Cytokine response signatures in disease progression and development of severe clinical outcomes for leptospirosis.

Detalhes bibliográficos
Autor(a) principal: Reis, Eliana Almeida Gomes
Data de Publicação: 2013
Outros Autores: Hagan, José Edward, Ribeiro, Guilherme de Sousa, Carvalho, Andréa Teixeira de, Martins Filho, Olindo Assis, Montgomery, Ruth R, Shaw, Albert C, Ko, Albert Icksang, Reis, Mitermayer Galvão dos
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/7481
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil
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spelling Reis, Eliana Almeida GomesHagan, José EdwardRibeiro, Guilherme de SousaCarvalho, Andréa Teixeira deMartins Filho, Olindo AssisMontgomery, Ruth RShaw, Albert CKo, Albert IcksangReis, Mitermayer Galvão dos2014-04-01T16:45:51Z2014-04-01T16:45:51Z2013REIS, E. A. G. et al. Cytokine response signatures in disease progression and development of severe clinical outcomes for leptospirosis. PLoS Neglected Tropical Diseases, v. 7, n. 9, p. e2457, 2013.1935-273510.1371/journal.pntd.0002457https://www.arca.fiocruz.br/handle/icict/7481engPublic Library of ScienceCytokine response signatures in disease progression and development of severe clinical outcomes for leptospirosis.info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil / Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven, Connecticut, USA.Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil / Federal University of Bahia. Institute of Collective Health. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Belo Horizonte, MG, BrasilFundação Oswaldo Cruz. Centro de Pesquisa René Rachou. Belo Horizonte, MG, BrasilYale University School of Medicine. Yale University. Yale Department of Internal Medicine. New Haven, Connecticut, USAYale University School of Medicine. Yale University. Yale Department of Internal Medicine. New Haven, Connecticut, USAFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil / Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven, Connecticut, USA.Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil / Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven, Connecticut, USA.BACKGROUND: The role of the immune response in influencing leptospirosis clinical outcomes is not yet well understood. We hypothesized that acute-phase serum cytokine responses may play a role in disease progression, risk for death, and severe pulmonary hemorrhage syndrome (SPHS). METHODOLOGY/PRINCIPAL FINDINGS: We performed a case-control study design to compare cytokine profiles in patients with mild and severe forms of leptospirosis. Among patients hospitalized with severe disease, we compared those with fatal and nonfatal outcomes. During active outpatient and hospital-based surveillance we prospectively enrolled 172 patients, 23 with mild disease (outpatient) and 149 with severe leptospirosis (hospitalized). Circulating concentrations of pro- and anti-inflammatory cytokines at the time of patient presentation were measured using a multiplex bead array assay. Concentrations of IL-1ß, IL-2, IL-4, IL-6, IL-8, IL-10, IL-17A, and TNF-α were significantly higher (P<0.05) in severe disease compared to mild disease. Among severe patients, levels of IL-6 (P<0.001), IL-8 (P = 0.0049) and IL-10 (P<0.001), were higher in fatal compared to non-fatal cases. High levels of IL-6 and IL-10 were independently associated (P<0.05) with case fatality after adjustment for age and days of symptoms. IL-6 levels were higher (P = 0.0519) among fatal cases who developed SPHS than among who did not. CONCLUSION/SIGNIFICANCE: This study shows that severe cases of leptospirosis are differentiated from mild disease by a "cytokine storm" process, and that IL-6 and IL-10 may play an immunopathogenic role in the development of life-threatening outcomes in human leptospirosis.Marcadores Biológicos/sangueCitocinas/sangueLeptospirose/imunologiaLeptospirose/patologiaAdolescenteAdultoEstudos de Casos e ControlesProgressão da DoençaFemininoHumanosLeptospirose/mortalidadeAnálise de SobrevidaMeia-IdadeMasculinoAdulto Joveminfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALReis AGE Cytokine....pdfReis AGE Cytokine....pdfapplication/pdf443031https://www.arca.fiocruz.br/bitstream/icict/7481/1/Reis%20AGE%20Cytokine....pdfdc7eb85a412ebaeae7d6d200b4683e1eMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81867https://www.arca.fiocruz.br/bitstream/icict/7481/2/license.txt89d048e714e969a1adcda05fdb1978beMD52TEXTReis AGE Cytokine....pdf.txtReis AGE Cytokine....pdf.txtExtracted texttext/plain35221https://www.arca.fiocruz.br/bitstream/icict/7481/5/Reis%20AGE%20Cytokine....pdf.txt3c0b2ac17398ff9c6da25c16b5ce40e7MD55THUMBNAILReis AGE Cytokine....pdf.jpgReis AGE Cytokine....pdf.jpgGenerated Thumbnailimage/jpeg2528https://www.arca.fiocruz.br/bitstream/icict/7481/4/Reis%20AGE%20Cytokine....pdf.jpg556b2f25321ada75fe275d9ac397abecMD54icict/74812023-03-15 14:33:19.325oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:19Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Cytokine response signatures in disease progression and development of severe clinical outcomes for leptospirosis.
title Cytokine response signatures in disease progression and development of severe clinical outcomes for leptospirosis.
spellingShingle Cytokine response signatures in disease progression and development of severe clinical outcomes for leptospirosis.
Reis, Eliana Almeida Gomes
Marcadores Biológicos/sangue
Citocinas/sangue
Leptospirose/imunologia
Leptospirose/patologia
Adolescente
Adulto
Estudos de Casos e Controles
Progressão da Doença
Feminino
Humanos
Leptospirose/mortalidade
Análise de Sobrevida
Meia-Idade
Masculino
Adulto Jovem
title_short Cytokine response signatures in disease progression and development of severe clinical outcomes for leptospirosis.
title_full Cytokine response signatures in disease progression and development of severe clinical outcomes for leptospirosis.
title_fullStr Cytokine response signatures in disease progression and development of severe clinical outcomes for leptospirosis.
title_full_unstemmed Cytokine response signatures in disease progression and development of severe clinical outcomes for leptospirosis.
title_sort Cytokine response signatures in disease progression and development of severe clinical outcomes for leptospirosis.
author Reis, Eliana Almeida Gomes
author_facet Reis, Eliana Almeida Gomes
Hagan, José Edward
Ribeiro, Guilherme de Sousa
Carvalho, Andréa Teixeira de
Martins Filho, Olindo Assis
Montgomery, Ruth R
Shaw, Albert C
Ko, Albert Icksang
Reis, Mitermayer Galvão dos
author_role author
author2 Hagan, José Edward
Ribeiro, Guilherme de Sousa
Carvalho, Andréa Teixeira de
Martins Filho, Olindo Assis
Montgomery, Ruth R
Shaw, Albert C
Ko, Albert Icksang
Reis, Mitermayer Galvão dos
author2_role author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Reis, Eliana Almeida Gomes
Hagan, José Edward
Ribeiro, Guilherme de Sousa
Carvalho, Andréa Teixeira de
Martins Filho, Olindo Assis
Montgomery, Ruth R
Shaw, Albert C
Ko, Albert Icksang
Reis, Mitermayer Galvão dos
dc.subject.decs.pt_BR.fl_str_mv Marcadores Biológicos/sangue
Citocinas/sangue
Leptospirose/imunologia
Leptospirose/patologia
Adolescente
Adulto
Estudos de Casos e Controles
Progressão da Doença
Feminino
Humanos
Leptospirose/mortalidade
Análise de Sobrevida
Meia-Idade
Masculino
Adulto Jovem
topic Marcadores Biológicos/sangue
Citocinas/sangue
Leptospirose/imunologia
Leptospirose/patologia
Adolescente
Adulto
Estudos de Casos e Controles
Progressão da Doença
Feminino
Humanos
Leptospirose/mortalidade
Análise de Sobrevida
Meia-Idade
Masculino
Adulto Jovem
description Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Patologia e Biologia Molecular. Salvador, BA, Brasil
publishDate 2013
dc.date.issued.fl_str_mv 2013
dc.date.accessioned.fl_str_mv 2014-04-01T16:45:51Z
dc.date.available.fl_str_mv 2014-04-01T16:45:51Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv REIS, E. A. G. et al. Cytokine response signatures in disease progression and development of severe clinical outcomes for leptospirosis. PLoS Neglected Tropical Diseases, v. 7, n. 9, p. e2457, 2013.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/7481
dc.identifier.issn.none.fl_str_mv 1935-2735
10.1371/journal.pntd.0002457
identifier_str_mv REIS, E. A. G. et al. Cytokine response signatures in disease progression and development of severe clinical outcomes for leptospirosis. PLoS Neglected Tropical Diseases, v. 7, n. 9, p. e2457, 2013.
1935-2735
10.1371/journal.pntd.0002457
url https://www.arca.fiocruz.br/handle/icict/7481
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
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