Nitric oxide protection against murine cerebral malaria is associated with improved cerebral microcirculatory physiology

Detalhes bibliográficos
Autor(a) principal: Cabrales, Pedro
Data de Publicação: 2011
Outros Autores: Zanini, Graziela M., Meays, Diana, Frangos, John A., Carvalho, Leonardo J. M.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/33940
Resumo: 2020-07-10
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spelling Cabrales, PedroZanini, Graziela M.Meays, DianaFrangos, John A.Carvalho, Leonardo J. M.2019-07-10T13:14:59Z2019-07-10T13:14:59Z2011CABRALES, Pedro et al. Nitric oxide protection against murine cerebral malaria is associated with improved cerebral microcirculatory physiology. Journal of Infectious Diseases, v. 203, p. 1454-1463, 2011.0022-1899https://www.arca.fiocruz.br/handle/icict/3394010.1093/infdis/jir0581537-6613engOxford University PressNitric oxide protection against murine cerebral malaria is associated with improved cerebral microcirculatory physiologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2020-07-10La Jolla Bioengineering Institute. San Diego, CA, USA / University of California, San Diego. Department of Bioengineering. San Diego, CA, USA.La Jolla Bioengineering Institute. San Diego, CA, USA / Fundação Oswaldo Cruz. Instituto de Pesquisas Clinicas Evandro Chagas. Serviço de Parasitologia. Rio de Janeiro, RJ, Brasil.La Jolla Bioengineering Institute. San Diego, CA, USA.La Jolla Bioengineering Institute. San Diego, CA, USALa Jolla Bioengineering Institute. San Diego, CA, USACerebral malaria (CM) is a leading cause of death in Plasmodium falciparum infections. In the Plasmodium berghei ANKA (PbA) murine model, CM pathogenesis is associated with low nitric oxide (NO) bioavailability and brain microcirculatory complications, with a marked decrease in cerebral blood flow, vasoconstriction, vascular plugging by adherent cells, and hemorrhages. Using intravital microscopy through a closed cranial window, here we show that NO supplementation in the form of a NO donor (dipropylenetriamine NONOate [DPTA-NO]) prevented vasoconstriction and improved blood flow in pial vessels of PbA-infected mice. Arterioles and venules of smaller diameters (20-35.5 μm) showed better response to treatment than vessels of larger diameters (36-63 μm). Exogenous NO provided protection against brain hemorrhages (mean, 1.4 vs 24.5 hemorrhagic foci per section) and inflammation (mean, 2.5 vs 10.9 adherent leukocytes per 100 μm vessel length) compared with saline treatment. In conclusion, NO protection against CM is associated with improved brain microcirculatory hemodynamics and decreased vascular pathology.Cerebral malariaMurine modelNitric oxideCerebral microcirculatory physiologyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83101https://www.arca.fiocruz.br/bitstream/icict/33940/1/license.txt63df43feba17d7507b32704290dbf79aMD51ORIGINALNitric oxide protection against murine cerebral malaria is associated with improved cerebral microcirculatory physiology.pdfNitric oxide protection against murine cerebral malaria is associated with improved cerebral microcirculatory physiology.pdfapplication/pdf423188https://www.arca.fiocruz.br/bitstream/icict/33940/2/Nitric%20oxide%20protection%20against%20murine%20cerebral%20malaria%20is%20associated%20with%20improved%20cerebral%20microcirculatory%20physiology.pdf9c94174c3e130cd09b1f0f8c892e1769MD52TEXTNitric oxide protection against murine cerebral malaria is associated with improved cerebral microcirculatory physiology.pdf.txtNitric oxide protection against murine cerebral malaria is associated with improved cerebral microcirculatory physiology.pdf.txtExtracted texttext/plain43487https://www.arca.fiocruz.br/bitstream/icict/33940/3/Nitric%20oxide%20protection%20against%20murine%20cerebral%20malaria%20is%20associated%20with%20improved%20cerebral%20microcirculatory%20physiology.pdf.txt82549b9d6735ebe8023d959a5b4f056aMD53icict/339402021-03-24 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dc.title.pt_BR.fl_str_mv Nitric oxide protection against murine cerebral malaria is associated with improved cerebral microcirculatory physiology
title Nitric oxide protection against murine cerebral malaria is associated with improved cerebral microcirculatory physiology
spellingShingle Nitric oxide protection against murine cerebral malaria is associated with improved cerebral microcirculatory physiology
Cabrales, Pedro
Cerebral malaria
Murine model
Nitric oxide
Cerebral microcirculatory physiology
title_short Nitric oxide protection against murine cerebral malaria is associated with improved cerebral microcirculatory physiology
title_full Nitric oxide protection against murine cerebral malaria is associated with improved cerebral microcirculatory physiology
title_fullStr Nitric oxide protection against murine cerebral malaria is associated with improved cerebral microcirculatory physiology
title_full_unstemmed Nitric oxide protection against murine cerebral malaria is associated with improved cerebral microcirculatory physiology
title_sort Nitric oxide protection against murine cerebral malaria is associated with improved cerebral microcirculatory physiology
author Cabrales, Pedro
author_facet Cabrales, Pedro
Zanini, Graziela M.
Meays, Diana
Frangos, John A.
Carvalho, Leonardo J. M.
author_role author
author2 Zanini, Graziela M.
Meays, Diana
Frangos, John A.
Carvalho, Leonardo J. M.
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Cabrales, Pedro
Zanini, Graziela M.
Meays, Diana
Frangos, John A.
Carvalho, Leonardo J. M.
dc.subject.en.pt_BR.fl_str_mv Cerebral malaria
Murine model
Nitric oxide
Cerebral microcirculatory physiology
topic Cerebral malaria
Murine model
Nitric oxide
Cerebral microcirculatory physiology
description 2020-07-10
publishDate 2011
dc.date.issued.fl_str_mv 2011
dc.date.accessioned.fl_str_mv 2019-07-10T13:14:59Z
dc.date.available.fl_str_mv 2019-07-10T13:14:59Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CABRALES, Pedro et al. Nitric oxide protection against murine cerebral malaria is associated with improved cerebral microcirculatory physiology. Journal of Infectious Diseases, v. 203, p. 1454-1463, 2011.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/33940
dc.identifier.issn.pt_BR.fl_str_mv 0022-1899
dc.identifier.doi.none.fl_str_mv 10.1093/infdis/jir058
dc.identifier.eissn.none.fl_str_mv 1537-6613
identifier_str_mv CABRALES, Pedro et al. Nitric oxide protection against murine cerebral malaria is associated with improved cerebral microcirculatory physiology. Journal of Infectious Diseases, v. 203, p. 1454-1463, 2011.
0022-1899
10.1093/infdis/jir058
1537-6613
url https://www.arca.fiocruz.br/handle/icict/33940
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/33940/1/license.txt
https://www.arca.fiocruz.br/bitstream/icict/33940/2/Nitric%20oxide%20protection%20against%20murine%20cerebral%20malaria%20is%20associated%20with%20improved%20cerebral%20microcirculatory%20physiology.pdf
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