Neurodevelopment of children exposed intra-uterus by Zika virus: a case series
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/40757 |
Resumo: | Data underlying the study cannot be made publicly available due to ethical concerns, as data contain personally identifiable information about a vulnerable population. Data are available from the Research Department (rb.zurcoif.ffi@asiuqsep) or Ethics Committee (rb.zurcoif.ffi@ffipec) for researchers who meet the criteria for access to confidential data. |
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Peçanha, Pedro MassaroniGomes Junior, Saint Clair dos SantosPone, Sheila MouraPone, Marcos Vinicius da SilvaVasconcelos, Zilton Farias Meira deZin, Andrea A.Vilibor, Renata Hydee HasueCosta, Roozemeria PereiraMeio, Maria Dalva Barbosa BakerNielsen-Saines, KarinBrasil, PatríciaBrickley, ElizabethMoreira, Maria Elisabeth Lopes2020-04-14T19:16:38Z2020-04-14T19:16:38Z2020PEÇANHA, Pedro Massaroni et al. Neurodevelopment of children exposed intra-uterus by Zika virus: a case series. PLoS ONE, v. 15, n. 2, p. 1-11, 28 Feb. 2020.1932-6203https://www.arca.fiocruz.br/handle/icict/4075710.1371/journal.pone.0229434Data underlying the study cannot be made publicly available due to ethical concerns, as data contain personally identifiable information about a vulnerable population. Data are available from the Research Department (rb.zurcoif.ffi@asiuqsep) or Ethics Committee (rb.zurcoif.ffi@ffipec) for researchers who meet the criteria for access to confidential data.O principal objetivo deste manuscrito foi investigar o neurodesenvolvimento de crianças expostas ao vírus Zika no período intra-uterino, assintomáticas ao nascimento. Recém-nascidos com exposição documentada ao vírus Zika durante o período intra-uterino que eram assintomáticos ao nascimento foram acompanhados nos dois primeiros anos de vida para o desenvolvimento neurológico usando o teste de Bayley III. As crianças foram classificadas como tendo neurodesenvolvimento normal ou tardio para a idade, com base nos resultados mais recentes da avaliação de Bayley III. Oitenta e quatro crianças foram incluídas no estudo. A primeira avaliação de Bayley III foi realizada com idade cronológica média de 9,7 ± 3,1 meses; 13 crianças (15%) apresentaram atraso em um dos três domínios, distribuídos da seguinte forma: 10 (12%) no domínio da linguagem e 3 (3,5%) no domínio motor. A avaliação mais recente de Bayley III foi realizada com idade média de 15,3 ± 3,1 meses; 42 crianças (50%) apresentaram atraso em um dos três domínios: 4 (5%) em cognição, 31 (37%) em linguagem e 20 (24%) em desempenho motor. Não houve diferenças estatísticas em gênero, idade gestacional, peso ao nascer e circunferência da cabeça ao nascer entre crianças com neurodesenvolvimento normal e tardio para a idade. Uma proporção muito alta de crianças expostas ao ZIKV durante a gravidez, assintomáticas ao nascimento, demonstrou um atraso no desenvolvimento neurológico, principalmente no domínio da linguagem, nos primeiros dois anos de vida.The main goal of this manuscript was to investigate the neurodevelopment of children exposed by Zika virus in the intrauterine period who are asymptomatic at birth. Newborns with documented Zika virus exposure during the intrauterine period who were asymptomatic at birth were followed in the first two years of life for neurodevelopment using Bayley III test. Children were classified as having normal or delayed neurodevelopment for age based on most recent Bayley III evaluation results. Eighty-four infants were included in the study. The first Bayley III evaluation was performed at a mean chronological age of 9.7±3.1 month; 13 children (15%) had a delay in one of the three domains, distributed as follow: 10 (12%) in the language domain and 3 (3.5%) in the motor domain. The most recent Bayley III evaluation was performed at a mean age 15.3±3.1 months; 42 children (50%) had a delay in one of the three domains: 4 (5%) in cognition, 31 (37%) in language, and 20 (24%) in motor performance. There were no statistical differences in Gender, Gestational Age, Birth Weight and Head Circurference at birth between children with normal and delayed neurodevelopment for age. A very high proportion of children exposed ZIKV during pregnancy who were asymptomatic at birth demonstrated a delay in neurodevelopment, mainly in the language domain, the first two years of life.Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil.Universidade de São Paulo. São Paulo, SP, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil.Universidade da California. Los Angeles, CA, USA.Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.London School of Hygiene & Tropical Medicine. London, United Kingdom.Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil.engPublic Library of ScienceNeurodevelopment of children exposed intra-uterus by Zika virus: a case seriesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleZika virusPregnancyNeonatesMicrocephalyNeurodevelopmentBayley III testInfantsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83099https://www.arca.fiocruz.br/bitstream/icict/40757/1/license.txt586c046dcfeef936e32f0323bb9a47c0MD51ORIGINALNeurodevelopment_Patricia_Brasil_etal_INI_2020.pdfNeurodevelopment_Patricia_Brasil_etal_INI_2020.pdfapplication/pdf1311871https://www.arca.fiocruz.br/bitstream/icict/40757/2/Neurodevelopment_Patricia_Brasil_etal_INI_2020.pdf89e550ca6b660034259d72323f36792fMD52TEXTNeurodevelopment_Patricia_Brasil_etal_INI_2020.pdf.txtNeurodevelopment_Patricia_Brasil_etal_INI_2020.pdf.txtExtracted 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| dc.title.en.fl_str_mv |
Neurodevelopment of children exposed intra-uterus by Zika virus: a case series |
| title |
Neurodevelopment of children exposed intra-uterus by Zika virus: a case series |
| spellingShingle |
Neurodevelopment of children exposed intra-uterus by Zika virus: a case series Peçanha, Pedro Massaroni Zika virus Pregnancy Neonates Microcephaly Neurodevelopment Bayley III test Infants |
| title_short |
Neurodevelopment of children exposed intra-uterus by Zika virus: a case series |
| title_full |
Neurodevelopment of children exposed intra-uterus by Zika virus: a case series |
| title_fullStr |
Neurodevelopment of children exposed intra-uterus by Zika virus: a case series |
| title_full_unstemmed |
Neurodevelopment of children exposed intra-uterus by Zika virus: a case series |
| title_sort |
Neurodevelopment of children exposed intra-uterus by Zika virus: a case series |
| author |
Peçanha, Pedro Massaroni |
| author_facet |
Peçanha, Pedro Massaroni Gomes Junior, Saint Clair dos Santos Pone, Sheila Moura Pone, Marcos Vinicius da Silva Vasconcelos, Zilton Farias Meira de Zin, Andrea A. Vilibor, Renata Hydee Hasue Costa, Roozemeria Pereira Meio, Maria Dalva Barbosa Baker Nielsen-Saines, Karin Brasil, Patrícia Brickley, Elizabeth Moreira, Maria Elisabeth Lopes |
| author_role |
author |
| author2 |
Gomes Junior, Saint Clair dos Santos Pone, Sheila Moura Pone, Marcos Vinicius da Silva Vasconcelos, Zilton Farias Meira de Zin, Andrea A. Vilibor, Renata Hydee Hasue Costa, Roozemeria Pereira Meio, Maria Dalva Barbosa Baker Nielsen-Saines, Karin Brasil, Patrícia Brickley, Elizabeth Moreira, Maria Elisabeth Lopes |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Peçanha, Pedro Massaroni Gomes Junior, Saint Clair dos Santos Pone, Sheila Moura Pone, Marcos Vinicius da Silva Vasconcelos, Zilton Farias Meira de Zin, Andrea A. Vilibor, Renata Hydee Hasue Costa, Roozemeria Pereira Meio, Maria Dalva Barbosa Baker Nielsen-Saines, Karin Brasil, Patrícia Brickley, Elizabeth Moreira, Maria Elisabeth Lopes |
| dc.subject.en.pt_BR.fl_str_mv |
Zika virus |
| topic |
Zika virus Pregnancy Neonates Microcephaly Neurodevelopment Bayley III test Infants |
| dc.subject.en.en.fl_str_mv |
Pregnancy Neonates Microcephaly Neurodevelopment Bayley III test Infants |
| description |
Data underlying the study cannot be made publicly available due to ethical concerns, as data contain personally identifiable information about a vulnerable population. Data are available from the Research Department (rb.zurcoif.ffi@asiuqsep) or Ethics Committee (rb.zurcoif.ffi@ffipec) for researchers who meet the criteria for access to confidential data. |
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2020 |
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2020-04-14T19:16:38Z |
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2020-04-14T19:16:38Z |
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2020 |
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PEÇANHA, Pedro Massaroni et al. Neurodevelopment of children exposed intra-uterus by Zika virus: a case series. PLoS ONE, v. 15, n. 2, p. 1-11, 28 Feb. 2020. |
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https://www.arca.fiocruz.br/handle/icict/40757 |
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1932-6203 |
| dc.identifier.doi.pt_BR.fl_str_mv |
10.1371/journal.pone.0229434 |
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PEÇANHA, Pedro Massaroni et al. Neurodevelopment of children exposed intra-uterus by Zika virus: a case series. PLoS ONE, v. 15, n. 2, p. 1-11, 28 Feb. 2020. 1932-6203 10.1371/journal.pone.0229434 |
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