Long-term administration of IgG2a anti-NK1.1 monoclonal antibody ameliorates lupus-like disease in NZB/W mice in spite of an early worsening induced by an IgG2a-dependent BAFF/BLyS production.
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/10918 |
Resumo: | University of São Paulo. Heart Institute. Immunology Laboratory. São Paulo, SP, Brasil |
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Postól, EdilbertoMeyer, André VillanovaCardillo, FabíolaAlencar, Raquel dePessina, Daniel HuberNihei, Jorge SadaoMariano, MárioMengele Junior, José Orivaldo2015-06-18T17:21:29Z2015-06-18T17:21:29Z2008POSTÓL, E. et al. Long-term administration of IgG2a anti-NK1.1 monoclonal antibody ameliorates lupus-like disease in NZB/W mice in spite of an early worsening induced by an IgG2a-dependent BAFF/BLyS production. Immunology, v. 125, n. 2, p. 184-196, 2008.1365-2567https://www.arca.fiocruz.br/handle/icict/1091810.1111/j.1365-2567.2008.02835.xengWileyLong-term administration of IgG2a anti-NK1.1 monoclonal antibody ameliorates lupus-like disease in NZB/W mice in spite of an early worsening induced by an IgG2a-dependent BAFF/BLyS production.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversity of São Paulo. Heart Institute. Immunology Laboratory. São Paulo, SP, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilUniversity of São Paulo. Heart Institute. Immunology Laboratory. São Paulo, SP, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFederal University of São Paulo. Department of Microbiology, Immunology and Parasitology. São Paulo, SP, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilThe role of natural killer (NK) T cells in the development of lupus-like disease in mice is still controversial. We treated NZB/W mice with anti- NK1.1 monoclonal antibodies (mAbs) and our results revealed that administration of either an irrelevant immunoglobulin G2a (IgG2a) mAb or an IgG2a anti-NK1.1 mAb increased the production of anti-dsDNA antibodies in young NZB/W mice. However, the continuous administration of an anti-NK1.1 mAb protected aged NZB/W mice from glomerular injury, leading to prolonged survival and stabilization of the proteinuria. Conversely, the administration of the control IgG2a mAb led to an aggravation of the lupus-like disease. Augmented titres of anti-dsDNA in NZB/ W mice, upon IgG2a administration, correlated with the production of BAFF/BLyS by dendritic, B and T cells. Treatment with an anti-NK1.1 mAb reduced the levels of interleukin-16, produced by T cells, in spleen cell culture supernatants from aged NZB/W. Adoptive transfer of NK T cells from aged to young NZB/W accelerated the production of antidsDNA in recipient NZB/W mice, suggesting that NK T cells from aged NZB/W are endowed with a B-cell helper activity. In vitro studies, using purified NK T cells from aged NZB/W, showed that these cells provided helper B-cell activity for the production of anti-dsDNA. We concluded that NK T cells are involved in the progression of lupus-like disease in mature NZB/W mice and that immunoglobulin of the IgG2a isotype has an enhancing effect on antibody synthesis due to the induction of BAFF/ BLyS, and therefore have a deleterious effect in the NZB/W mouse physiology.BAFF/BLySFc receptorInterleukin-16Natural killer T cellsSystemic lupus erythematosusToll-like receptoAnticorpos Monoclonais/uso terapêuticoFator Ativador de Células B/biossínteseImunoglobulina G/uso terapêuticoNefrite Lúpica/prevenção & controleEnvelhecimento/imunologiaAnimaisAnticorpos Antinucleares/biossínteseAnticorpos Monoclonais/imunologiaAntígenos Ly/imunologiaCélulas CultivadasProgressão da DoençaFemininoImunoglobulina G/imunologiaInterleucina-16/biossínteseCélulas Matadoras Naturais/imunologiaLipopolissacarídeos/imunologiaFígado/imunologiaNefrite Lúpica/imunologiaCamundongosSubfamília B de Receptores Semelhantes a Lectina de CélulasÍndice de Gravidade de DoençaLinfócitos T Auxiliares-Indutores/imunologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv |
Long-term administration of IgG2a anti-NK1.1 monoclonal antibody ameliorates lupus-like disease in NZB/W mice in spite of an early worsening induced by an IgG2a-dependent BAFF/BLyS production. |
title |
Long-term administration of IgG2a anti-NK1.1 monoclonal antibody ameliorates lupus-like disease in NZB/W mice in spite of an early worsening induced by an IgG2a-dependent BAFF/BLyS production. |
spellingShingle |
Long-term administration of IgG2a anti-NK1.1 monoclonal antibody ameliorates lupus-like disease in NZB/W mice in spite of an early worsening induced by an IgG2a-dependent BAFF/BLyS production. Postól, Edilberto BAFF/BLyS Fc receptor Interleukin-16 Natural killer T cells Systemic lupus erythematosus Toll-like recepto Anticorpos Monoclonais/uso terapêutico Fator Ativador de Células B/biossíntese Imunoglobulina G/uso terapêutico Nefrite Lúpica/prevenção & controle Envelhecimento/imunologia Animais Anticorpos Antinucleares/biossíntese Anticorpos Monoclonais/imunologia Antígenos Ly/imunologia Células Cultivadas Progressão da Doença Feminino Imunoglobulina G/imunologia Interleucina-16/biossíntese Células Matadoras Naturais/imunologia Lipopolissacarídeos/imunologia Fígado/imunologia Nefrite Lúpica/imunologia Camundongos Subfamília B de Receptores Semelhantes a Lectina de Células Índice de Gravidade de Doença Linfócitos T Auxiliares-Indutores/imunologia |
title_short |
Long-term administration of IgG2a anti-NK1.1 monoclonal antibody ameliorates lupus-like disease in NZB/W mice in spite of an early worsening induced by an IgG2a-dependent BAFF/BLyS production. |
title_full |
Long-term administration of IgG2a anti-NK1.1 monoclonal antibody ameliorates lupus-like disease in NZB/W mice in spite of an early worsening induced by an IgG2a-dependent BAFF/BLyS production. |
title_fullStr |
Long-term administration of IgG2a anti-NK1.1 monoclonal antibody ameliorates lupus-like disease in NZB/W mice in spite of an early worsening induced by an IgG2a-dependent BAFF/BLyS production. |
title_full_unstemmed |
Long-term administration of IgG2a anti-NK1.1 monoclonal antibody ameliorates lupus-like disease in NZB/W mice in spite of an early worsening induced by an IgG2a-dependent BAFF/BLyS production. |
title_sort |
Long-term administration of IgG2a anti-NK1.1 monoclonal antibody ameliorates lupus-like disease in NZB/W mice in spite of an early worsening induced by an IgG2a-dependent BAFF/BLyS production. |
author |
Postól, Edilberto |
author_facet |
Postól, Edilberto Meyer, André Villanova Cardillo, Fabíola Alencar, Raquel de Pessina, Daniel Huber Nihei, Jorge Sadao Mariano, Mário Mengele Junior, José Orivaldo |
author_role |
author |
author2 |
Meyer, André Villanova Cardillo, Fabíola Alencar, Raquel de Pessina, Daniel Huber Nihei, Jorge Sadao Mariano, Mário Mengele Junior, José Orivaldo |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Postól, Edilberto Meyer, André Villanova Cardillo, Fabíola Alencar, Raquel de Pessina, Daniel Huber Nihei, Jorge Sadao Mariano, Mário Mengele Junior, José Orivaldo |
dc.subject.en.pt_BR.fl_str_mv |
BAFF/BLyS Fc receptor Interleukin-16 Natural killer T cells Systemic lupus erythematosus Toll-like recepto |
topic |
BAFF/BLyS Fc receptor Interleukin-16 Natural killer T cells Systemic lupus erythematosus Toll-like recepto Anticorpos Monoclonais/uso terapêutico Fator Ativador de Células B/biossíntese Imunoglobulina G/uso terapêutico Nefrite Lúpica/prevenção & controle Envelhecimento/imunologia Animais Anticorpos Antinucleares/biossíntese Anticorpos Monoclonais/imunologia Antígenos Ly/imunologia Células Cultivadas Progressão da Doença Feminino Imunoglobulina G/imunologia Interleucina-16/biossíntese Células Matadoras Naturais/imunologia Lipopolissacarídeos/imunologia Fígado/imunologia Nefrite Lúpica/imunologia Camundongos Subfamília B de Receptores Semelhantes a Lectina de Células Índice de Gravidade de Doença Linfócitos T Auxiliares-Indutores/imunologia |
dc.subject.decs.pt_BR.fl_str_mv |
Anticorpos Monoclonais/uso terapêutico Fator Ativador de Células B/biossíntese Imunoglobulina G/uso terapêutico Nefrite Lúpica/prevenção & controle Envelhecimento/imunologia Animais Anticorpos Antinucleares/biossíntese Anticorpos Monoclonais/imunologia Antígenos Ly/imunologia Células Cultivadas Progressão da Doença Feminino Imunoglobulina G/imunologia Interleucina-16/biossíntese Células Matadoras Naturais/imunologia Lipopolissacarídeos/imunologia Fígado/imunologia Nefrite Lúpica/imunologia Camundongos Subfamília B de Receptores Semelhantes a Lectina de Células Índice de Gravidade de Doença Linfócitos T Auxiliares-Indutores/imunologia |
description |
University of São Paulo. Heart Institute. Immunology Laboratory. São Paulo, SP, Brasil |
publishDate |
2008 |
dc.date.issued.fl_str_mv |
2008 |
dc.date.accessioned.fl_str_mv |
2015-06-18T17:21:29Z |
dc.date.available.fl_str_mv |
2015-06-18T17:21:29Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
POSTÓL, E. et al. Long-term administration of IgG2a anti-NK1.1 monoclonal antibody ameliorates lupus-like disease in NZB/W mice in spite of an early worsening induced by an IgG2a-dependent BAFF/BLyS production. Immunology, v. 125, n. 2, p. 184-196, 2008. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/10918 |
dc.identifier.issn.none.fl_str_mv |
1365-2567 |
dc.identifier.doi.none.fl_str_mv |
10.1111/j.1365-2567.2008.02835.x |
identifier_str_mv |
POSTÓL, E. et al. Long-term administration of IgG2a anti-NK1.1 monoclonal antibody ameliorates lupus-like disease in NZB/W mice in spite of an early worsening induced by an IgG2a-dependent BAFF/BLyS production. Immunology, v. 125, n. 2, p. 184-196, 2008. 1365-2567 10.1111/j.1365-2567.2008.02835.x |
url |
https://www.arca.fiocruz.br/handle/icict/10918 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
Wiley |
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Wiley |
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