Evaluation of microvascular endothelial function and capillary density in patients with infective endocarditis using laser speckle contrast imaging and video-capillaroscopy

Detalhes bibliográficos
Autor(a) principal: Barcelos, Amanda
Data de Publicação: 2018
Outros Autores: Tibirica, Eduardo, Lamas, Cristiane
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
DOI: 10.1016/j.mvr.2018.02.007
Texto Completo: https://www.arca.fiocruz.br/handle/icict/33747
Resumo: 2020-07-01
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spelling Barcelos, AmandaTibirica, EduardoLamas, Cristiane2019-07-01T13:34:32Z2019-07-01T13:34:32Z2018BARCELOS, Amanda; TIBIRICA, Eduardo; LAMAS, Cristiane. Evaluation of microvascular endothelial function and capillary density in patients with infective endocarditis using laser speckle contrast imaging and video-capillaroscopy. Microvascular Research, v. 118, p. 61-68, 2018.0026-2862https://www.arca.fiocruz.br/handle/icict/3374710.1016/j.mvr.2018.02.0071095-9319engElsevierEvaluation of microvascular endothelial function and capillary density in patients with infective endocarditis using laser speckle contrast imaging and video-capillaroscopyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2020-07-01Ministry of Health. National Institute of Cardiology. Rio de Janeiro, RJ, Brazil.Ministry of Health. National Institute of Cardiology. Rio de Janeiro, RJ, Brazil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil.Ministry of Health. National Institute of Cardiology. Rio de Janeiro, RJ, Brazil / Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil / Universidade do Grande Rio. Duque de Caxias, RJ, Brasil.Objective: To evaluate the systemic microcirculation of patients with infective endocarditis (IE). Methods: This is a comparative study of patients with definite IE by the modified Duke criteria admitted to our center for treatment. A reference group of sex- and age-matched healthy volunteers was included. Microvascular flow was evaluated in the forearm using a laser speckle contrast imaging system, for noninvasive measurement of cutaneous microvascular perfusion, in combination with skin iontophoresis of acetylcholine (ACh) and sodium nitroprusside (SNP) to test microvascular reactivity. Microvascular density was evaluated using skin video-ca-pillaroscopy. Results: We studied 22 patients with IE; 15 were male and seven female. The mean age and standard deviation(SD) were 45.5 ± 17.3 years. Basal skin microvascular conductance was significantly increased in patients with IE, compared with healthy individuals (0.36 ± 0.13 versus 0.21 ± 0.08 APU/mmHg;P< 0.0001). The in-crease in microvascular conductance induced by ACh in patients was 0.21 ± 0.17 and in the reference group, it was 0.37 ± 0.14 APU/mmHg (P= 0.0012). The increase in microvascular conductance induced by SNP inpatients was 0.18 ± 0.14 and it was 0.29 ± 0.15 APU/mmHg (P= 0.0140) in the reference group. The basal mean skin capillary density of patients (135 ± 24 capillaries/mm2) was significantly higher, compared with controls (97 ± 21 capillaries/mm2;P< 0.0001).Conclusions: The main findings in the microcirculation of patients with IE were greater basal vasodilation and areduction of the endothelium-dependent and -independent microvascular reactivity, as well as greater functionalskin capillary density compared to healthy individuals.Infective endocarditisMicrocirculationMicrovascular dysfunctionCapillary densitySpeckle contrast imagingSkin video-capillaroscopyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1748https://www.arca.fiocruz.br/bitstream/icict/33747/1/license.txt8a4605be74aa9ea9d79846c1fba20a33MD51ORIGINALve_Barcelos_Amanda_etal_INI_2108.pdfve_Barcelos_Amanda_etal_INI_2108.pdfapplication/pdf1005483https://www.arca.fiocruz.br/bitstream/icict/33747/2/ve_Barcelos_Amanda_etal_INI_2108.pdf98e3454b33e2e3d05d7ca02f24876640MD52TEXTve_Barcelos_Amanda_etal_INI_2108.pdf.txtve_Barcelos_Amanda_etal_INI_2108.pdf.txtExtracted texttext/plain43752https://www.arca.fiocruz.br/bitstream/icict/33747/3/ve_Barcelos_Amanda_etal_INI_2108.pdf.txt0378a566707e583d837d71d6209b2a47MD53icict/337472021-03-24 16:32:33.87oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352021-03-24T19:32:33Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Evaluation of microvascular endothelial function and capillary density in patients with infective endocarditis using laser speckle contrast imaging and video-capillaroscopy
title Evaluation of microvascular endothelial function and capillary density in patients with infective endocarditis using laser speckle contrast imaging and video-capillaroscopy
spellingShingle Evaluation of microvascular endothelial function and capillary density in patients with infective endocarditis using laser speckle contrast imaging and video-capillaroscopy
Barcelos, Amanda
Infective endocarditis
Microcirculation
Microvascular dysfunction
Capillary density
Speckle contrast imaging
Skin video-capillaroscopy
title_short Evaluation of microvascular endothelial function and capillary density in patients with infective endocarditis using laser speckle contrast imaging and video-capillaroscopy
title_full Evaluation of microvascular endothelial function and capillary density in patients with infective endocarditis using laser speckle contrast imaging and video-capillaroscopy
title_fullStr Evaluation of microvascular endothelial function and capillary density in patients with infective endocarditis using laser speckle contrast imaging and video-capillaroscopy
title_full_unstemmed Evaluation of microvascular endothelial function and capillary density in patients with infective endocarditis using laser speckle contrast imaging and video-capillaroscopy
title_sort Evaluation of microvascular endothelial function and capillary density in patients with infective endocarditis using laser speckle contrast imaging and video-capillaroscopy
author Barcelos, Amanda
author_facet Barcelos, Amanda
Tibirica, Eduardo
Lamas, Cristiane
author_role author
author2 Tibirica, Eduardo
Lamas, Cristiane
author2_role author
author
dc.contributor.author.fl_str_mv Barcelos, Amanda
Tibirica, Eduardo
Lamas, Cristiane
dc.subject.en.pt_BR.fl_str_mv Infective endocarditis
Microcirculation
Microvascular dysfunction
Capillary density
Speckle contrast imaging
Skin video-capillaroscopy
topic Infective endocarditis
Microcirculation
Microvascular dysfunction
Capillary density
Speckle contrast imaging
Skin video-capillaroscopy
description 2020-07-01
publishDate 2018
dc.date.issued.fl_str_mv 2018
dc.date.accessioned.fl_str_mv 2019-07-01T13:34:32Z
dc.date.available.fl_str_mv 2019-07-01T13:34:32Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BARCELOS, Amanda; TIBIRICA, Eduardo; LAMAS, Cristiane. Evaluation of microvascular endothelial function and capillary density in patients with infective endocarditis using laser speckle contrast imaging and video-capillaroscopy. Microvascular Research, v. 118, p. 61-68, 2018.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/33747
dc.identifier.issn.pt_BR.fl_str_mv 0026-2862
dc.identifier.doi.none.fl_str_mv 10.1016/j.mvr.2018.02.007
dc.identifier.eissn.none.fl_str_mv 1095-9319
identifier_str_mv BARCELOS, Amanda; TIBIRICA, Eduardo; LAMAS, Cristiane. Evaluation of microvascular endothelial function and capillary density in patients with infective endocarditis using laser speckle contrast imaging and video-capillaroscopy. Microvascular Research, v. 118, p. 61-68, 2018.
0026-2862
10.1016/j.mvr.2018.02.007
1095-9319
url https://www.arca.fiocruz.br/handle/icict/33747
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
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