Extensively drug-resistant tuberculosis: epidemiology and management

Detalhes bibliográficos
Autor(a) principal: Matteelli, Alberto
Data de Publicação: 2014
Outros Autores: Roggi, Alberto, Carvalho, Anna C. C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/11066
Resumo: University of Brescia. WHO Collaborating Centre for TB/HIV Co-Infection. Institute of Infectious and Tropical Diseases. Brescia, Italy.
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spelling Matteelli, AlbertoRoggi, AlbertoCarvalho, Anna C. C.2015-07-03T12:34:37Z2015-07-03T12:34:37Z2014MATTEELLI, Alberto; ROGGI, Alberto; CARVALHO, Anna C. C. Extensively drug-resistant tuberculosis: epidemiology and management. Clinical Epidemiology, v.2014:6, p.111-118, 2014.1179-1349https://www.arca.fiocruz.br/handle/icict/1106610.2147/CLEP.S35839engDovepressEpidemiologiaTuberculoseDiagnósticoResistência a MedicamentosXDR-TBEpidemiologyControlDiagnosisTreatmentTuberculosisExtensively drug-resistant tuberculosis: epidemiology and managementinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversity of Brescia. WHO Collaborating Centre for TB/HIV Co-Infection. Institute of Infectious and Tropical Diseases. Brescia, Italy.University of Brescia. WHO Collaborating Centre for TB/HIV Co-Infection. Institute of Infectious and Tropical Diseases. Brescia, Italy.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.Laboratório de Inovações em Terapias, Educação e Bioprodutos. Rio de Janeiro, RJ, Brasil.The advent of antibiotics for the treatment of tuberculosis (TB) represented a major breakthrough in the fight against the disease. However, since its first use, antibiotic therapy has been associated with the emergence of resistance to drugs. The incorrect use of anti-TB drugs, either due to prescription errors, low patient compliance, or poor quality of drugs, led to the widespread emergence of Mycobacterium tuberculosis strains with an expanding spectrum of resistance. The spread of multidrug-resistant (MDR) strains (ie, strains resistant to both isoniazid and rifampicin) has represented a major threat to TB control since the 1990s. In 2006, the first cases of MDR strains with further resistance to fluoroquinolone and injectable drugs were described and named extensively drug-resistant TB (XDR-TB). The emergence of XDR-TB strains is a result of mismanagement of MDR cases, and treatment relies on drugs that are less potent and more toxic than those used to treat drug-susceptible or MDR strains. Furthermore, treatment success is lower and mortality higher than achieved in MDR-TB cases, and the number of drugs necessary in the intensive phase of treatment may be higher than the four drugs recommended for MDR-TB. Linezolid may represent a valuable drug to treat cases of XDR-TB. Delamanid, bedaquiline, and PA-824 are new anti-TB agents in the development pipeline that have the potential to enhance the cure rate of XDR-TB. The best measures to prevent new cases of XDR-TB are the correct management of MDR-TB patients, early detection, and proper treatment of existing patients with XDR-TB.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txttext/plain1914https://www.arca.fiocruz.br/bitstream/icict/11066/1/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD51ORIGINALanna_carvalhoetal_IOC_2014.pdfapplication/pdf201529https://www.arca.fiocruz.br/bitstream/icict/11066/2/anna_carvalhoetal_IOC_2014.pdf0fcabedef7266395e62967b8969ca3fdMD52TEXTanna_carvalhoetal_IOC_2014.pdf.txtanna_carvalhoetal_IOC_2014.pdf.txtExtracted texttext/plain44401https://www.arca.fiocruz.br/bitstream/icict/11066/3/anna_carvalhoetal_IOC_2014.pdf.txtff9774ca1d5b526d0d1f20c7362e727fMD53icict/110662022-06-24 13:08:42.652oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-06-24T16:08:42Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Extensively drug-resistant tuberculosis: epidemiology and management
title Extensively drug-resistant tuberculosis: epidemiology and management
spellingShingle Extensively drug-resistant tuberculosis: epidemiology and management
Matteelli, Alberto
Epidemiologia
Tuberculose
Diagnóstico
Resistência a Medicamentos
XDR-TB
Epidemiology
Control
Diagnosis
Treatment
Tuberculosis
title_short Extensively drug-resistant tuberculosis: epidemiology and management
title_full Extensively drug-resistant tuberculosis: epidemiology and management
title_fullStr Extensively drug-resistant tuberculosis: epidemiology and management
title_full_unstemmed Extensively drug-resistant tuberculosis: epidemiology and management
title_sort Extensively drug-resistant tuberculosis: epidemiology and management
author Matteelli, Alberto
author_facet Matteelli, Alberto
Roggi, Alberto
Carvalho, Anna C. C.
author_role author
author2 Roggi, Alberto
Carvalho, Anna C. C.
author2_role author
author
dc.contributor.author.fl_str_mv Matteelli, Alberto
Roggi, Alberto
Carvalho, Anna C. C.
dc.subject.other.pt_BR.fl_str_mv Epidemiologia
Tuberculose
Diagnóstico
Resistência a Medicamentos
topic Epidemiologia
Tuberculose
Diagnóstico
Resistência a Medicamentos
XDR-TB
Epidemiology
Control
Diagnosis
Treatment
Tuberculosis
dc.subject.en.pt_BR.fl_str_mv XDR-TB
Epidemiology
Control
Diagnosis
Treatment
Tuberculosis
description University of Brescia. WHO Collaborating Centre for TB/HIV Co-Infection. Institute of Infectious and Tropical Diseases. Brescia, Italy.
publishDate 2014
dc.date.issued.fl_str_mv 2014
dc.date.accessioned.fl_str_mv 2015-07-03T12:34:37Z
dc.date.available.fl_str_mv 2015-07-03T12:34:37Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MATTEELLI, Alberto; ROGGI, Alberto; CARVALHO, Anna C. C. Extensively drug-resistant tuberculosis: epidemiology and management. Clinical Epidemiology, v.2014:6, p.111-118, 2014.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/11066
dc.identifier.issn.pt_BR.fl_str_mv 1179-1349
dc.identifier.doi.pt_BR.fl_str_mv 10.2147/CLEP.S35839
identifier_str_mv MATTEELLI, Alberto; ROGGI, Alberto; CARVALHO, Anna C. C. Extensively drug-resistant tuberculosis: epidemiology and management. Clinical Epidemiology, v.2014:6, p.111-118, 2014.
1179-1349
10.2147/CLEP.S35839
url https://www.arca.fiocruz.br/handle/icict/11066
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Dovepress
publisher.none.fl_str_mv Dovepress
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
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