The conduction system of the heart in mice chronically infected with Trypanosoma cruzi: histopathological lesions and electrocardiographic correlations.

Andrade, Sonia Gumes; Sadigursky, Moysés

The conduction system of the heart in mice chronically infected with Trypanosoma cruzi: histopathological lesions and electrocardiographic correlations.

Detalhes bibliográficos
Autor(a) principal:	Andrade, Sonia Gumes
Data de Publicação:	1987
Outros Autores:	Sadigursky, Moysés
Tipo de documento:	Artigo
Idioma:	eng
Título da fonte:	Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo:	https://www.arca.fiocruz.br/handle/icict/5738
Resumo:	Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil

Metadados do item

id	CRUZ_2df5eb4ea11d6d21785832db40af29e3
oai_identifier_str	oai:www.arca.fiocruz.br:icict/5738
network_acronym_str	CRUZ
network_name_str	Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str	2135
spelling	Andrade, Sonia GumesSadigursky, Moysés2012-10-26T17:57:46Z2012-10-26T17:57:46Z1987ANDRADE, S.G.; SADIGURSKY, M. The conduction system of the heart in mice chronically infected with Trypanosoma cruzi: histopathological lesions and electrocardiographic correlations. Memórias do Instituto Oswaldo Cruz, v. 82, n. 1, p. 59-66, jan.-mar. 1987.0074-0276https://www.arca.fiocruz.br/handle/icict/5738engThe conduction system of the heart in mice chronically infected with Trypanosoma cruzi: histopathological lesions and electrocardiographic correlations.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilChronic focal and diffuse myocarditis with interstitial fibrosis developed in Swiss outbred mice and in the inbred AKR and A/J strains of mice which were chronically infected with several Trypanosoma cruzi strains belonging to three biological types (Type I, II and III). High incidence of electrocardiographic changes with predominance of intraventricular conduction disturbances, 1st. and 2nd. degree AV block, arrhythmias, comparable with those found in human Chagas' disease, were also present. Morphological study of the conduction tissue of the heart revealed inflammatory and fibrotic changes. The presence of inflammation in the inter-atrial septum almost always coincided with the inflammatory involvement of the ventricular conduction system. Focal inflammation was associated with vacuolization and focal necrosis of the specific fibers. Most of the lesions were seen affecting the His bundle (76.3% of the cases), the right bundle branch (73.3%), AV node (43.9%) and left bundle branch (37.5%). Correlation between morphological changes in the conduction tissue and electrocardiographic alteration occurred in 53.0 to 62.5% of the cases, according to the experimental groups.Conduction system of the heartTrypanosoma cruziChronic myocarditisChronic T. cruziInfection in miceElectrocardiogram in miceCardiomiopatia Chagásica/fisiopatologiaEletrocardiografiaSistema de Condução Cardíaco/fisiopatologiaMiocárdio/patologiaAnimaisBloqueio Cardíaco/patologiaCamundongosCamundongos Endogâmicos ACamundongos Endogâmicos AKRinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALAndrade SG The conduction system of the....pdfAndrade SG The conduction system of the....pdfapplication/pdf499321https://www.arca.fiocruz.br/bitstream/icict/5738/1/Andrade%20SG%20The%20conduction%20system%20of%20the....pdfe26a362c01781c976a549c99d91cd4faMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-82008https://www.arca.fiocruz.br/bitstream/icict/5738/2/license.txt06db3f0df647fd9ddff657403bbe0ee2MD52TEXTAndrade SG The conduction system of the....pdf.txtAndrade SG The conduction system of the....pdf.txtExtracted texttext/plain8https://www.arca.fiocruz.br/bitstream/icict/5738/5/Andrade%20SG%20The%20conduction%20system%20of%20the....pdf.txt8d1b69dd9bdc9df4a8073c7a8193c7afMD55THUMBNAILAndrade SG The conduction system of the....pdf.jpgAndrade SG The conduction system of the....pdf.jpgGenerated Thumbnailimage/jpeg2469https://www.arca.fiocruz.br/bitstream/icict/5738/4/Andrade%20SG%20The%20conduction%20system%20of%20the....pdf.jpg70697e64928d4c9139cf360f5265f50eMD54icict/57382023-03-15 14:32:57.794oai:www.arca.fiocruz.br:icict/5738TElDRU7Dh0EgREUgRElTVFJJQlVJw4fDg08gTsODTy1FWENMVVNJVkEKCkFvIGFzc2luYXIgZSBlbnRyZWdhciBlc3RhIGxpY2Vuw6dhLCBvL2EgU3IuL1NyYS4gKGF1dG9yIG91IGRldGVudG9yIGRvcyBkaXJlaXRvcyBkbyBhdXRvcik6CgpBbyBjb25jb3JkYXIgZSBhY2VpdGFyIGVzdGEgbGljZW7Dp2Egdm9jw6ogKGF1dG9yIG91IGRldGVudG9yIGRvcyBkaXJlaXRvcyBhdXRvcmFpcyk6CgphKSBEZWNsYXJhIHF1ZSBjb25oZWNlIGEgcG9sw610aWNhIGRlIGNvcHlyaWdodCBkYSBlZGl0b3JhIGRvIHNldSBkb2N1bWVudG8uCgpiKSBEZWNsYXJhIHF1ZSBjb25oZWNlIGUgYWNlaXRhIGFzIERpcmV0cml6ZXMgcGFyYSBvIFJlcG9zaXTDs3JpbyBJbnN0aXR1Y2lvbmFsIGRhIEZ1bmRhw6fDo28gT3N3YWxkbyBDcnV6IChGSU9DUlVaKS4KCmMpIENvbmNlZGUgw6AgRklPQ1JVWiBvIGRpcmVpdG8gbsOjby1leGNsdXNpdm8gZGUgYXJxdWl2YXIsIHJlcHJvZHV6aXIsIGNvbnZlcnRlciAoY29tbyBkZWZpbmlkbyBhIHNlZ3VpciksIGNvbXVuaWNhcgogCmUvb3UgZGlzdHJpYnVpciBubyBSZXBvc2l0w7NyaW8gZGEgRklPQ1JVWiwgbyBkb2N1bWVudG8gZW50cmVndWUgKGluY2x1aW5kbyBvIHJlc3Vtby9hYnN0cmFjdCkgZW0gZm9ybWF0byBkaWdpdGFsIG91IAoKcG9yIHF1YWxxdWVyIG91dHJvIG1laW8uCgpkKSBEZWNsYXJhIHF1ZSBhdXRvcml6YSBhIEZJT0NSVVogYSBhcnF1aXZhciBtYWlzIGRlIHVtYSBjw7NwaWEgZGVzdGUgZG9jdW1lbnRvIGUgY29udmVydMOqLWxvLCBzZW0gYWx0ZXJhciBvIHNldSBjb250ZcO6ZG8sIAoKcGFyYSBxdWFscXVlciBmb3JtYXRvIGRlIGFycXVpdm8sIG1laW8gb3Ugc3Vwb3J0ZSwgcGFyYSBlZmVpdG9zIGRlIHNlZ3VyYW7Dp2EsIHByZXNlcnZhw6fDo28gKGJhY2t1cCkgZSBhY2Vzc28uCgplKSBEZWNsYXJhIHF1ZSBvIGRvY3VtZW50byBzdWJtZXRpZG8gw6kgbyBzZXUgdHJhYmFsaG8gb3JpZ2luYWwsIGUgcXVlIGRldMOpbSBvIGRpcmVpdG8gZGUgY29uY2VkZXIgYSB0ZXJjZWlyb3Mgb3MgZGlyZWl0b3MgCgpjb250aWRvcyBuZXN0YSBsaWNlbsOnYS4gRGVjbGFyYSB0YW1iw6ltIHF1ZSBhIGVudHJlZ2EgZG8gZG9jdW1lbnRvIG7Do28gaW5mcmluZ2Ugb3MgZGlyZWl0b3MgZGUgcXVhbHF1ZXIgb3V0cmEgcGVzc29hIG91IGVudGlkYWRlLgoKZikgRGVjbGFyYSBxdWUsIG5vIGNhc28gZG8gZG9jdW1lbnRvIHN1Ym1ldGlkbyBjb250ZXIgbWF0ZXJpYWwgZG8gcXVhbCBuw6NvIGRldMOpbSBvcyBkaXJlaXRvcyBkZSBhdXRvciwgb2J0ZXZlIGEgYXV0b3JpemHDp8OjbyAKCmlycmVzdHJpdGEgZG8gcmVzcGVjdGl2byBkZXRlbnRvciBkZXNzZXMgZGlyZWl0b3MsIHBhcmEgY2VkZXIgYSBGSU9DUlVaIG9zIGRpcmVpdG9zIHJlcXVlcmlkb3MgcG9yIGVzdGEgTGljZW7Dp2EgZSBhdXRvcml6YXIgYSAKCnV0aWxpesOhLWxvcyBsZWdhbG1lbnRlLiBEZWNsYXJhIHRhbWLDqW0gcXVlIGVzc2UgbWF0ZXJpYWwgY3Vqb3MgZGlyZWl0b3Mgc8OjbyBkZSB0ZXJjZWlyb3MgZXN0w6EgY2xhcmFtZW50ZSBpZGVudGlmaWNhZG8gZSByZWNvbmhlY2lkbyAKCm5vIHRleHRvIG91IGNvbnRlw7pkbyBkbyBkb2N1bWVudG8gZW50cmVndWUuCgpnKSBTRSBPIERPQ1VNRU5UTyBFTlRSRUdVRSDDiSBCQVNFQURPIEVNIFRSQUJBTEhPIEZJTkFOQ0lBRE8gT1UgQVBPSUFETyBQT1IgT1VUUkEgSU5TVElUVUnDh8ODTyBRVUUgTsODTyBBIEZJT0NSVVosIERFQ0xBUkEgUVVFIENVTVBSSVUgCgpRVUFJU1FVRVIgT0JSSUdBw4fDlUVTIEVYSUdJREFTIFBFTE8gUkVTUEVDVElWTyBDT05UUkFUTyBPVSBBQ09SRE8uIEEgRklPQ1JVWiBpZGVudGlmaWNhcsOhIGNsYXJhbWVudGUgbyhzKSBub21lKHMpIGRvKHMpIGF1dG9yKGVzKSBkb3MgCgpkaXJlaXRvcyBkbyBkb2N1bWVudG8gZW50cmVndWUgZSBuw6NvIGZhcsOhIHF1YWxxdWVyIGFsdGVyYcOnw6NvLCBwYXJhIGFsw6ltIGRvIHByZXZpc3RvIG5hIGFsw61uZWEgYykuCg==Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:32:57Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv	The conduction system of the heart in mice chronically infected with Trypanosoma cruzi: histopathological lesions and electrocardiographic correlations.
title	The conduction system of the heart in mice chronically infected with Trypanosoma cruzi: histopathological lesions and electrocardiographic correlations.
spellingShingle	The conduction system of the heart in mice chronically infected with Trypanosoma cruzi: histopathological lesions and electrocardiographic correlations. Andrade, Sonia Gumes Conduction system of the heart Trypanosoma cruzi Chronic myocarditis Chronic T. cruzi Infection in mice Electrocardiogram in mice Cardiomiopatia Chagásica/fisiopatologia Eletrocardiografia Sistema de Condução Cardíaco/fisiopatologia Miocárdio/patologia Animais Bloqueio Cardíaco/patologia Camundongos Camundongos Endogâmicos A Camundongos Endogâmicos AKR
title_short	The conduction system of the heart in mice chronically infected with Trypanosoma cruzi: histopathological lesions and electrocardiographic correlations.
title_full	The conduction system of the heart in mice chronically infected with Trypanosoma cruzi: histopathological lesions and electrocardiographic correlations.
title_fullStr	The conduction system of the heart in mice chronically infected with Trypanosoma cruzi: histopathological lesions and electrocardiographic correlations.
title_full_unstemmed	The conduction system of the heart in mice chronically infected with Trypanosoma cruzi: histopathological lesions and electrocardiographic correlations.
title_sort	The conduction system of the heart in mice chronically infected with Trypanosoma cruzi: histopathological lesions and electrocardiographic correlations.
author	Andrade, Sonia Gumes
author_facet	Andrade, Sonia Gumes Sadigursky, Moysés
author_role	author
author2	Sadigursky, Moysés
author2_role	author
dc.contributor.author.fl_str_mv	Andrade, Sonia Gumes Sadigursky, Moysés
dc.subject.en.pt_BR.fl_str_mv	Conduction system of the heart Trypanosoma cruzi Chronic myocarditis Chronic T. cruzi Infection in mice Electrocardiogram in mice
topic	Conduction system of the heart Trypanosoma cruzi Chronic myocarditis Chronic T. cruzi Infection in mice Electrocardiogram in mice Cardiomiopatia Chagásica/fisiopatologia Eletrocardiografia Sistema de Condução Cardíaco/fisiopatologia Miocárdio/patologia Animais Bloqueio Cardíaco/patologia Camundongos Camundongos Endogâmicos A Camundongos Endogâmicos AKR
dc.subject.decs.pt_BR.fl_str_mv	Cardiomiopatia Chagásica/fisiopatologia Eletrocardiografia Sistema de Condução Cardíaco/fisiopatologia Miocárdio/patologia Animais Bloqueio Cardíaco/patologia Camundongos Camundongos Endogâmicos A Camundongos Endogâmicos AKR
description	Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
publishDate	1987
dc.date.issued.fl_str_mv	1987
dc.date.accessioned.fl_str_mv	2012-10-26T17:57:46Z
dc.date.available.fl_str_mv	2012-10-26T17:57:46Z
dc.type.status.fl_str_mv	info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv	info:eu-repo/semantics/article
format	article
status_str	publishedVersion
dc.identifier.citation.fl_str_mv	ANDRADE, S.G.; SADIGURSKY, M. The conduction system of the heart in mice chronically infected with Trypanosoma cruzi: histopathological lesions and electrocardiographic correlations. Memórias do Instituto Oswaldo Cruz, v. 82, n. 1, p. 59-66, jan.-mar. 1987.
dc.identifier.uri.fl_str_mv	https://www.arca.fiocruz.br/handle/icict/5738
dc.identifier.issn.none.fl_str_mv	0074-0276
identifier_str_mv	ANDRADE, S.G.; SADIGURSKY, M. The conduction system of the heart in mice chronically infected with Trypanosoma cruzi: histopathological lesions and electrocardiographic correlations. Memórias do Instituto Oswaldo Cruz, v. 82, n. 1, p. 59-66, jan.-mar. 1987. 0074-0276
url	https://www.arca.fiocruz.br/handle/icict/5738
dc.language.iso.fl_str_mv	eng
language	eng
dc.rights.driver.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.source.none.fl_str_mv	reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ
instname_str	Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str	FIOCRUZ
institution	FIOCRUZ
reponame_str	Repositório Institucional da FIOCRUZ (ARCA)
collection	Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv	https://www.arca.fiocruz.br/bitstream/icict/5738/1/Andrade%20SG%20The%20conduction%20system%20of%20the....pdf https://www.arca.fiocruz.br/bitstream/icict/5738/2/license.txt https://www.arca.fiocruz.br/bitstream/icict/5738/5/Andrade%20SG%20The%20conduction%20system%20of%20the....pdf.txt https://www.arca.fiocruz.br/bitstream/icict/5738/4/Andrade%20SG%20The%20conduction%20system%20of%20the....pdf.jpg
bitstream.checksum.fl_str_mv	e26a362c01781c976a549c99d91cd4fa 06db3f0df647fd9ddff657403bbe0ee2 8d1b69dd9bdc9df4a8073c7a8193c7af 70697e64928d4c9139cf360f5265f50e
bitstream.checksumAlgorithm.fl_str_mv	MD5 MD5 MD5 MD5
repository.name.fl_str_mv	Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv	repositorio.arca@fiocruz.br
_version_	1813008913583308800

The conduction system of the heart in mice chronically infected with Trypanosoma cruzi: histopathological lesions and electrocardiographic correlations.

Registros relacionados