Dimeric flavonoids from Arrabidaea brachypoda and assessment of their anti-Trypanosoma cruzi activity.
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2014 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/8460 |
Resumo: | Universidade Estadual Paulista. Laboratório de Biodiversidade e Sustentabilidade. UNESP Coastal Campus, Parque Bitaru |
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Rocha, Cláudia Quintino daQueiroz, Emerson FerreiraMeira, Cássio SantanaMoreira, Diogo Rodrigo MagalhãesSoares, Milena Botelho PereiraMarcourt, LaurenceVilegas, WagnerWolfender, Jean-Luc2014-09-26T17:59:03Z2014-09-26T17:59:03Z2014ROCHA, C. et al. Dimeric flavonoids from Arrabidaea brachypoda and assessment of their anti-Trypanosoma cruzi activity. Journal of Natural Products, v. 77, n. 66, p. 1345-1350, 2014.1520-6025https://www.arca.fiocruz.br/handle/icict/846010.1021/np401060jengACS PublicationsDimeric flavonoids from Arrabidaea brachypoda and assessment of their anti-Trypanosoma cruzi activity.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Estadual Paulista. Laboratório de Biodiversidade e Sustentabilidade. UNESP Coastal Campus, Parque BitaruThe nonpolar fraction of an aqueous ethanol extract of the roots of Arrabidaea brachypoda, a Brazilian medicinal plant, demonstrated significant in vitro activity against Trypanosoma cruzi, the parasite responsible for Chagas disease. Targeted isolation of the active constituents led to the isolation of three new dimeric flavonoids (1-3), and their structures were elucidated using UV, NMR, and HRMS analysis, as well as by chemical derivatization. The anti-T. cruzi activity and cytotoxicity toward mammalian cells were determined for these substances. Compound 1 exhibited no activity toward T. cruzi, while flavonoids 2 and 3 exhibited selective activity against these trypomastigotes. Compounds 2 and 3 inhibited the parasite invasion process and its intracellular development in host cells with similar potencies to benznidazole. In addition, compound 2 reduced the blood parasitemia of T. cruzi-infected mice. This study has revealed that these two dimeric flavonoids represent potential anti-T. cruzi lead compounds for further drug development.Bignoniaceae/químicaFlavonoides/isolamento & purificaçãoFlavonoides/farmacologiaTripanossomicidas/isolamento & purificaçãoTripanossomicidas/farmacologiaTrypanosoma cruzi/efeitos de drogasBrasilCercopithecus aethiopsFlavonoides/sangueFlavonoides/químicaMacrófagos Peritoneais/efeitos de drogasCamundongosEstrutura MolecularTestes de Sensibilidade ParasitáriaTripanossomicidas/sangueTripanossomicidas/químicaCelulas veroinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/8460/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALRocha C Dimeric Flavonoids....pdfRocha C Dimeric Flavonoids....pdfapplication/pdf1066770https://www.arca.fiocruz.br/bitstream/icict/8460/2/Rocha%20C%20Dimeric%20Flavonoids....pdfa5b3e18ce047987fdf06cfd92e572bbbMD52TEXTRocha C Dimeric Flavonoids....pdf.txtRocha C Dimeric Flavonoids....pdf.txtExtracted texttext/plain36436https://www.arca.fiocruz.br/bitstream/icict/8460/3/Rocha%20C%20Dimeric%20Flavonoids....pdf.txt514fef15ada05904da5a777c2d5f3d8dMD53icict/84602023-03-15 14:32:53.529oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:32:53Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Dimeric flavonoids from Arrabidaea brachypoda and assessment of their anti-Trypanosoma cruzi activity. |
| title |
Dimeric flavonoids from Arrabidaea brachypoda and assessment of their anti-Trypanosoma cruzi activity. |
| spellingShingle |
Dimeric flavonoids from Arrabidaea brachypoda and assessment of their anti-Trypanosoma cruzi activity. Rocha, Cláudia Quintino da Bignoniaceae/química Flavonoides/isolamento & purificação Flavonoides/farmacologia Tripanossomicidas/isolamento & purificação Tripanossomicidas/farmacologia Trypanosoma cruzi/efeitos de drogas Brasil Cercopithecus aethiops Flavonoides/sangue Flavonoides/química Macrófagos Peritoneais/efeitos de drogas Camundongos Estrutura Molecular Testes de Sensibilidade Parasitária Tripanossomicidas/sangue Tripanossomicidas/química Celulas vero |
| title_short |
Dimeric flavonoids from Arrabidaea brachypoda and assessment of their anti-Trypanosoma cruzi activity. |
| title_full |
Dimeric flavonoids from Arrabidaea brachypoda and assessment of their anti-Trypanosoma cruzi activity. |
| title_fullStr |
Dimeric flavonoids from Arrabidaea brachypoda and assessment of their anti-Trypanosoma cruzi activity. |
| title_full_unstemmed |
Dimeric flavonoids from Arrabidaea brachypoda and assessment of their anti-Trypanosoma cruzi activity. |
| title_sort |
Dimeric flavonoids from Arrabidaea brachypoda and assessment of their anti-Trypanosoma cruzi activity. |
| author |
Rocha, Cláudia Quintino da |
| author_facet |
Rocha, Cláudia Quintino da Queiroz, Emerson Ferreira Meira, Cássio Santana Moreira, Diogo Rodrigo Magalhães Soares, Milena Botelho Pereira Marcourt, Laurence Vilegas, Wagner Wolfender, Jean-Luc |
| author_role |
author |
| author2 |
Queiroz, Emerson Ferreira Meira, Cássio Santana Moreira, Diogo Rodrigo Magalhães Soares, Milena Botelho Pereira Marcourt, Laurence Vilegas, Wagner Wolfender, Jean-Luc |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Rocha, Cláudia Quintino da Queiroz, Emerson Ferreira Meira, Cássio Santana Moreira, Diogo Rodrigo Magalhães Soares, Milena Botelho Pereira Marcourt, Laurence Vilegas, Wagner Wolfender, Jean-Luc |
| dc.subject.decs.pt_BR.fl_str_mv |
Bignoniaceae/química Flavonoides/isolamento & purificação Flavonoides/farmacologia Tripanossomicidas/isolamento & purificação Tripanossomicidas/farmacologia Trypanosoma cruzi/efeitos de drogas Brasil Cercopithecus aethiops Flavonoides/sangue Flavonoides/química Macrófagos Peritoneais/efeitos de drogas Camundongos Estrutura Molecular Testes de Sensibilidade Parasitária Tripanossomicidas/sangue Tripanossomicidas/química Celulas vero |
| topic |
Bignoniaceae/química Flavonoides/isolamento & purificação Flavonoides/farmacologia Tripanossomicidas/isolamento & purificação Tripanossomicidas/farmacologia Trypanosoma cruzi/efeitos de drogas Brasil Cercopithecus aethiops Flavonoides/sangue Flavonoides/química Macrófagos Peritoneais/efeitos de drogas Camundongos Estrutura Molecular Testes de Sensibilidade Parasitária Tripanossomicidas/sangue Tripanossomicidas/química Celulas vero |
| description |
Universidade Estadual Paulista. Laboratório de Biodiversidade e Sustentabilidade. UNESP Coastal Campus, Parque Bitaru |
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2014 |
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2014-09-26T17:59:03Z |
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2014-09-26T17:59:03Z |
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2014 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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ROCHA, C. et al. Dimeric flavonoids from Arrabidaea brachypoda and assessment of their anti-Trypanosoma cruzi activity. Journal of Natural Products, v. 77, n. 66, p. 1345-1350, 2014. |
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https://www.arca.fiocruz.br/handle/icict/8460 |
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1520-6025 |
| dc.identifier.doi.none.fl_str_mv |
10.1021/np401060j |
| identifier_str_mv |
ROCHA, C. et al. Dimeric flavonoids from Arrabidaea brachypoda and assessment of their anti-Trypanosoma cruzi activity. Journal of Natural Products, v. 77, n. 66, p. 1345-1350, 2014. 1520-6025 10.1021/np401060j |
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https://www.arca.fiocruz.br/handle/icict/8460 |
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ACS Publications |
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ACS Publications |
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