Large-Scale Deployment and Establishment of Wolbachia Into the Aedes aegypti Population in Rio de Janeiro, Brazil

Detalhes bibliográficos
Autor(a) principal: Gesto, João Silveira Moledo
Data de Publicação: 2021
Outros Autores: Pinto, Sofia Bastos, Dias, Fernando Braga Stehling, Peixoto, Julia, Costa, Guilherme, Kutcher, Simon, Montgomery, Jacqui, Green, Benjamin R, Anders, Katherine L, Ryan, Peter A, Simmons, Cameron P, O'Neill, Scott L, Moreira, Luciano Andrade
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/51672
Resumo: Fundação Oswaldo Cruz. Instituto René Rachou. Grupo Mosquitos Vetores: Endossimbiontes e Interação Patógeno Vetor. Belo Horizonte, MG, Brazil/World Mosquito Program. Fundação Oswaldo Cruz. Rio de Janeiro, RJ, Brazil.
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spelling Gesto, João Silveira MoledoPinto, Sofia BastosDias, Fernando Braga StehlingPeixoto, JuliaCosta, GuilhermeKutcher, SimonMontgomery, JacquiGreen, Benjamin RAnders, Katherine LRyan, Peter ASimmons, Cameron PO'Neill, Scott LMoreira, Luciano Andrade2022-03-10T12:32:40Z2022-03-10T12:32:40Z2021GESTO, João Silveira Moledo et al. Large-Scale Deployment and Establishment of Wolbachia Into the Aedes aegypti Population in Rio de Janeiro, Brazil. Front Microbiol., v. 12:711107, 2021. doi: 10.3389/fmicb.2021.711107.1664-302Xhttps://www.arca.fiocruz.br/handle/icict/5167210.3389/fmicb.2021.711107engFrontiers Research FoundationLarge-Scale Deployment and Establishment of Wolbachia Into the Aedes aegypti Population in Rio de Janeiro, Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto René Rachou. Grupo Mosquitos Vetores: Endossimbiontes e Interação Patógeno Vetor. Belo Horizonte, MG, Brazil/World Mosquito Program. Fundação Oswaldo Cruz. Rio de Janeiro, RJ, Brazil.Fundação Oswaldo Cruz. Instituto René Rachou. Grupo Mosquitos Vetores: Endossimbiontes e Interação Patógeno Vetor. Belo Horizonte, MG, Brazil/World Mosquito Program. Fundação Oswaldo Cruz. Rio de Janeiro, RJ, Brazil.World Mosquito Program. Fundação Oswaldo Cruz. Rio de Janeiro, RJ, Brazil/Fundação Oswaldo Cruz. Gabinete da Presidência. Rio de Janeiro, RJ, Brazil.World Mosquito Program. Fundação Oswaldo Cruz. Rio de Janeiro, RJ, Brazil.World Mosquito Program. Fundação Oswaldo Cruz. Rio de Janeiro, RJ, Brazil.World Mosquito Program. Institute of Vector Borne Disease. Monash University. Clayton, VIC, Australia.World Mosquito Program. Institute of Vector Borne Disease. Monash University. Clayton, VIC, Australia.World Mosquito Program. Institute of Vector Borne Disease. Monash University. Clayton, VIC, Australia.World Mosquito Program. Institute of Vector Borne Disease. Monash University. Clayton, VIC, Australia.World Mosquito Program. Institute of Vector Borne Disease. Monash University. Clayton, VIC, Australia.World Mosquito Program. Institute of Vector Borne Disease. Monash University. Clayton, VIC, Australia.World Mosquito Program. Institute of Vector Borne Disease. Monash University. Clayton, VIC, Australia.Fundação Oswaldo Cruz. Instituto René Rachou. Grupo Mosquitos Vetores: Endossimbiontes e Interação Patógeno Vetor. Belo Horizonte, MG, Brazil/World Mosquito Program. Fundação Oswaldo Cruz. Rio de Janeiro, RJ, Brazil.Traditional methods of vector control have proven insufficient to reduce the alarming incidence of dengue, Zika, and chikungunya in endemic countries. The bacterium symbiont Wolbachia has emerged as an efficient pathogen-blocking and self-dispersing agent that reduces the vectorial potential of Aedes aegypti populations and potentially impairs arboviral disease transmission. In this work, we report the results of a large-scale Wolbachia intervention in Ilha do Governador, Rio de Janeiro, Brazil. wMel-infected adults were released across residential areas between August 2017 and March 2020. Over 131 weeks, including release and post-release phases, we monitored the wMel prevalence in field specimens and analyzed introgression profiles of two assigned intervention areas, RJ1 and RJ2. Our results revealed that wMel successfully invaded both areas, reaching overall infection rates of 50-70% in RJ1 and 30-60% in RJ2 by the end of the monitoring period. At the neighborhood-level, wMel introgression was heterogeneous in both RJ1 and RJ2, with some profiles sustaining a consistent increase in infection rates and others failing to elicit the same. Correlation analysis revealed a weak overall association between RJ1 and RJ2 (r = 0.2849, p = 0.0236), and an association at a higher degree when comparing different deployment strategies, vehicle or backpack-assisted, within RJ1 (r = 0.4676, p < 0.0001) or RJ2 (r = 0.6263, p < 0.0001). The frequency knockdown resistance (kdr) alleles in wMel-infected specimens from both areas were consistently high over this study. Altogether, these findings corroborate that wMel can be successfully deployed at large-scale as part of vector control intervention strategies and provide the basis for imminent disease impact studies in Southeastern Brazil.AedesWolbachiaarbovirusendosymbiontfield deploymentmosquitoinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALLarge-Scale Deployment and Establishment of Wolbachia Into the Aedes aegypti Population in Rio de Janeiro, Brazil - fmicb-12-711107.pdfLarge-Scale Deployment and Establishment of Wolbachia Into the Aedes aegypti Population in Rio de Janeiro, Brazil - fmicb-12-711107.pdfapplication/pdf5774049https://www.arca.fiocruz.br/bitstream/icict/51672/2/Large-Scale%20Deployment%20and%20Establishment%20of%20%ef%bb%bfWolbachia%ef%bb%bf%20Into%20the%20%ef%bb%bfAedes%20aegypti%ef%bb%bf%20Population%20in%20Rio%20de%20Janeiro%2c%20Brazil%20-%20fmicb-12-711107.pdfd18a9d832b220df936009c59004de9f4MD52LICENSElicense.txtlicense.txttext/plain; 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dc.title.pt_BR.fl_str_mv Large-Scale Deployment and Establishment of Wolbachia Into the Aedes aegypti Population in Rio de Janeiro, Brazil
title Large-Scale Deployment and Establishment of Wolbachia Into the Aedes aegypti Population in Rio de Janeiro, Brazil
spellingShingle Large-Scale Deployment and Establishment of Wolbachia Into the Aedes aegypti Population in Rio de Janeiro, Brazil
Gesto, João Silveira Moledo
Aedes
Wolbachia
arbovirus
endosymbiont
field deployment
mosquito
title_short Large-Scale Deployment and Establishment of Wolbachia Into the Aedes aegypti Population in Rio de Janeiro, Brazil
title_full Large-Scale Deployment and Establishment of Wolbachia Into the Aedes aegypti Population in Rio de Janeiro, Brazil
title_fullStr Large-Scale Deployment and Establishment of Wolbachia Into the Aedes aegypti Population in Rio de Janeiro, Brazil
title_full_unstemmed Large-Scale Deployment and Establishment of Wolbachia Into the Aedes aegypti Population in Rio de Janeiro, Brazil
title_sort Large-Scale Deployment and Establishment of Wolbachia Into the Aedes aegypti Population in Rio de Janeiro, Brazil
author Gesto, João Silveira Moledo
author_facet Gesto, João Silveira Moledo
Pinto, Sofia Bastos
Dias, Fernando Braga Stehling
Peixoto, Julia
Costa, Guilherme
Kutcher, Simon
Montgomery, Jacqui
Green, Benjamin R
Anders, Katherine L
Ryan, Peter A
Simmons, Cameron P
O'Neill, Scott L
Moreira, Luciano Andrade
author_role author
author2 Pinto, Sofia Bastos
Dias, Fernando Braga Stehling
Peixoto, Julia
Costa, Guilherme
Kutcher, Simon
Montgomery, Jacqui
Green, Benjamin R
Anders, Katherine L
Ryan, Peter A
Simmons, Cameron P
O'Neill, Scott L
Moreira, Luciano Andrade
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Gesto, João Silveira Moledo
Pinto, Sofia Bastos
Dias, Fernando Braga Stehling
Peixoto, Julia
Costa, Guilherme
Kutcher, Simon
Montgomery, Jacqui
Green, Benjamin R
Anders, Katherine L
Ryan, Peter A
Simmons, Cameron P
O'Neill, Scott L
Moreira, Luciano Andrade
dc.subject.en.pt_BR.fl_str_mv Aedes
Wolbachia
arbovirus
endosymbiont
field deployment
mosquito
topic Aedes
Wolbachia
arbovirus
endosymbiont
field deployment
mosquito
description Fundação Oswaldo Cruz. Instituto René Rachou. Grupo Mosquitos Vetores: Endossimbiontes e Interação Patógeno Vetor. Belo Horizonte, MG, Brazil/World Mosquito Program. Fundação Oswaldo Cruz. Rio de Janeiro, RJ, Brazil.
publishDate 2021
dc.date.issued.fl_str_mv 2021
dc.date.accessioned.fl_str_mv 2022-03-10T12:32:40Z
dc.date.available.fl_str_mv 2022-03-10T12:32:40Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv GESTO, João Silveira Moledo et al. Large-Scale Deployment and Establishment of Wolbachia Into the Aedes aegypti Population in Rio de Janeiro, Brazil. Front Microbiol., v. 12:711107, 2021. doi: 10.3389/fmicb.2021.711107.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/51672
dc.identifier.issn.pt_BR.fl_str_mv 1664-302X
dc.identifier.doi.none.fl_str_mv 10.3389/fmicb.2021.711107
identifier_str_mv GESTO, João Silveira Moledo et al. Large-Scale Deployment and Establishment of Wolbachia Into the Aedes aegypti Population in Rio de Janeiro, Brazil. Front Microbiol., v. 12:711107, 2021. doi: 10.3389/fmicb.2021.711107.
1664-302X
10.3389/fmicb.2021.711107
url https://www.arca.fiocruz.br/handle/icict/51672
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Research Foundation
publisher.none.fl_str_mv Frontiers Research Foundation
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/51672/2/Large-Scale%20Deployment%20and%20Establishment%20of%20%ef%bb%bfWolbachia%ef%bb%bf%20Into%20the%20%ef%bb%bfAedes%20aegypti%ef%bb%bf%20Population%20in%20Rio%20de%20Janeiro%2c%20Brazil%20-%20fmicb-12-711107.pdf
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