Brainstem gliomas: retrospective analysis of 86 patients

Detalhes bibliográficos
Autor(a) principal: Ueoka, Denis I.
Data de Publicação: 2009
Outros Autores: Nogueira, Janio, Campos, João C., Maranhão, Pericles, Ferman, Sima, Lima, Marco A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/38959
Resumo: Marco A. Lima. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.
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spelling Ueoka, Denis I.Nogueira, JanioCampos, João C.Maranhão, PericlesFerman, SimaLima, Marco A.2020-01-03T13:45:26Z2020-01-03T13:45:26Z2009UEOKA, Denis I. et al. Brainstem gliomas: retrospective analysis of 86 patients. Journal of the Neurological Sciences, v. 281, p. 20-23, 2009.0022-510Xhttps://www.arca.fiocruz.br/handle/icict/3895910.1016/j.jns.2009.03.0091878-5883Marco A. Lima. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.2021-01-03National Institute of Cancer. Department of Neurosurgery. Rio de Janeiro, RJ, Brazil.National Institute of Cancer. Department of Neurosurgery. Rio de Janeiro, RJ, Brazil.National Institute of Cancer. Department of Neurosurgery. Rio de Janeiro, RJ, Brazil.National Institute of Cancer. Department of Neurosurgery. Rio de Janeiro, RJ, Brazil.National Institute of Cancer. Department of Pediatric Oncology. Rio de Janeiro, RJ, Brazil.National Institute of Cancer. Department of Neurosurgery. Rio de Janeiro, RJ, Brazil.Brainstem gliomas constitute 10% of brain tumors in children and less than 2% in adults. Since therapeutic options are limited and brainstem gliomas are associated with a high morbidity and mortality, we sought to analyze the prognostic factors associated with a better outcome. We reviewed the records of 86 patients with brainstem gliomas treated between 1996 and 2006. We recorded demographic and clinical variables as well as radiological findings and survival. Patients were divided in two groups regarding overall survival: late progressors (survival ≥ 12 months) or early progressors (survival< 12 months). Of 86 patients with brainstem gliomas, 55.8% were females. The mean age at diagnosis was 14.2 years (range 1 to 52 years). Twenty-four (27.9%) patients were adults. Lesions were located at pons in 75.6% of patients, midbrain in 15.1% and medulla in 9.3%. There was no difference between early and late progressors concerning gender, age at onset, location at pons, presence of necrosis or contrast enhancement observed at MRI or surgical resection. In both univariate and multivariate analysis, only a short duration of symptoms before diagnosis (< 3 months) was associated with a worst prognosis (odds ratio 5.59, 95% CI 1.94 to 16, p = 0.0014). A short duration of symptoms, which may imply a more aggressive tumor, was associated with a worst prognosis in patients with brainstem gliomas. This information may be useful in the selection of patients for future therapeutic trials.engElsevierBrainstem gliomas: retrospective analysis of 86 patientsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleBrainstemGliomaSurvivalinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/38959/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALve_Ueoka_Denis_etal_INI_2009.pdfve_Ueoka_Denis_etal_INI_2009.pdfapplication/pdf361470https://www.arca.fiocruz.br/bitstream/icict/38959/2/ve_Ueoka_Denis_etal_INI_2009.pdfcaea346f7a4d24b875c32ced7e71f240MD52TEXTve_Ueoka_Denis_etal_INI_2009.pdf.txtve_Ueoka_Denis_etal_INI_2009.pdf.txtExtracted texttext/plain16116https://www.arca.fiocruz.br/bitstream/icict/38959/3/ve_Ueoka_Denis_etal_INI_2009.pdf.txt776fedb78b0b3f783245fe7de8d06650MD53icict/389592021-03-24 16:32:42.111oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352021-03-24T19:32:42Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Brainstem gliomas: retrospective analysis of 86 patients
title Brainstem gliomas: retrospective analysis of 86 patients
spellingShingle Brainstem gliomas: retrospective analysis of 86 patients
Ueoka, Denis I.
Brainstem
Glioma
Survival
title_short Brainstem gliomas: retrospective analysis of 86 patients
title_full Brainstem gliomas: retrospective analysis of 86 patients
title_fullStr Brainstem gliomas: retrospective analysis of 86 patients
title_full_unstemmed Brainstem gliomas: retrospective analysis of 86 patients
title_sort Brainstem gliomas: retrospective analysis of 86 patients
author Ueoka, Denis I.
author_facet Ueoka, Denis I.
Nogueira, Janio
Campos, João C.
Maranhão, Pericles
Ferman, Sima
Lima, Marco A.
author_role author
author2 Nogueira, Janio
Campos, João C.
Maranhão, Pericles
Ferman, Sima
Lima, Marco A.
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Ueoka, Denis I.
Nogueira, Janio
Campos, João C.
Maranhão, Pericles
Ferman, Sima
Lima, Marco A.
dc.subject.en.pt_BR.fl_str_mv Brainstem
Glioma
Survival
topic Brainstem
Glioma
Survival
description Marco A. Lima. Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta a informação no documento.
publishDate 2009
dc.date.issued.fl_str_mv 2009
dc.date.accessioned.fl_str_mv 2020-01-03T13:45:26Z
dc.date.available.fl_str_mv 2020-01-03T13:45:26Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv UEOKA, Denis I. et al. Brainstem gliomas: retrospective analysis of 86 patients. Journal of the Neurological Sciences, v. 281, p. 20-23, 2009.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/38959
dc.identifier.issn.pt_BR.fl_str_mv 0022-510X
dc.identifier.doi.none.fl_str_mv 10.1016/j.jns.2009.03.009
dc.identifier.eissn.none.fl_str_mv 1878-5883
identifier_str_mv UEOKA, Denis I. et al. Brainstem gliomas: retrospective analysis of 86 patients. Journal of the Neurological Sciences, v. 281, p. 20-23, 2009.
0022-510X
10.1016/j.jns.2009.03.009
1878-5883
url https://www.arca.fiocruz.br/handle/icict/38959
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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