Safety of benznidazole use in the treatment of chronic Chagas' disease

Detalhes bibliográficos
Autor(a) principal: Hasslocher-Moreno, Alejandro Marcel
Data de Publicação: 2012
Outros Autores: Brasil, Pedro Emmanuel Alvarenga Americano do, Sousa, Andrea S. de, Xavier, Sergio S., Chambela, Mayara C., Silva, Gilberto M. Sperandio da
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/36592
Resumo: 2020-10-21
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spelling Hasslocher-Moreno, Alejandro MarcelBrasil, Pedro Emmanuel Alvarenga Americano doSousa, Andrea S. deXavier, Sergio S.Chambela, Mayara C.Silva, Gilberto M. Sperandio da2019-10-21T13:00:46Z2019-10-21T13:00:46Z2012HASSLOCHER-MORENO, Alejandro M. et al. Safety of benznidazole use in the treatment of chronic Chagas’ disease. Journal of Antimicrobial Chemotherapy, v. 67, p. 1261-1266, 2012.0305-7453https://www.arca.fiocruz.br/handle/icict/3659210.1093/jac/dks0271460-2091engOxford University PressSafety of benznidazole use in the treatment of chronic Chagas' diseaseinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2020-10-21Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Doença de Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Doença de Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Doença de Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Doença de Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Doença de Chagas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Laboratório de Pesquisa Clínica em Doença de Chagas. Rio de Janeiro, RJ, Brasil.Objectives: To assess the safety of benznidazole use in adult patients with chronic Chagas’ disease. Methods: The Naranjo algorithm was applied to classify the causality of adverse drug reactions (ADRs). Results: In total, 190 patients were treated with benznidazole over a period of 4–180 days (mean 58.90+36.54 days) with a dose of 50–500 mg/day (221.33+57.16 mg/day). Of the 190 patients treated, 93 had ADRs and 59 of these interrupted treatment. There was a higher incidence of ADRs among female and young adult patients. There was a higher incidence of ADRs during the first 30 days of treatment. Interruption of treatment was more frequent in women. Among the patients who interrupted treatment, 39 had mild ADRs, 19 had moderate ADRs and 1 had a severe ADR. There were no interruptions in treatment for 97 patients without ADRs. The survival curves indicated that the time until interruption of treatment in patients with moderate and severe ADRs was lower than in patients with mild or no ADRs. The most frequent disorders were in the skin (26.3%), gastrointestinal system (9.5%) and nervous system (5.3%). Conclusions: The Naranjo algorithm was a useful tool to reduce the underreporting of ADRs. Events were common, but were associated with low morbidity and were reversible upon discontinuation of drug treatment. Moreover, there were no fatal events; therefore, benznidazole treatment was considered safe.Trypanosoma cruziAdverse drug reactionsTreatment interruptionNaranjo algorithminfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/36592/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALve_Hasslocher-Moreno_Alejandro_etal_INI_2012.pdfve_Hasslocher-Moreno_Alejandro_etal_INI_2012.pdfapplication/pdf221423https://www.arca.fiocruz.br/bitstream/icict/36592/2/ve_Hasslocher-Moreno_Alejandro_etal_INI_2012.pdf4769cfa63722a0d06a833fcf45d6fe39MD52TEXTve_Hasslocher-Moreno_Alejandro_etal_INI_2012.pdf.txtve_Hasslocher-Moreno_Alejandro_etal_INI_2012.pdf.txtExtracted texttext/plain29158https://www.arca.fiocruz.br/bitstream/icict/36592/3/ve_Hasslocher-Moreno_Alejandro_etal_INI_2012.pdf.txt2b77c106354e484cddd5b3b8a38d3027MD53icict/365922023-03-08 09:38:35.986oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-08T12:38:35Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Safety of benznidazole use in the treatment of chronic Chagas' disease
title Safety of benznidazole use in the treatment of chronic Chagas' disease
spellingShingle Safety of benznidazole use in the treatment of chronic Chagas' disease
Hasslocher-Moreno, Alejandro Marcel
Trypanosoma cruzi
Adverse drug reactions
Treatment interruption
Naranjo algorithm
title_short Safety of benznidazole use in the treatment of chronic Chagas' disease
title_full Safety of benznidazole use in the treatment of chronic Chagas' disease
title_fullStr Safety of benznidazole use in the treatment of chronic Chagas' disease
title_full_unstemmed Safety of benznidazole use in the treatment of chronic Chagas' disease
title_sort Safety of benznidazole use in the treatment of chronic Chagas' disease
author Hasslocher-Moreno, Alejandro Marcel
author_facet Hasslocher-Moreno, Alejandro Marcel
Brasil, Pedro Emmanuel Alvarenga Americano do
Sousa, Andrea S. de
Xavier, Sergio S.
Chambela, Mayara C.
Silva, Gilberto M. Sperandio da
author_role author
author2 Brasil, Pedro Emmanuel Alvarenga Americano do
Sousa, Andrea S. de
Xavier, Sergio S.
Chambela, Mayara C.
Silva, Gilberto M. Sperandio da
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Hasslocher-Moreno, Alejandro Marcel
Brasil, Pedro Emmanuel Alvarenga Americano do
Sousa, Andrea S. de
Xavier, Sergio S.
Chambela, Mayara C.
Silva, Gilberto M. Sperandio da
dc.subject.en.pt_BR.fl_str_mv Trypanosoma cruzi
Adverse drug reactions
Treatment interruption
Naranjo algorithm
topic Trypanosoma cruzi
Adverse drug reactions
Treatment interruption
Naranjo algorithm
description 2020-10-21
publishDate 2012
dc.date.issued.fl_str_mv 2012
dc.date.accessioned.fl_str_mv 2019-10-21T13:00:46Z
dc.date.available.fl_str_mv 2019-10-21T13:00:46Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv HASSLOCHER-MORENO, Alejandro M. et al. Safety of benznidazole use in the treatment of chronic Chagas’ disease. Journal of Antimicrobial Chemotherapy, v. 67, p. 1261-1266, 2012.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/36592
dc.identifier.issn.pt_BR.fl_str_mv 0305-7453
dc.identifier.doi.none.fl_str_mv 10.1093/jac/dks027
dc.identifier.eissn.none.fl_str_mv 1460-2091
identifier_str_mv HASSLOCHER-MORENO, Alejandro M. et al. Safety of benznidazole use in the treatment of chronic Chagas’ disease. Journal of Antimicrobial Chemotherapy, v. 67, p. 1261-1266, 2012.
0305-7453
10.1093/jac/dks027
1460-2091
url https://www.arca.fiocruz.br/handle/icict/36592
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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