Zika virus vertical transmission in children with confirmed antenatal exposure
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/43557 |
Resumo: | Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. |
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Brasil, PatríciaVasconcelos, Zilton Farias Meira deKerin, TaraGabaglia, Claudia RajaRibeiro, Ieda P.Bonaldo, Myrna C.Damasceno, LuanaPone, Marcos V.Pone, Sheila MouraZin, AndreaTsui, IrenaAdachi, KristinaPereira Jr, Jose PauloGaw, Stephanie L.Carvalho, LiegeCunha, Denise C.Guida, LeticiaRocha, MirzaCherry, James D.Wang, LulanAliyari, SabaCheng, GenhongFoo, Suan-SinChen, WeiqiangJung, JaeBrickley, ElizabethMoreira, Maria Elisabeth L.Nielsen-Saines, Karin2020-09-22T19:35:07Z2020-09-22T19:35:07Z2020BRASIL, Patrícia et al. Zika virus vertical transmission in children with confirmed antenatal exposure. Nature Communications, v. 11, n. 1, p. 1-8, 2020.2041-1723https://www.arca.fiocruz.br/handle/icict/4355710.1038/s41467-020-17331-0engNature ResearchZika virus vertical transmission in children with confirmed antenatal exposureinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Rio de Janeiro, RJ, Brasil.David Geffen UCLA School of Medicine. Los Angeles, CA, USA.Biomedical Research Institute of Southern California. Oceanside, CA, USA.Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Rio de Janeiro, RJ, Brasil.David Geffen UCLA School of Medicine. Los Angeles, CA, USA.David Geffen UCLA School of Medicine. Los Angeles, CA, USA.Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Rio de Janeiro, RJ, Brasil.University of California. San Francisco School of Medicine. San Francisco, CA, USA.Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sérgio Arouca. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Rio de Janeiro, RJ, Brasil.David Geffen UCLA School of Medicine. Los Angeles, CA, USA.David Geffen UCLA School of Medicine. Los Angeles, CA, USA.David Geffen UCLA School of Medicine. Los Angeles, CA, USA.David Geffen UCLA School of Medicine. Los Angeles, CA, USA.University of Southern California. Los Angeles, CA, USA.University of Southern California. Los Angeles, CA, USA.University of Southern California. Los Angeles, CA, USA.London School of Hygiene and Tropical Medicine. Department of Infectious Disease Epidemiology. London, UK.Fundação Oswaldo Cruz. Instituto Fernandes Figueira. Rio de Janeiro, RJ, Brasil.David Geffen UCLA School of Medicine. Los Angeles, CA, USA.We report Zika virus (ZIKV) vertical transmission in 130 infants born to PCR+ mothers at the time of the Rio de Janeiro epidemic of 2015-2016. Serum and urine collected from birth through the first year of life were tested by quantitative reverse transcriptase polymerase chain reaction (PCR) and/or IgM Zika MAC-ELISA. Four hundred and seven specimens are evaluated; 161 sera tested by PCR and IgM assays, 85 urines by PCR. Sixty-five percent of children (N = 84) are positive in at least one assay. Of 94 children tested within 3 months of age, 70% are positive. Positivity declines to 33% after 3 months. Five children are PCR+ beyond 200 days of life. Concordance between IgM and PCR results is 52%, sensitivity 65%, specificity 40% (positive PCR results as gold standard). IgM and serum PCR are 61% concordant; serum and urine PCR 55%. Most children (65%) are clinically normal. Equal numbers of children with abnormal findings (29 of 45, 64%) and normal findings (55 of 85, 65%) have positive results, p = 0.98. Earlier maternal trimester of infection is associated with positive results (p = 0.04) but not clinical disease (p = 0.98). ZIKV vertical transmission is frequent but laboratory confirmed infection is not necessarily associated with infant abnormalities.Zika virusInfectious diseasesViral infectioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83099https://www.arca.fiocruz.br/bitstream/icict/43557/1/license.txt586c046dcfeef936e32f0323bb9a47c0MD51ORIGINALZika_Patricia_Brasil_etal_INI_2020.pdfZika_Patricia_Brasil_etal_INI_2020.pdfapplication/pdf673578https://www.arca.fiocruz.br/bitstream/icict/43557/2/Zika_Patricia_Brasil_etal_INI_2020.pdf0c816410bcb9c48dc6f51e21ac5bbc85MD52TEXTZika_Patricia_Brasil_etal_INI_2020.pdf.txtZika_Patricia_Brasil_etal_INI_2020.pdf.txtExtracted texttext/plain48299https://www.arca.fiocruz.br/bitstream/icict/43557/3/Zika_Patricia_Brasil_etal_INI_2020.pdf.txt6abafc1cca90ac43088a2d48430360daMD53icict/435572020-12-03 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| dc.title.pt_BR.fl_str_mv |
Zika virus vertical transmission in children with confirmed antenatal exposure |
| title |
Zika virus vertical transmission in children with confirmed antenatal exposure |
| spellingShingle |
Zika virus vertical transmission in children with confirmed antenatal exposure Brasil, Patrícia Zika virus Infectious diseases Viral infection |
| title_short |
Zika virus vertical transmission in children with confirmed antenatal exposure |
| title_full |
Zika virus vertical transmission in children with confirmed antenatal exposure |
| title_fullStr |
Zika virus vertical transmission in children with confirmed antenatal exposure |
| title_full_unstemmed |
Zika virus vertical transmission in children with confirmed antenatal exposure |
| title_sort |
Zika virus vertical transmission in children with confirmed antenatal exposure |
| author |
Brasil, Patrícia |
| author_facet |
Brasil, Patrícia Vasconcelos, Zilton Farias Meira de Kerin, Tara Gabaglia, Claudia Raja Ribeiro, Ieda P. Bonaldo, Myrna C. Damasceno, Luana Pone, Marcos V. Pone, Sheila Moura Zin, Andrea Tsui, Irena Adachi, Kristina Pereira Jr, Jose Paulo Gaw, Stephanie L. Carvalho, Liege Cunha, Denise C. Guida, Leticia Rocha, Mirza Cherry, James D. Wang, Lulan Aliyari, Saba Cheng, Genhong Foo, Suan-Sin Chen, Weiqiang Jung, Jae Brickley, Elizabeth Moreira, Maria Elisabeth L. Nielsen-Saines, Karin |
| author_role |
author |
| author2 |
Vasconcelos, Zilton Farias Meira de Kerin, Tara Gabaglia, Claudia Raja Ribeiro, Ieda P. Bonaldo, Myrna C. Damasceno, Luana Pone, Marcos V. Pone, Sheila Moura Zin, Andrea Tsui, Irena Adachi, Kristina Pereira Jr, Jose Paulo Gaw, Stephanie L. Carvalho, Liege Cunha, Denise C. Guida, Leticia Rocha, Mirza Cherry, James D. Wang, Lulan Aliyari, Saba Cheng, Genhong Foo, Suan-Sin Chen, Weiqiang Jung, Jae Brickley, Elizabeth Moreira, Maria Elisabeth L. Nielsen-Saines, Karin |
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author author author author author author author author author author author author author author author author author author author author author author author author author author author |
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Brasil, Patrícia Vasconcelos, Zilton Farias Meira de Kerin, Tara Gabaglia, Claudia Raja Ribeiro, Ieda P. Bonaldo, Myrna C. Damasceno, Luana Pone, Marcos V. Pone, Sheila Moura Zin, Andrea Tsui, Irena Adachi, Kristina Pereira Jr, Jose Paulo Gaw, Stephanie L. Carvalho, Liege Cunha, Denise C. Guida, Leticia Rocha, Mirza Cherry, James D. Wang, Lulan Aliyari, Saba Cheng, Genhong Foo, Suan-Sin Chen, Weiqiang Jung, Jae Brickley, Elizabeth Moreira, Maria Elisabeth L. Nielsen-Saines, Karin |
| dc.subject.en.pt_BR.fl_str_mv |
Zika virus Infectious diseases Viral infection |
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Zika virus Infectious diseases Viral infection |
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Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil. |
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2020 |
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2020-09-22T19:35:07Z |
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2020-09-22T19:35:07Z |
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2020 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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BRASIL, Patrícia et al. Zika virus vertical transmission in children with confirmed antenatal exposure. Nature Communications, v. 11, n. 1, p. 1-8, 2020. |
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https://www.arca.fiocruz.br/handle/icict/43557 |
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2041-1723 |
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10.1038/s41467-020-17331-0 |
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BRASIL, Patrícia et al. Zika virus vertical transmission in children with confirmed antenatal exposure. Nature Communications, v. 11, n. 1, p. 1-8, 2020. 2041-1723 10.1038/s41467-020-17331-0 |
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