Large-Scale Deployment and Establishment of Wolbachia Into the Aedes aegypti Population in Rio de Janeiro, Brazil
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/51672 |
Resumo: | Fundação Oswaldo Cruz. Instituto René Rachou. Grupo Mosquitos Vetores: Endossimbiontes e Interação Patógeno Vetor. Belo Horizonte, MG, Brazil/World Mosquito Program. Fundação Oswaldo Cruz. Rio de Janeiro, RJ, Brazil. |
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Gesto, João Silveira MoledoPinto, Sofia BastosDias, Fernando Braga StehlingPeixoto, JuliaCosta, GuilhermeKutcher, SimonMontgomery, JacquiGreen, Benjamin RAnders, Katherine LRyan, Peter ASimmons, Cameron PO'Neill, Scott LMoreira, Luciano Andrade2022-03-10T12:32:40Z2022-03-10T12:32:40Z2021GESTO, João Silveira Moledo et al. Large-Scale Deployment and Establishment of Wolbachia Into the Aedes aegypti Population in Rio de Janeiro, Brazil. Front Microbiol., v. 12:711107, 2021. doi: 10.3389/fmicb.2021.711107.1664-302Xhttps://www.arca.fiocruz.br/handle/icict/5167210.3389/fmicb.2021.711107engFrontiers Research FoundationLarge-Scale Deployment and Establishment of Wolbachia Into the Aedes aegypti Population in Rio de Janeiro, Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto René Rachou. Grupo Mosquitos Vetores: Endossimbiontes e Interação Patógeno Vetor. Belo Horizonte, MG, Brazil/World Mosquito Program. Fundação Oswaldo Cruz. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Grupo Mosquitos Vetores: Endossimbiontes e Interação Patógeno Vetor. Belo Horizonte, MG, Brazil/World Mosquito Program. Fundação Oswaldo Cruz. Rio de Janeiro, RJ, Brazil.World Mosquito Program. Fundação Oswaldo Cruz. Rio de Janeiro, RJ, Brazil/Fundação Oswaldo Cruz. Gabinete da Presidência. Rio de Janeiro, RJ, Brazil.World Mosquito Program. Fundação Oswaldo Cruz. Rio de Janeiro, RJ, Brazil.World Mosquito Program. Fundação Oswaldo Cruz. Rio de Janeiro, RJ, Brazil.World Mosquito Program. Institute of Vector Borne Disease. Monash University. Clayton, VIC, Australia.World Mosquito Program. Institute of Vector Borne Disease. Monash University. Clayton, VIC, Australia.World Mosquito Program. Institute of Vector Borne Disease. Monash University. Clayton, VIC, Australia.World Mosquito Program. Institute of Vector Borne Disease. Monash University. Clayton, VIC, Australia.World Mosquito Program. Institute of Vector Borne Disease. Monash University. Clayton, VIC, Australia.World Mosquito Program. Institute of Vector Borne Disease. Monash University. Clayton, VIC, Australia.World Mosquito Program. Institute of Vector Borne Disease. Monash University. Clayton, VIC, Australia.Fundação Oswaldo Cruz. Instituto René Rachou. Grupo Mosquitos Vetores: Endossimbiontes e Interação Patógeno Vetor. Belo Horizonte, MG, Brazil/World Mosquito Program. Fundação Oswaldo Cruz. Rio de Janeiro, RJ, Brazil.Traditional methods of vector control have proven insufficient to reduce the alarming incidence of dengue, Zika, and chikungunya in endemic countries. The bacterium symbiont Wolbachia has emerged as an efficient pathogen-blocking and self-dispersing agent that reduces the vectorial potential of Aedes aegypti populations and potentially impairs arboviral disease transmission. In this work, we report the results of a large-scale Wolbachia intervention in Ilha do Governador, Rio de Janeiro, Brazil. wMel-infected adults were released across residential areas between August 2017 and March 2020. Over 131 weeks, including release and post-release phases, we monitored the wMel prevalence in field specimens and analyzed introgression profiles of two assigned intervention areas, RJ1 and RJ2. Our results revealed that wMel successfully invaded both areas, reaching overall infection rates of 50-70% in RJ1 and 30-60% in RJ2 by the end of the monitoring period. At the neighborhood-level, wMel introgression was heterogeneous in both RJ1 and RJ2, with some profiles sustaining a consistent increase in infection rates and others failing to elicit the same. Correlation analysis revealed a weak overall association between RJ1 and RJ2 (r = 0.2849, p = 0.0236), and an association at a higher degree when comparing different deployment strategies, vehicle or backpack-assisted, within RJ1 (r = 0.4676, p < 0.0001) or RJ2 (r = 0.6263, p < 0.0001). The frequency knockdown resistance (kdr) alleles in wMel-infected specimens from both areas were consistently high over this study. Altogether, these findings corroborate that wMel can be successfully deployed at large-scale as part of vector control intervention strategies and provide the basis for imminent disease impact studies in Southeastern Brazil.AedesWolbachiaarbovirusendosymbiontfield deploymentmosquitoinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALLarge-Scale Deployment and Establishment of Wolbachia Into the Aedes aegypti Population in Rio de Janeiro, Brazil - fmicb-12-711107.pdfLarge-Scale Deployment and Establishment of Wolbachia Into the Aedes aegypti Population in Rio de Janeiro, Brazil - fmicb-12-711107.pdfapplication/pdf5774049https://www.arca.fiocruz.br/bitstream/icict/51672/2/Large-Scale%20Deployment%20and%20Establishment%20of%20%ef%bb%bfWolbachia%ef%bb%bf%20Into%20the%20%ef%bb%bfAedes%20aegypti%ef%bb%bf%20Population%20in%20Rio%20de%20Janeiro%2c%20Brazil%20-%20fmicb-12-711107.pdfd18a9d832b220df936009c59004de9f4MD52LICENSElicense.txtlicense.txttext/plain; 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| dc.title.pt_BR.fl_str_mv |
Large-Scale Deployment and Establishment of Wolbachia Into the Aedes aegypti Population in Rio de Janeiro, Brazil |
| title |
Large-Scale Deployment and Establishment of Wolbachia Into the Aedes aegypti Population in Rio de Janeiro, Brazil |
| spellingShingle |
Large-Scale Deployment and Establishment of Wolbachia Into the Aedes aegypti Population in Rio de Janeiro, Brazil Gesto, João Silveira Moledo Aedes Wolbachia arbovirus endosymbiont field deployment mosquito |
| title_short |
Large-Scale Deployment and Establishment of Wolbachia Into the Aedes aegypti Population in Rio de Janeiro, Brazil |
| title_full |
Large-Scale Deployment and Establishment of Wolbachia Into the Aedes aegypti Population in Rio de Janeiro, Brazil |
| title_fullStr |
Large-Scale Deployment and Establishment of Wolbachia Into the Aedes aegypti Population in Rio de Janeiro, Brazil |
| title_full_unstemmed |
Large-Scale Deployment and Establishment of Wolbachia Into the Aedes aegypti Population in Rio de Janeiro, Brazil |
| title_sort |
Large-Scale Deployment and Establishment of Wolbachia Into the Aedes aegypti Population in Rio de Janeiro, Brazil |
| author |
Gesto, João Silveira Moledo |
| author_facet |
Gesto, João Silveira Moledo Pinto, Sofia Bastos Dias, Fernando Braga Stehling Peixoto, Julia Costa, Guilherme Kutcher, Simon Montgomery, Jacqui Green, Benjamin R Anders, Katherine L Ryan, Peter A Simmons, Cameron P O'Neill, Scott L Moreira, Luciano Andrade |
| author_role |
author |
| author2 |
Pinto, Sofia Bastos Dias, Fernando Braga Stehling Peixoto, Julia Costa, Guilherme Kutcher, Simon Montgomery, Jacqui Green, Benjamin R Anders, Katherine L Ryan, Peter A Simmons, Cameron P O'Neill, Scott L Moreira, Luciano Andrade |
| author2_role |
author author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Gesto, João Silveira Moledo Pinto, Sofia Bastos Dias, Fernando Braga Stehling Peixoto, Julia Costa, Guilherme Kutcher, Simon Montgomery, Jacqui Green, Benjamin R Anders, Katherine L Ryan, Peter A Simmons, Cameron P O'Neill, Scott L Moreira, Luciano Andrade |
| dc.subject.en.pt_BR.fl_str_mv |
Aedes Wolbachia arbovirus endosymbiont field deployment mosquito |
| topic |
Aedes Wolbachia arbovirus endosymbiont field deployment mosquito |
| description |
Fundação Oswaldo Cruz. Instituto René Rachou. Grupo Mosquitos Vetores: Endossimbiontes e Interação Patógeno Vetor. Belo Horizonte, MG, Brazil/World Mosquito Program. Fundação Oswaldo Cruz. Rio de Janeiro, RJ, Brazil. |
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2021 |
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2021 |
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2022-03-10T12:32:40Z |
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2022-03-10T12:32:40Z |
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GESTO, João Silveira Moledo et al. Large-Scale Deployment and Establishment of Wolbachia Into the Aedes aegypti Population in Rio de Janeiro, Brazil. Front Microbiol., v. 12:711107, 2021. doi: 10.3389/fmicb.2021.711107. |
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https://www.arca.fiocruz.br/handle/icict/51672 |
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1664-302X |
| dc.identifier.doi.none.fl_str_mv |
10.3389/fmicb.2021.711107 |
| identifier_str_mv |
GESTO, João Silveira Moledo et al. Large-Scale Deployment and Establishment of Wolbachia Into the Aedes aegypti Population in Rio de Janeiro, Brazil. Front Microbiol., v. 12:711107, 2021. doi: 10.3389/fmicb.2021.711107. 1664-302X 10.3389/fmicb.2021.711107 |
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Frontiers Research Foundation |
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Frontiers Research Foundation |
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