Computational drug discovery for the Zika virus
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2018 |
| Outros Autores: | , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/31942 |
Resumo: | Universidade Federal de Goiás. Faculdade de Farmácia. Laboratório de Modelagem Molecular e Design de Drogas. Goiânia, GO, Brasil. |
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Mottin, MelinaBorba, Joyce Villa Verde BastosMelo Filho, Cleber CamiloNeves, Bruno JuniorMuratov, EugeneTorres, Pedro Henrique MonteiroBraga, Rodolpho CamposPerryman, AlexanderEkins, SeanAndrade, Carolina Horta2019-02-28T16:19:02Z2019-02-28T16:19:02Z2018MOTTIN, Melina; et al. Computational drug discovery for the Zika virus. Brazilian Journal of Pharmaceutical Sciences. v.54, Special, e01002, 10p, 2018.1984-8250https://www.arca.fiocruz.br/handle/icict/3194210.1590/s2175-979020180000010022175-9790engUniversidade de São PauloZikaFlavivírusAntiviralProjeto assistido por computadorTriagem virtualDescoberta de drogasVirtual screeningDrug discoveryComputer-assisted drug designZikaFlavivírusAntiviralComputational drug discovery for the Zika virusinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal de Goiás. Faculdade de Farmácia. Laboratório de Modelagem Molecular e Design de Drogas. Goiânia, GO, Brasil.Universidade Federal de Goiás. Faculdade de Farmácia. Laboratório de Modelagem Molecular e Design de Drogas. Goiânia, GO, Brasil.Universidade Federal de Goiás. Faculdade de Farmácia. Laboratório de Modelagem Molecular e Design de Drogas. Goiânia, GO, Brasil.Universidade Federal de Goiás. Faculdade de Farmácia. Laboratório de Modelagem Molecular e Design de Drogas. Goiânia, GO, Brasil / UniEvangélica. Centro Universitário de Anápolis. Laboratório de Cheminformática. Anápolis, GO, Brasil.University of North Carolina. Eshelman School of Pharmacy. Division of Chemical Biology and Medicinal Chemistry. Laboratory for Molecular Modeling. Chapell Hill, NC, USA. / Odessa National Polytechnic University. Department of Checmical Technology. Odessa, Ukraine.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ. Brasil.Universidade Federal de Goiás. Faculdade de Farmácia. Laboratório de Modelagem Molecular e Design de Drogas. Goiânia, GO, Brasil.Rutgers University–New Jersey Medical School. Department of Pharmacology, Physiology and Neuroscience. Newark, NJ,, USA.Collaborations Pharmaceuticals, Inc. Raleigh, NC, USA.Universidade Federal de Goiás. Faculdade de Farmácia. Laboratório de Modelagem Molecular e Design de Drogas. Goiânia, GO, Brasil / Universidade Estadual de Campinas. Instituto de Biologia. Departamento de Genética, Evolução, Microbiologia e Imunologia. Campinas, SP, Brasil.Few Zika virus (ZIKV) outbreaks had been reported since its first detection in 1947, until the recent epidemics occurred in South America (2014/2015) and expeditiously became a global public health emergency. This arbovirus reached 0.5-1.3 million cases of ZIKV infection in Brazil in 2015 and rapidly spread in new geographic areas such as the Americas. Despite the mild symptoms of the Zika fever, the major concern is related to the related severe neurological disorders, especially microcephaly in newborns. Advances in ZIKV drug discovery have been made recently and constitute promising approaches to ZIKV treatment. In this review, we summarize current computational drug discovery efforts and their applicability to discovery of anti-ZIKV drugs. Lastly, we present successful examples of the use of computational approaches to ZIKV drug discovery.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/31942/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALpedrohenriquem_torres_etal_IOC_2018.pdfpedrohenriquem_torres_etal_IOC_2018.pdfapplication/pdf3123363https://www.arca.fiocruz.br/bitstream/icict/31942/2/pedrohenriquem_torres_etal_IOC_2018.pdf23bb17a6a474f8e0c49b093b09f8df18MD52TEXTpedrohenriquem_torres_etal_IOC_2018.pdf.txtpedrohenriquem_torres_etal_IOC_2018.pdf.txtExtracted texttext/plain37459https://www.arca.fiocruz.br/bitstream/icict/31942/3/pedrohenriquem_torres_etal_IOC_2018.pdf.txt8702863205c7a606d0137b6286d4378eMD53icict/319422023-09-14 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| dc.title.pt_BR.fl_str_mv |
Computational drug discovery for the Zika virus |
| title |
Computational drug discovery for the Zika virus |
| spellingShingle |
Computational drug discovery for the Zika virus Mottin, Melina Zika Flavivírus Antiviral Projeto assistido por computador Triagem virtual Descoberta de drogas Virtual screening Drug discovery Computer-assisted drug design Zika Flavivírus Antiviral |
| title_short |
Computational drug discovery for the Zika virus |
| title_full |
Computational drug discovery for the Zika virus |
| title_fullStr |
Computational drug discovery for the Zika virus |
| title_full_unstemmed |
Computational drug discovery for the Zika virus |
| title_sort |
Computational drug discovery for the Zika virus |
| author |
Mottin, Melina |
| author_facet |
Mottin, Melina Borba, Joyce Villa Verde Bastos Melo Filho, Cleber Camilo Neves, Bruno Junior Muratov, Eugene Torres, Pedro Henrique Monteiro Braga, Rodolpho Campos Perryman, Alexander Ekins, Sean Andrade, Carolina Horta |
| author_role |
author |
| author2 |
Borba, Joyce Villa Verde Bastos Melo Filho, Cleber Camilo Neves, Bruno Junior Muratov, Eugene Torres, Pedro Henrique Monteiro Braga, Rodolpho Campos Perryman, Alexander Ekins, Sean Andrade, Carolina Horta |
| author2_role |
author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Mottin, Melina Borba, Joyce Villa Verde Bastos Melo Filho, Cleber Camilo Neves, Bruno Junior Muratov, Eugene Torres, Pedro Henrique Monteiro Braga, Rodolpho Campos Perryman, Alexander Ekins, Sean Andrade, Carolina Horta |
| dc.subject.other.pt_BR.fl_str_mv |
Zika Flavivírus Antiviral Projeto assistido por computador Triagem virtual Descoberta de drogas |
| topic |
Zika Flavivírus Antiviral Projeto assistido por computador Triagem virtual Descoberta de drogas Virtual screening Drug discovery Computer-assisted drug design Zika Flavivírus Antiviral |
| dc.subject.en.pt_BR.fl_str_mv |
Virtual screening Drug discovery Computer-assisted drug design Zika Flavivírus Antiviral |
| description |
Universidade Federal de Goiás. Faculdade de Farmácia. Laboratório de Modelagem Molecular e Design de Drogas. Goiânia, GO, Brasil. |
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2018 |
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2018 |
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2019-02-28T16:19:02Z |
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2019-02-28T16:19:02Z |
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MOTTIN, Melina; et al. Computational drug discovery for the Zika virus. Brazilian Journal of Pharmaceutical Sciences. v.54, Special, e01002, 10p, 2018. |
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https://www.arca.fiocruz.br/handle/icict/31942 |
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1984-8250 |
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10.1590/s2175-97902018000001002 |
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2175-9790 |
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MOTTIN, Melina; et al. Computational drug discovery for the Zika virus. Brazilian Journal of Pharmaceutical Sciences. v.54, Special, e01002, 10p, 2018. 1984-8250 10.1590/s2175-97902018000001002 2175-9790 |
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Universidade de São Paulo |
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Universidade de São Paulo |
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