Persistence of Zika Virus After Birth: Clinical, Virological, Neuroimaging, and Neuropathological Documentation in a 5-Month Infant With Congenital Zika Syndrome

Detalhes bibliográficos
Autor(a) principal: Chimelli, Leila
Data de Publicação: 2018
Outros Autores: Pone, Sheila Moura, Avvad-Portari, Elyzabeth, Vasconcelos, Zilton Farias Meira de, Zin, Andrea A., Cunha, Daniela Prado, Thompson, Nathalia Raposo, Moreira, Maria Elisabeth Lopes, Wiley, Clayton A., Pone, Marcos Vinicius da Silva
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/30639
Resumo: 2019-03-01
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spelling Chimelli, LeilaPone, Sheila MouraAvvad-Portari, ElyzabethVasconcelos, Zilton Farias Meira deZin, Andrea A.Cunha, Daniela PradoThompson, Nathalia RaposoMoreira, Maria Elisabeth LopesWiley, Clayton A.Pone, Marcos Vinicius da Silva2018-12-17T17:35:13Z2018-12-17T17:35:13Z2018CHIMELLI, Leila et al. Persistence of Zika Virus After Birth: Clinical, Virological, Neuroimaging, and Neuropathological Documentation in a 5-Month Infant With Congenital Zika Syndrome. ournal of Neuropathology and Experimental Neurology. v. 77. n. 3. mar. 20180022-3069https://www.arca.fiocruz.br/handle/icict/3063910.1093/jnen/nlx116engOxford University PressArtrogriposeCalcificaçãoHidrocefaliaMicrocefaliaNeuropatologiaRT-qPCRZika VirusArthrogryposisCalcificationHydrocephalusMicrocephalNeuropathologyRT-qPCRZika VirusPersistence of Zika Virus After Birth: Clinical, Virological, Neuroimaging, and Neuropathological Documentation in a 5-Month Infant With Congenital Zika Syndromeinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2019-03-01Instituto Estadual do Cérebro Paulo Niemeyer. Laboratório de Neuropatologia. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Rio de Janeiro.Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Enfermaria de Doenças Infecciosas em Pediatria. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil.Hospital Pró Criança Jutta Batista. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil.UPMC Presbiterian Hospital. Division of Neuropathology. Pittsburgh, Pennsylvania, United States.Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil.During the Zika epidemic in Brazil, a baby was born at term with microcephaly and arthrogryposis. The mother had Zika symptoms at 10 weeks of gestation. At 17 weeks, ultrasound showed cerebral malformation and ventriculomegaly. At 24 weeks, the amniotic fluid contained ZIKV RNA and at birth, placenta and maternal blood were also positive using RT-qPCR. At birth the baby urine contained ZIKV RNA, whereas CSF at birth and urine at 17 days did not. Seizures started at 6 days. EEG was abnormal and CT scan showed cerebral atrophy, calcifications, lissencephaly, ventriculomegaly, and cerebellar hypoplasia. Bacterial sepsis at 2 months was treated. A sudden increase in head circumference occurred at 4 months necessitating ventricle-peritoneal shunt placement. At 5 months, the infant died with sepsis due to bacterial meningitis. Neuropathological findings were as severe as some of those found in neonates who died soon after birth, including hydrocephalus, destructive lesions/calcification, gliosis, abnormal neuronal migration, dysmaturation of nerve cells, hypomyelination, loss of descending axons, and spinal motor neurons. ZIKV RNA was detected only in frozen brain tissue using RT-qPCR, but infected cells were not detected by in situ hybridization. Progressive gliosis and microgliosis in the midbrain may have contributed to aqueduct compression and subsequent hydrocephalus. The etiology of progressive disease after in utero infection is not clear and requires investigation.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-83142https://www.arca.fiocruz.br/bitstream/icict/30639/1/license.txt37a74d92f1f1fd437ab11671160e0230MD51ORIGINALve_CHIMELLI_Leila_etal_2018.pdfve_CHIMELLI_Leila_etal_2018.pdfapplication/pdf733804https://www.arca.fiocruz.br/bitstream/icict/30639/2/ve_CHIMELLI_Leila_etal_2018.pdf97eccb3db933e23e3b5787a4130d8928MD52TEXTve_CHIMELLI_Leila_etal_2018.pdf.txtve_CHIMELLI_Leila_etal_2018.pdf.txtExtracted texttext/plain24470https://www.arca.fiocruz.br/bitstream/icict/30639/3/ve_CHIMELLI_Leila_etal_2018.pdf.txt49c232b3ce2a1eae775e3cd7b9baea21MD53icict/306392021-03-24 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dc.title.pt_BR.fl_str_mv Persistence of Zika Virus After Birth: Clinical, Virological, Neuroimaging, and Neuropathological Documentation in a 5-Month Infant With Congenital Zika Syndrome
title Persistence of Zika Virus After Birth: Clinical, Virological, Neuroimaging, and Neuropathological Documentation in a 5-Month Infant With Congenital Zika Syndrome
spellingShingle Persistence of Zika Virus After Birth: Clinical, Virological, Neuroimaging, and Neuropathological Documentation in a 5-Month Infant With Congenital Zika Syndrome
Chimelli, Leila
Artrogripose
Calcificação
Hidrocefalia
Microcefalia
Neuropatologia
RT-qPCR
Zika Virus
Arthrogryposis
Calcification
Hydrocephalus
Microcephal
Neuropathology
RT-qPCR
Zika Virus
title_short Persistence of Zika Virus After Birth: Clinical, Virological, Neuroimaging, and Neuropathological Documentation in a 5-Month Infant With Congenital Zika Syndrome
title_full Persistence of Zika Virus After Birth: Clinical, Virological, Neuroimaging, and Neuropathological Documentation in a 5-Month Infant With Congenital Zika Syndrome
title_fullStr Persistence of Zika Virus After Birth: Clinical, Virological, Neuroimaging, and Neuropathological Documentation in a 5-Month Infant With Congenital Zika Syndrome
title_full_unstemmed Persistence of Zika Virus After Birth: Clinical, Virological, Neuroimaging, and Neuropathological Documentation in a 5-Month Infant With Congenital Zika Syndrome
title_sort Persistence of Zika Virus After Birth: Clinical, Virological, Neuroimaging, and Neuropathological Documentation in a 5-Month Infant With Congenital Zika Syndrome
author Chimelli, Leila
author_facet Chimelli, Leila
Pone, Sheila Moura
Avvad-Portari, Elyzabeth
Vasconcelos, Zilton Farias Meira de
Zin, Andrea A.
Cunha, Daniela Prado
Thompson, Nathalia Raposo
Moreira, Maria Elisabeth Lopes
Wiley, Clayton A.
Pone, Marcos Vinicius da Silva
author_role author
author2 Pone, Sheila Moura
Avvad-Portari, Elyzabeth
Vasconcelos, Zilton Farias Meira de
Zin, Andrea A.
Cunha, Daniela Prado
Thompson, Nathalia Raposo
Moreira, Maria Elisabeth Lopes
Wiley, Clayton A.
Pone, Marcos Vinicius da Silva
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Chimelli, Leila
Pone, Sheila Moura
Avvad-Portari, Elyzabeth
Vasconcelos, Zilton Farias Meira de
Zin, Andrea A.
Cunha, Daniela Prado
Thompson, Nathalia Raposo
Moreira, Maria Elisabeth Lopes
Wiley, Clayton A.
Pone, Marcos Vinicius da Silva
dc.subject.other.pt_BR.fl_str_mv Artrogripose
Calcificação
Hidrocefalia
Microcefalia
Neuropatologia
RT-qPCR
Zika Virus
topic Artrogripose
Calcificação
Hidrocefalia
Microcefalia
Neuropatologia
RT-qPCR
Zika Virus
Arthrogryposis
Calcification
Hydrocephalus
Microcephal
Neuropathology
RT-qPCR
Zika Virus
dc.subject.en.pt_BR.fl_str_mv Arthrogryposis
Calcification
Hydrocephalus
Microcephal
Neuropathology
RT-qPCR
Zika Virus
description 2019-03-01
publishDate 2018
dc.date.accessioned.fl_str_mv 2018-12-17T17:35:13Z
dc.date.available.fl_str_mv 2018-12-17T17:35:13Z
dc.date.issued.fl_str_mv 2018
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CHIMELLI, Leila et al. Persistence of Zika Virus After Birth: Clinical, Virological, Neuroimaging, and Neuropathological Documentation in a 5-Month Infant With Congenital Zika Syndrome. ournal of Neuropathology and Experimental Neurology. v. 77. n. 3. mar. 2018
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/30639
dc.identifier.issn.pt_BR.fl_str_mv 0022-3069
dc.identifier.doi.none.fl_str_mv 10.1093/jnen/nlx116
identifier_str_mv CHIMELLI, Leila et al. Persistence of Zika Virus After Birth: Clinical, Virological, Neuroimaging, and Neuropathological Documentation in a 5-Month Infant With Congenital Zika Syndrome. ournal of Neuropathology and Experimental Neurology. v. 77. n. 3. mar. 2018
0022-3069
10.1093/jnen/nlx116
url https://www.arca.fiocruz.br/handle/icict/30639
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
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