Type III interferons produced by human placental trophoblasts confer protection against Zika Virus infection

Detalhes bibliográficos
Autor(a) principal: Bayer, Avraham
Data de Publicação: 2016
Outros Autores: Lennemann, Nicholas J., Ouyang, Yingshi, Bramley, John. C., Morosky, Stefanie, Jr Marques, Ernesto Torres de Azevedo, Cherry, Sara, Sadovsky, Yoel, Coyne, Carolyn B.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/13973
Resumo: 2017-04-04
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spelling Bayer, AvrahamLennemann, Nicholas J.Ouyang, YingshiBramley, John. C.Morosky, StefanieJr Marques, Ernesto Torres de AzevedoCherry, SaraSadovsky, YoelCoyne, Carolyn B.2016-04-26T16:54:57Z2016BAYER, Avraham; LENNEMANN, Nicholas J.; OUYANG, Yingshi; BRAMLEY, John C.; MOROSKY, Stefanie; MARQUES JR., Ernesto Torres de Azevedo; CHERRY, Sara; SADOVSKY, Yoel; COYNE, Carolyn B. Type III Interferons Produced by Human Placental Trophoblasts Confer Protection against Zika Virus Infection. Cell Host and Microbe, p. 1-8, Apr 5, 2016.1931-3128https://www.arca.fiocruz.br/handle/icict/1397310.1016/j.chom.2016.03.008engElsevierVírus ZikaEpidemiaInfecção pelo Vírus ZikaZika VirusInfectious DiseaseInfectious by Zika VirusHuman Placental TrophoblastsZika virusEpidemiaType III interferons produced by human placental trophoblasts confer protection against Zika Virus infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2017-04-04University of Pittsburgh. Magee-Womens Research Institute. Pittsburgh, PA, USA / University of Pittsburgh. Department of Obstetrics, Gynecology, and Reproductive Science. Pittsburgh, PA, USA.University of Pittsburgh. Department of Microbiology and Molecular Genetics. Pittsburgh, PA, USA.University of Pittsburgh. Magee-Womens Research Institute. Pittsburgh, PA, USA / University of Pittsburgh. Department of Obstetrics, Gynecology, and Reproductive Science. Pittsburgh, PA, USA.University of Pittsburgh. Department of Microbiology and Molecular Genetics. Pittsburgh, PA, USA.University of Pittsburgh. Department of Microbiology and Molecular Genetics. Pittsburgh, PA, USA.University of Pittsburgh. Center for Vaccine Research. Pittsburgh, PA, USA / Fundação Osvaldo Cruz. Centro de Pesquisas Aggeu Magalhães. Recife, PE, Brasil.University of Pennsylvania. Department of Microbiology. Philadelphia, PA, USA.University of Pittsburgh. Magee-Womens Research Institute. Pittsburgh, PA, USA / University of Pittsburgh. Department of Obstetrics, Gynecology, and Reproductive Science. Pittsburgh, PA, USA / University of Pittsburgh. Department of Microbiology and Molecular Genetics. Pittsburgh, Pittsburgh, PA, USA.University of Pittsburgh. Magee-Womens Research Institute. Pittsburgh, PA, USA / University of Pittsburgh. Department of Obstetrics, Gynecology, and Reproductive Science. Pittsburgh, PA, USA / University of Pittsburgh. Department of Microbiology and Molecular Genetics. Pittsburgh, Pittsburgh, PA, USA.During mammalian pregnancy, the placenta acts as a barrier between the maternal and fetal compartments. The recently observed association between Zika virus (ZIKV) infection during human pregnancy and fetal microcephaly and other anomalies suggests that ZIKV may bypass the placenta to reach the fetus. This led us to investigate ZIKV infection of primary human trophoblasts (PHTs), which are the barrier cells of the placenta. We discovered that PHT cells from full-term placentas are refractory to ZIKV infection. In addition, medium from uninfected PHT cells protects non-placental cells from ZIKV infection. PHT cells constitutively release the type III interferon (IFN) IFNl1, which functions in both a paracrine and autocrine manner to protect trophoblast and non-trophoblast cells from ZIKV infection. Our data suggest that for ZIKV to access the fetal compartment, it must evade restriction by trophoblast-derived IFNl1 and other trophoblast-specific antiviral factors and/or use alternative strategies to cross the placental barrier.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/13973/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALType III Interferons Produced by Human Placental Trophoblasts Confer Protection against Zika Virus infection.pdfType III Interferons Produced by Human Placental Trophoblasts Confer Protection against Zika Virus 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dc.title.pt_BR.fl_str_mv Type III interferons produced by human placental trophoblasts confer protection against Zika Virus infection
title Type III interferons produced by human placental trophoblasts confer protection against Zika Virus infection
spellingShingle Type III interferons produced by human placental trophoblasts confer protection against Zika Virus infection
Bayer, Avraham
Vírus Zika
Epidemia
Infecção pelo Vírus Zika
Zika Virus
Infectious Disease
Infectious by Zika Virus
Human Placental Trophoblasts
Zika virus
Epidemia
title_short Type III interferons produced by human placental trophoblasts confer protection against Zika Virus infection
title_full Type III interferons produced by human placental trophoblasts confer protection against Zika Virus infection
title_fullStr Type III interferons produced by human placental trophoblasts confer protection against Zika Virus infection
title_full_unstemmed Type III interferons produced by human placental trophoblasts confer protection against Zika Virus infection
title_sort Type III interferons produced by human placental trophoblasts confer protection against Zika Virus infection
author Bayer, Avraham
author_facet Bayer, Avraham
Lennemann, Nicholas J.
Ouyang, Yingshi
Bramley, John. C.
Morosky, Stefanie
Jr Marques, Ernesto Torres de Azevedo
Cherry, Sara
Sadovsky, Yoel
Coyne, Carolyn B.
author_role author
author2 Lennemann, Nicholas J.
Ouyang, Yingshi
Bramley, John. C.
Morosky, Stefanie
Jr Marques, Ernesto Torres de Azevedo
Cherry, Sara
Sadovsky, Yoel
Coyne, Carolyn B.
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Bayer, Avraham
Lennemann, Nicholas J.
Ouyang, Yingshi
Bramley, John. C.
Morosky, Stefanie
Jr Marques, Ernesto Torres de Azevedo
Cherry, Sara
Sadovsky, Yoel
Coyne, Carolyn B.
dc.subject.other.pt_BR.fl_str_mv Vírus Zika
Epidemia
Infecção pelo Vírus Zika
topic Vírus Zika
Epidemia
Infecção pelo Vírus Zika
Zika Virus
Infectious Disease
Infectious by Zika Virus
Human Placental Trophoblasts
Zika virus
Epidemia
dc.subject.en.pt_BR.fl_str_mv Zika Virus
Infectious Disease
Infectious by Zika Virus
Human Placental Trophoblasts
dc.subject.decs.pt_BR.fl_str_mv Zika virus
Epidemia
description 2017-04-04
publishDate 2016
dc.date.accessioned.fl_str_mv 2016-04-26T16:54:57Z
dc.date.issued.fl_str_mv 2016
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv BAYER, Avraham; LENNEMANN, Nicholas J.; OUYANG, Yingshi; BRAMLEY, John C.; MOROSKY, Stefanie; MARQUES JR., Ernesto Torres de Azevedo; CHERRY, Sara; SADOVSKY, Yoel; COYNE, Carolyn B. Type III Interferons Produced by Human Placental Trophoblasts Confer Protection against Zika Virus Infection. Cell Host and Microbe, p. 1-8, Apr 5, 2016.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/13973
dc.identifier.issn.none.fl_str_mv 1931-3128
dc.identifier.doi.none.fl_str_mv 10.1016/j.chom.2016.03.008
identifier_str_mv BAYER, Avraham; LENNEMANN, Nicholas J.; OUYANG, Yingshi; BRAMLEY, John C.; MOROSKY, Stefanie; MARQUES JR., Ernesto Torres de Azevedo; CHERRY, Sara; SADOVSKY, Yoel; COYNE, Carolyn B. Type III Interferons Produced by Human Placental Trophoblasts Confer Protection against Zika Virus Infection. Cell Host and Microbe, p. 1-8, Apr 5, 2016.
1931-3128
10.1016/j.chom.2016.03.008
url https://www.arca.fiocruz.br/handle/icict/13973
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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