Murine cerebral malaria is associated with a vasospasm-like microcirculatory dysfunction, and survival upon rescue treatment is markedly increased by nimodipine

Detalhes bibliográficos
Autor(a) principal: Cabrales, Pedro
Data de Publicação: 2010
Outros Autores: Zanini, Graziela M., Meays, Diana, Frangos, John A., Carvalho, Leonardo J. M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/33945
Resumo: 2020-07-10
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spelling Cabrales, PedroZanini, Graziela M.Meays, DianaFrangos, John A.Carvalho, Leonardo J. M.2019-07-10T13:53:13Z2019-07-10T13:53:13Z2010CABRALES, Pedro et al. Murine cerebral malaria is associated with a vasospasm-like microcirculatory dysfunction, and survival upon rescue treatment is markedly increased by nimodipine. American Journal of Pathology, v. 176, n. 3, Mar. 2010.0002-9440https://www.arca.fiocruz.br/handle/icict/3394510.2353/ajpath.2010.0906911525-2191engElsevierMurine cerebral malaria is associated with a vasospasm-like microcirculatory dysfunction, and survival upon rescue treatment is markedly increased by nimodipineinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2020-07-10La Jolla Bioengineering Institute. San Diego, CA, USA.La Jolla Bioengineering Institute. San Diego, CA, USA / Fundação Oswaldo Cruz. Instituto de Pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.La Jolla Bioengineering Institute. San Diego, CA, USA.La Jolla Bioengineering Institute. San Diego, CA, USA.La Jolla Bioengineering Institute. San Diego, CA, USA.Brain hemodynamics in cerebral malaria (CM) is poorly understood, with apparently conflicting data showing microcirculatory hypoperfusion and normal or even increased blood flow in large arteries. Using intravital microscopy to assess the pial microvasculature through a closed cranial window in the murine model of CM by Plasmodium berghei ANKA, we show that murine CM is associated with marked decreases (mean: 60%) of pial arteriolar blood flow attributable to vasoconstriction and decreased blood velocity. Leukocyte sequestration further decreased perfusion by narrowing luminal diameters in the affected vessels and blocking capillaries. Remarkably, vascular collapse at various degrees was observed in 44% of mice with CM, which also presented more severe vasoconstriction. Coadministration of artemether and nimodipine, a calcium channel blocker used to treat postsubarachnoid hemorrhage vasospasm, to mice presenting CM markedly increased survival compared with artemether plus vehicle only. Administration of nimodipine induced vasodilation and increased pial blood flow. We conclude that vasoconstriction and vascular collapse play a role in murine CM pathogenesis and nimodipine holds potential as adjunctive therapy for CM.Murine cerebral malariaVasospasmMicrocirculatory dysfunctionNimodipineinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83101https://www.arca.fiocruz.br/bitstream/icict/33945/1/license.txt63df43feba17d7507b32704290dbf79aMD51ORIGINALMurine cerebral malaria is associated with a vasospasm-like microcirculatory dysfunction, and survival upon rescue treatment is markedly increased by nimodipine..pdfMurine cerebral malaria is associated with a vasospasm-like microcirculatory dysfunction, and survival upon rescue treatment is markedly increased by nimodipine..pdfapplication/pdf460862https://www.arca.fiocruz.br/bitstream/icict/33945/2/Murine%20cerebral%20malaria%20is%20associated%20with%20a%20vasospasm-like%20microcirculatory%20dysfunction%2c%20and%20survival%20upon%20rescue%20treatment%20is%20markedly%20increased%20by%20nimodipine..pdfe140a9d3a50ab1776befc771aa369f00MD52TEXTMurine cerebral malaria is associated with a vasospasm-like microcirculatory dysfunction, and survival upon rescue treatment is markedly increased by nimodipine..pdf.txtMurine cerebral malaria is associated with a vasospasm-like microcirculatory dysfunction, and survival upon rescue treatment is markedly increased by nimodipine..pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Murine cerebral malaria is associated with a vasospasm-like microcirculatory dysfunction, and survival upon rescue treatment is markedly increased by nimodipine
title Murine cerebral malaria is associated with a vasospasm-like microcirculatory dysfunction, and survival upon rescue treatment is markedly increased by nimodipine
spellingShingle Murine cerebral malaria is associated with a vasospasm-like microcirculatory dysfunction, and survival upon rescue treatment is markedly increased by nimodipine
Cabrales, Pedro
Murine cerebral malaria
Vasospasm
Microcirculatory dysfunction
Nimodipine
title_short Murine cerebral malaria is associated with a vasospasm-like microcirculatory dysfunction, and survival upon rescue treatment is markedly increased by nimodipine
title_full Murine cerebral malaria is associated with a vasospasm-like microcirculatory dysfunction, and survival upon rescue treatment is markedly increased by nimodipine
title_fullStr Murine cerebral malaria is associated with a vasospasm-like microcirculatory dysfunction, and survival upon rescue treatment is markedly increased by nimodipine
title_full_unstemmed Murine cerebral malaria is associated with a vasospasm-like microcirculatory dysfunction, and survival upon rescue treatment is markedly increased by nimodipine
title_sort Murine cerebral malaria is associated with a vasospasm-like microcirculatory dysfunction, and survival upon rescue treatment is markedly increased by nimodipine
author Cabrales, Pedro
author_facet Cabrales, Pedro
Zanini, Graziela M.
Meays, Diana
Frangos, John A.
Carvalho, Leonardo J. M.
author_role author
author2 Zanini, Graziela M.
Meays, Diana
Frangos, John A.
Carvalho, Leonardo J. M.
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Cabrales, Pedro
Zanini, Graziela M.
Meays, Diana
Frangos, John A.
Carvalho, Leonardo J. M.
dc.subject.en.pt_BR.fl_str_mv Murine cerebral malaria
Vasospasm
Microcirculatory dysfunction
Nimodipine
topic Murine cerebral malaria
Vasospasm
Microcirculatory dysfunction
Nimodipine
description 2020-07-10
publishDate 2010
dc.date.issued.fl_str_mv 2010
dc.date.accessioned.fl_str_mv 2019-07-10T13:53:13Z
dc.date.available.fl_str_mv 2019-07-10T13:53:13Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CABRALES, Pedro et al. Murine cerebral malaria is associated with a vasospasm-like microcirculatory dysfunction, and survival upon rescue treatment is markedly increased by nimodipine. American Journal of Pathology, v. 176, n. 3, Mar. 2010.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/33945
dc.identifier.issn.pt_BR.fl_str_mv 0002-9440
dc.identifier.doi.none.fl_str_mv 10.2353/ajpath.2010.090691
dc.identifier.eissn.none.fl_str_mv 1525-2191
identifier_str_mv CABRALES, Pedro et al. Murine cerebral malaria is associated with a vasospasm-like microcirculatory dysfunction, and survival upon rescue treatment is markedly increased by nimodipine. American Journal of Pathology, v. 176, n. 3, Mar. 2010.
0002-9440
10.2353/ajpath.2010.090691
1525-2191
url https://www.arca.fiocruz.br/handle/icict/33945
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/33945/1/license.txt
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