Experimental hepatic fibrosis due to Capillaria hepatica infection (differential features presented by rats and mice)

Detalhes bibliográficos
Autor(a) principal: Andrade, Stelamares Boyda de
Data de Publicação: 2004
Outros Autores: Andrade, Zilton de Araújo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/3266
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.
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spelling Andrade, Stelamares Boyda deAndrade, Zilton de Araújo2011-10-20T20:09:01Z2011-10-20T20:09:01Z2004ANDRADE, Stelamares Boyda de; ANDRADE, Zilton de Araújo. Experimental hepatic fibrosis due to Capillaria hepatica infection (differential features presented by rats and mice). Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 99, n. 4, p. 399-406, jun. 2004.0074-0276https://www.arca.fiocruz.br/handle/icict/326610.1590/S0074-02762004000400010engExperimental hepatic fibrosis due to Capillaria hepatica infection (differential features presented by rats and mice)info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.Rats and mice are among the most susceptible hosts for the helminth Capillaria hepatica. More information on the similarities and differences between the hepatic pathology presented by these two parasite hosts are needed, since they may represent good models for the study of hepatic fibrosis. Early changes are similar for both hosts and are represented by necro-inflammatory lesions around dead parasites and their eggs and diffuse and intense reactive hepatitis. Although worms remain alive longer in mice than in rats, hepatic changes are more rapidly and deeply modulated in the former, even leading to almost complete disappearance of fibrosis. As for the rats, the modulation of the focal lesions is followed by the formation of septal fibrosis, a process where fine and long fibrous septa appear connecting portal spaces and central veins in such a way as to form a final morphologic picture of cirrhosis. Hepatic functional changes usually present good correlations with the morphologic findings at the different phases of the infection evolution. Therefore C. hepatica infection in rats and mice represent two different models of hepatic fibrosis and these differences, if properly known and understood, can be explored to answer different questions regarding several aspects of hepatic fibrosis.Capillaria hepaticaSeptal fibrosisHepatic fibrosisPathogenesisAnticorpos Anti-HelmínticosCapillariaInfecções por EnoplidaInterações Hospedeiro-ParasitaCirrose Hepática ExperimentalMasculinoCamundongosRatosRatos WistarFatores de Tempoinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALAndrade SB Experimental hepatic fibrosis....pdfAndrade SB Experimental hepatic fibrosis....pdfapplication/pdf261418https://www.arca.fiocruz.br/bitstream/icict/3266/1/Andrade%20SB%20Experimental%20hepatic%20fibrosis....pdf8ffb7231cf228a9083ecf3be242f1212MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81648https://www.arca.fiocruz.br/bitstream/icict/3266/2/license.txte095249ac7cacefbfe39684dfe45e706MD52TEXTAndrade SB Experimental hepatic fibrosis....pdf.txtAndrade SB Experimental hepatic fibrosis....pdf.txtExtracted texttext/plain27140https://www.arca.fiocruz.br/bitstream/icict/3266/5/Andrade%20SB%20Experimental%20hepatic%20fibrosis....pdf.txt2eaa77d50848e86668ea6d747c8b9593MD55THUMBNAILAndrade SB Experimental hepatic fibrosis....pdf.jpgAndrade SB Experimental hepatic fibrosis....pdf.jpgGenerated Thumbnailimage/jpeg2374https://www.arca.fiocruz.br/bitstream/icict/3266/4/Andrade%20SB%20Experimental%20hepatic%20fibrosis....pdf.jpg650d25b1dc37807b9a75e7a07303d03eMD54icict/32662023-03-15 14:32:59.37oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:32:59Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Experimental hepatic fibrosis due to Capillaria hepatica infection (differential features presented by rats and mice)
title Experimental hepatic fibrosis due to Capillaria hepatica infection (differential features presented by rats and mice)
spellingShingle Experimental hepatic fibrosis due to Capillaria hepatica infection (differential features presented by rats and mice)
Andrade, Stelamares Boyda de
Capillaria hepatica
Septal fibrosis
Hepatic fibrosis
Pathogenesis
Anticorpos Anti-Helmínticos
Capillaria
Infecções por Enoplida
Interações Hospedeiro-Parasita
Cirrose Hepática Experimental
Masculino
Camundongos
Ratos
Ratos Wistar
Fatores de Tempo
title_short Experimental hepatic fibrosis due to Capillaria hepatica infection (differential features presented by rats and mice)
title_full Experimental hepatic fibrosis due to Capillaria hepatica infection (differential features presented by rats and mice)
title_fullStr Experimental hepatic fibrosis due to Capillaria hepatica infection (differential features presented by rats and mice)
title_full_unstemmed Experimental hepatic fibrosis due to Capillaria hepatica infection (differential features presented by rats and mice)
title_sort Experimental hepatic fibrosis due to Capillaria hepatica infection (differential features presented by rats and mice)
author Andrade, Stelamares Boyda de
author_facet Andrade, Stelamares Boyda de
Andrade, Zilton de Araújo
author_role author
author2 Andrade, Zilton de Araújo
author2_role author
dc.contributor.author.fl_str_mv Andrade, Stelamares Boyda de
Andrade, Zilton de Araújo
dc.subject.en.pt_BR.fl_str_mv Capillaria hepatica
Septal fibrosis
Hepatic fibrosis
Pathogenesis
topic Capillaria hepatica
Septal fibrosis
Hepatic fibrosis
Pathogenesis
Anticorpos Anti-Helmínticos
Capillaria
Infecções por Enoplida
Interações Hospedeiro-Parasita
Cirrose Hepática Experimental
Masculino
Camundongos
Ratos
Ratos Wistar
Fatores de Tempo
dc.subject.decs.pt_BR.fl_str_mv Anticorpos Anti-Helmínticos
Capillaria
Infecções por Enoplida
Interações Hospedeiro-Parasita
Cirrose Hepática Experimental
Masculino
Camundongos
Ratos
Ratos Wistar
Fatores de Tempo
description Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.
publishDate 2004
dc.date.issued.fl_str_mv 2004
dc.date.accessioned.fl_str_mv 2011-10-20T20:09:01Z
dc.date.available.fl_str_mv 2011-10-20T20:09:01Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv ANDRADE, Stelamares Boyda de; ANDRADE, Zilton de Araújo. Experimental hepatic fibrosis due to Capillaria hepatica infection (differential features presented by rats and mice). Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 99, n. 4, p. 399-406, jun. 2004.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/3266
dc.identifier.issn.none.fl_str_mv 0074-0276
dc.identifier.doi.pt_BR.fl_str_mv 10.1590/S0074-02762004000400010
identifier_str_mv ANDRADE, Stelamares Boyda de; ANDRADE, Zilton de Araújo. Experimental hepatic fibrosis due to Capillaria hepatica infection (differential features presented by rats and mice). Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 99, n. 4, p. 399-406, jun. 2004.
0074-0276
10.1590/S0074-02762004000400010
url https://www.arca.fiocruz.br/handle/icict/3266
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
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dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
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reponame_str Repositório Institucional da FIOCRUZ (ARCA)
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