Macrophage polarization in Leishmaniasis: broadening horizons

Detalhes bibliográficos
Autor(a) principal: Tomiotto-Pellissier, Fernanda
Data de Publicação: 2018
Outros Autores: Bortoleti, Bruna Taciane da Silva, Assolini, João Paulo, Gonçalves, Manoela Daiele, Carloto, Amanda Cristina Machado, Miranda-Sapla, Milena Menegazzo, Conchon-Costa, Ivete, Bordignon, Juliano, Pavanelli, Wander Rogério
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.3389/fimmu.2018.02529
Texto Completo: https://www.arca.fiocruz.br/handle/icict/38784
Resumo: Fundação Oswaldo Cruz. Instituto Carlos Chagas. Programa de Pós-Graduação em Biociências e Biotecnologia. Curitiba, PR, Brasil / Universidade Estadual de Londrina. Departamento de Ciências Patológicas. Laboratório de Imunoparasitologia. Londrina, PR, Brasil.
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spelling Tomiotto-Pellissier, FernandaBortoleti, Bruna Taciane da SilvaAssolini, João PauloGonçalves, Manoela DaieleCarloto, Amanda Cristina MachadoMiranda-Sapla, Milena MenegazzoConchon-Costa, IveteBordignon, JulianoPavanelli, Wander Rogério2019-12-20T19:30:10Z2019-12-20T19:30:10Z2018TOMIOTTO-PELISSIER, Fernanda et al. Macrophage polarization in Leishmaniasis: broadening horizons. Frontiers in Immunology, v. 9, n. 2529, p. 1-18, 2018.1664-3224https://www.arca.fiocruz.br/handle/icict/3878410.3389/fimmu.2018.025291664-3224porFrontiers MediaLeishmaniaMacrophagesImmunomodulationChemokinesInmunomodulaciónMacrófagosSalivaImunomodulaçãoQuimiocinasMacrophage polarization in Leishmaniasis: broadening horizonsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Carlos Chagas. Programa de Pós-Graduação em Biociências e Biotecnologia. Curitiba, PR, Brasil / Universidade Estadual de Londrina. Departamento de Ciências Patológicas. Laboratório de Imunoparasitologia. Londrina, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Programa de Pós-Graduação em Biociências e Biotecnologia. Curitiba, PR, Brasil / Universidade Estadual de Londrina. Departamento de Ciências Patológicas. Laboratório de Imunoparasitologia. Londrina, PR, Brasil.Universidade Estadual de Londrina. Departamento de Ciências Patológicas. Laboratório de Imunoparasitologia. Londrina, PR, Brasil.Universidade Estadual de Londrina. Departamento de Química. Laboratório de Biotransformação e Fitoquímica. Londrina, PR, Brasil.Universidade Estadual de Londrina. Departamento de Ciências Patológicas. Laboratório de Imunoparasitologia. Londrina, PR, Brasil.Universidade Estadual de Londrina. Departamento de Ciências Patológicas. Laboratório de Imunoparasitologia. Londrina, PR, Brasil.Universidade Estadual de Londrina. Departamento de Ciências Patológicas. Laboratório de Imunoparasitologia. Londrina, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Programa de Pós-Graduação em Biociências e Biotecnologia. Curitiba, PR, Brasil / Fundação Oswaldo Cruz. Instituto Carlos Chagas. Laboratório de Virologia Molecular. Curitiba, PR, Brasil.Fundação Oswaldo Cruz. Instituto Carlos Chagas. Programa de Pós-Graduação em Biociências e Biotecnologia. Curitiba, PR, Brasil / Universidade Estadual de Londrina. Departamento de Ciências Patológicas. Laboratório de Imunoparasitologia. Londrina, PR, Brasil.Leishmaniasis is a vector-borne neglected tropical disease that affects more than 700,000 people annually. Leishmania parasites cause the disease, and different species trigger a distinct immune response and clinical manifestations. Macrophages are the final host cells for the proliferation of Leishmania parasites, and these cells are the key to a controlled or exacerbated response that culminates in clinical manifestations. M1 and M2 are the two main macrophage phenotypes. M1 is a pro-inflammatory subtype with microbicidal properties, and M2, or alternatively activated, is an anti-inflammatory/regulatory subtype that is related to inflammation resolution and tissue repair. The present review elucidates the roles of M1 and M2 polarization in leishmaniasis and highlights the role of the salivary components of the vector and the action of the parasite in the macrophage plasticity.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83084https://www.arca.fiocruz.br/bitstream/icict/38784/1/license.txt783568c2893d2e25a99990b126be1772MD51ORIGINALfimmu-09-02529ok.pdffimmu-09-02529ok.pdfapplication/pdf867609https://www.arca.fiocruz.br/bitstream/icict/38784/2/fimmu-09-02529ok.pdf2d8d3684b5991f6db192288a0eb46e4fMD52TEXTfimmu-09-02529ok.pdf.txtfimmu-09-02529ok.pdf.txtExtracted texttext/plain74062https://www.arca.fiocruz.br/bitstream/icict/38784/3/fimmu-09-02529ok.pdf.txt651a7abeb25b44b9cbd17ecb5515f906MD53icict/387842020-01-30 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dc.title.pt_BR.fl_str_mv Macrophage polarization in Leishmaniasis: broadening horizons
title Macrophage polarization in Leishmaniasis: broadening horizons
spellingShingle Macrophage polarization in Leishmaniasis: broadening horizons
Tomiotto-Pellissier, Fernanda
Leishmania
Macrophages
Immunomodulation
Chemokines
Inmunomodulación
Macrófagos
Saliva
Imunomodulação
Quimiocinas
title_short Macrophage polarization in Leishmaniasis: broadening horizons
title_full Macrophage polarization in Leishmaniasis: broadening horizons
title_fullStr Macrophage polarization in Leishmaniasis: broadening horizons
title_full_unstemmed Macrophage polarization in Leishmaniasis: broadening horizons
title_sort Macrophage polarization in Leishmaniasis: broadening horizons
author Tomiotto-Pellissier, Fernanda
author_facet Tomiotto-Pellissier, Fernanda
Bortoleti, Bruna Taciane da Silva
Assolini, João Paulo
Gonçalves, Manoela Daiele
Carloto, Amanda Cristina Machado
Miranda-Sapla, Milena Menegazzo
Conchon-Costa, Ivete
Bordignon, Juliano
Pavanelli, Wander Rogério
author_role author
author2 Bortoleti, Bruna Taciane da Silva
Assolini, João Paulo
Gonçalves, Manoela Daiele
Carloto, Amanda Cristina Machado
Miranda-Sapla, Milena Menegazzo
Conchon-Costa, Ivete
Bordignon, Juliano
Pavanelli, Wander Rogério
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Tomiotto-Pellissier, Fernanda
Bortoleti, Bruna Taciane da Silva
Assolini, João Paulo
Gonçalves, Manoela Daiele
Carloto, Amanda Cristina Machado
Miranda-Sapla, Milena Menegazzo
Conchon-Costa, Ivete
Bordignon, Juliano
Pavanelli, Wander Rogério
dc.subject.other.pt_BR.fl_str_mv Leishmania
topic Leishmania
Macrophages
Immunomodulation
Chemokines
Inmunomodulación
Macrófagos
Saliva
Imunomodulação
Quimiocinas
dc.subject.en.pt_BR.fl_str_mv Macrophages
Immunomodulation
Chemokines
dc.subject.es.pt_BR.fl_str_mv Inmunomodulación
dc.subject.decs.pt_BR.fl_str_mv Macrófagos
Saliva
Imunomodulação
Quimiocinas
description Fundação Oswaldo Cruz. Instituto Carlos Chagas. Programa de Pós-Graduação em Biociências e Biotecnologia. Curitiba, PR, Brasil / Universidade Estadual de Londrina. Departamento de Ciências Patológicas. Laboratório de Imunoparasitologia. Londrina, PR, Brasil.
publishDate 2018
dc.date.issued.fl_str_mv 2018
dc.date.accessioned.fl_str_mv 2019-12-20T19:30:10Z
dc.date.available.fl_str_mv 2019-12-20T19:30:10Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv TOMIOTTO-PELISSIER, Fernanda et al. Macrophage polarization in Leishmaniasis: broadening horizons. Frontiers in Immunology, v. 9, n. 2529, p. 1-18, 2018.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/38784
dc.identifier.issn.pt_BR.fl_str_mv 1664-3224
dc.identifier.doi.none.fl_str_mv 10.3389/fimmu.2018.02529
dc.identifier.eissn.none.fl_str_mv 1664-3224
identifier_str_mv TOMIOTTO-PELISSIER, Fernanda et al. Macrophage polarization in Leishmaniasis: broadening horizons. Frontiers in Immunology, v. 9, n. 2529, p. 1-18, 2018.
1664-3224
10.3389/fimmu.2018.02529
url https://www.arca.fiocruz.br/handle/icict/38784
dc.language.iso.fl_str_mv por
language por
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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