Effect of a conditional cash transfer programme on leprosy treatment adherence and cure in patients from the nationwide 100 million Brazilian cohort: a quasi-experimental study
| Autor(a) principal: | |
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| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/41357 |
Resumo: | Artigo encontra-se em acesso aberto no site do Editor. |
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Pescarini, Júlia MoreiraWilliamson, ElizabethNery, Joilda SilvaRamond, AnnaIchihara, Maria Yury TravassosFiaccone, Rosemeire LeovigildoPenna, Maria Lucia FernandesSmeeth, LiamRodrigues, Laura CunhaPenna, Gerson OliveiraBrickley, Elizabeth B.Barreto, Maurício Lima2020-05-22T13:32:09Z2020-05-22T13:32:09Z2020PESCARINI, Júlia Moreira et al. Effect of a conditional cash transfer programme on leprosy treatment adherence and cure in patients from the nationwide 100 million Brazilian cohort: a quasi-experimental study. The Lancet Infectious Diseases, [London], v. 20, n. 5, p. 618-627, Feb. 2020.1473-3099https://www.arca.fiocruz.br/handle/icict/4135710.1016/S1473-3099(19)30624-3Artigo encontra-se em acesso aberto no site do Editor.CONFAP/ESRC/MRC/BBSRC/CNPq/FAPDF/CAPES/UK Medical Research CouncilFundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.London School of Hygiene & Tropical Medicine. Department of Medical Statistics. London, United Kingdom.Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil.London School of Hygiene & Tropical Medicine. Department of Infectious Disease Epidemiology. London, United Kingdom.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Universidade Federal Fluminense. Instituto de Saúde da Comunidade. Niterói, RJ, Brasil.London School of Hygiene & Tropical Medicine. Department of Non-communicable Disease Epidemiology. London, United Kingdom.London School of Hygiene & Tropical Medicine. Department of Infectious Disease Epidemiology. London, United Kingdom.Universidade de Brasília. Faculdade de Medicina. Núcleo de Medicina Tropical. Brasília, DF, Brasil / Fundação Oswaldo Cruz. Fiocruz Brasília. Brasília, DF, Brasil.London School of Hygiene & Tropical Medicine. Department of Infectious Disease Epidemiology. London, United Kingdom.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Background Indirect financial costs and barriers to health-care access might contribute to leprosy treatment nonadherence. We estimated the association of the Brazilian conditional cash transfer programme, the Programa Bolsa Família (PBF), on leprosy treatment adherence and cure in patients in Brazil. Methods In this quasi-experimental study, we linked baseline demographic and socioeconomic information for individuals who entered the 100 Million Brazilian Cohort between Jan 1, 2007, and Dec 31, 2014, with the PBF payroll database and the Information System for Notifiable Diseases, which includes nationwide leprosy registries. Individuals were eligible for inclusion if they had a household member older than 15 years and had not received PBF aid or been diagnosed with leprosy before entering the 100 Million Brazilian Cohort; they were excluded if they were partial receivers of PBF benefits, had missing data, or had a monthly per-capita income greater than BRL200 (US$50). Individuals who were PBF beneficiaries before leprosy diagnosis were matched to those who were not beneficiaries through propensityscore matching (1:1) with replacement on the basis of baseline covariates, including sex, age, race or ethnicity, education, work, income, place of residence, and household characteristics. We used logistic regression to assess the average treatment effect on the treated of receipt of PBF benefits on leprosy treatment adherence (six or more multidrug therapy doses for paucibacillary cases or 12 or more doses for multibacillary cases) and cure in individuals of all ages. We stratified our analysis according to operational disease classification (paucibacillary or multibacillary). We also did a subgroup analysis of paediatric leprosy restricted to children aged up to 15 years. Findings We included 11 456 new leprosy cases, of whom 8750 (76•3%) had received PBF before diagnosis and 2706 (23•6%) had not. Overall, 9508 (83•0%) patients adhered to treatment and 10 077 (88•0%) were cured. After propensity score matching, receiving PBF before diagnosis was associated with adherence to treatment (OR 1•22, 95% CI 1•01–1•48) and cure (1•26, 1•01–1•58). PBF receipt did not significantly improve treatment adherence (1•37, 0•98–1•91) or cure (1•12, 0•75–1•67) in patients with paucibacillary leprosy. For patients with multibacillary disease, PBF beneficiaries had better treatment adherence (1•37, 1•08–1•74) and cure (1•43, 1•09–1•90) than non-beneficiaries. In the propensity score-matched analysis in 2654 children younger than 15 years with leprosy, PBF exposure was not associated with leprosy treatment adherence (1•55, 0•89–2•68) or cure (1•57, 0•83–2•97). Interpretation Our results suggest that being a beneficiary of the PBF, which facilitates cash transfers and improved access to health care, is associated with greater leprosy multidrug therapy adherence and cure in multibacillary cases. These results are especially relevant for patients with multibacillary disease, who are treated for a longer period and have lower cure rates than those with paucibacillary disease.engElsevierLeprosyTreatment OutcomeMycobacterium lepraeCost ControlLeprosyNutrition Programs and PoliciesPrograma Bolsa FamíliaCost ControlHanseníaseProgramas e Políticas de Nutrição e AlimentaçãoMycobacterium lepraeDoenças TransmissíveisControle de CustosEffect of a conditional cash transfer programme on leprosy treatment adherence and cure in patients from the nationwide 100 million Brazilian cohort: a quasi-experimental studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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| dc.title.en.fl_str_mv |
Effect of a conditional cash transfer programme on leprosy treatment adherence and cure in patients from the nationwide 100 million Brazilian cohort: a quasi-experimental study |
| title |
Effect of a conditional cash transfer programme on leprosy treatment adherence and cure in patients from the nationwide 100 million Brazilian cohort: a quasi-experimental study |
| spellingShingle |
Effect of a conditional cash transfer programme on leprosy treatment adherence and cure in patients from the nationwide 100 million Brazilian cohort: a quasi-experimental study Pescarini, Júlia Moreira Leprosy Treatment Outcome Mycobacterium leprae Cost Control Leprosy Nutrition Programs and Policies Programa Bolsa Família Cost Control Hanseníase Programas e Políticas de Nutrição e Alimentação Mycobacterium leprae Doenças Transmissíveis Controle de Custos |
| title_short |
Effect of a conditional cash transfer programme on leprosy treatment adherence and cure in patients from the nationwide 100 million Brazilian cohort: a quasi-experimental study |
| title_full |
Effect of a conditional cash transfer programme on leprosy treatment adherence and cure in patients from the nationwide 100 million Brazilian cohort: a quasi-experimental study |
| title_fullStr |
Effect of a conditional cash transfer programme on leprosy treatment adherence and cure in patients from the nationwide 100 million Brazilian cohort: a quasi-experimental study |
| title_full_unstemmed |
Effect of a conditional cash transfer programme on leprosy treatment adherence and cure in patients from the nationwide 100 million Brazilian cohort: a quasi-experimental study |
| title_sort |
Effect of a conditional cash transfer programme on leprosy treatment adherence and cure in patients from the nationwide 100 million Brazilian cohort: a quasi-experimental study |
| author |
Pescarini, Júlia Moreira |
| author_facet |
Pescarini, Júlia Moreira Williamson, Elizabeth Nery, Joilda Silva Ramond, Anna Ichihara, Maria Yury Travassos Fiaccone, Rosemeire Leovigildo Penna, Maria Lucia Fernandes Smeeth, Liam Rodrigues, Laura Cunha Penna, Gerson Oliveira Brickley, Elizabeth B. Barreto, Maurício Lima |
| author_role |
author |
| author2 |
Williamson, Elizabeth Nery, Joilda Silva Ramond, Anna Ichihara, Maria Yury Travassos Fiaccone, Rosemeire Leovigildo Penna, Maria Lucia Fernandes Smeeth, Liam Rodrigues, Laura Cunha Penna, Gerson Oliveira Brickley, Elizabeth B. Barreto, Maurício Lima |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Pescarini, Júlia Moreira Williamson, Elizabeth Nery, Joilda Silva Ramond, Anna Ichihara, Maria Yury Travassos Fiaccone, Rosemeire Leovigildo Penna, Maria Lucia Fernandes Smeeth, Liam Rodrigues, Laura Cunha Penna, Gerson Oliveira Brickley, Elizabeth B. Barreto, Maurício Lima |
| dc.subject.mesh.pt_BR.fl_str_mv |
Leprosy Treatment Outcome Mycobacterium leprae Cost Control |
| topic |
Leprosy Treatment Outcome Mycobacterium leprae Cost Control Leprosy Nutrition Programs and Policies Programa Bolsa Família Cost Control Hanseníase Programas e Políticas de Nutrição e Alimentação Mycobacterium leprae Doenças Transmissíveis Controle de Custos |
| dc.subject.en.en.fl_str_mv |
Leprosy Nutrition Programs and Policies Programa Bolsa Família Cost Control |
| dc.subject.decs.pt_BR.fl_str_mv |
Hanseníase Programas e Políticas de Nutrição e Alimentação Mycobacterium leprae Doenças Transmissíveis Controle de Custos |
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Artigo encontra-se em acesso aberto no site do Editor. |
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2020 |
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2020-05-22T13:32:09Z |
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2020-05-22T13:32:09Z |
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2020 |
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PESCARINI, Júlia Moreira et al. Effect of a conditional cash transfer programme on leprosy treatment adherence and cure in patients from the nationwide 100 million Brazilian cohort: a quasi-experimental study. The Lancet Infectious Diseases, [London], v. 20, n. 5, p. 618-627, Feb. 2020. |
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https://www.arca.fiocruz.br/handle/icict/41357 |
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1473-3099 |
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10.1016/S1473-3099(19)30624-3 |
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PESCARINI, Júlia Moreira et al. Effect of a conditional cash transfer programme on leprosy treatment adherence and cure in patients from the nationwide 100 million Brazilian cohort: a quasi-experimental study. The Lancet Infectious Diseases, [London], v. 20, n. 5, p. 618-627, Feb. 2020. 1473-3099 10.1016/S1473-3099(19)30624-3 |
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