Clinical and immunopathological aspects of disseminated cutaneous leishmaniasis

Detalhes bibliográficos
Autor(a) principal: Carvalho, Edgar Marcelino de
Data de Publicação: 1994
Outros Autores: Barral, Aldina Maria Prado, Costa, Jackson Mauricio Lopes, Bittencourt, Achilea Candida Lisboa, Marsden, Philip
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/22838
Resumo: Barral, Aldina Maria Prado. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
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spelling Carvalho, Edgar Marcelino deBarral, Aldina Maria PradoCosta, Jackson Mauricio LopesBittencourt, Achilea Candida LisboaMarsden, Philip2017-10-17T12:24:38Z2017-10-17T12:24:38Z1994CARVALHO, E. M. et al. Clinical and immunopathological aspects of disseminated cutaneous leishmaniasis. Acta Tropica, v. 56, p. 315-325, 1994.0001-706Xhttps://www.arca.fiocruz.br/handle/icict/22838Barral, Aldina Maria Prado. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.Grant AI30639 from the National Institutes of Health and UNDP World Bank/WHO Special Program for Research and Training in Tropical Diseases and CNPq.Hospital Universitdrio Professor Edgard Santos. Departamento de Patologia. Service de Imunologia. Salvador, BA, BrasilHospital Universitdrio Professor Edgard Santos. Departamento de Patologia. Service de Imunologia. Salvador, BA, BrasilUniversidade Federal do Maranhão. São Luís, MA, BrasilHospital Universitdrio Professor Edgard Santos. Departamento de Patologia. Service de Imunologia. Salvador, BA, BrasilUniversidade de Brasilia. Brasília, DF, BrasilThe ciinico-pathological and immunological findings in eight patients from Bahia, Brazil with disseminated cutaneous leishmaniasis are described. This condition differs from anergic diffuse cutaneous leishmaniasis (DCL) and from classical American cutaneous leishmaniasis (ACL). The number of lesions in these patients ranged from 75 to 800 and were characterized by papules and an acneiform type of lesion with a few ulcers rather than nodules that are the main characteristic of DCL. On the other hand the high incidence of mucosal disease (38%) in patients with disseminated cutaneous leishmaniasis make the prevalence of mucosal involvement in this condition higher than that observed in ACL. L. amazonensis (five cases) and L. braziliensis (two cases) were the causal agents in the patients where the infecting agent was characterized. Antibody titers in disseminated cutaneous leishmaniasis were higher than those observed in ACL and patients with the highest antibody titers had mucosal envolvement. Abnormalities in cellular immunity that are not observed in ACL such as decrease in CD4 + cells and absence of T cell response to leishmania antigen were observed in several patients with disseminated cutaneous leishmaniasis but restoration of these abnormalities occurred after treatment. In spite of the great number of lesions, the therapeutic response was good in six patients with disappearance of the lesions in a period shorter than that observed in ACL. In the two patients that presented therapeutic failure the causal agent was L. amazonensis. In such patients there was a predominance of ulcerated lesions, and a high titer of antibody was detectedengElsevierLeishmanioseLeishmaniose cutâneaLeishmaniose cutânea disseminadaLeishmaniose tegumentarImunologia em leishmanioseLeishmaniasisCutaneous leishmaniasisDisseminated cutaneous leishmaniasisTegumentary leishmaniasisImmunology in leishmaniasisClinical and immunopathological aspects of disseminated cutaneous leishmaniasisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/22838/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALCarvalho EM Clinical and immunopathological....pdfCarvalho EM Clinical and 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dc.title.pt_BR.fl_str_mv Clinical and immunopathological aspects of disseminated cutaneous leishmaniasis
title Clinical and immunopathological aspects of disseminated cutaneous leishmaniasis
spellingShingle Clinical and immunopathological aspects of disseminated cutaneous leishmaniasis
Carvalho, Edgar Marcelino de
Leishmaniose
Leishmaniose cutânea
Leishmaniose cutânea disseminada
Leishmaniose tegumentar
Imunologia em leishmaniose
Leishmaniasis
Cutaneous leishmaniasis
Disseminated cutaneous leishmaniasis
Tegumentary leishmaniasis
Immunology in leishmaniasis
title_short Clinical and immunopathological aspects of disseminated cutaneous leishmaniasis
title_full Clinical and immunopathological aspects of disseminated cutaneous leishmaniasis
title_fullStr Clinical and immunopathological aspects of disseminated cutaneous leishmaniasis
title_full_unstemmed Clinical and immunopathological aspects of disseminated cutaneous leishmaniasis
title_sort Clinical and immunopathological aspects of disseminated cutaneous leishmaniasis
author Carvalho, Edgar Marcelino de
author_facet Carvalho, Edgar Marcelino de
Barral, Aldina Maria Prado
Costa, Jackson Mauricio Lopes
Bittencourt, Achilea Candida Lisboa
Marsden, Philip
author_role author
author2 Barral, Aldina Maria Prado
Costa, Jackson Mauricio Lopes
Bittencourt, Achilea Candida Lisboa
Marsden, Philip
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Carvalho, Edgar Marcelino de
Barral, Aldina Maria Prado
Costa, Jackson Mauricio Lopes
Bittencourt, Achilea Candida Lisboa
Marsden, Philip
dc.subject.other.pt_BR.fl_str_mv Leishmaniose
Leishmaniose cutânea
Leishmaniose cutânea disseminada
Leishmaniose tegumentar
Imunologia em leishmaniose
topic Leishmaniose
Leishmaniose cutânea
Leishmaniose cutânea disseminada
Leishmaniose tegumentar
Imunologia em leishmaniose
Leishmaniasis
Cutaneous leishmaniasis
Disseminated cutaneous leishmaniasis
Tegumentary leishmaniasis
Immunology in leishmaniasis
dc.subject.en.pt_BR.fl_str_mv Leishmaniasis
Cutaneous leishmaniasis
Disseminated cutaneous leishmaniasis
Tegumentary leishmaniasis
Immunology in leishmaniasis
description Barral, Aldina Maria Prado. “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
publishDate 1994
dc.date.issued.fl_str_mv 1994
dc.date.accessioned.fl_str_mv 2017-10-17T12:24:38Z
dc.date.available.fl_str_mv 2017-10-17T12:24:38Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv CARVALHO, E. M. et al. Clinical and immunopathological aspects of disseminated cutaneous leishmaniasis. Acta Tropica, v. 56, p. 315-325, 1994.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/22838
dc.identifier.issn.pt_BR.fl_str_mv 0001-706X
identifier_str_mv CARVALHO, E. M. et al. Clinical and immunopathological aspects of disseminated cutaneous leishmaniasis. Acta Tropica, v. 56, p. 315-325, 1994.
0001-706X
url https://www.arca.fiocruz.br/handle/icict/22838
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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