Expression of the chemokine receptor CXCR4 on lymphocytes of leprosy patients
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2011 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/8958 |
Resumo: | Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Laboratório de Imunofarmacologia. Belo Horizonte, MG, Brasil/Universidade Federal dos Vales do Jequitinhonha e Mucuri. Laboratório de Imunologia. Diamantina, MG, Brasil |
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Mendonça, Vanessa AmaralMelo, Gustavo Eustáquio Brito Alvim deAraujo, Marcelo GrossiBorges, Valdinéria OliveiraCosta, Rosane DiasMartins Filho, Olindo AssisCarvalho, Andréa TeixeiraAvelar, Renato SathlerTeixeira, Mauro MartinsTeixeira Junior, Antonio Lucio2014-11-25T16:46:08Z2014-11-25T16:46:08Z2011MENDONÇA, Vanessa Amaral et al. Expression of the chemokine receptor CXCR4 on lymphocytes of leprosy patients. BRAZ J MED BIOL RES, v. 44, n. 12, p. 1256-1260, 2011. 1414-431Xhttps://www.arca.fiocruz.br/handle/icict/895810.1590/S0100-879X2011007500131engAssociação Brasileira de Divulgação CientíficaExpression of the chemokine receptor CXCR4 on lymphocytes of leprosy patientsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Laboratório de Imunofarmacologia. Belo Horizonte, MG, Brasil/Universidade Federal dos Vales do Jequitinhonha e Mucuri. Laboratório de Imunologia. Diamantina, MG, BrasilUniversidade Federal dos Vales do Jequitinhonha e Mucuri. Laboratório de Imunologia. Diamantina, MG, BrasilUniversidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Clínica Médica. Belo Horizonte, MG, BrasilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Laboratório de Imunofarmacologia. Belo Horizonte, MG, BrasilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Laboratório de Imunofarmacologia. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil/ Centro Universitário Newton Paiva. Belo Horizonte, MG, Brasil/Universidade Vale do Rio Verde. Belo Horizonte, MG, BrasilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Laboratório de Imunofarmacologia. Belo Horizonte, MG, BrasilUniversidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Laboratório de Imunofarmacologia. Belo Horizonte, MG, Brasil/Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Clínica Médica. Belo Horizonte, MG, BrasilLeprosy is caused by Mycobacterium leprae, which induces chronic granulomatous infection of the skin and peripheral nerves. The disease ranges from the tuberculoid to the lepromatous forms, depending on the cellular immune response of the host.Chemokines are thought to be involved in the immunopathogenesis of leprosy, but few studies have investigated the expression of chemokine receptors on leukocytes of leprosy patients. In the present study, we evaluated 21 leprosy patients (M/F: 16/5) with a new diagnosis from the Dermatology Outpatient Clinic of the University Hospital, Federal University of Minas Gerais. The control group was composed of 20 healthy members (M/F: 15/5) of the community recruited by means of announcements. The expression of CCR2, CCR3, CCR5, and CXCR4 was investigated by flow cytometry on the surface of peripheral blood lymphocytes. There was a decrease in percentage of CD3+CXCR4+ and CD4+CXCR4+ lymphocytes in the peripheral blood of leprosy patients (median [range], 17.6 [2.7-41.9] and 65.3 [3.9-91.9], respectively) compared to the control group (median [range], 43.0 [3.7-61.3] and 77.2 [43.6-93.5], respectively). The percentage of CD4+CXCR4+ was significantly lower in patients with the tuberculoid form (median [range], 45.7 [0.0-83.1]) of the disease, but not in lepromatous patients (median [range], 81.5 [44.9-91.9]). The CXCR4 chemokine receptor may play a role in leprosy immunopathogenesis, probably directing cell migration to tissue lesions in tuberculoid leprosy patients.LeprosyChemokine receptorsCXCR4Leukocytesinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/8958/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALExpression of the chemokine receptor CXCR4 on lymphocytes of leprosy patients..pdfExpression of the chemokine receptor CXCR4 on lymphocytes of leprosy patients..pdfapplication/pdf219393https://www.arca.fiocruz.br/bitstream/icict/8958/2/Expression%20of%20the%20chemokine%20receptor%20CXCR4%20on%20lymphocytes%20of%20leprosy%20patients..pdffd257a2469de7fd6e36b9c20f1501b9bMD52TEXTExpression of the chemokine receptor CXCR4 on lymphocytes of leprosy patients..pdf.txtExpression of the chemokine receptor CXCR4 on lymphocytes of leprosy patients..pdf.txtExtracted texttext/plain21581https://www.arca.fiocruz.br/bitstream/icict/8958/3/Expression%20of%20the%20chemokine%20receptor%20CXCR4%20on%20lymphocytes%20of%20leprosy%20patients..pdf.txte6a06d3ecaba9af318100b3aad973df8MD53icict/89582019-06-19 10:11:36.386oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352019-06-19T13:11:36Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Expression of the chemokine receptor CXCR4 on lymphocytes of leprosy patients |
| title |
Expression of the chemokine receptor CXCR4 on lymphocytes of leprosy patients |
| spellingShingle |
Expression of the chemokine receptor CXCR4 on lymphocytes of leprosy patients Mendonça, Vanessa Amaral Leprosy Chemokine receptors CXCR4 Leukocytes |
| title_short |
Expression of the chemokine receptor CXCR4 on lymphocytes of leprosy patients |
| title_full |
Expression of the chemokine receptor CXCR4 on lymphocytes of leprosy patients |
| title_fullStr |
Expression of the chemokine receptor CXCR4 on lymphocytes of leprosy patients |
| title_full_unstemmed |
Expression of the chemokine receptor CXCR4 on lymphocytes of leprosy patients |
| title_sort |
Expression of the chemokine receptor CXCR4 on lymphocytes of leprosy patients |
| author |
Mendonça, Vanessa Amaral |
| author_facet |
Mendonça, Vanessa Amaral Melo, Gustavo Eustáquio Brito Alvim de Araujo, Marcelo Grossi Borges, Valdinéria Oliveira Costa, Rosane Dias Martins Filho, Olindo Assis Carvalho, Andréa Teixeira Avelar, Renato Sathler Teixeira, Mauro Martins Teixeira Junior, Antonio Lucio |
| author_role |
author |
| author2 |
Melo, Gustavo Eustáquio Brito Alvim de Araujo, Marcelo Grossi Borges, Valdinéria Oliveira Costa, Rosane Dias Martins Filho, Olindo Assis Carvalho, Andréa Teixeira Avelar, Renato Sathler Teixeira, Mauro Martins Teixeira Junior, Antonio Lucio |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Mendonça, Vanessa Amaral Melo, Gustavo Eustáquio Brito Alvim de Araujo, Marcelo Grossi Borges, Valdinéria Oliveira Costa, Rosane Dias Martins Filho, Olindo Assis Carvalho, Andréa Teixeira Avelar, Renato Sathler Teixeira, Mauro Martins Teixeira Junior, Antonio Lucio |
| dc.subject.en.pt_BR.fl_str_mv |
Leprosy Chemokine receptors CXCR4 Leukocytes |
| topic |
Leprosy Chemokine receptors CXCR4 Leukocytes |
| description |
Universidade Federal de Minas Gerais. Instituto de Ciências Biológicas. Laboratório de Imunofarmacologia. Belo Horizonte, MG, Brasil/Universidade Federal dos Vales do Jequitinhonha e Mucuri. Laboratório de Imunologia. Diamantina, MG, Brasil |
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2011 |
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2011 |
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2014-11-25T16:46:08Z |
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2014-11-25T16:46:08Z |
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info:eu-repo/semantics/article |
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article |
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MENDONÇA, Vanessa Amaral et al. Expression of the chemokine receptor CXCR4 on lymphocytes of leprosy patients. BRAZ J MED BIOL RES, v. 44, n. 12, p. 1256-1260, 2011 |
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https://www.arca.fiocruz.br/handle/icict/8958 |
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. 1414-431X |
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10.1590/S0100-879X2011007500131 |
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MENDONÇA, Vanessa Amaral et al. Expression of the chemokine receptor CXCR4 on lymphocytes of leprosy patients. BRAZ J MED BIOL RES, v. 44, n. 12, p. 1256-1260, 2011 . 1414-431X 10.1590/S0100-879X2011007500131 |
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