Influence of Trypanosoma cruzi strain on the pathogenesis of chronic myocardiopathy in mice

Detalhes bibliográficos
Autor(a) principal: Andrade, Sonia Gumes
Data de Publicação: 1990
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/5714
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.
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spelling Andrade, Sonia Gumes2012-10-22T21:15:23Z2012-10-22T21:15:23Z1990ANDRADE, Sonia Gumes. Influence of Trypanosoma cruzi strain on the pathogenesis of chronic myocardiopathy in mice. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 85, n. 1, p. 17-27, jan./mar. 1990.0074-0276https://www.arca.fiocruz.br/handle/icict/571410.1590/S0074-02761990000100003engInfluence of Trypanosoma cruzi strain on the pathogenesis of chronic myocardiopathy in miceinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.The murine model of chronic Chaga's myocardiopathy was developed in 201 inbred and outbred mice. The experimental groups consisted of 1st: 73 inbred AKR and A/J mice inoculated with one of the following Trypanosoma cruzi strains: Peruvian (Type I), 12 SF (Type II) or Colombian (Type III); 2nd: 128 outbred Swiss mice, chronically infected either with Type II or Type III strains isolated from human patients from different geographical areas. All T. cruzi strains were previously characterized by their morphobiological behaviour in mice and by isoenzymatic patterns. For the 1st group the inoculum was 5 x 10(4) for the Peruvian strain and 1 x 10(5) for the 12 SF and Colombian strains. In the 2nd group-Swiss mice the inoculum size varied from 2 x 10(4) to 2 x 10(5). The inbred animals were killed at a 3 time-point scale (90, 180 and 240 days) post-infection. The Swiss mice were killed from 180 to 660 days after infection. The evaluation of parasitemia and serology (xenodiagnosis and indirect immunofluorescent test) was performed. The incidence of macroscopic alterations of the heart and cardiac index were evaluated. Histopathological lesions of the myocardium were graded. The influence of T. cruzi strain on the intensity of cardiac lesions was evaluated by the Chi-square test; the incidence of inflammatory lesions and its relationship to the parasite strain was evaluated by the Fisher test. The influence of the duration of infection was evaluated by using the Gamma Coefficient of Kruskal and Goodman and its measure of significance. Slight to severe microscopic alterations occurred in 85% of the chronically infected mice. There were a clear predominance on the incidence and intensity of inflammatory and fibrotic alterations for the mice infected with Type III strains. Statistical analysis has shown significant differences among the infected groups, in the inflammatory and fibrotic lesions. Macroscopic alterations (right cavities dilatation and apex aneurism of left ventricle), differed in incidence according to mice strains; in Swiss and AKR mice, significant differences were seen in mice infected with different T. cruzi strains, but the A/J mice failed to show significant differences correlated with different parasite strains. The duration of infection, from 90 to 240 days, could not be correlated with the degree of lesions in the several groups.Trypanosoma cruziChronic myocardiopathyMurine model of Chaga's diseaseTrypanosoma cruzi strainsCardiomiopatia Chagásica/parasitologiaTrypanosoma cruzi/fisiologiaAnimaisCardiomiopatia Chagásica/patologiaFibrose Endomiocárdica/patologiaInterações Hospedeiro-ParasitaCamundongosCamundongos Endogâmicos ACamundongos Endogâmicos AKRMiocárdio/patologiaEspecificidade da EspécieTrypanosoma cruzi/classificaçãoinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALAndrade SG Influence of Trypanosoma cruzi strain ....pdfAndrade SG Influence of Trypanosoma cruzi strain ....pdfapplication/pdf653616https://www.arca.fiocruz.br/bitstream/icict/5714/1/Andrade%20SG%20Influence%20of%20Trypanosoma%20cruzi%20strain%20....pdf5e9e5181c3b42b2cad19d08e29b59c70MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-82008https://www.arca.fiocruz.br/bitstream/icict/5714/2/license.txt06db3f0df647fd9ddff657403bbe0ee2MD52TEXTAndrade SG Influence of Trypanosoma cruzi strain ....pdf.txtAndrade SG Influence of Trypanosoma cruzi strain ....pdf.txtExtracted texttext/plain11https://www.arca.fiocruz.br/bitstream/icict/5714/5/Andrade%20SG%20Influence%20of%20Trypanosoma%20cruzi%20strain%20....pdf.txtb308b7fe5c1c2bbdc0cb686d451b84aaMD55THUMBNAILAndrade SG Influence of Trypanosoma cruzi strain ....pdf.jpgAndrade SG Influence of Trypanosoma cruzi strain ....pdf.jpgGenerated Thumbnailimage/jpeg2662https://www.arca.fiocruz.br/bitstream/icict/5714/4/Andrade%20SG%20Influence%20of%20Trypanosoma%20cruzi%20strain%20....pdf.jpg6fa1c1a1d59d36774cd96aa3be1e24eaMD54icict/57142023-03-15 14:34:02.946oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:34:02Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Influence of Trypanosoma cruzi strain on the pathogenesis of chronic myocardiopathy in mice
title Influence of Trypanosoma cruzi strain on the pathogenesis of chronic myocardiopathy in mice
spellingShingle Influence of Trypanosoma cruzi strain on the pathogenesis of chronic myocardiopathy in mice
Andrade, Sonia Gumes
Trypanosoma cruzi
Chronic myocardiopathy
Murine model of Chaga's disease
Trypanosoma cruzi strains
Cardiomiopatia Chagásica/parasitologia
Trypanosoma cruzi/fisiologia
Animais
Cardiomiopatia Chagásica/patologia
Fibrose Endomiocárdica/patologia
Interações Hospedeiro-Parasita
Camundongos
Camundongos Endogâmicos A
Camundongos Endogâmicos AKR
Miocárdio/patologia
Especificidade da Espécie
Trypanosoma cruzi/classificação
title_short Influence of Trypanosoma cruzi strain on the pathogenesis of chronic myocardiopathy in mice
title_full Influence of Trypanosoma cruzi strain on the pathogenesis of chronic myocardiopathy in mice
title_fullStr Influence of Trypanosoma cruzi strain on the pathogenesis of chronic myocardiopathy in mice
title_full_unstemmed Influence of Trypanosoma cruzi strain on the pathogenesis of chronic myocardiopathy in mice
title_sort Influence of Trypanosoma cruzi strain on the pathogenesis of chronic myocardiopathy in mice
author Andrade, Sonia Gumes
author_facet Andrade, Sonia Gumes
author_role author
dc.contributor.author.fl_str_mv Andrade, Sonia Gumes
dc.subject.en.pt_BR.fl_str_mv Trypanosoma cruzi
Chronic myocardiopathy
Murine model of Chaga's disease
Trypanosoma cruzi strains
topic Trypanosoma cruzi
Chronic myocardiopathy
Murine model of Chaga's disease
Trypanosoma cruzi strains
Cardiomiopatia Chagásica/parasitologia
Trypanosoma cruzi/fisiologia
Animais
Cardiomiopatia Chagásica/patologia
Fibrose Endomiocárdica/patologia
Interações Hospedeiro-Parasita
Camundongos
Camundongos Endogâmicos A
Camundongos Endogâmicos AKR
Miocárdio/patologia
Especificidade da Espécie
Trypanosoma cruzi/classificação
dc.subject.decs.pt_BR.fl_str_mv Cardiomiopatia Chagásica/parasitologia
Trypanosoma cruzi/fisiologia
Animais
Cardiomiopatia Chagásica/patologia
Fibrose Endomiocárdica/patologia
Interações Hospedeiro-Parasita
Camundongos
Camundongos Endogâmicos A
Camundongos Endogâmicos AKR
Miocárdio/patologia
Especificidade da Espécie
Trypanosoma cruzi/classificação
description Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.
publishDate 1990
dc.date.issued.fl_str_mv 1990
dc.date.accessioned.fl_str_mv 2012-10-22T21:15:23Z
dc.date.available.fl_str_mv 2012-10-22T21:15:23Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ANDRADE, Sonia Gumes. Influence of Trypanosoma cruzi strain on the pathogenesis of chronic myocardiopathy in mice. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 85, n. 1, p. 17-27, jan./mar. 1990.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/5714
dc.identifier.issn.none.fl_str_mv 0074-0276
dc.identifier.doi.pt_BR.fl_str_mv 10.1590/S0074-02761990000100003
identifier_str_mv ANDRADE, Sonia Gumes. Influence of Trypanosoma cruzi strain on the pathogenesis of chronic myocardiopathy in mice. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 85, n. 1, p. 17-27, jan./mar. 1990.
0074-0276
10.1590/S0074-02761990000100003
url https://www.arca.fiocruz.br/handle/icict/5714
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
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