C7a, a biphosphinic cyclopalladated compound, efficiently controls the development of a patient-derived xenograft model of adult T cell leukemia/lymphoma.
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2011 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/8497 |
Resumo: | Universidade Federal de São Paulo. UNIFESP-EPM. Unidade de Oncologia Experimental, Departamento de Microbiologia, Imunologia e Parasitologia. São Paulo, SP, Brasil |
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Correa, Ana Beatriz GuimarãesCrawford, Lindsey BFigueiredo, Carlos RGimenes, Karina PanizziPinto, Lorena AnaGrassi, Maria Fernanda RiosFeuer, GeroldTravassos, Luiz RodolphoCaires, Antonio Carlos FáveroRodrigues, Elaine GMarriott, Susan J2014-10-03T18:50:40Z2014-10-03T18:50:40Z2011CORREA, A. B. G. et al. C7a, a biphosphinic cyclopalladated compound, efficiently controls the development of a patient-derived xenograft model of adult T cell leukemia/lymphoma. Viruses, v. 3, n. 7, p. 1041-1058, 2011.1999-491510.3390/v3071041https://www.arca.fiocruz.br/handle/icict/8497engMDPIC7a, a biphosphinic cyclopalladated compound, efficiently controls the development of a patient-derived xenograft model of adult T cell leukemia/lymphoma.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de São Paulo. UNIFESP-EPM. Unidade de Oncologia Experimental, Departamento de Microbiologia, Imunologia e Parasitologia. São Paulo, SP, BrasilSUNY Upstate Medical University. Syracuse Department of Microbiology and Immunology. New York, USAUniversidade Federal de São Paulo. UNIFESP-EPM. Unidade de Oncologia Experimental, Departamento de Microbiologia, Imunologia e Parasitologia. São Paulo, SP, BrasilUniversidade Federal de São Paulo. UNIFESP-EPM. Unidade de Oncologia Experimental, Departamento de Microbiologia, Imunologia e Parasitologia. São Paulo, SP, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, BrasilHumurine Technologies. Arrow Highway, La Verne, USAUniversidade Federal de São Paulo. UNIFESP-EPM. Unidade de Oncologia Experimental, Departamento de Microbiologia, Imunologia e Parasitologia. São Paulo, SP, BrasilUniversidade de Mogi de Cruzes. Centro Interdisciplinar de Investigação Bioquímica. Mogi das Cruzes, SP, BrasilUniversidade Federal de São Paulo. UNIFESP-EPM. Unidade de Oncologia Experimental, Departamento de Microbiologia, Imunologia e Parasitologia. São Paulo, SP, BrasilBaylor College of Medicine. Department of Molecular Virology and Microbiology. Houston Texas, USAAdult T-cell leukemia/lymphoma (ATLL) is a highly aggressive disease that occurs in individuals infected with the human T lymphotropic virus type 1 (HTLV-1). Patients with aggressive ATLL have a poor prognosis because the leukemic cells are resistant to conventional chemotherapy. We have investigated the therapeutic efficacy of a biphosphinic cyclopalladated complex {Pd(2) [S(-)C(2), N-dmpa](2) (µ-dppe)Cl(2)}, termed C7a, in a patient-derived xenograft model of ATLL, and investigated the mechanism of C7a action in HTLV-1-positive and negative transformed T cell lines in vitro. In vivo survival studies in immunocompromised mice inoculated with human RV-ATL cells and intraperitoneally treated with C7a led to significantly increased survival of the treated mice. We investigated the mechanism of C7a activity in vitro and found that it induced mitochondrial release of cytochrome c, caspase activation, nuclear condensation and DNA degradation. These results suggest that C7a triggers apoptotic cell death in both HTLV-1 infected and uninfected human transformed T-cell lines. Significantly, C7a was not cytotoxic to peripheral blood mononuclear cells (PBMC) from healthy donors and HTLV-1-infected individuals. C7a inhibited more than 60% of the ex vivo spontaneous proliferation of PBMC from HTLV-1-infected individuals. These results support a potential therapeutic role for C7a in both ATLL and HTLV-1-negative T-cell lymphomas.Cyclopalladated compoundHTLV-1ATLLChemotherapyXenograft modelApoptosisApoptose/efeitos de drogasComplexos de Coordenação/farmacologiaVírus 1 Linfotrópico T Humano/crescimento & desenvolvimentoLeucemia-Linfoma de Células T do Adulto/quimioterapiaPaládio/farmacologiaFeniramina/análogos & derivadosAnimaisLinhagem Celular TransformadaSobrevivência Celular/efeitos de drogasCitocromos c/metabolismoCitometria de FluxoHumanosLeucemia-Linfoma de Células T do Adulto/virologiaCamundongosCamundongos SCIDFeniramina/farmacologiaOrganismos Livres de Patógenos EspecíficosEnsaios Antitumorais Modelo de Xenoenxertoinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/8497/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALCorreia ABG C7a a Biphosphinic....pdfCorreia ABG C7a a Biphosphinic....pdfapplication/pdf780743https://www.arca.fiocruz.br/bitstream/icict/8497/2/Correia%20ABG%20C7a%20a%20Biphosphinic....pdf005cdd6045b4745755308b3f78929ee9MD52TEXTCorreia ABG C7a a Biphosphinic....pdf.txtCorreia ABG C7a a Biphosphinic....pdf.txtExtracted texttext/plain52139https://www.arca.fiocruz.br/bitstream/icict/8497/3/Correia%20ABG%20C7a%20a%20Biphosphinic....pdf.txt7d16bcc83602c2e7bffdae335c6e31deMD53icict/84972023-03-15 14:33:22.094oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:22Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
C7a, a biphosphinic cyclopalladated compound, efficiently controls the development of a patient-derived xenograft model of adult T cell leukemia/lymphoma. |
| title |
C7a, a biphosphinic cyclopalladated compound, efficiently controls the development of a patient-derived xenograft model of adult T cell leukemia/lymphoma. |
| spellingShingle |
C7a, a biphosphinic cyclopalladated compound, efficiently controls the development of a patient-derived xenograft model of adult T cell leukemia/lymphoma. Correa, Ana Beatriz Guimarães Cyclopalladated compound HTLV-1 ATLL Chemotherapy Xenograft model Apoptosis Apoptose/efeitos de drogas Complexos de Coordenação/farmacologia Vírus 1 Linfotrópico T Humano/crescimento & desenvolvimento Leucemia-Linfoma de Células T do Adulto/quimioterapia Paládio/farmacologia Feniramina/análogos & derivados Animais Linhagem Celular Transformada Sobrevivência Celular/efeitos de drogas Citocromos c/metabolismo Citometria de Fluxo Humanos Leucemia-Linfoma de Células T do Adulto/virologia Camundongos Camundongos SCID Feniramina/farmacologia Organismos Livres de Patógenos Específicos Ensaios Antitumorais Modelo de Xenoenxerto |
| title_short |
C7a, a biphosphinic cyclopalladated compound, efficiently controls the development of a patient-derived xenograft model of adult T cell leukemia/lymphoma. |
| title_full |
C7a, a biphosphinic cyclopalladated compound, efficiently controls the development of a patient-derived xenograft model of adult T cell leukemia/lymphoma. |
| title_fullStr |
C7a, a biphosphinic cyclopalladated compound, efficiently controls the development of a patient-derived xenograft model of adult T cell leukemia/lymphoma. |
| title_full_unstemmed |
C7a, a biphosphinic cyclopalladated compound, efficiently controls the development of a patient-derived xenograft model of adult T cell leukemia/lymphoma. |
| title_sort |
C7a, a biphosphinic cyclopalladated compound, efficiently controls the development of a patient-derived xenograft model of adult T cell leukemia/lymphoma. |
| author |
Correa, Ana Beatriz Guimarães |
| author_facet |
Correa, Ana Beatriz Guimarães Crawford, Lindsey B Figueiredo, Carlos R Gimenes, Karina Panizzi Pinto, Lorena Ana Grassi, Maria Fernanda Rios Feuer, Gerold Travassos, Luiz Rodolpho Caires, Antonio Carlos Fávero Rodrigues, Elaine G Marriott, Susan J |
| author_role |
author |
| author2 |
Crawford, Lindsey B Figueiredo, Carlos R Gimenes, Karina Panizzi Pinto, Lorena Ana Grassi, Maria Fernanda Rios Feuer, Gerold Travassos, Luiz Rodolpho Caires, Antonio Carlos Fávero Rodrigues, Elaine G Marriott, Susan J |
| author2_role |
author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Correa, Ana Beatriz Guimarães Crawford, Lindsey B Figueiredo, Carlos R Gimenes, Karina Panizzi Pinto, Lorena Ana Grassi, Maria Fernanda Rios Feuer, Gerold Travassos, Luiz Rodolpho Caires, Antonio Carlos Fávero Rodrigues, Elaine G Marriott, Susan J |
| dc.subject.en.pt_BR.fl_str_mv |
Cyclopalladated compound HTLV-1 ATLL Chemotherapy Xenograft model Apoptosis |
| topic |
Cyclopalladated compound HTLV-1 ATLL Chemotherapy Xenograft model Apoptosis Apoptose/efeitos de drogas Complexos de Coordenação/farmacologia Vírus 1 Linfotrópico T Humano/crescimento & desenvolvimento Leucemia-Linfoma de Células T do Adulto/quimioterapia Paládio/farmacologia Feniramina/análogos & derivados Animais Linhagem Celular Transformada Sobrevivência Celular/efeitos de drogas Citocromos c/metabolismo Citometria de Fluxo Humanos Leucemia-Linfoma de Células T do Adulto/virologia Camundongos Camundongos SCID Feniramina/farmacologia Organismos Livres de Patógenos Específicos Ensaios Antitumorais Modelo de Xenoenxerto |
| dc.subject.decs.pt_BR.fl_str_mv |
Apoptose/efeitos de drogas Complexos de Coordenação/farmacologia Vírus 1 Linfotrópico T Humano/crescimento & desenvolvimento Leucemia-Linfoma de Células T do Adulto/quimioterapia Paládio/farmacologia Feniramina/análogos & derivados Animais Linhagem Celular Transformada Sobrevivência Celular/efeitos de drogas Citocromos c/metabolismo Citometria de Fluxo Humanos Leucemia-Linfoma de Células T do Adulto/virologia Camundongos Camundongos SCID Feniramina/farmacologia Organismos Livres de Patógenos Específicos Ensaios Antitumorais Modelo de Xenoenxerto |
| description |
Universidade Federal de São Paulo. UNIFESP-EPM. Unidade de Oncologia Experimental, Departamento de Microbiologia, Imunologia e Parasitologia. São Paulo, SP, Brasil |
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2011 |
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2011 |
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2014-10-03T18:50:40Z |
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2014-10-03T18:50:40Z |
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CORREA, A. B. G. et al. C7a, a biphosphinic cyclopalladated compound, efficiently controls the development of a patient-derived xenograft model of adult T cell leukemia/lymphoma. Viruses, v. 3, n. 7, p. 1041-1058, 2011. |
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https://www.arca.fiocruz.br/handle/icict/8497 |
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1999-4915 10.3390/v3071041 |
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CORREA, A. B. G. et al. C7a, a biphosphinic cyclopalladated compound, efficiently controls the development of a patient-derived xenograft model of adult T cell leukemia/lymphoma. Viruses, v. 3, n. 7, p. 1041-1058, 2011. 1999-4915 10.3390/v3071041 |
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