas Relacionadas com a AIDS/imunologia
Infecções por HIV/patologia
HIV-I
Humanos
Pulmão/microbiologia
Pulmão/patologia
Mycobacterium tuberculosis
Tuberculose Pulmonar/imunologia
Tuberculose Pulmonar/patologia
title_short Lung granulomas from Mycobacterium tuberculosis/HIV-1 co-infected patients display decreased in situ TNF production.
title_full Lung granulomas from Mycobacterium tuberculosis/HIV-1 co-infected patients display decreased in situ TNF production.
title_fullStr Lung granulomas from Mycobacterium tuberculosis/HIV-1 co-infected patients display decreased in situ TNF production.
title_full_unstemmed Lung granulomas from Mycobacterium tuberculosis/HIV-1 co-infected patients display decreased in situ TNF production.
title_sort Lung granulomas from Mycobacterium tuberculosis/HIV-1 co-infected patients display decreased in situ TNF production.
author Noronha, Almério Libório Lopes de
author_facet Noronha, Almério Libório Lopes de
Bafica, Andre Luiz Barbosa
Nogueira, Lucas L
Barral, Aldina Maria Prado
Barral Netto, Manoel
author_role author
author2 Bafica, Andre Luiz Barbosa
Nogueira, Lucas L
Barral, Aldina Maria Prado
Barral Netto, Manoel
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Noronha, Almério Libório Lopes de
Bafica, Andre Luiz Barbosa
Nogueira, Lucas L
Barral, Aldina Maria Prado
Barral Netto, Manoel
dc.subject.en.pt_BR.fl_str_mv Mycobacterium tuberculosis
Autopsy
Granuloma
HIV
TNF
topic Mycobacterium tuberculosis
Autopsy
Granuloma
HIV
TNF
Granuloma do Sistema Respiratório/imunologia
Infecções por HIV/complicações
Pulmão/imunologia
Tuberculose Pulmonar/complicações
Fator de Necrose Tumoral alfa/biossíntese
Infecções Oportunistas Relacionadas com a AIDS/imunologia
Infecções Oportunistas Relacionadas com a AIDS/patologia
Granuloma do Sistema Respiratório/microbiologia
Granuloma do Sistema Respiratório/patologia
Infecções Oportunistas Relacionadas com a AIDS/imunologia
Infecções por HIV/patologia
HIV-I
Humanos
Pulmão/microbiologia
Pulmão/patologia
Mycobacterium tuberculosis
Tuberculose Pulmonar/imunologia
Tuberculose Pulmonar/patologia
dc.subject.decs.pt_BR.fl_str_mv Granuloma do Sistema Respiratório/imunologia
Infecções por HIV/complicações
Pulmão/imunologia
Tuberculose Pulmonar/complicações
Fator de Necrose Tumoral alfa/biossíntese
Infecções Oportunistas Relacionadas com a AIDS/imunologia
Infecções Oportunistas Relacionadas com a AIDS/patologia
Granuloma do Sistema Respiratório/microbiologia
Granuloma do Sistema Respiratório/patologia
Infecções Oportunistas Relacionadas com a AIDS/imunologia
Infecções por HIV/patologia
HIV-I
Humanos
Pulmão/microbiologia
Pulmão/patologia
Mycobacterium tuberculosis
Tuberculose Pulmonar/imunologia
Tuberculose Pulmonar/patologia
description Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil
publishDate 2008
dc.date.issued.fl_str_mv 2008
dc.date.accessioned.fl_str_mv 2014-03-13T14:01:44Z
dc.date.available.fl_str_mv 2014-03-13T14:01:44Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv NORONHA, A. L. L. de Lung granulomas from Mycobacterium tuberculosis/HIV-1 co-infected patients display decreased in situ TNF production. Pathology, Research and Practice, v. 204, p. 155–161, 2008.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/7402
dc.identifier.issn.none.fl_str_mv 0344-0338
10.1016/j.prp.2007.10.008
identifier_str_mv NORONHA, A. L. L. de Lung granulomas from Mycobacterium tuberculosis/HIV-1 co-infected patients display decreased in situ TNF production. Pathology, Research and Practice, v. 204, p. 155–161, 2008.
0344-0338
10.1016/j.prp.2007.10.008
url https://www.arca.fiocruz.br/handle/icict/7402
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dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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