Effects of helminth co-infections on atopy, asthma and cytokine production in children living in a poor urban area in Latin America
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2014 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/10436 |
Resumo: | Universidade Federal da Bahia. Instituto de Ciências da Saúde. Departamento de Ciências da Biointeração. Salvador, BA, Brasil. |
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Neves, Neuza Maria AlcântaraBritto, Gabriela de Sales GuerreiroVeiga, Rafael ValenteFigueiredo, Camila Alexandrina VianaFiaccone, Rosimeire LeovigildoConceição, Jackson S. daCruz, Álvaro AugustoRodrigues, Laura CunhaCooper, Philip JohnPontes-de-Carvalho, Lain CarlosBarreto, Maurício Lima2015-05-19T19:06:46Z2015-05-19T19:06:46Z2014NEVES, N. M. A. et al. Effects of helminth co-infections on atopy, asthma and cytokine production in children living in a poor urban area in Latin America. BMC Research Notes, v. 7, p. 1-11, 2014.1756-0500https://www.arca.fiocruz.br/handle/icict/1043610.1186/1756-0500-7-817engSpringer VerlagEffects of helminth co-infections on atopy, asthma and cytokine production in children living in a poor urban area in Latin Americainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal da Bahia. Instituto de Ciências da Saúde. Departamento de Ciências da Biointeração. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto de Ciências da Saúde. Departamento de Ciências da Biointeração. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto de Ciências da Saúde. Departamento de Ciências da Biointeração. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto de Ciências da Saúde. Departamento de Ciências da Biointeração. Salvador, BA, Brasil.Universidade Federal da Bahia. Instituto de Matemática. Salvador, BA, Brasil / Universidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, BrasilUniversidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, BrasilUniversidade Federal da Bahia. ProAR – Nucleo de Excelência em Asma. Salvador, BA, Brasil.University of London. London School of Hygiene and Tropical Medicine. London, UKPontifícia Universidad Católica Del Ecuador. Escuela de Biologia. Quito, Ecuador / St George’s University of London. Institute of Infection and Immunity. London, UKFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilUniversidade Federal da Bahia. Instituto de Saúde Coletiva. Salvador, BA, Brasil.BACKGROUND: Helminths are modulators of the host immune system, and infections with these parasites have been associated with protection against allergies and autoimmune diseases. The human host is often infected with multiple helminth parasites and most studies to date have investigated the effects of helminths in the context of infections with single parasite or types of parasites (e.g. geohelminths). In this study, we investigated how co-infections with three nematodes affect markers of allergic inflammation and asthma in children. We selected Ascaris lumbricoides and Trichuris trichiura, two parasites that inhabit the human intestine and Toxocara spp (Toxocara canis and/or T. cati), intestinal roundworms of dogs and cats that cause systemic larval infection in humans. These parasites were selected as the most prevalent helminth parasites in our study population. RESULTS: 36.4% of children were infected with one parasite; 12.7% with 2 and 5.2% with 3. Eosinophilia>4% and >10% was present in 74.3% and 25.5% of the children, respectively. Total IgE>200 IU/mL, sIgE≥0.70 kU/L and SPT positivity were present in 59.7%, 37.1% and 30% of the children, respectively. 22.7% had recent asthma (12.0% non-atopic and 10.7% atopic). Helminth infections were associated in a dose-dependent way to decrease in the prevalence of SPT and increase in eosinophilia, total IgE, and the production of the regulatory cytokine IL-10 by unstimulated peripheral blood leukocytes. No association with asthma was observed. CONCLUSIONS: Helminth co-infections in this population were associated with increased markers of the Th2 immune response, and with a host immune regulatory phenotype that may suppress allergic effector responses such as immediate hypersensitivity reactions in the skin.Helminth infectionsEosinophiliaTotal IgEAtopyAsthmaCytokinesTreg cellsinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82352https://www.arca.fiocruz.br/bitstream/icict/10436/1/license.txtafbdf7d7a9bcf771a1cc7edf5f618413MD51ORIGINALNeves NMA Effects of the....pdfNeves NMA Effects of the....pdfapplication/pdf891641https://www.arca.fiocruz.br/bitstream/icict/10436/2/Neves%20NMA%20Effects%20of%20the....pdfde0ac68d5cf494f22019d447635435f2MD52TEXTNeves NMA Effects of the....pdf.txtNeves NMA Effects of the....pdf.txtExtracted texttext/plain53890https://www.arca.fiocruz.br/bitstream/icict/10436/3/Neves%20NMA%20Effects%20of%20the....pdf.txt67db1bc747aa25e3d6ded850964d3077MD53icict/104362023-03-15 14:33:07.056oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:07Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Effects of helminth co-infections on atopy, asthma and cytokine production in children living in a poor urban area in Latin America |
| title |
Effects of helminth co-infections on atopy, asthma and cytokine production in children living in a poor urban area in Latin America |
| spellingShingle |
Effects of helminth co-infections on atopy, asthma and cytokine production in children living in a poor urban area in Latin America Neves, Neuza Maria Alcântara Helminth infections Eosinophilia Total IgE Atopy Asthma Cytokines Treg cells |
| title_short |
Effects of helminth co-infections on atopy, asthma and cytokine production in children living in a poor urban area in Latin America |
| title_full |
Effects of helminth co-infections on atopy, asthma and cytokine production in children living in a poor urban area in Latin America |
| title_fullStr |
Effects of helminth co-infections on atopy, asthma and cytokine production in children living in a poor urban area in Latin America |
| title_full_unstemmed |
Effects of helminth co-infections on atopy, asthma and cytokine production in children living in a poor urban area in Latin America |
| title_sort |
Effects of helminth co-infections on atopy, asthma and cytokine production in children living in a poor urban area in Latin America |
| author |
Neves, Neuza Maria Alcântara |
| author_facet |
Neves, Neuza Maria Alcântara Britto, Gabriela de Sales Guerreiro Veiga, Rafael Valente Figueiredo, Camila Alexandrina Viana Fiaccone, Rosimeire Leovigildo Conceição, Jackson S. da Cruz, Álvaro Augusto Rodrigues, Laura Cunha Cooper, Philip John Pontes-de-Carvalho, Lain Carlos Barreto, Maurício Lima |
| author_role |
author |
| author2 |
Britto, Gabriela de Sales Guerreiro Veiga, Rafael Valente Figueiredo, Camila Alexandrina Viana Fiaccone, Rosimeire Leovigildo Conceição, Jackson S. da Cruz, Álvaro Augusto Rodrigues, Laura Cunha Cooper, Philip John Pontes-de-Carvalho, Lain Carlos Barreto, Maurício Lima |
| author2_role |
author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Neves, Neuza Maria Alcântara Britto, Gabriela de Sales Guerreiro Veiga, Rafael Valente Figueiredo, Camila Alexandrina Viana Fiaccone, Rosimeire Leovigildo Conceição, Jackson S. da Cruz, Álvaro Augusto Rodrigues, Laura Cunha Cooper, Philip John Pontes-de-Carvalho, Lain Carlos Barreto, Maurício Lima |
| dc.subject.en.pt_BR.fl_str_mv |
Helminth infections Eosinophilia Total IgE Atopy Asthma Cytokines Treg cells |
| topic |
Helminth infections Eosinophilia Total IgE Atopy Asthma Cytokines Treg cells |
| description |
Universidade Federal da Bahia. Instituto de Ciências da Saúde. Departamento de Ciências da Biointeração. Salvador, BA, Brasil. |
| publishDate |
2014 |
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2014 |
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2015-05-19T19:06:46Z |
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2015-05-19T19:06:46Z |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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NEVES, N. M. A. et al. Effects of helminth co-infections on atopy, asthma and cytokine production in children living in a poor urban area in Latin America. BMC Research Notes, v. 7, p. 1-11, 2014. |
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https://www.arca.fiocruz.br/handle/icict/10436 |
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1756-0500 |
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10.1186/1756-0500-7-817 |
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NEVES, N. M. A. et al. Effects of helminth co-infections on atopy, asthma and cytokine production in children living in a poor urban area in Latin America. BMC Research Notes, v. 7, p. 1-11, 2014. 1756-0500 10.1186/1756-0500-7-817 |
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