Vaccines in leishmaniasis: advances in the last five years

Detalhes bibliográficos
Autor(a) principal: Brodskyn, Claudia Ida
Data de Publicação: 2003
Outros Autores: Oliveira, Camila Indiani de, Barral, Aldina Maria Prado, Barral Netto, Manoel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/7433
Resumo: Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Imunoregulação. Salvador, BA, Brasil
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spelling Brodskyn, Claudia IdaOliveira, Camila Indiani deBarral, Aldina Maria PradoBarral Netto, Manoel2014-03-21T12:48:03Z2014-03-21T12:48:03Z2003BRODSKYN C. et al. Vaccines in leishmaniasis: advances in the last five years. Expert Review of Vaccines, v.2, n.5, p. 705-717, 2003.1476-0584https://www.arca.fiocruz.br/handle/icict/7433engFuture Drugs LTDVaccines in leishmaniasis: advances in the last five yearsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Imunoregulação. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Imunoregulação. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Imunoregulação. Salvador, BA, BrasilFundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Imunoregulação. Salvador, BA, BrasilThe leishmaniases are a group of diseases caused by protozoa of the genus Leishmania which affects millions of people worldwide. The leishmaniases are transmitted to the vertebrate hosts by phlebotomine sand flies. In this review, we focus on clinical aspects of the leishmaniases and on the immune response against the parasite, both in animal models and humans. These aspects are of key importance to understand the many attempts to obtain an effective vaccine against Leishmania. We considered the last advances in new generation vaccines, including the use of new adjuvants to improve the protective response against the parasite. Finally, the possibility to use components of the sand fly saliva as part of vaccines against the infection by Leishmania is mentionedCo stimulatory moleculesCytokinesImmunoregulationIVPLeishmaniaLeishmaniasisSandy flyVaccineLeishmaniose Cutânea/prevenção & controleLeishmaniose Visceral/prevenção & controleVacinas Protozoárias/imunologiaAnimaisAntiprotozoários/uso terapêuticoHumanosLeishmania/imunologiaLeishmania/patogenicidadeLeishmaniose Cutânea/quimioterapiaLeishmaniose Cutânea/parasitologiaLeishmaniose Visceral/quimioterapiaLeishmaniose Visceral/parasitologiaVacinas Protozoárias/administração & dosageminfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALBrodskyn C Vaccines in leishmaniasis....pdfBrodskyn C Vaccines in leishmaniasis....pdfapplication/pdf5989170https://www.arca.fiocruz.br/bitstream/icict/7433/1/Brodskyn%20C%20Vaccines%20in%20leishmaniasis....pdf350e2f3d68dd56b108cda92e142362f7MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/7433/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTBrodskyn C Vaccines in leishmaniasis....pdf.txtBrodskyn C Vaccines in leishmaniasis....pdf.txtExtracted texttext/plain13https://www.arca.fiocruz.br/bitstream/icict/7433/5/Brodskyn%20C%20Vaccines%20in%20leishmaniasis....pdf.txt67e866c735744ec6037b77b623ee022dMD55THUMBNAILBrodskyn C Vaccines in leishmaniasis....pdf.jpgBrodskyn C Vaccines in leishmaniasis....pdf.jpgGenerated Thumbnailimage/jpeg2320https://www.arca.fiocruz.br/bitstream/icict/7433/4/Brodskyn%20C%20Vaccines%20in%20leishmaniasis....pdf.jpg6d3c7d0ee8cf2149f23dcf58ff6d901dMD54icict/74332023-03-15 14:33:22.579oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:22Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv Vaccines in leishmaniasis: advances in the last five years
title Vaccines in leishmaniasis: advances in the last five years
spellingShingle Vaccines in leishmaniasis: advances in the last five years
Brodskyn, Claudia Ida
Co stimulatory molecules
Cytokines
Immunoregulation
IVP
Leishmania
Leishmaniasis
Sandy fly
Vaccine
Leishmaniose Cutânea/prevenção & controle
Leishmaniose Visceral/prevenção & controle
Vacinas Protozoárias/imunologia
Animais
Antiprotozoários/uso terapêutico
Humanos
Leishmania/imunologia
Leishmania/patogenicidade
Leishmaniose Cutânea/quimioterapia
Leishmaniose Cutânea/parasitologia
Leishmaniose Visceral/quimioterapia
Leishmaniose Visceral/parasitologia
Vacinas Protozoárias/administração & dosagem
title_short Vaccines in leishmaniasis: advances in the last five years
title_full Vaccines in leishmaniasis: advances in the last five years
title_fullStr Vaccines in leishmaniasis: advances in the last five years
title_full_unstemmed Vaccines in leishmaniasis: advances in the last five years
title_sort Vaccines in leishmaniasis: advances in the last five years
author Brodskyn, Claudia Ida
author_facet Brodskyn, Claudia Ida
Oliveira, Camila Indiani de
Barral, Aldina Maria Prado
Barral Netto, Manoel
author_role author
author2 Oliveira, Camila Indiani de
Barral, Aldina Maria Prado
Barral Netto, Manoel
author2_role author
author
author
dc.contributor.author.fl_str_mv Brodskyn, Claudia Ida
Oliveira, Camila Indiani de
Barral, Aldina Maria Prado
Barral Netto, Manoel
dc.subject.en.pt_BR.fl_str_mv Co stimulatory molecules
Cytokines
Immunoregulation
IVP
Leishmania
Leishmaniasis
Sandy fly
Vaccine
topic Co stimulatory molecules
Cytokines
Immunoregulation
IVP
Leishmania
Leishmaniasis
Sandy fly
Vaccine
Leishmaniose Cutânea/prevenção & controle
Leishmaniose Visceral/prevenção & controle
Vacinas Protozoárias/imunologia
Animais
Antiprotozoários/uso terapêutico
Humanos
Leishmania/imunologia
Leishmania/patogenicidade
Leishmaniose Cutânea/quimioterapia
Leishmaniose Cutânea/parasitologia
Leishmaniose Visceral/quimioterapia
Leishmaniose Visceral/parasitologia
Vacinas Protozoárias/administração & dosagem
dc.subject.decs.pt_BR.fl_str_mv Leishmaniose Cutânea/prevenção & controle
Leishmaniose Visceral/prevenção & controle
Vacinas Protozoárias/imunologia
Animais
Antiprotozoários/uso terapêutico
Humanos
Leishmania/imunologia
Leishmania/patogenicidade
Leishmaniose Cutânea/quimioterapia
Leishmaniose Cutânea/parasitologia
Leishmaniose Visceral/quimioterapia
Leishmaniose Visceral/parasitologia
Vacinas Protozoárias/administração & dosagem
description Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Laboratório de Imunoregulação. Salvador, BA, Brasil
publishDate 2003
dc.date.issued.fl_str_mv 2003
dc.date.accessioned.fl_str_mv 2014-03-21T12:48:03Z
dc.date.available.fl_str_mv 2014-03-21T12:48:03Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv BRODSKYN C. et al. Vaccines in leishmaniasis: advances in the last five years. Expert Review of Vaccines, v.2, n.5, p. 705-717, 2003.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/7433
dc.identifier.issn.none.fl_str_mv 1476-0584
identifier_str_mv BRODSKYN C. et al. Vaccines in leishmaniasis: advances in the last five years. Expert Review of Vaccines, v.2, n.5, p. 705-717, 2003.
1476-0584
url https://www.arca.fiocruz.br/handle/icict/7433
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Future Drugs LTD
publisher.none.fl_str_mv Future Drugs LTD
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
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institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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