Chronic hepatitis B virus infection drives changes in systemic immune activation profile in patients coinfected with Plasmodium vivax malaria

Detalhes bibliográficos
Autor(a) principal: Cruz, Luís Antonio Bahiana
Data de Publicação: 2019
Outros Autores: Moraes, Marina Oliveira de Albuquerque, Barros, Matheus Rodrigues Queiroga, Fukutani, Kiyoshi Ferreira, Barral Netto, Manoel, Andrade, Bruno de Bezerril
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/34195
Resumo: National Institutes of Health (NIH U01AI115940). The work of KFF was supported by CAPES. LABC received a fellowship from CNPq (154872/2017-2). MOAM. received a fellowship from Fundac¸ão de Amparo à Pesquisa do Estado da Bahia (FAPESB).
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spelling Cruz, Luís Antonio BahianaMoraes, Marina Oliveira de AlbuquerqueBarros, Matheus Rodrigues QueirogaFukutani, Kiyoshi FerreiraBarral Netto, ManoelAndrade, Bruno de Bezerril2019-07-17T16:20:02Z2019-07-17T16:20:02Z2019CRUZ, Luís Antonio Bahiana et al. Chronic hepatitis B virus infection drives changes in systemic immune activation profile in patients coinfected with Plasmodium vivax malaria. PLoS Neglected Tropical Diseases, p. 1-17, June 2019.1935-2727https://www.arca.fiocruz.br/handle/icict/3419510.1371/journal.pntd.00075351935-2735National Institutes of Health (NIH U01AI115940). The work of KFF was supported by CAPES. LABC received a fellowship from CNPq (154872/2017-2). MOAM. received a fellowship from Fundac¸ão de Amparo à Pesquisa do Estado da Bahia (FAPESB).Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Faculdade de Tecnologia e Ciências. Salvador, BA, Brasil / Fundação José Silveira. Multinational Organization Network Sponsoring Translational and Epidemiological Research. Initiative. Salvador, BA, Brazil.Fundação José Silveira. Multinational Organization Network Sponsoring Translational and Epidemiological Research. Initiative. Salvador, BA, Brazil / Universidade Salvador. Laureate Universities, Salvador, BA, Brazil.Fundação José Silveira. Multinational Organization Network Sponsoring Translational and Epidemiological Research. Initiative. Salvador, BA, Brazil / Universidade Salvador. Laureate Universities, Salvador, BA, Brazil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Faculdade de Tecnologia e Ciências. Salvador, BA, Brasil / Fundação José Silveira. Multinational Organization Network Sponsoring Translational and Epidemiological Research. Initiative. Salvador, BA, Brazil / Universidade Salvador. Laureate Universities, Salvador, BA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Universidade Federal da Bahia. Faculdade de Medicina. Salvador, BA, Brasil / Instituto Nacional de Ciência e Tecnologia. Instituto de Investigação em Imunologia. São Paulo, SP, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Faculdade de Tecnologia e Ciências. Salvador, BA, Brasil / Fundação José Silveira. Multinational Organization Network Sponsoring Translational and Epidemiological Research. Initiative. Salvador, BA, Brazil / Universidade Salvador. Laureate Universities, Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, Bahia, Brasil.Background: Plasmodium vivax and Hepatitis B virus (HBV) are globally outspread in similar geographic regions. The concurrence of both infections and its association with some degree of protection against symptomatic and/or severe vivax malaria has been already described. Nevertheless, data on how host response to both pathogens undermines the natural progression of the malarial infection are scarce. Here, a large cohort of vivax malaria and HBV patients is retrospectively analyzed in an attempt to depict how inflammatory characteristics could be potentially related to the protection to severe malaria in coinfection. Methods: A retrospective analysis of a databank containing 601 individuals from the Brazilian Amazon, including 179 symptomatic P. vivax monoinfected patients, 145 individuals with asymptomatic P. vivax monoinfection, 28 P. vivax-HBV coinfected patients, 29 HBV monoinfected subjects and 165 healthy controls, was performed. Data on plasma levels of multiple chemokines, cytokines, acute phase proteins, hepatic enzymes, bilirubin and creatinine were analyzed to describe and compare biochemical profiles associated to each type of infection. Results: Coinfected individuals predominantly presented asymptomatic malaria, referred increased number of previous malaria episodes than symptomatic vivax-monoinfected patients, and were predominantly younger than asymptomatic vivax-monoinfected individuals. Coinfection was hallmarked by substantially elevated concentrations of interleukin (IL)-10 and heightened levels of C-C motif chemokine ligand (CCL)2. Correlation matrices showed that coinfected individuals presented a distinct biomarker profile when compared to asymptomatic or symptomatic P. vivax patients, or HBV-monoinfected individuals. Parasitemia could distinguish coinfected from symptomatic or asymptomatic P. vivax-monoinfected patients. HBV viremia was associated to distinct inflammatory profiles in HBV-monoinfected and coinfected patients. Conclusion: The findings demonstrate a distinct inflammatory profile in coinfected patients, with characteristics associated with immune responses to both pathogens. These host responses to P. vivax and HBV, in conjunction, could be potentially associated, if not mainly responsible, for the protection against symptomatic vivax malaria.engPublic Library of ScienceHepatite B crônicaMaláriaPlasmodium vivaxAnálise de coortesInfecçãoHumanosChronic hepatitis BMalariaPlasmodium vivaxCohort studiesInfectionHumansChronic hepatitis B virus infection drives changes in systemic immune activation profile in patients coinfected with Plasmodium vivax malariainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/34195/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALCruz, L.A. Chronic hepatitis B... 2019.pdfCruz, L.A. 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dc.title.pt_BR.fl_str_mv Chronic hepatitis B virus infection drives changes in systemic immune activation profile in patients coinfected with Plasmodium vivax malaria
title Chronic hepatitis B virus infection drives changes in systemic immune activation profile in patients coinfected with Plasmodium vivax malaria
spellingShingle Chronic hepatitis B virus infection drives changes in systemic immune activation profile in patients coinfected with Plasmodium vivax malaria
Cruz, Luís Antonio Bahiana
Hepatite B crônica
Malária
Plasmodium vivax
Análise de coortes
Infecção
Humanos
Chronic hepatitis B
Malaria
Plasmodium vivax
Cohort studies
Infection
Humans
title_short Chronic hepatitis B virus infection drives changes in systemic immune activation profile in patients coinfected with Plasmodium vivax malaria
title_full Chronic hepatitis B virus infection drives changes in systemic immune activation profile in patients coinfected with Plasmodium vivax malaria
title_fullStr Chronic hepatitis B virus infection drives changes in systemic immune activation profile in patients coinfected with Plasmodium vivax malaria
title_full_unstemmed Chronic hepatitis B virus infection drives changes in systemic immune activation profile in patients coinfected with Plasmodium vivax malaria
title_sort Chronic hepatitis B virus infection drives changes in systemic immune activation profile in patients coinfected with Plasmodium vivax malaria
author Cruz, Luís Antonio Bahiana
author_facet Cruz, Luís Antonio Bahiana
Moraes, Marina Oliveira de Albuquerque
Barros, Matheus Rodrigues Queiroga
Fukutani, Kiyoshi Ferreira
Barral Netto, Manoel
Andrade, Bruno de Bezerril
author_role author
author2 Moraes, Marina Oliveira de Albuquerque
Barros, Matheus Rodrigues Queiroga
Fukutani, Kiyoshi Ferreira
Barral Netto, Manoel
Andrade, Bruno de Bezerril
author2_role author
author
author
author
author
dc.contributor.author.fl_str_mv Cruz, Luís Antonio Bahiana
Moraes, Marina Oliveira de Albuquerque
Barros, Matheus Rodrigues Queiroga
Fukutani, Kiyoshi Ferreira
Barral Netto, Manoel
Andrade, Bruno de Bezerril
dc.subject.other.pt_BR.fl_str_mv Hepatite B crônica
Malária
Plasmodium vivax
Análise de coortes
Infecção
Humanos
topic Hepatite B crônica
Malária
Plasmodium vivax
Análise de coortes
Infecção
Humanos
Chronic hepatitis B
Malaria
Plasmodium vivax
Cohort studies
Infection
Humans
dc.subject.en.en.fl_str_mv Chronic hepatitis B
Malaria
Plasmodium vivax
Cohort studies
Infection
Humans
description National Institutes of Health (NIH U01AI115940). The work of KFF was supported by CAPES. LABC received a fellowship from CNPq (154872/2017-2). MOAM. received a fellowship from Fundac¸ão de Amparo à Pesquisa do Estado da Bahia (FAPESB).
publishDate 2019
dc.date.accessioned.fl_str_mv 2019-07-17T16:20:02Z
dc.date.available.fl_str_mv 2019-07-17T16:20:02Z
dc.date.issued.fl_str_mv 2019
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CRUZ, Luís Antonio Bahiana et al. Chronic hepatitis B virus infection drives changes in systemic immune activation profile in patients coinfected with Plasmodium vivax malaria. PLoS Neglected Tropical Diseases, p. 1-17, June 2019.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/34195
dc.identifier.issn.pt_BR.fl_str_mv 1935-2727
dc.identifier.doi.pt_BR.fl_str_mv 10.1371/journal.pntd.0007535
dc.identifier.eissn.pt_BR.fl_str_mv 1935-2735
identifier_str_mv CRUZ, Luís Antonio Bahiana et al. Chronic hepatitis B virus infection drives changes in systemic immune activation profile in patients coinfected with Plasmodium vivax malaria. PLoS Neglected Tropical Diseases, p. 1-17, June 2019.
1935-2727
10.1371/journal.pntd.0007535
1935-2735
url https://www.arca.fiocruz.br/handle/icict/34195
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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collection Repositório Institucional da FIOCRUZ (ARCA)
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