Synthesis, Cruzain docking, and in vitro studies of aryl-4-oxothiazolylhydrazones against Trypanosoma cruzi.
Autor(a) principal: | |
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Data de Publicação: | 2007 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/10036 |
Resumo: | Universidade Federal de Pernambuco. Departamento de Ciências Farmacêuticas. Laboratório de Planejamento. Avaliação e Síntese de Fármacos. Recife, PE, Brasil |
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Leite, Ana Cristina LimaLima, Renata Souza deMoreira, Diogo Rodrigo MagalhãesCardoso, Marcos Veríssimo de OliveiraBrito, Ana Carolina Gouveia deSantos, Luciene Maria Farias dosHernandes, Marcelo ZaldiniKiperstok, Alice CostaLima, Ricardo Santana deSoares, Milena Botelho Pereira2015-04-16T18:10:59Z2015-04-16T18:10:59Z2007LEITE, A. C. L. et al. Synthesis, cruzain docking, and in vitro studies of aryl-4-oxothiazolylhydrazones against Trypanosoma cruzi. Bioorganic & Medicinal Chemistry, v. 14, p. 3749–3757, 2007.1860-7187https://www.arca.fiocruz.br/handle/icict/1003610.1016/j.bmc.2006.01.034engElsevierSynthesis, Cruzain docking, and in vitro studies of aryl-4-oxothiazolylhydrazones against Trypanosoma cruzi.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Pernambuco. Departamento de Ciências Farmacêuticas. Laboratório de Planejamento. Avaliação e Síntese de Fármacos. Recife, PE, BrasilUniversidade Federal de Pernambuco. Departamento de Ciências Farmacêuticas. Laboratório de Planejamento. Avaliação e Síntese de Fármacos. Recife, PE, BrasilUniversidade Federal de Pernambuco. Departamento de Ciências Farmacêuticas. Laboratório de Planejamento. Avaliação e Síntese de Fármacos. Recife, PE, BrasilUniversidade Federal de Pernambuco. Departamento de Ciências Farmacêuticas. Laboratório de Planejamento. Avaliação e Síntese de Fármacos. Recife, PE, BrasilUniversidade Federal de Pernambuco. Departamento de Ciências Farmacêuticas. Laboratório de Planejamento. Avaliação e Síntese de Fármacos. Recife, PE, BrasilUniversidade Federal de Pernambuco. Departamento de Ciências Farmacêuticas. Laboratório de Planejamento. Avaliação e Síntese de Fármacos. Recife, PE, BrasilUniversidade Federal de Pernambuco. Departamento de Ciências Farmacêuticas. Laboratório de Química Teórica Medicinal. Recife, PE, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilResearch in recent years has demonstrated that the Trypanosoma cruzi cysteine protease cruzain (TCC) is a valid chemotherapeutic target. Herein we describe a small library of aryl-4-oxothiazolylhydrazones that have been tested in assays against T. cruzi cell cultures. The docking studies carried out suggest that these compounds are potential ligands for the TCC enzyme. The most promising compound of this series, N-(4-oxo-5-ethyl-2'-thiazolin-2-yl)-N'-phenylthio-(Z)-ethylidenehydrazone (6 f), was shown to be very active at non-cytotoxic concentrations in in vitro assays with mammalian cells and has a potency comparable with reference drugs such as nifurtimox (Nfx) and benznidazole (Bdz).Cisteína Endopeptidases/metabolismoHidrazonas/síntese químicaHidrazonas/farmacologiaProteínas de Protozoários/metabolismoTripanossomicidas/síntese químicaTripanossomicidas/farmacologiaTrypanosoma cruzi/efeitos de drogasAnimaisTécnicas In VitroEspectroscopia de Ressonância MagnéticaModelos Molecularesinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82352https://www.arca.fiocruz.br/bitstream/icict/10036/1/license.txtafbdf7d7a9bcf771a1cc7edf5f618413MD51ORIGINALLeite A C L Synthesis, docking....pdfLeite A C L Synthesis, docking....pdfapplication/pdf610757https://www.arca.fiocruz.br/bitstream/icict/10036/2/Leite%20A%20C%20L%20Synthesis%2c%20docking....pdf9534d4781408434b33184616f3a5f517MD52TEXTLeite A C L Synthesis, docking....pdf.txtLeite A C L Synthesis, docking....pdf.txtExtracted texttext/plain34247https://www.arca.fiocruz.br/bitstream/icict/10036/3/Leite%20A%20C%20L%20Synthesis%2c%20docking....pdf.txtc293e31346b45bb79dbc6cd275a2f187MD53icict/100362023-03-15 14:33:06.77oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:06Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
dc.title.pt_BR.fl_str_mv |
Synthesis, Cruzain docking, and in vitro studies of aryl-4-oxothiazolylhydrazones against Trypanosoma cruzi. |
title |
Synthesis, Cruzain docking, and in vitro studies of aryl-4-oxothiazolylhydrazones against Trypanosoma cruzi. |
spellingShingle |
Synthesis, Cruzain docking, and in vitro studies of aryl-4-oxothiazolylhydrazones against Trypanosoma cruzi. Leite, Ana Cristina Lima Cisteína Endopeptidases/metabolismo Hidrazonas/síntese química Hidrazonas/farmacologia Proteínas de Protozoários/metabolismo Tripanossomicidas/síntese química Tripanossomicidas/farmacologia Trypanosoma cruzi/efeitos de drogas Animais Técnicas In Vitro Espectroscopia de Ressonância Magnética Modelos Moleculares |
title_short |
Synthesis, Cruzain docking, and in vitro studies of aryl-4-oxothiazolylhydrazones against Trypanosoma cruzi. |
title_full |
Synthesis, Cruzain docking, and in vitro studies of aryl-4-oxothiazolylhydrazones against Trypanosoma cruzi. |
title_fullStr |
Synthesis, Cruzain docking, and in vitro studies of aryl-4-oxothiazolylhydrazones against Trypanosoma cruzi. |
title_full_unstemmed |
Synthesis, Cruzain docking, and in vitro studies of aryl-4-oxothiazolylhydrazones against Trypanosoma cruzi. |
title_sort |
Synthesis, Cruzain docking, and in vitro studies of aryl-4-oxothiazolylhydrazones against Trypanosoma cruzi. |
author |
Leite, Ana Cristina Lima |
author_facet |
Leite, Ana Cristina Lima Lima, Renata Souza de Moreira, Diogo Rodrigo Magalhães Cardoso, Marcos Veríssimo de Oliveira Brito, Ana Carolina Gouveia de Santos, Luciene Maria Farias dos Hernandes, Marcelo Zaldini Kiperstok, Alice Costa Lima, Ricardo Santana de Soares, Milena Botelho Pereira |
author_role |
author |
author2 |
Lima, Renata Souza de Moreira, Diogo Rodrigo Magalhães Cardoso, Marcos Veríssimo de Oliveira Brito, Ana Carolina Gouveia de Santos, Luciene Maria Farias dos Hernandes, Marcelo Zaldini Kiperstok, Alice Costa Lima, Ricardo Santana de Soares, Milena Botelho Pereira |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Leite, Ana Cristina Lima Lima, Renata Souza de Moreira, Diogo Rodrigo Magalhães Cardoso, Marcos Veríssimo de Oliveira Brito, Ana Carolina Gouveia de Santos, Luciene Maria Farias dos Hernandes, Marcelo Zaldini Kiperstok, Alice Costa Lima, Ricardo Santana de Soares, Milena Botelho Pereira |
dc.subject.decs.pt_BR.fl_str_mv |
Cisteína Endopeptidases/metabolismo Hidrazonas/síntese química Hidrazonas/farmacologia Proteínas de Protozoários/metabolismo Tripanossomicidas/síntese química Tripanossomicidas/farmacologia Trypanosoma cruzi/efeitos de drogas Animais Técnicas In Vitro Espectroscopia de Ressonância Magnética Modelos Moleculares |
topic |
Cisteína Endopeptidases/metabolismo Hidrazonas/síntese química Hidrazonas/farmacologia Proteínas de Protozoários/metabolismo Tripanossomicidas/síntese química Tripanossomicidas/farmacologia Trypanosoma cruzi/efeitos de drogas Animais Técnicas In Vitro Espectroscopia de Ressonância Magnética Modelos Moleculares |
description |
Universidade Federal de Pernambuco. Departamento de Ciências Farmacêuticas. Laboratório de Planejamento. Avaliação e Síntese de Fármacos. Recife, PE, Brasil |
publishDate |
2007 |
dc.date.issued.fl_str_mv |
2007 |
dc.date.accessioned.fl_str_mv |
2015-04-16T18:10:59Z |
dc.date.available.fl_str_mv |
2015-04-16T18:10:59Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
LEITE, A. C. L. et al. Synthesis, cruzain docking, and in vitro studies of aryl-4-oxothiazolylhydrazones against Trypanosoma cruzi. Bioorganic & Medicinal Chemistry, v. 14, p. 3749–3757, 2007. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/10036 |
dc.identifier.issn.none.fl_str_mv |
1860-7187 |
dc.identifier.doi.none.fl_str_mv |
10.1016/j.bmc.2006.01.034 |
identifier_str_mv |
LEITE, A. C. L. et al. Synthesis, cruzain docking, and in vitro studies of aryl-4-oxothiazolylhydrazones against Trypanosoma cruzi. Bioorganic & Medicinal Chemistry, v. 14, p. 3749–3757, 2007. 1860-7187 10.1016/j.bmc.2006.01.034 |
url |
https://www.arca.fiocruz.br/handle/icict/10036 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
Elsevier |
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Elsevier |
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