Immunity to Lutzomyia intermedia saliva modulates the inflammatory environment induced by Leishmania braziliensis

Detalhes bibliográficos
Autor(a) principal: Moura, Tatiana Rodrigues de
Data de Publicação: 2010
Outros Autores: Oliveira, Fabiano, Rodrigues, Gabriele C, Carneiro, Marcia Weber, Fukutani, Kiyoshi Ferreira, Novais, Fernanda Oliveira, Miranda, José Carlos, Barral Netto, Manoel, Brodskyn, Claudia Ida, Barral, Aldina Maria Prado, Oliveira, Camila Indiani de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/1801
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
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spelling Moura, Tatiana Rodrigues deOliveira, FabianoRodrigues, Gabriele CCarneiro, Marcia WeberFukutani, Kiyoshi FerreiraNovais, Fernanda OliveiraMiranda, José CarlosBarral Netto, ManoelBrodskyn, Claudia IdaBarral, Aldina Maria PradoOliveira, Camila Indiani de2011-03-30T14:23:24Z2011-03-30T14:23:24Z2010MOURA, T. R. de et al. Immunity to Lutzomyia intermedia saliva modulates the inflammatory environment induced by Leishmania braziliensis. PLoS Neglected Tropical Diseases, v.4, n.6, p. e712, 2010.https://www.arca.fiocruz.br/handle/icict/180110.1371/journal.pntd.0000712engImmunity to Lutzomyia intermedia saliva modulates the inflammatory environment induced by Leishmania braziliensisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilNational Institute of Allergy and Infectious Diseases. National Institutes of Health. Vector Molecular Biology Unit. Bethesda, MD, United States of AmericaFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilBACKGROUND: During blood feeding, sand flies inject Leishmania parasites in the presence of saliva. The types and functions of cells present at the first host-parasite contact are critical to the outcome on infection and sand fly saliva has been shown to play an important role in this setting. Herein, we investigated the in vivo chemotactic effects of Lutzomyia intermedia saliva, the vector of Leishmania braziliensis, combined or not with the parasite. METHODS AND FINDINGS: We tested the initial response induced by Lutzomyia intermedia salivary gland sonicate (SGS) in BALB/c mice employing the air pouch model of inflammation. L. intermedia SGS induced a rapid influx of macrophages and neutrophils. In mice that were pre-sensitized with L. intermedia saliva, injection of SGS was associated with increased neutrophil recruitment and a significant up-regulation of CXCL1, CCL2, CCL4 and TNF-alpha expression. Surprisingly, in mice that were pre-exposed to SGS, a combination of SGS and L. braziliensis induced a significant migration of neutrophils and an important modulation in cytokine and chemokine expression as shown by decreased CXCL10 expression and increased IL-10 expression. CONCLUSION: These results confirm that sand fly saliva modulates the initial host response. More importantly, pre-exposure to L. intermedia saliva significantly modifies the host's response to L. braziliensis, in terms of cellular recruitment and expression of cytokines and chemokines. This particular immune modulation may, in turn, favor parasite multiplication.Saliva/IMPsychodidae/IMLeishmaniose cutânea/IMLeishmania braziliensis/IMInflamação/IMCamundongos Endogâmicos BALB Cinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALImmunity to Lutzomyia intermedia Saliva.pdfImmunity to Lutzomyia intermedia Saliva.pdfapplication/pdf2303990https://www.arca.fiocruz.br/bitstream/icict/1801/1/Immunity%20to%20Lutzomyia%20intermedia%20Saliva.pdfd1b2cada44c96cb500082a7a33d1bc46MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://www.arca.fiocruz.br/bitstream/icict/1801/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52TEXTImmunity to Lutzomyia intermedia Saliva.pdf.txtImmunity to Lutzomyia intermedia Saliva.pdf.txtExtracted texttext/plain49094https://www.arca.fiocruz.br/bitstream/icict/1801/5/Immunity%20to%20Lutzomyia%20intermedia%20Saliva.pdf.txtdb139856268290768ab8e07fddc8f887MD55THUMBNAILImmunity to Lutzomyia intermedia Saliva.pdf.jpgImmunity to Lutzomyia intermedia Saliva.pdf.jpgGenerated Thumbnailimage/jpeg2055https://www.arca.fiocruz.br/bitstream/icict/1801/4/Immunity%20to%20Lutzomyia%20intermedia%20Saliva.pdf.jpg00885d0e97817dec918c34197b17afebMD54icict/18012023-03-15 14:33:19.794oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:19Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Immunity to Lutzomyia intermedia saliva modulates the inflammatory environment induced by Leishmania braziliensis
title Immunity to Lutzomyia intermedia saliva modulates the inflammatory environment induced by Leishmania braziliensis
spellingShingle Immunity to Lutzomyia intermedia saliva modulates the inflammatory environment induced by Leishmania braziliensis
Moura, Tatiana Rodrigues de
Saliva/IM
Psychodidae/IM
Leishmaniose cutânea/IM
Leishmania braziliensis/IM
Inflamação/IM
Camundongos Endogâmicos BALB C
title_short Immunity to Lutzomyia intermedia saliva modulates the inflammatory environment induced by Leishmania braziliensis
title_full Immunity to Lutzomyia intermedia saliva modulates the inflammatory environment induced by Leishmania braziliensis
title_fullStr Immunity to Lutzomyia intermedia saliva modulates the inflammatory environment induced by Leishmania braziliensis
title_full_unstemmed Immunity to Lutzomyia intermedia saliva modulates the inflammatory environment induced by Leishmania braziliensis
title_sort Immunity to Lutzomyia intermedia saliva modulates the inflammatory environment induced by Leishmania braziliensis
author Moura, Tatiana Rodrigues de
author_facet Moura, Tatiana Rodrigues de
Oliveira, Fabiano
Rodrigues, Gabriele C
Carneiro, Marcia Weber
Fukutani, Kiyoshi Ferreira
Novais, Fernanda Oliveira
Miranda, José Carlos
Barral Netto, Manoel
Brodskyn, Claudia Ida
Barral, Aldina Maria Prado
Oliveira, Camila Indiani de
author_role author
author2 Oliveira, Fabiano
Rodrigues, Gabriele C
Carneiro, Marcia Weber
Fukutani, Kiyoshi Ferreira
Novais, Fernanda Oliveira
Miranda, José Carlos
Barral Netto, Manoel
Brodskyn, Claudia Ida
Barral, Aldina Maria Prado
Oliveira, Camila Indiani de
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Moura, Tatiana Rodrigues de
Oliveira, Fabiano
Rodrigues, Gabriele C
Carneiro, Marcia Weber
Fukutani, Kiyoshi Ferreira
Novais, Fernanda Oliveira
Miranda, José Carlos
Barral Netto, Manoel
Brodskyn, Claudia Ida
Barral, Aldina Maria Prado
Oliveira, Camila Indiani de
dc.subject.decs.pt_BR.fl_str_mv Saliva/IM
Psychodidae/IM
Leishmaniose cutânea/IM
Leishmania braziliensis/IM
Inflamação/IM
Camundongos Endogâmicos BALB C
topic Saliva/IM
Psychodidae/IM
Leishmaniose cutânea/IM
Leishmania braziliensis/IM
Inflamação/IM
Camundongos Endogâmicos BALB C
description Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
publishDate 2010
dc.date.issued.fl_str_mv 2010
dc.date.accessioned.fl_str_mv 2011-03-30T14:23:24Z
dc.date.available.fl_str_mv 2011-03-30T14:23:24Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv MOURA, T. R. de et al. Immunity to Lutzomyia intermedia saliva modulates the inflammatory environment induced by Leishmania braziliensis. PLoS Neglected Tropical Diseases, v.4, n.6, p. e712, 2010.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/1801
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pntd.0000712
identifier_str_mv MOURA, T. R. de et al. Immunity to Lutzomyia intermedia saliva modulates the inflammatory environment induced by Leishmania braziliensis. PLoS Neglected Tropical Diseases, v.4, n.6, p. e712, 2010.
10.1371/journal.pntd.0000712
url https://www.arca.fiocruz.br/handle/icict/1801
dc.language.iso.fl_str_mv eng
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