CXCR3 chemokine receptor contributes to specific CD8+ T cell activation by pDC during infection with intracellular pathogens

Detalhes bibliográficos
Autor(a) principal: Ferreira, Camila Pontes
Data de Publicação: 2020
Outros Autores: Cariste, Leonardo de Moro, Noronha, Isaú Henrique, Durso, Danielle Fernandes, Lannes-Vieira, Joseli, Bortoluci, Karina Ramalho, Ribeiro, Daniel Araki, Golenbock, Douglas, Gazzinelli, Ricardo Tostes, Vasconcelos, José Ronnie Carvalho de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/42230
Resumo: Universidade Federal de São Paulo. Departamento de Microbiologia, Imunologia e Parasitologia. São Paulo, SP, Brasil.
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spelling Ferreira, Camila PontesCariste, Leonardo de MoroNoronha, Isaú HenriqueDurso, Danielle FernandesLannes-Vieira, JoseliBortoluci, Karina RamalhoRibeiro, Daniel ArakiGolenbock, DouglasGazzinelli, Ricardo TostesVasconcelos, José Ronnie Carvalho de2020-07-13T18:10:03Z2020-07-13T18:10:03Z2020FERREIRA, Camila Pontes et al. CXCR3 chemokine receptor contributes to specific CD8+ T cell activation by pDC during infection with intracellular pathogens. Plos Negl Trop Dis., v. 14, n. 6, e0008414, 22p, June 2020.1935-2727https://www.arca.fiocruz.br/handle/icict/4223010.1371/journal.pntd.00084141935-2735engPublic Library of ScienceReceptor de quimiocina CXCR3CD8+ T cell activationInfecçãoPatógenos intracelularesCXCR3 chemokine receptorCD8+ T cell activationInfectionIntracellular pathogensCXCR3 chemokine receptor contributes to specific CD8+ T cell activation by pDC during infection with intracellular pathogensinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de São Paulo. Departamento de Microbiologia, Imunologia e Parasitologia. São Paulo, SP, Brasil.Universidade Federal de São Paulo. Departamento de Biociências. Santos, SP, Brasil.Universidade Federal de São Paulo. Departamento de Microbiologia, Imunologia e Parasitologia. São Paulo, SP, Brasil.University of Massachusetts Medical School. Department of Medicine. Worcester, Massachusetts,USA.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia das Interações. Rio de Janeiro, RJ, Brasil.Universidade Federal de São Paulo. Departamento de Ciências Biológicas. São Paulo, SP, Brasil.Universidade Federal de São Paulo. Departamento de Biociências. Santos, SP, Brasil.University of Massachusetts Medical School. Department of Medicine. Worcester, Massachusetts,USA.University of Massachusetts Medical School. Department of Medicine. Worcester, Massachusetts,USA.Universidade Federal de São Paulo. Departamento de Microbiologia, Imunologia e Parasitologia. São Paulo, SP, Brasil / Universidade Federal de São Paulo. Departamento de Biociências. Santos, SP, Brasil.Chemokine receptor type 3 (CXCR3) plays an important role in CD8+ T cells migration during intracellular infections, such as Trypanosoma cruzi. In addition to chemotaxis, CXCR3 receptor has been described as important to the interaction between antigen-presenting cells and effector cells. We hypothesized that CXCR3 is fundamental to T. cruzi-specific CD8+ T cell activation, migration and effector function. Anti-CXCR3 neutralizing antibody administration to acutely T. cruzi-infected mice decreased the number of specific CD8+ T cells in the spleen, and those cells had impaired in activation and cytokine production but unaltered proliferative response. In addition, anti-CXCR3-treated mice showed decreased frequency of CD8+ T cells in the heart and numbers of plasmacytoid dendritic cells in spleen and lymph node. As CD8+ T cells interacted with plasmacytoid dendritic cells during infection by T. cruzi, we suggest that anti-CXCR3 treatment lowers the quantity of plasmacytoid dendritic cells, which may contribute to impair the prime of CD8+ T cells. Understanding which molecules and mechanisms guide CD8+ T cell activation and migration might be a key to vaccine development against Chagas disease as those cells play an important role in T. cruzi infection control.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/42230/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALJoselyLVieira_etal_ 2020.pdfJoselyLVieira_etal_ 2020.pdfapplication/pdf3694254https://www.arca.fiocruz.br/bitstream/icict/42230/2/JoselyLVieira_etal_%202020.pdfa0e6d7a1b3e7ba6bec40f83ebd10db1fMD52TEXTJoselyLVieira_etal_ 2020.pdf.txtJoselyLVieira_etal_ 2020.pdf.txtExtracted texttext/plain72634https://www.arca.fiocruz.br/bitstream/icict/42230/3/JoselyLVieira_etal_%202020.pdf.txt225b49c4d6da598ab1f4023834d2960cMD53icict/422302020-07-14 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dc.title.pt_BR.fl_str_mv CXCR3 chemokine receptor contributes to specific CD8+ T cell activation by pDC during infection with intracellular pathogens
title CXCR3 chemokine receptor contributes to specific CD8+ T cell activation by pDC during infection with intracellular pathogens
spellingShingle CXCR3 chemokine receptor contributes to specific CD8+ T cell activation by pDC during infection with intracellular pathogens
Ferreira, Camila Pontes
Receptor de quimiocina CXCR3
CD8+ T cell activation
Infecção
Patógenos intracelulares
CXCR3 chemokine receptor
CD8+ T cell activation
Infection
Intracellular pathogens
title_short CXCR3 chemokine receptor contributes to specific CD8+ T cell activation by pDC during infection with intracellular pathogens
title_full CXCR3 chemokine receptor contributes to specific CD8+ T cell activation by pDC during infection with intracellular pathogens
title_fullStr CXCR3 chemokine receptor contributes to specific CD8+ T cell activation by pDC during infection with intracellular pathogens
title_full_unstemmed CXCR3 chemokine receptor contributes to specific CD8+ T cell activation by pDC during infection with intracellular pathogens
title_sort CXCR3 chemokine receptor contributes to specific CD8+ T cell activation by pDC during infection with intracellular pathogens
author Ferreira, Camila Pontes
author_facet Ferreira, Camila Pontes
Cariste, Leonardo de Moro
Noronha, Isaú Henrique
Durso, Danielle Fernandes
Lannes-Vieira, Joseli
Bortoluci, Karina Ramalho
Ribeiro, Daniel Araki
Golenbock, Douglas
Gazzinelli, Ricardo Tostes
Vasconcelos, José Ronnie Carvalho de
author_role author
author2 Cariste, Leonardo de Moro
Noronha, Isaú Henrique
Durso, Danielle Fernandes
Lannes-Vieira, Joseli
Bortoluci, Karina Ramalho
Ribeiro, Daniel Araki
Golenbock, Douglas
Gazzinelli, Ricardo Tostes
Vasconcelos, José Ronnie Carvalho de
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Ferreira, Camila Pontes
Cariste, Leonardo de Moro
Noronha, Isaú Henrique
Durso, Danielle Fernandes
Lannes-Vieira, Joseli
Bortoluci, Karina Ramalho
Ribeiro, Daniel Araki
Golenbock, Douglas
Gazzinelli, Ricardo Tostes
Vasconcelos, José Ronnie Carvalho de
dc.subject.other.pt_BR.fl_str_mv Receptor de quimiocina CXCR3
CD8+ T cell activation
Infecção
Patógenos intracelulares
topic Receptor de quimiocina CXCR3
CD8+ T cell activation
Infecção
Patógenos intracelulares
CXCR3 chemokine receptor
CD8+ T cell activation
Infection
Intracellular pathogens
dc.subject.en.pt_BR.fl_str_mv CXCR3 chemokine receptor
CD8+ T cell activation
Infection
Intracellular pathogens
description Universidade Federal de São Paulo. Departamento de Microbiologia, Imunologia e Parasitologia. São Paulo, SP, Brasil.
publishDate 2020
dc.date.accessioned.fl_str_mv 2020-07-13T18:10:03Z
dc.date.available.fl_str_mv 2020-07-13T18:10:03Z
dc.date.issued.fl_str_mv 2020
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv FERREIRA, Camila Pontes et al. CXCR3 chemokine receptor contributes to specific CD8+ T cell activation by pDC during infection with intracellular pathogens. Plos Negl Trop Dis., v. 14, n. 6, e0008414, 22p, June 2020.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/42230
dc.identifier.issn.pt_BR.fl_str_mv 1935-2727
dc.identifier.doi.none.fl_str_mv 10.1371/journal.pntd.0008414
dc.identifier.eissn.none.fl_str_mv 1935-2735
identifier_str_mv FERREIRA, Camila Pontes et al. CXCR3 chemokine receptor contributes to specific CD8+ T cell activation by pDC during infection with intracellular pathogens. Plos Negl Trop Dis., v. 14, n. 6, e0008414, 22p, June 2020.
1935-2727
10.1371/journal.pntd.0008414
1935-2735
url https://www.arca.fiocruz.br/handle/icict/42230
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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