Trypanosoma cruzi gene expression in response to gamma radiation
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/7593 |
Resumo: | Universidade Federal de Minas Gerais. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brazil |
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Grynberg, PriscilaSilva, Danielle Gomes PassosMourão, Marina de MoraesHirata Junior, RobertoMacedo, Andrea MaraMachado, Carlos RenatoBartholomeu, Daniella CastanheiraFranco, Glória Regina2014-05-08T18:39:52Z2014-05-08T18:39:52Z2012GRYNBERG, Priscila et al. Trypanosoma cruzi gene expression in response to gamma radiation. Plos One. 2012, vol.7, pp. e29596.https://www.arca.fiocruz.br/handle/icict/759310.1371/journal.pone.0029596engPublic Library Of ScienceTrypanosoma cruzi gene expression in response to gamma radiationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Minas Gerais. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, BrazilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Grupo de Genômica e Biologia Computacional. Belo Horizonte, MG, Brazil/Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Instituto Nacional de Ciência e Tecnologia em Doenças Tropicais Belo Horizonte, MG, BrazilUniversidade de São Paulo. Instituto de Matemática e Estatística. São Paulo, SP, BrazilUniversidade Federal de Minas Gerais. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Departamento de Parasitologia. Belo Horizonte, MG, BrazilUniversidade Federal de Minas Gerais. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, BrazilTrypanosoma cruzi is an organism highly resistant to ionizing radiation. Following a dose of 500 Gy of gamma radiation, the fragmented genomic DNA is gradually reconstructed and the pattern of chromosomal bands is restored in less than 48 hours. Cell growth arrests after irradiation but, while DNA is completely fragmented, RNA maintains its integrity. In this work we compared the transcriptional profiles of irradiated and non-irradiated epimastigotes at different time points after irradiation using microarray. In total, 273 genes were differentially expressed; from these, 160 were up-regulated and 113 down-regulated. We found that genes with predicted functions are the most prevalent in the down-regulated gene category. Translation and protein metabolic processes, as well as generation of precursor of metabolites and energy pathways were affected. In contrast, the up-regulated category was mainly composed of obsolete sequences (which included some genes of the kinetoplast DNA), genes coding for hypothetical proteins, and Retrotransposon Hot Spot genes. Finally, the tyrosyl-DNA phosphodiesterase 1, a gene involved in double-strand DNA break repair process, was up-regulated. Our study demonstrated the peculiar response to ionizing radiation, raising questions about how this organism changes its gene expression to manage such a harmful stress.DNA repairGamma radiation Gene expressionGenomic databases Ionizing radiationMicroarrays RNA extractionTrypanosoma cruziinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALTrypanosoma cruzi gene expression in response to gamma radiation.pdfTrypanosoma cruzi gene expression in response to gamma radiation.pdfapplication/pdf1836923https://www.arca.fiocruz.br/bitstream/icict/7593/1/Trypanosoma%20cruzi%20gene%20expression%20in%20response%20to%20gamma%20radiation.pdfe3ffa4dc31ec7bfb1f0c0c0dd96d7573MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7593/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTTrypanosoma cruzi gene expression in response to gamma radiation.pdf.txtTrypanosoma cruzi gene expression in response to gamma radiation.pdf.txtExtracted texttext/plain68043https://www.arca.fiocruz.br/bitstream/icict/7593/5/Trypanosoma%20cruzi%20gene%20expression%20in%20response%20to%20gamma%20radiation.pdf.txt4e9e0e4bd693765d71db62ae00236623MD55THUMBNAILTrypanosoma cruzi gene expression in response to gamma radiation.pdf.jpgTrypanosoma cruzi gene expression in response to gamma radiation.pdf.jpgGenerated Thumbnailimage/jpeg2090https://www.arca.fiocruz.br/bitstream/icict/7593/4/Trypanosoma%20cruzi%20gene%20expression%20in%20response%20to%20gamma%20radiation.pdf.jpg20acc1bb85caca264bf6a590dbee4b8eMD54icict/75932018-04-06 08:43:53.861oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352018-04-06T11:43:53Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
dc.title.pt_BR.fl_str_mv |
Trypanosoma cruzi gene expression in response to gamma radiation |
title |
Trypanosoma cruzi gene expression in response to gamma radiation |
spellingShingle |
Trypanosoma cruzi gene expression in response to gamma radiation Grynberg, Priscila DNA repair Gamma radiation Gene expression Genomic databases Ionizing radiation Microarrays RNA extraction Trypanosoma cruzi |
title_short |
Trypanosoma cruzi gene expression in response to gamma radiation |
title_full |
Trypanosoma cruzi gene expression in response to gamma radiation |
title_fullStr |
Trypanosoma cruzi gene expression in response to gamma radiation |
title_full_unstemmed |
Trypanosoma cruzi gene expression in response to gamma radiation |
title_sort |
Trypanosoma cruzi gene expression in response to gamma radiation |
author |
Grynberg, Priscila |
author_facet |
Grynberg, Priscila Silva, Danielle Gomes Passos Mourão, Marina de Moraes Hirata Junior, Roberto Macedo, Andrea Mara Machado, Carlos Renato Bartholomeu, Daniella Castanheira Franco, Glória Regina |
author_role |
author |
author2 |
Silva, Danielle Gomes Passos Mourão, Marina de Moraes Hirata Junior, Roberto Macedo, Andrea Mara Machado, Carlos Renato Bartholomeu, Daniella Castanheira Franco, Glória Regina |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Grynberg, Priscila Silva, Danielle Gomes Passos Mourão, Marina de Moraes Hirata Junior, Roberto Macedo, Andrea Mara Machado, Carlos Renato Bartholomeu, Daniella Castanheira Franco, Glória Regina |
dc.subject.en.pt_BR.fl_str_mv |
DNA repair Gamma radiation Gene expression Genomic databases Ionizing radiation Microarrays RNA extraction Trypanosoma cruzi |
topic |
DNA repair Gamma radiation Gene expression Genomic databases Ionizing radiation Microarrays RNA extraction Trypanosoma cruzi |
description |
Universidade Federal de Minas Gerais. Departamento de Bioquímica e Imunologia. Belo Horizonte, MG, Brazil |
publishDate |
2012 |
dc.date.issued.fl_str_mv |
2012 |
dc.date.accessioned.fl_str_mv |
2014-05-08T18:39:52Z |
dc.date.available.fl_str_mv |
2014-05-08T18:39:52Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
GRYNBERG, Priscila et al. Trypanosoma cruzi gene expression in response to gamma radiation. Plos One. 2012, vol.7, pp. e29596. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/7593 |
dc.identifier.doi.none.fl_str_mv |
10.1371/journal.pone.0029596 |
identifier_str_mv |
GRYNBERG, Priscila et al. Trypanosoma cruzi gene expression in response to gamma radiation. Plos One. 2012, vol.7, pp. e29596. 10.1371/journal.pone.0029596 |
url |
https://www.arca.fiocruz.br/handle/icict/7593 |
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eng |
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eng |
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openAccess |
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Public Library Of Science |
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Public Library Of Science |
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