Different Therapeutic Outcomes of Benznidazole and VNI Treatments in Different Genders in Mouse Experimental Models of Trypanosoma cruzi Infection
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2015 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/14816 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil. |
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Silva, F. H. Guedes daBatista, D. G. J.Silva, C. F. daMeuser, M. B.Silva, M. R. SimõesAraújo, J. S. deFerreira, C. G.Moreira, O. C.Britto, C.Lepesheva, G. I.Soeiro, Maria de Nazaré C.2016-07-07T14:14:37Z2016-07-08T18:49:12Z2016-07-07T14:14:37Z2016-07-08T18:49:12Z2015SILVA, F. H. Guedes da; et al. Different Therapeutic Outcomes of Benznidazole and VNI Treatments in Different Genders in Mouse Experimental Models of Trypanosoma cruzi Infection. Antimicrob Agents Chemother., v.59, n.12, p.7564–7570, Dec. 2015.0066-4804https://www.arca.fiocruz.br/handle/icict/1481610.1128/AAC.01294-151098-6596engAmerican Society for MicrobiologyTrypanosoma cruziDoença de ChagasTratamentoTrypanosoma cruziChagas diseaseBenznidazoleTreatmentDifferent Therapeutic Outcomes of Benznidazole and VNI Treatments in Different Genders in Mouse Experimental Models of Trypanosoma cruzi Infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular e Doenças Endêmicas. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular e Doenças Endêmicas. Rio de Janeiro, RJ, Brasil.Vanderbilt University. Institute for Global Health. Department of Biochemistry. Nashville, Tennessee, USA.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil.The lack of translation between preclinical assays and clinical trials for novel therapies for Chagas disease (CD) indicates a need for more feasible and standardized protocols and experimental models. Here, we investigated the effects of treatment with benznidazole (Bz) and with the potent experimental T. cruzi CYP51 inhibitor VNI in mouse models of Chagas disease by using different animal genders and parasite strains and employing distinct types of therapeutic schemes. Our findings confirm that female mice are less vulnerable to the infection than males, show that male models are less susceptible to treatment with both Bz and VNI, and thus suggest that male models are much more suitable for selection of the most promising antichagasic agents. Additionally, we have found that preventive protocols (compound given at 1 dpi) result in higher treatment success rates, which also should be avoided during advanced steps of in vivo trials of novel anti-T. cruzi drug candidates. Another consideration is the relevance of immunosuppression methods in order to verify the therapeutic profile of novel compounds, besides the usefulness of molecular diagnostic tools (quantitative PCR) to ascertain compound efficacy in experimental animals. Our study aims to contribute to the development of more reliable methods and decision gates for in vivo assays of novel antiparasitic compounds in order to move them from preclinical to clinical trials for CD.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZTEXTmr_simoesilva_etal_IOC_2015.pdf.txtmr_simoesilva_etal_IOC_2015.pdf.txtExtracted texttext/plain34912https://www.arca.fiocruz.br/bitstream/icict/14816/4/mr_simoesilva_etal_IOC_2015.pdf.txt34763813cfce0c7561c2ff44b036ea3fMD54ORIGINALmr_simoesilva_etal_IOC_2015.pdfapplication/pdf513565https://www.arca.fiocruz.br/bitstream/icict/14816/2/mr_simoesilva_etal_IOC_2015.pdf09ae369d749583eb59ce9bb08b6a7f89MD52LICENSElicense.txttext/plain2991https://www.arca.fiocruz.br/bitstream/icict/14816/3/license.txt5a560609d32a3863062d77ff32785d58MD53icict/148162022-06-24 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| dc.title.pt_BR.fl_str_mv |
Different Therapeutic Outcomes of Benznidazole and VNI Treatments in Different Genders in Mouse Experimental Models of Trypanosoma cruzi Infection |
| title |
Different Therapeutic Outcomes of Benznidazole and VNI Treatments in Different Genders in Mouse Experimental Models of Trypanosoma cruzi Infection |
| spellingShingle |
Different Therapeutic Outcomes of Benznidazole and VNI Treatments in Different Genders in Mouse Experimental Models of Trypanosoma cruzi Infection Silva, F. H. Guedes da Trypanosoma cruzi Doença de Chagas Tratamento Trypanosoma cruzi Chagas disease Benznidazole Treatment |
| title_short |
Different Therapeutic Outcomes of Benznidazole and VNI Treatments in Different Genders in Mouse Experimental Models of Trypanosoma cruzi Infection |
| title_full |
Different Therapeutic Outcomes of Benznidazole and VNI Treatments in Different Genders in Mouse Experimental Models of Trypanosoma cruzi Infection |
| title_fullStr |
Different Therapeutic Outcomes of Benznidazole and VNI Treatments in Different Genders in Mouse Experimental Models of Trypanosoma cruzi Infection |
| title_full_unstemmed |
Different Therapeutic Outcomes of Benznidazole and VNI Treatments in Different Genders in Mouse Experimental Models of Trypanosoma cruzi Infection |
| title_sort |
Different Therapeutic Outcomes of Benznidazole and VNI Treatments in Different Genders in Mouse Experimental Models of Trypanosoma cruzi Infection |
| author |
Silva, F. H. Guedes da |
| author_facet |
Silva, F. H. Guedes da Batista, D. G. J. Silva, C. F. da Meuser, M. B. Silva, M. R. Simões Araújo, J. S. de Ferreira, C. G. Moreira, O. C. Britto, C. Lepesheva, G. I. Soeiro, Maria de Nazaré C. |
| author_role |
author |
| author2 |
Batista, D. G. J. Silva, C. F. da Meuser, M. B. Silva, M. R. Simões Araújo, J. S. de Ferreira, C. G. Moreira, O. C. Britto, C. Lepesheva, G. I. Soeiro, Maria de Nazaré C. |
| author2_role |
author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Silva, F. H. Guedes da Batista, D. G. J. Silva, C. F. da Meuser, M. B. Silva, M. R. Simões Araújo, J. S. de Ferreira, C. G. Moreira, O. C. Britto, C. Lepesheva, G. I. Soeiro, Maria de Nazaré C. |
| dc.subject.other.pt_BR.fl_str_mv |
Trypanosoma cruzi Doença de Chagas Tratamento |
| topic |
Trypanosoma cruzi Doença de Chagas Tratamento Trypanosoma cruzi Chagas disease Benznidazole Treatment |
| dc.subject.en.pt_BR.fl_str_mv |
Trypanosoma cruzi Chagas disease Benznidazole Treatment |
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Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Celular. Rio de Janeiro, RJ, Brasil. |
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2015 |
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2015 |
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2016-07-07T14:14:37Z 2016-07-08T18:49:12Z |
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2016-07-07T14:14:37Z 2016-07-08T18:49:12Z |
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SILVA, F. H. Guedes da; et al. Different Therapeutic Outcomes of Benznidazole and VNI Treatments in Different Genders in Mouse Experimental Models of Trypanosoma cruzi Infection. Antimicrob Agents Chemother., v.59, n.12, p.7564–7570, Dec. 2015. |
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https://www.arca.fiocruz.br/handle/icict/14816 |
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0066-4804 |
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10.1128/AAC.01294-15 |
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1098-6596 |
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SILVA, F. H. Guedes da; et al. Different Therapeutic Outcomes of Benznidazole and VNI Treatments in Different Genders in Mouse Experimental Models of Trypanosoma cruzi Infection. Antimicrob Agents Chemother., v.59, n.12, p.7564–7570, Dec. 2015. 0066-4804 10.1128/AAC.01294-15 1098-6596 |
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American Society for Microbiology |
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American Society for Microbiology |
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