Experimental hepatic fibrosis due to Capillaria hepatica infection (differential features presented by rats and mice)
Autor(a) principal: | |
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Data de Publicação: | 2004 |
Outros Autores: | |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/3266 |
Resumo: | Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil. |
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Andrade, Stelamares Boyda deAndrade, Zilton de Araújo2011-10-20T20:09:01Z2011-10-20T20:09:01Z2004ANDRADE, Stelamares Boyda de; ANDRADE, Zilton de Araújo. Experimental hepatic fibrosis due to Capillaria hepatica infection (differential features presented by rats and mice). Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 99, n. 4, p. 399-406, jun. 2004.0074-0276https://www.arca.fiocruz.br/handle/icict/326610.1590/S0074-02762004000400010engExperimental hepatic fibrosis due to Capillaria hepatica infection (differential features presented by rats and mice)info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.Rats and mice are among the most susceptible hosts for the helminth Capillaria hepatica. More information on the similarities and differences between the hepatic pathology presented by these two parasite hosts are needed, since they may represent good models for the study of hepatic fibrosis. Early changes are similar for both hosts and are represented by necro-inflammatory lesions around dead parasites and their eggs and diffuse and intense reactive hepatitis. Although worms remain alive longer in mice than in rats, hepatic changes are more rapidly and deeply modulated in the former, even leading to almost complete disappearance of fibrosis. As for the rats, the modulation of the focal lesions is followed by the formation of septal fibrosis, a process where fine and long fibrous septa appear connecting portal spaces and central veins in such a way as to form a final morphologic picture of cirrhosis. Hepatic functional changes usually present good correlations with the morphologic findings at the different phases of the infection evolution. Therefore C. hepatica infection in rats and mice represent two different models of hepatic fibrosis and these differences, if properly known and understood, can be explored to answer different questions regarding several aspects of hepatic fibrosis.Capillaria hepaticaSeptal fibrosisHepatic fibrosisPathogenesisAnticorpos Anti-HelmínticosCapillariaInfecções por EnoplidaInterações Hospedeiro-ParasitaCirrose Hepática ExperimentalMasculinoCamundongosRatosRatos WistarFatores de Tempoinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALAndrade SB Experimental hepatic fibrosis....pdfAndrade SB Experimental hepatic fibrosis....pdfapplication/pdf261418https://www.arca.fiocruz.br/bitstream/icict/3266/1/Andrade%20SB%20Experimental%20hepatic%20fibrosis....pdf8ffb7231cf228a9083ecf3be242f1212MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81648https://www.arca.fiocruz.br/bitstream/icict/3266/2/license.txte095249ac7cacefbfe39684dfe45e706MD52TEXTAndrade SB Experimental hepatic fibrosis....pdf.txtAndrade SB Experimental hepatic fibrosis....pdf.txtExtracted texttext/plain27140https://www.arca.fiocruz.br/bitstream/icict/3266/5/Andrade%20SB%20Experimental%20hepatic%20fibrosis....pdf.txt2eaa77d50848e86668ea6d747c8b9593MD55THUMBNAILAndrade SB Experimental hepatic fibrosis....pdf.jpgAndrade SB Experimental hepatic fibrosis....pdf.jpgGenerated Thumbnailimage/jpeg2374https://www.arca.fiocruz.br/bitstream/icict/3266/4/Andrade%20SB%20Experimental%20hepatic%20fibrosis....pdf.jpg650d25b1dc37807b9a75e7a07303d03eMD54icict/32662023-03-15 14:32:59.37oai:www.arca.fiocruz.br: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Repositório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:32:59Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
dc.title.pt_BR.fl_str_mv |
Experimental hepatic fibrosis due to Capillaria hepatica infection (differential features presented by rats and mice) |
title |
Experimental hepatic fibrosis due to Capillaria hepatica infection (differential features presented by rats and mice) |
spellingShingle |
Experimental hepatic fibrosis due to Capillaria hepatica infection (differential features presented by rats and mice) Andrade, Stelamares Boyda de Capillaria hepatica Septal fibrosis Hepatic fibrosis Pathogenesis Anticorpos Anti-Helmínticos Capillaria Infecções por Enoplida Interações Hospedeiro-Parasita Cirrose Hepática Experimental Masculino Camundongos Ratos Ratos Wistar Fatores de Tempo |
title_short |
Experimental hepatic fibrosis due to Capillaria hepatica infection (differential features presented by rats and mice) |
title_full |
Experimental hepatic fibrosis due to Capillaria hepatica infection (differential features presented by rats and mice) |
title_fullStr |
Experimental hepatic fibrosis due to Capillaria hepatica infection (differential features presented by rats and mice) |
title_full_unstemmed |
Experimental hepatic fibrosis due to Capillaria hepatica infection (differential features presented by rats and mice) |
title_sort |
Experimental hepatic fibrosis due to Capillaria hepatica infection (differential features presented by rats and mice) |
author |
Andrade, Stelamares Boyda de |
author_facet |
Andrade, Stelamares Boyda de Andrade, Zilton de Araújo |
author_role |
author |
author2 |
Andrade, Zilton de Araújo |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Andrade, Stelamares Boyda de Andrade, Zilton de Araújo |
dc.subject.en.pt_BR.fl_str_mv |
Capillaria hepatica Septal fibrosis Hepatic fibrosis Pathogenesis |
topic |
Capillaria hepatica Septal fibrosis Hepatic fibrosis Pathogenesis Anticorpos Anti-Helmínticos Capillaria Infecções por Enoplida Interações Hospedeiro-Parasita Cirrose Hepática Experimental Masculino Camundongos Ratos Ratos Wistar Fatores de Tempo |
dc.subject.decs.pt_BR.fl_str_mv |
Anticorpos Anti-Helmínticos Capillaria Infecções por Enoplida Interações Hospedeiro-Parasita Cirrose Hepática Experimental Masculino Camundongos Ratos Ratos Wistar Fatores de Tempo |
description |
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil. |
publishDate |
2004 |
dc.date.issued.fl_str_mv |
2004 |
dc.date.accessioned.fl_str_mv |
2011-10-20T20:09:01Z |
dc.date.available.fl_str_mv |
2011-10-20T20:09:01Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
ANDRADE, Stelamares Boyda de; ANDRADE, Zilton de Araújo. Experimental hepatic fibrosis due to Capillaria hepatica infection (differential features presented by rats and mice). Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 99, n. 4, p. 399-406, jun. 2004. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/3266 |
dc.identifier.issn.none.fl_str_mv |
0074-0276 |
dc.identifier.doi.pt_BR.fl_str_mv |
10.1590/S0074-02762004000400010 |
identifier_str_mv |
ANDRADE, Stelamares Boyda de; ANDRADE, Zilton de Araújo. Experimental hepatic fibrosis due to Capillaria hepatica infection (differential features presented by rats and mice). Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 99, n. 4, p. 399-406, jun. 2004. 0074-0276 10.1590/S0074-02762004000400010 |
url |
https://www.arca.fiocruz.br/handle/icict/3266 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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