Lung granulomas from Mycobacterium tuberculosis/HIV-1 co-infected patients display decreased in situ TNF production

Detalhes bibliográficos
Autor(a) principal: Noronha, Almério Libório Lopes de
Data de Publicação: 2008
Outros Autores: Báfica, Andre Luiz Barbosa, Nogueira, Lucas, Barral, Aldina Maria Prado, Barral-Netto, Manoel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/14266
Resumo: Texto completo: acesso restrito. p. 155-161
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spelling Noronha, Almério Libório Lopes deBáfica, Andre Luiz BarbosaNogueira, LucasBarral, Aldina Maria PradoBarral-Netto, ManoelNoronha, Almério Libório Lopes deBáfica, Andre Luiz BarbosaNogueira, LucasBarral, Aldina Maria PradoBarral-Netto, Manoel2014-01-06T13:12:10Z20080344-0338http://repositorio.ufba.br/ri/handle/ri/14266v. 204, n. 3Texto completo: acesso restrito. p. 155-161Tuberculosis/HIV-1 co-infection is responsible for thousands of deaths each year, and previous studies have reported that co-infected individuals display major morphological alterations in tissue granulomas. The purpose of this study was to evaluate immunohistopathological characteristics in lung tissues from pulmonary TB/HIV-1-co-infected individuals. Following autopsy, tuberculosis-positive HIV-1-negative cases displayed granulomas with normal architecture, mainly composed of a mononuclear infiltrate with typical epithelioid, as well as giant cells, and exhibiting caseous necrosis. In contrast, lesions from the TB/HIV-1-co-infected group showed extensive necrosis, poorly formed granulomas, and a marked presence of polymorphonuclear cells. More importantly, TNF staining was greatly reduced in the TB/HIV-1-co-infected individuals. Our data suggest that HIV-1 infection alters the organization of pulmonary granulomas by modulating TNF and, possibly, cell trafficking, leading to an impaired anti-tuberculosis response.Submitted by Suelen Reis (suziy.ellen@gmail.com) on 2013-12-16T12:38:14Z No. of bitstreams: 1 1-s2.0-S0344033807002464-main.pdf: 1241291 bytes, checksum: 0c8fb78284e08bfc7c166f805429a8b1 (MD5)Approved for entry into archive by Flávia Ferreira (flaviaccf@yahoo.com.br) on 2014-01-06T13:12:10Z (GMT) No. of bitstreams: 1 1-s2.0-S0344033807002464-main.pdf: 1241291 bytes, checksum: 0c8fb78284e08bfc7c166f805429a8b1 (MD5)Made available in DSpace on 2014-01-06T13:12:10Z (GMT). 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dc.title.pt_BR.fl_str_mv Lung granulomas from Mycobacterium tuberculosis/HIV-1 co-infected patients display decreased in situ TNF production
dc.title.alternative.pt_BR.fl_str_mv Pathology - Research and Practice
title Lung granulomas from Mycobacterium tuberculosis/HIV-1 co-infected patients display decreased in situ TNF production
spellingShingle Lung granulomas from Mycobacterium tuberculosis/HIV-1 co-infected patients display decreased in situ TNF production
Noronha, Almério Libório Lopes de
Mycobacterium tuberculosis
Autopsy
Granuloma
HIV
TNF
title_short Lung granulomas from Mycobacterium tuberculosis/HIV-1 co-infected patients display decreased in situ TNF production
title_full Lung granulomas from Mycobacterium tuberculosis/HIV-1 co-infected patients display decreased in situ TNF production
title_fullStr Lung granulomas from Mycobacterium tuberculosis/HIV-1 co-infected patients display decreased in situ TNF production
title_full_unstemmed Lung granulomas from Mycobacterium tuberculosis/HIV-1 co-infected patients display decreased in situ TNF production
title_sort Lung granulomas from Mycobacterium tuberculosis/HIV-1 co-infected patients display decreased in situ TNF production
author Noronha, Almério Libório Lopes de
author_facet Noronha, Almério Libório Lopes de
Báfica, Andre Luiz Barbosa
Nogueira, Lucas
Barral, Aldina Maria Prado
Barral-Netto, Manoel
author_role author
author2 Báfica, Andre Luiz Barbosa
Nogueira, Lucas
Barral, Aldina Maria Prado
Barral-Netto, Manoel
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Noronha, Almério Libório Lopes de
Báfica, Andre Luiz Barbosa
Nogueira, Lucas
Barral, Aldina Maria Prado
Barral-Netto, Manoel
Noronha, Almério Libório Lopes de
Báfica, Andre Luiz Barbosa
Nogueira, Lucas
Barral, Aldina Maria Prado
Barral-Netto, Manoel
dc.subject.por.fl_str_mv Mycobacterium tuberculosis
Autopsy
Granuloma
HIV
TNF
topic Mycobacterium tuberculosis
Autopsy
Granuloma
HIV
TNF
description Texto completo: acesso restrito. p. 155-161
publishDate 2008
dc.date.issued.fl_str_mv 2008
dc.date.accessioned.fl_str_mv 2014-01-06T13:12:10Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/14266
dc.identifier.issn.none.fl_str_mv 0344-0338
dc.identifier.number.pt_BR.fl_str_mv v. 204, n. 3
identifier_str_mv 0344-0338
v. 204, n. 3
url http://repositorio.ufba.br/ri/handle/ri/14266
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org/10.1016/j.prp.2007.10.008
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
instname:Universidade Federal da Bahia (UFBA)
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instname_str Universidade Federal da Bahia (UFBA)
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reponame_str Repositório Institucional da UFBA
collection Repositório Institucional da UFBA
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