The effect of single and multiple infections on atopy and wheezing in children
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2012 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UFBA |
| Texto Completo: | http://repositorio.ufba.br/ri/handle/ri/15697 |
Resumo: | Texto completo: acesso restrito. p. 359–367 |
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Alcântara-Neves, Neuza MariaVeiga, Rafael ValenteDattoli, Vitor Camilo CavalcanteFiaccone, Rosimeire LeovigildoEsquivel, RenataCruz Filho, Álvaro Augusto Souza daCooper, Philip JohnRodrigues, Laura CunhaBarreto, Mauricio LimaAlcântara-Neves, Neuza MariaVeiga, Rafael ValenteDattoli, Vitor Camilo CavalcanteFiaccone, Rosimeire LeovigildoEsquivel, RenataCruz Filho, Álvaro Augusto Souza daCooper, Philip JohnRodrigues, Laura CunhaBarreto, Mauricio Lima2014-08-25T17:33:59Z20120091-6749http://repositorio.ufba.br/ri/handle/ri/15697v. 129, n. 2Texto completo: acesso restrito. p. 359–367Background The current epidemic of asthma and atopy has been explained by alterations in immune responses related to reduction in childhood infections. However, the findings of epidemiologic studies investigating the association between infection with atopy and asthma have been inconsistent. Objective We sought to investigate the effect of single or multiple infections (pathogen burden) on atopy and wheeze in urban children from Latin America. Methods Specific IgE against aeroallergens (sIgE) and skin prick test (SPT) reactivity for the most common local allergens were measured in 1128 children aged 4 to 11 years. Data on wheezing and potential confounders were collected by questionnaire. Infections by 8 pathogens were assessed by using serology and stool examination. Associations of wheeze and atopic outcomes with single and multiple infections were analyzed by means of logistic regression. Results Negative results for Toxoplasma gondii were associated with a higher prevalence of sIgE (≥0.70 kU/L), whereas negative results for Ascaris lumbricoides, T gondii, herpes simplex virus, and EBV were associated with a higher prevalence of SPT reactivity. Children with 3 or fewer infection markers had a higher prevalence of sIgE and SPT reactivity compared with those with 4 or more infection markers. However, isolated infections or pathogen burden were not associated with the prevalence of atopic or nonatopic wheeze. Conclusion The findings provide support for the idea that the hygiene hypothesis is operating in an urban Latin American context, but its expression is thus far restricted to the atopic status of patients and not the perceived asthma symptoms.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2014-08-25T14:49:23Z No. of bitstreams: 1 Neuza Maria Alcantara Neves.pdf: 151918 bytes, checksum: 3cb35f6f28103a45dc6d2792a7313309 (MD5)Approved for entry into archive by Patricia Barroso (pbarroso@ufba.br) on 2014-08-25T17:33:59Z (GMT) No. of bitstreams: 1 Neuza Maria Alcantara Neves.pdf: 151918 bytes, checksum: 3cb35f6f28103a45dc6d2792a7313309 (MD5)Made available in DSpace on 2014-08-25T17:33:59Z (GMT). No. of bitstreams: 1 Neuza Maria Alcantara Neves.pdf: 151918 bytes, checksum: 3cb35f6f28103a45dc6d2792a7313309 (MD5) Previous issue date: 2012http://dx.doi.org/ 10.1016/j.jaci.2011.09.015reponame:Repositório Institucional da UFBAinstname:Universidade Federal da Bahia (UFBA)instacron:UFBAAtopyInfectionsPathogen exposureAllergen-specific IgESkin prick testWheezing illnessesAsthmaThe effect of single and multiple infections on atopy and wheezing in childrenJournal of Allergy and Clinical Immunologyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article10000-01-01info:eu-repo/semantics/openAccessengLICENSElicense.txtlicense.txttext/plain1345https://repositorio.ufba.br/bitstream/ri/15697/2/license.txtff6eaa8b858ea317fded99f125f5fcd0MD52ORIGINALNeuza Maria Alcantara Neves.pdfNeuza Maria Alcantara Neves.pdfapplication/pdf151918https://repositorio.ufba.br/bitstream/ri/15697/1/Neuza%20Maria%20Alcantara%20Neves.pdf3cb35f6f28103a45dc6d2792a7313309MD51TEXTNeuza Maria Alcantara Neves.pdf.txtNeuza Maria Alcantara Neves.pdf.txtExtracted texttext/plain58887https://repositorio.ufba.br/bitstream/ri/15697/3/Neuza%20Maria%20Alcantara%20Neves.pdf.txt065fe9b6b6ca2bd91454e91974904f46MD53ri/156972022-08-08 13:17:25.734oai:repositorio.ufba.br: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Repositório InstitucionalPUBhttp://192.188.11.11:8080/oai/requestopendoar:19322022-08-08T16:17:25Repositório Institucional da UFBA - Universidade Federal da Bahia (UFBA)false |
| dc.title.pt_BR.fl_str_mv |
The effect of single and multiple infections on atopy and wheezing in children |
| dc.title.alternative.pt_BR.fl_str_mv |
Journal of Allergy and Clinical Immunology |
| title |
The effect of single and multiple infections on atopy and wheezing in children |
| spellingShingle |
The effect of single and multiple infections on atopy and wheezing in children Alcântara-Neves, Neuza Maria Atopy Infections Pathogen exposure Allergen-specific IgE Skin prick test Wheezing illnesses Asthma |
| title_short |
The effect of single and multiple infections on atopy and wheezing in children |
| title_full |
The effect of single and multiple infections on atopy and wheezing in children |
| title_fullStr |
The effect of single and multiple infections on atopy and wheezing in children |
| title_full_unstemmed |
The effect of single and multiple infections on atopy and wheezing in children |
| title_sort |
The effect of single and multiple infections on atopy and wheezing in children |
| author |
Alcântara-Neves, Neuza Maria |
| author_facet |
Alcântara-Neves, Neuza Maria Veiga, Rafael Valente Dattoli, Vitor Camilo Cavalcante Fiaccone, Rosimeire Leovigildo Esquivel, Renata Cruz Filho, Álvaro Augusto Souza da Cooper, Philip John Rodrigues, Laura Cunha Barreto, Mauricio Lima |
| author_role |
author |
| author2 |
Veiga, Rafael Valente Dattoli, Vitor Camilo Cavalcante Fiaccone, Rosimeire Leovigildo Esquivel, Renata Cruz Filho, Álvaro Augusto Souza da Cooper, Philip John Rodrigues, Laura Cunha Barreto, Mauricio Lima |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Alcântara-Neves, Neuza Maria Veiga, Rafael Valente Dattoli, Vitor Camilo Cavalcante Fiaccone, Rosimeire Leovigildo Esquivel, Renata Cruz Filho, Álvaro Augusto Souza da Cooper, Philip John Rodrigues, Laura Cunha Barreto, Mauricio Lima Alcântara-Neves, Neuza Maria Veiga, Rafael Valente Dattoli, Vitor Camilo Cavalcante Fiaccone, Rosimeire Leovigildo Esquivel, Renata Cruz Filho, Álvaro Augusto Souza da Cooper, Philip John Rodrigues, Laura Cunha Barreto, Mauricio Lima |
| dc.subject.por.fl_str_mv |
Atopy Infections Pathogen exposure Allergen-specific IgE Skin prick test Wheezing illnesses Asthma |
| topic |
Atopy Infections Pathogen exposure Allergen-specific IgE Skin prick test Wheezing illnesses Asthma |
| description |
Texto completo: acesso restrito. p. 359–367 |
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2012 |
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2012 |
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2014-08-25T17:33:59Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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http://repositorio.ufba.br/ri/handle/ri/15697 |
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0091-6749 |
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v. 129, n. 2 |
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0091-6749 v. 129, n. 2 |
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http://repositorio.ufba.br/ri/handle/ri/15697 |
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