Detection of delayed hypersensitivity to Fonsecaea pedrosoi metabolic antigen (chromomycin).
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
Texto Completo: | https://www.arca.fiocruz.br/handle/icict/9803 |
Resumo: | Federal University of Maranhão. Nucleus of Tropical Pathology and Social Medicine. Department of Pathology. São Luis, MA, Brasil |
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Marques, Sirlei GarciaSilva, Conceição de Maria Pedroso eResende, Maria AparecidaSilva, Antonio Augusto Moura daCaldas, Arlene de Jesus MendesCosta, Jackson Mauricio Lopes2015-03-23T13:16:47Z2015-03-23T13:16:47Z2008MARQUES, S. G. et al. Detection of delayed hypersensitivity to Fonsecaea pedrosoi metabolic antigen (chromomycin). Japanese Journal of Mycology, v. 49, n. 2, p.95-101, 2008.0916-4804https://www.arca.fiocruz.br/handle/icict/9803engJapanese Journal of Medical MycologyDetection of delayed hypersensitivity to Fonsecaea pedrosoi metabolic antigen (chromomycin).info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFederal University of Maranhão. Nucleus of Tropical Pathology and Social Medicine. Department of Pathology. São Luis, MA, BrasilFederal University of Maranhão. Nucleus of Tropical Pathology and Social Medicine. Department of Pathology. São Luis, MA, BrasilFederal University of Minas Gerais. Institute of Biological Sciences. Department of Microbiology. Belo Horizonte, MG, BrasilFederal University of Maranhão. Department of Public Health. São Luis, MA, BrasilFederal University of Maranhão. Nucleus of Tropical Pathology and Social Medicine. Department of Pathology. São Luis, MA, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, BrasilAn experimental study was conducted between January 2002 and April 2003 for the detection of delayed hypersensitivity to Fonsecaea pedrosoi metabolic antigen (chromomycin) in skin tests. A total of 194 subjects were attended by spontaneous demand at the Infectious and Parasitic Diseases outpatient clinic of the Federal University of Maranhão-UFMA and at the Department of Microbiology, Federal University of Minas Gerais-UFMG and classified into three groups: patients with chromoblastomycosis caused by F. pedrosoi (n=20), healthy subjects (n=86) and patients with other diseases (n=88). For the skin test, 0.1 ml of the antigen was applied to the anterior side of the right forearm and 0.1 ml Smith medium was applied to the anterior side of the left forearm as control. The results were analyzed 48 h after inoculation of the antigen and an induration >/= 5 mm was considered to indicate a positive test. A cellular immune response to chromomycin was detected in 18 (90.0%) of the 20 patients with chromoblastomycosis caused by F. pedrosoi, and one of the patients with a negative test had reactional leprosy. Eighty-five (98.8%) of the 86 healthy subjects presented a negative reaction and only one reacted positively to the antigen. The skin test was negative in all 88 (100%) patients with other diseases, such as dermatophytosis, paracoccidioidomycosis, pulmonary aspergilloma, candidiasis, pityriasis versicolor, tuberculosis, leprosy, tegumentary leishmaniasis and syphilis, and one case of chromoblastomycosis caused by Rhinocladiella aquaspersa. Chromomycin was effective in detecting delayed hypersensitivity in patients with chromoblastomycosis caused by F. pedrosoi, with a sensitivity and specificity of 90.0% and 98.8%, respectively. These results suggest that this antigen can be used in the auxiliary diagnosis of the disease and also in epidemiological studies for determination of the prevalence of chromoblastomycosis infection in endemic areas.CromoblastomycosisFonsecaea pedrosoiChromomycinSkin testMetabolic antigenAntígenos de Fungos/imunologiaCromoblastomicose/diagnósticoCromomicinas/imunologiaHipersensibilidade TardiaPhialophora/imunologiaTestes Cutâneos/métodosAdultoIdosoAntígenos de Fungos/uso diagnósticoCromomicinas/uso diagnósticoFemininoHumanosMasculinoMeia-IdadeSensibilidade e Especificidadeinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82352https://www.arca.fiocruz.br/bitstream/icict/9803/1/license.txtafbdf7d7a9bcf771a1cc7edf5f618413MD51ORIGINALMarques SG Detection of delayed............pdfMarques SG Detection of delayed............pdfapplication/pdf77704https://www.arca.fiocruz.br/bitstream/icict/9803/2/Marques%20SG%20Detection%20of%20delayed............pdfc9b14a2e6f2c037cf0c24c410b106a78MD52TEXTMarques SG Detection of delayed............pdf.txtMarques SG Detection of delayed............pdf.txtExtracted texttext/plain27621https://www.arca.fiocruz.br/bitstream/icict/9803/3/Marques%20SG%20Detection%20of%20delayed............pdf.txt07cfe7b5db8c6fce2dbe47fdebaed284MD53icict/98032023-03-15 14:33:12.008oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-03-15T17:33:12Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
dc.title.pt_BR.fl_str_mv |
Detection of delayed hypersensitivity to Fonsecaea pedrosoi metabolic antigen (chromomycin). |
title |
Detection of delayed hypersensitivity to Fonsecaea pedrosoi metabolic antigen (chromomycin). |
spellingShingle |
Detection of delayed hypersensitivity to Fonsecaea pedrosoi metabolic antigen (chromomycin). Marques, Sirlei Garcia Cromoblastomycosis Fonsecaea pedrosoi Chromomycin Skin test Metabolic antigen Antígenos de Fungos/imunologia Cromoblastomicose/diagnóstico Cromomicinas/imunologia Hipersensibilidade Tardia Phialophora/imunologia Testes Cutâneos/métodos Adulto Idoso Antígenos de Fungos/uso diagnóstico Cromomicinas/uso diagnóstico Feminino Humanos Masculino Meia-Idade Sensibilidade e Especificidade |
title_short |
Detection of delayed hypersensitivity to Fonsecaea pedrosoi metabolic antigen (chromomycin). |
title_full |
Detection of delayed hypersensitivity to Fonsecaea pedrosoi metabolic antigen (chromomycin). |
title_fullStr |
Detection of delayed hypersensitivity to Fonsecaea pedrosoi metabolic antigen (chromomycin). |
title_full_unstemmed |
Detection of delayed hypersensitivity to Fonsecaea pedrosoi metabolic antigen (chromomycin). |
title_sort |
Detection of delayed hypersensitivity to Fonsecaea pedrosoi metabolic antigen (chromomycin). |
author |
Marques, Sirlei Garcia |
author_facet |
Marques, Sirlei Garcia Silva, Conceição de Maria Pedroso e Resende, Maria Aparecida Silva, Antonio Augusto Moura da Caldas, Arlene de Jesus Mendes Costa, Jackson Mauricio Lopes |
author_role |
author |
author2 |
Silva, Conceição de Maria Pedroso e Resende, Maria Aparecida Silva, Antonio Augusto Moura da Caldas, Arlene de Jesus Mendes Costa, Jackson Mauricio Lopes |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Marques, Sirlei Garcia Silva, Conceição de Maria Pedroso e Resende, Maria Aparecida Silva, Antonio Augusto Moura da Caldas, Arlene de Jesus Mendes Costa, Jackson Mauricio Lopes |
dc.subject.en.pt_BR.fl_str_mv |
Cromoblastomycosis Fonsecaea pedrosoi Chromomycin Skin test Metabolic antigen |
topic |
Cromoblastomycosis Fonsecaea pedrosoi Chromomycin Skin test Metabolic antigen Antígenos de Fungos/imunologia Cromoblastomicose/diagnóstico Cromomicinas/imunologia Hipersensibilidade Tardia Phialophora/imunologia Testes Cutâneos/métodos Adulto Idoso Antígenos de Fungos/uso diagnóstico Cromomicinas/uso diagnóstico Feminino Humanos Masculino Meia-Idade Sensibilidade e Especificidade |
dc.subject.decs.pt_BR.fl_str_mv |
Antígenos de Fungos/imunologia Cromoblastomicose/diagnóstico Cromomicinas/imunologia Hipersensibilidade Tardia Phialophora/imunologia Testes Cutâneos/métodos Adulto Idoso Antígenos de Fungos/uso diagnóstico Cromomicinas/uso diagnóstico Feminino Humanos Masculino Meia-Idade Sensibilidade e Especificidade |
description |
Federal University of Maranhão. Nucleus of Tropical Pathology and Social Medicine. Department of Pathology. São Luis, MA, Brasil |
publishDate |
2008 |
dc.date.issued.fl_str_mv |
2008 |
dc.date.accessioned.fl_str_mv |
2015-03-23T13:16:47Z |
dc.date.available.fl_str_mv |
2015-03-23T13:16:47Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
MARQUES, S. G. et al. Detection of delayed hypersensitivity to Fonsecaea pedrosoi metabolic antigen (chromomycin). Japanese Journal of Mycology, v. 49, n. 2, p.95-101, 2008. |
dc.identifier.uri.fl_str_mv |
https://www.arca.fiocruz.br/handle/icict/9803 |
dc.identifier.issn.none.fl_str_mv |
0916-4804 |
identifier_str_mv |
MARQUES, S. G. et al. Detection of delayed hypersensitivity to Fonsecaea pedrosoi metabolic antigen (chromomycin). Japanese Journal of Mycology, v. 49, n. 2, p.95-101, 2008. 0916-4804 |
url |
https://www.arca.fiocruz.br/handle/icict/9803 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
dc.publisher.none.fl_str_mv |
Japanese Journal of Medical Mycology |
publisher.none.fl_str_mv |
Japanese Journal of Medical Mycology |
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reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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