Congenital Zika virus infection: a neuropathological review

Detalhes bibliográficos
Autor(a) principal: Chimelli, Leila
Data de Publicação: 2017
Outros Autores: Portari, Elyzabeth Avvad
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/23618
Resumo: 2018-12-31
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spelling Chimelli, LeilaPortari, Elyzabeth Avvad2017-12-12T12:50:44Z2017-12-12T12:50:44Z2017CHIMELLI, Leila; PORTARI, Elyzabeth Avvad. Congenital Zika virus infection: a neuropathological review. Child's Nervous System, p. 1-5, Nov. 2017.1433-0350https://www.arca.fiocruz.br/handle/icict/2361810.1007/s00381-017-3651-3engSpringer VerlagInfecção Congênita por Virus ZikaNeuropatologiaMicrocefaliaVentriculomegaliaCalcificaçãoCongenital Zika virus infectionNeuropathologyMicrocephalyVentriculomegalyCalcificationCongenital Zika virus infection: a neuropathological reviewinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2018-12-31State Institute of Brain Paulo Niemeyer and Federal University of Rio de Janeiro. Laboratory of Neuropathology. Rio de Janeiro, Brazil.Fundação Oswaldo Cruz. Instituto Nacional de Saúde da Mulher, da Criança e do Adolescente Fernandes Figueira. Rio de Janeiro, RJ, Brasil / Universidade do Estado do Rio de Janeiro. Rio de Janeiro, RJ, Brasil.Background A relationship between Zika virus (ZikV) infection in pregnancy and the occurrence of microcephaly wasestablished during the Zika outbreak in Brazil (2015– 2016). Neuropathological findings in congenital Zika syndromem helped to understand its pathogenetic mechanisms. Results The most relevant postmortem findings in the central nervous system (CNS) of fetuses and neonates infected with ZikV early in gestation are microcephaly with ex-vacuo ventriculomegaly and large head circumference associated with obstructive hydrocephalus due to severe midbrain and aqueduct distortion. Babies with severe brain lesions are born with arthrogryposis. Histologically, there is extensive destruction of the hemispheric parenchyma, calcifications, various distur- bances of neuronal migration, reactive gliosis, microglial hyper- plasia and occasional perivascular cuffs of lymphocytes, also in the meninges. Hypoplastic lesions secondary to the lack of de- scending nerve fibers include small basis pontis, pyramids and spinal corticospinal tracts. Cerebellar hypoplasia is also com- mon. Severe nerve motor nerve cell loss is observed in the anterior horn of the spinal cord. Conclusion A spectrum of neuropathological changes, from severe microcephaly to obstructive hydrocephalus was ob- served. The severity of the lesions is directly related to the gestational age, the most severe occurring when the mother is infected in the first trimester. 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dc.title.pt_BR.fl_str_mv Congenital Zika virus infection: a neuropathological review
title Congenital Zika virus infection: a neuropathological review
spellingShingle Congenital Zika virus infection: a neuropathological review
Chimelli, Leila
Infecção Congênita por Virus Zika
Neuropatologia
Microcefalia
Ventriculomegalia
Calcificação
Congenital Zika virus infection
Neuropathology
Microcephaly
Ventriculomegaly
Calcification
title_short Congenital Zika virus infection: a neuropathological review
title_full Congenital Zika virus infection: a neuropathological review
title_fullStr Congenital Zika virus infection: a neuropathological review
title_full_unstemmed Congenital Zika virus infection: a neuropathological review
title_sort Congenital Zika virus infection: a neuropathological review
author Chimelli, Leila
author_facet Chimelli, Leila
Portari, Elyzabeth Avvad
author_role author
author2 Portari, Elyzabeth Avvad
author2_role author
dc.contributor.author.fl_str_mv Chimelli, Leila
Portari, Elyzabeth Avvad
dc.subject.other.pt_BR.fl_str_mv Infecção Congênita por Virus Zika
Neuropatologia
Microcefalia
Ventriculomegalia
Calcificação
topic Infecção Congênita por Virus Zika
Neuropatologia
Microcefalia
Ventriculomegalia
Calcificação
Congenital Zika virus infection
Neuropathology
Microcephaly
Ventriculomegaly
Calcification
dc.subject.en.pt_BR.fl_str_mv Congenital Zika virus infection
Neuropathology
Microcephaly
Ventriculomegaly
Calcification
description 2018-12-31
publishDate 2017
dc.date.accessioned.fl_str_mv 2017-12-12T12:50:44Z
dc.date.available.fl_str_mv 2017-12-12T12:50:44Z
dc.date.issued.fl_str_mv 2017
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CHIMELLI, Leila; PORTARI, Elyzabeth Avvad. Congenital Zika virus infection: a neuropathological review. Child's Nervous System, p. 1-5, Nov. 2017.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/23618
dc.identifier.issn.pt_BR.fl_str_mv 1433-0350
dc.identifier.doi.none.fl_str_mv 10.1007/s00381-017-3651-3
identifier_str_mv CHIMELLI, Leila; PORTARI, Elyzabeth Avvad. Congenital Zika virus infection: a neuropathological review. Child's Nervous System, p. 1-5, Nov. 2017.
1433-0350
10.1007/s00381-017-3651-3
url https://www.arca.fiocruz.br/handle/icict/23618
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Springer Verlag
publisher.none.fl_str_mv Springer Verlag
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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