Penile microvascular endothelial function in hypertensive patients: effects of acute type 5 phosphodiesterase inhibition

Detalhes bibliográficos
Autor(a) principal: Verri, V.
Data de Publicação: 2018
Outros Autores: Brandão, A. A., Tibiriçá, Eduardo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/28869
Resumo: Ministério da Saúde. Instituto Nacional de Cardiologia. Rio de Janeiro, RJ, Brasil.
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spelling Verri, V.Brandão, A. A.Tibiriçá, Eduardo2018-09-18T16:38:27Z2018-09-18T16:38:27Z2018VERN, V.; BRANDÃO, A. A.; TIBIRIÇÁ, Eduardo. Penile microvascular endothelial function in hypertensive patients: effects of acute type 5 phosphodiesterase inhibition. Brazilian Journal of Medical and Biological Research, v. 51, n. 3, p.1-10, 2018.0100-879Xhttps://www.arca.fiocruz.br/handle/icict/2886910.1590/1414-431X201766011414-431XengAssociação Brasileira de Divulgação CientíficaHipertensãoDisfunção microvascularImagem de contraste de speckle a laserMicrocirculação PenianaMicrovascular dysfunctionHypertensionLaser speckle contrast imagingPenile microcirculationPenile microvascular endothelial function in hypertensive patients: effects of acute type 5 phosphodiesterase inhibitioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleMinistério da Saúde. Instituto Nacional de Cardiologia. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.Ministério da Saúde. Instituto Nacional de Cardiologia. Rio de Janeiro, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil.The primary aim of this study was to evaluate penile endothelial microvascular function in patients with primary arterial hypertension and age-matched normotensive subjects using laser speckle contrast imaging (LSCI). Additionally, we analyzed the acute penile microvascular effects induced by oral phosphodiesterase type 5 inhibitor (sildenafil; SIL) administration. Endothelium-dependent microvascular reactivity was evaluated in the penises and forearms of hypertensive patients (aged 58.8±6.6 years, n=34) and age-matched healthy volunteers (n=33) at rest and 60 min following oral SIL (100 mg) administration. LSCI was coupled with cutaneous acetylcholine (ACh) iontophoresis using increasing anodal currents. Basal penile cutaneous vascular conductance (CVC) values were not significantly different between control subjects and hypertensive individuals. Penile CVC values increased significantly after SIL administration in control (P<0.0001) and hypertensive (P<0.0001) subjects. Peak CVC values were not different between the two groups during penile ACh iontophoresis before SIL administration (P=0.2052). Peak CVC values were higher in control subjects than in hypertensive subjects after SIL administration (P=0.0427). Penile endothelium-dependent microvascular function is, to some extent, preserved in patients presenting with primary arterial hypertension under effective anti-hypertensive treatment. LSCI may be a valuable non-invasive tool for the evaluation of penile vascular responses to phosphodiesterase type 5 inhibitor.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/28869/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALeduardo_tibiriça_etal_IOC_2018.pdfeduardo_tibiriça_etal_IOC_2018.pdfapplication/pdf642086https://www.arca.fiocruz.br/bitstream/icict/28869/2/eduardo_tibiri%c3%a7a_etal_IOC_2018.pdf452bdb566810aa55904fd12bb0e541f6MD52TEXTeduardo_tibiriça_etal_IOC_2018.pdf.txteduardo_tibiriça_etal_IOC_2018.pdf.txtExtracted texttext/plain42230https://www.arca.fiocruz.br/bitstream/icict/28869/3/eduardo_tibiri%c3%a7a_etal_IOC_2018.pdf.txt32944dc47e6991093e9fc8e2074824adMD53icict/288692023-09-05 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dc.title.pt_BR.fl_str_mv Penile microvascular endothelial function in hypertensive patients: effects of acute type 5 phosphodiesterase inhibition
title Penile microvascular endothelial function in hypertensive patients: effects of acute type 5 phosphodiesterase inhibition
spellingShingle Penile microvascular endothelial function in hypertensive patients: effects of acute type 5 phosphodiesterase inhibition
Verri, V.
Hipertensão
Disfunção microvascular
Imagem de contraste de speckle a laser
Microcirculação Peniana
Microvascular dysfunction
Hypertension
Laser speckle contrast imaging
Penile microcirculation
title_short Penile microvascular endothelial function in hypertensive patients: effects of acute type 5 phosphodiesterase inhibition
title_full Penile microvascular endothelial function in hypertensive patients: effects of acute type 5 phosphodiesterase inhibition
title_fullStr Penile microvascular endothelial function in hypertensive patients: effects of acute type 5 phosphodiesterase inhibition
title_full_unstemmed Penile microvascular endothelial function in hypertensive patients: effects of acute type 5 phosphodiesterase inhibition
title_sort Penile microvascular endothelial function in hypertensive patients: effects of acute type 5 phosphodiesterase inhibition
author Verri, V.
author_facet Verri, V.
Brandão, A. A.
Tibiriçá, Eduardo
author_role author
author2 Brandão, A. A.
Tibiriçá, Eduardo
author2_role author
author
dc.contributor.author.fl_str_mv Verri, V.
Brandão, A. A.
Tibiriçá, Eduardo
dc.subject.other.pt_BR.fl_str_mv Hipertensão
Disfunção microvascular
Imagem de contraste de speckle a laser
Microcirculação Peniana
topic Hipertensão
Disfunção microvascular
Imagem de contraste de speckle a laser
Microcirculação Peniana
Microvascular dysfunction
Hypertension
Laser speckle contrast imaging
Penile microcirculation
dc.subject.en.pt_BR.fl_str_mv Microvascular dysfunction
Hypertension
Laser speckle contrast imaging
Penile microcirculation
description Ministério da Saúde. Instituto Nacional de Cardiologia. Rio de Janeiro, RJ, Brasil.
publishDate 2018
dc.date.accessioned.fl_str_mv 2018-09-18T16:38:27Z
dc.date.available.fl_str_mv 2018-09-18T16:38:27Z
dc.date.issued.fl_str_mv 2018
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv VERN, V.; BRANDÃO, A. A.; TIBIRIÇÁ, Eduardo. Penile microvascular endothelial function in hypertensive patients: effects of acute type 5 phosphodiesterase inhibition. Brazilian Journal of Medical and Biological Research, v. 51, n. 3, p.1-10, 2018.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/28869
dc.identifier.issn.pt_BR.fl_str_mv 0100-879X
dc.identifier.doi.none.fl_str_mv 10.1590/1414-431X20176601
dc.identifier.eissn.none.fl_str_mv 1414-431X
identifier_str_mv VERN, V.; BRANDÃO, A. A.; TIBIRIÇÁ, Eduardo. Penile microvascular endothelial function in hypertensive patients: effects of acute type 5 phosphodiesterase inhibition. Brazilian Journal of Medical and Biological Research, v. 51, n. 3, p.1-10, 2018.
0100-879X
10.1590/1414-431X20176601
1414-431X
url https://www.arca.fiocruz.br/handle/icict/28869
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
publisher.none.fl_str_mv Associação Brasileira de Divulgação Científica
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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