Dissociation between vasodilation and Leishmania infection-enhancing effects of sand fly saliva and maxadilan
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2001 |
| Outros Autores: | , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/6289 |
Resumo: | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Imunologia Molecular e Celular. Salvador, BA, Brasil |
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Sousa, Fábio CastroSilva, Moacir ParanhosSherlock, Ítalo Rodrigues de AraújoPaixão, Mariza SPontes-de-Carvalho, Lain CarlosdosSantos, Washington Luis Conrado2013-02-01T18:16:14Z2013-02-01T18:16:14Z2001SOUSA, F. C. et al. Dissociation between vasodilation and Leishmania infection-enhancing effects of sand fly saliva and maxadilan. Memórias do Instituto Oswaldo Cruz, v. 96, n. 7, p.997-999, 2001.0074-0276https://www.arca.fiocruz.br/handle/icict/6289engDissociation between vasodilation and Leishmania infection-enhancing effects of sand fly saliva and maxadilaninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Imunologia Molecular e Celular. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Imunologia Molecular e Celular. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Imunologia Molecular e Celular. Salvador, BA, BrasilSecretaria da Saúde do Estado da Bahia. Laboratório Central. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, BrasilIn this study, the ability of maxadilan and Lutzomyia longipalpis salivary gland lysate to enhance the infection of CBA mice by Leishmania major and of BALB/c mice by L. braziliensis was tested. No difference was observed between sizes of lesion in CBA mice infected with L. major and treated or not with salivary gland lysate or maxadilan, although they were injected in concentrations that induced cutaneous vasodilation. Although parasites were more frequently observed in foot pads and spleens of animals treated with maxadilan than in the animals treated with salivary gland lysate or saline, the differences were small and not statistically significant. The lesions in BALB/c mice infected with L. braziliensis and treated with maxadilan were slightly larger than in animals that received Leishmania alone. Such differences disappeared 14 weeks after infection, and were statistically significant only in one of two experiments.Lutzomyia longipalpis salivaMaxadilanLeishmania majorLeishmania braziliensisVasodilationLeishmaniose Cutânea/parasitologiaPsychodidae/químicaVasodilatadores/farmacologiaExtratos de Tecidos/farmacologiaLeishmania/patogenicidadeLeishmaniose Cutânea/imunologiaLeishmaniose Cutânea/patologiaPsychodidae/efeitos de drogasCamundongos Endogâmicos BALB CLeishmania braziliensis/patogenicidadeLeishmania majorGlândulas Salivares/químicaGlândulas Salivares/efeitos de drogasAnimaisCamundongosinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALCastro-Sousa, Fábio Dissociation....pdfCastro-Sousa, Fábio Dissociation....pdfapplication/pdf59638https://www.arca.fiocruz.br/bitstream/icict/6289/1/Castro-Sousa%2c%20F%c3%a1bio%20Dissociation....pdf787f1af1d99ed5b0a98559df86143888MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/6289/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTCastro-Sousa, Fábio Dissociation....pdf.txtCastro-Sousa, Fábio Dissociation....pdf.txtExtracted texttext/plain11598https://www.arca.fiocruz.br/bitstream/icict/6289/5/Castro-Sousa%2c%20F%c3%a1bio%20Dissociation....pdf.txt928bbc3ae43f64bbd552a9463818a9e1MD55THUMBNAILCastro-Sousa, Fábio Dissociation....pdf.jpgCastro-Sousa, Fábio Dissociation....pdf.jpgGenerated Thumbnailimage/jpeg2363https://www.arca.fiocruz.br/bitstream/icict/6289/4/Castro-Sousa%2c%20F%c3%a1bio%20Dissociation....pdf.jpg23794a5990545f0a3bd0b9a6277f2460MD54icict/62892023-03-15 14:33:00.194oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Dissociation between vasodilation and Leishmania infection-enhancing effects of sand fly saliva and maxadilan |
| title |
Dissociation between vasodilation and Leishmania infection-enhancing effects of sand fly saliva and maxadilan |
| spellingShingle |
Dissociation between vasodilation and Leishmania infection-enhancing effects of sand fly saliva and maxadilan Sousa, Fábio Castro Lutzomyia longipalpis saliva Maxadilan Leishmania major Leishmania braziliensis Vasodilation Leishmaniose Cutânea/parasitologia Psychodidae/química Vasodilatadores/farmacologia Extratos de Tecidos/farmacologia Leishmania/patogenicidade Leishmaniose Cutânea/imunologia Leishmaniose Cutânea/patologia Psychodidae/efeitos de drogas Camundongos Endogâmicos BALB C Leishmania braziliensis/patogenicidade Leishmania major Glândulas Salivares/química Glândulas Salivares/efeitos de drogas Animais Camundongos |
| title_short |
Dissociation between vasodilation and Leishmania infection-enhancing effects of sand fly saliva and maxadilan |
| title_full |
Dissociation between vasodilation and Leishmania infection-enhancing effects of sand fly saliva and maxadilan |
| title_fullStr |
Dissociation between vasodilation and Leishmania infection-enhancing effects of sand fly saliva and maxadilan |
| title_full_unstemmed |
Dissociation between vasodilation and Leishmania infection-enhancing effects of sand fly saliva and maxadilan |
| title_sort |
Dissociation between vasodilation and Leishmania infection-enhancing effects of sand fly saliva and maxadilan |
| author |
Sousa, Fábio Castro |
| author_facet |
Sousa, Fábio Castro Silva, Moacir Paranhos Sherlock, Ítalo Rodrigues de Araújo Paixão, Mariza S Pontes-de-Carvalho, Lain Carlos dosSantos, Washington Luis Conrado |
| author_role |
author |
| author2 |
Silva, Moacir Paranhos Sherlock, Ítalo Rodrigues de Araújo Paixão, Mariza S Pontes-de-Carvalho, Lain Carlos dosSantos, Washington Luis Conrado |
| author2_role |
author author author author author |
| dc.contributor.author.fl_str_mv |
Sousa, Fábio Castro Silva, Moacir Paranhos Sherlock, Ítalo Rodrigues de Araújo Paixão, Mariza S Pontes-de-Carvalho, Lain Carlos dosSantos, Washington Luis Conrado |
| dc.subject.en.pt_BR.fl_str_mv |
Lutzomyia longipalpis saliva Maxadilan Leishmania major Leishmania braziliensis Vasodilation |
| topic |
Lutzomyia longipalpis saliva Maxadilan Leishmania major Leishmania braziliensis Vasodilation Leishmaniose Cutânea/parasitologia Psychodidae/química Vasodilatadores/farmacologia Extratos de Tecidos/farmacologia Leishmania/patogenicidade Leishmaniose Cutânea/imunologia Leishmaniose Cutânea/patologia Psychodidae/efeitos de drogas Camundongos Endogâmicos BALB C Leishmania braziliensis/patogenicidade Leishmania major Glândulas Salivares/química Glândulas Salivares/efeitos de drogas Animais Camundongos |
| dc.subject.decs.pt_BR.fl_str_mv |
Leishmaniose Cutânea/parasitologia Psychodidae/química Vasodilatadores/farmacologia Extratos de Tecidos/farmacologia Leishmania/patogenicidade Leishmaniose Cutânea/imunologia Leishmaniose Cutânea/patologia Psychodidae/efeitos de drogas Camundongos Endogâmicos BALB C Leishmania braziliensis/patogenicidade Leishmania major Glândulas Salivares/química Glândulas Salivares/efeitos de drogas Animais Camundongos |
| description |
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Imunologia Molecular e Celular. Salvador, BA, Brasil |
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2001 |
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2001 |
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2013-02-01T18:16:14Z |
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2013-02-01T18:16:14Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.citation.fl_str_mv |
SOUSA, F. C. et al. Dissociation between vasodilation and Leishmania infection-enhancing effects of sand fly saliva and maxadilan. Memórias do Instituto Oswaldo Cruz, v. 96, n. 7, p.997-999, 2001. |
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https://www.arca.fiocruz.br/handle/icict/6289 |
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0074-0276 |
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SOUSA, F. C. et al. Dissociation between vasodilation and Leishmania infection-enhancing effects of sand fly saliva and maxadilan. Memórias do Instituto Oswaldo Cruz, v. 96, n. 7, p.997-999, 2001. 0074-0276 |
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