Alterations in cytokines and haematological parameters during the acute and convalescent phases of Plasmodium falciparum and Plasmodium vivax infections
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2014 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/9889 |
Resumo: | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil. |
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Rodrigues-Da-Silva, Rodrigo NunesLima Jr., Josue da CostaFonseca, Bruna De Paula Fonseca eAntas, Paulo Renato ZuquimBaldez, ArleteStorer, Fabio LuizSantos, FatimaBanic, Dalma MariaOliveira-Ferreira, Joseli de2015-04-06T17:18:20Z2015-04-06T17:18:20Z2014RODRIGUES-DA-SILVA, RODRIGO NUNES; et al. Alterations in cytokines and haematological parameters during the acute and convalescent phases of plasmodium falciparum and plasmodium vivax infections. Memórias do Instituto Oswaldo Cruz (Impresso), v.109, n.ahead, p. 154-162,2014.00740276https://www.arca.fiocruz.br/handle/icict/9889DOI:10.1590/0074-0276140275engFundação Oswaldo CruzProteínas de Fase AgudaCitocinasLuminexMalária HumanaEnsaio ClínicoÓxido NítricoCytokinesChemokinesPlateletsP. falciparumP. vivaxCiências da SaúdeCiências BiológicasCiências BiológicasAlterations in cytokines and haematological parameters during the acute and convalescent phases of Plasmodium falciparum and Plasmodium vivax infectionsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Bio-Manguinhos.Laboratório de Tecnologia Diagnóstica. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunologia Clínica. Rio de Janeiro, RJ, Brasil.Secretaria de Estado de Saúde. Agência de Vigilância em Saúde. Porto Velho, RO, Brasil.Faculdade São Lucas. Porto Velho, RO, BrasilOdebrecht Energia. Usina Hidrelétrica Santo Antônio. Porto Velho, RO, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Simulídeos e Oncocercose. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil.Haematological and cytokine alterations in malaria are a broad and controversial subject in the literature. However, few studies have simultaneously evaluated various cytokines in a single patient group during the acute and convalescent phases of infection. The aim of this study was to sequentially characterise alterations in haematological patters and circulating plasma cytokine and chemokine levels in patients infected with Plasmodium vivax or Plasmodium falciparum from a Brazilian endemic area during the acute and convalescent phases of infection. During the acute phase, thrombocytopaenia, eosinopaenia, lymphopaenia and an increased number of band cells were observed in the majority of the patients. During the convalescent phase, the haematologic parameters returned to normal. During the acute phase, P. vivax and P. falciparum patients had significantly higher interleukin (IL)-6, IL-8, IL-17, interferon-γ, tumour necrosis factor (TNF)-α, macrophage inflammatory protein-1β and granulocyte-colony stimulating factor levels than controls and maintained high levels during the convalescent phase. IL-10 was detected at high concentrations during the acute phase, but returned to normal levels during the convalescent phase. Plasma IL-10 concentration was positively correlated with parasitaemia in P. vivax and P. falciparum-infected patients. The same was true for the TNF-α concentration in P. falciparum-infected patients. Finally, the haematological and cytokine profiles were similar between uncomplicated P. falciparum and P. vivax infections.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALrodrigo_rodriguesdasilvaetal_IOC_2014.pdfapplication/pdf746048https://www.arca.fiocruz.br/bitstream/icict/9889/1/rodrigo_rodriguesdasilvaetal_IOC_2014.pdf1cc3324452506b47456e50d0dc43123dMD51LICENSElicense.txttext/plain1914https://www.arca.fiocruz.br/bitstream/icict/9889/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTrodrigo_rodriguesdasilvaetal_IOC_2014.pdf.txtrodrigo_rodriguesdasilvaetal_IOC_2014.pdf.txtExtracted texttext/plain47494https://www.arca.fiocruz.br/bitstream/icict/9889/3/rodrigo_rodriguesdasilvaetal_IOC_2014.pdf.txt3cf0a5152f7aef8380411375179a574dMD53icict/98892022-06-24 13:10:45.144oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352022-06-24T16:10:45Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.pt_BR.fl_str_mv |
Alterations in cytokines and haematological parameters during the acute and convalescent phases of Plasmodium falciparum and Plasmodium vivax infections |
| title |
Alterations in cytokines and haematological parameters during the acute and convalescent phases of Plasmodium falciparum and Plasmodium vivax infections |
| spellingShingle |
Alterations in cytokines and haematological parameters during the acute and convalescent phases of Plasmodium falciparum and Plasmodium vivax infections Rodrigues-Da-Silva, Rodrigo Nunes Proteínas de Fase Aguda Citocinas Luminex Malária Humana Ensaio Clínico Óxido Nítrico Cytokines Chemokines Platelets P. falciparum P. vivax Ciências da Saúde Ciências Biológicas Ciências Biológicas |
| title_short |
Alterations in cytokines and haematological parameters during the acute and convalescent phases of Plasmodium falciparum and Plasmodium vivax infections |
| title_full |
Alterations in cytokines and haematological parameters during the acute and convalescent phases of Plasmodium falciparum and Plasmodium vivax infections |
| title_fullStr |
Alterations in cytokines and haematological parameters during the acute and convalescent phases of Plasmodium falciparum and Plasmodium vivax infections |
| title_full_unstemmed |
Alterations in cytokines and haematological parameters during the acute and convalescent phases of Plasmodium falciparum and Plasmodium vivax infections |
| title_sort |
Alterations in cytokines and haematological parameters during the acute and convalescent phases of Plasmodium falciparum and Plasmodium vivax infections |
| author |
Rodrigues-Da-Silva, Rodrigo Nunes |
| author_facet |
Rodrigues-Da-Silva, Rodrigo Nunes Lima Jr., Josue da Costa Fonseca, Bruna De Paula Fonseca e Antas, Paulo Renato Zuquim Baldez, Arlete Storer, Fabio Luiz Santos, Fatima Banic, Dalma Maria Oliveira-Ferreira, Joseli de |
| author_role |
author |
| author2 |
Lima Jr., Josue da Costa Fonseca, Bruna De Paula Fonseca e Antas, Paulo Renato Zuquim Baldez, Arlete Storer, Fabio Luiz Santos, Fatima Banic, Dalma Maria Oliveira-Ferreira, Joseli de |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Rodrigues-Da-Silva, Rodrigo Nunes Lima Jr., Josue da Costa Fonseca, Bruna De Paula Fonseca e Antas, Paulo Renato Zuquim Baldez, Arlete Storer, Fabio Luiz Santos, Fatima Banic, Dalma Maria Oliveira-Ferreira, Joseli de |
| dc.subject.other.pt_BR.fl_str_mv |
Proteínas de Fase Aguda Citocinas Luminex Malária Humana Ensaio Clínico Óxido Nítrico |
| topic |
Proteínas de Fase Aguda Citocinas Luminex Malária Humana Ensaio Clínico Óxido Nítrico Cytokines Chemokines Platelets P. falciparum P. vivax Ciências da Saúde Ciências Biológicas Ciências Biológicas |
| dc.subject.en.en.fl_str_mv |
Cytokines Chemokines Platelets P. falciparum P. vivax |
| dc.subject.decs.pt_BR.fl_str_mv |
Ciências da Saúde Ciências Biológicas Ciências Biológicas |
| description |
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunoparasitologia. Rio de Janeiro, RJ, Brasil. |
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2014 |
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2014 |
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2015-04-06T17:18:20Z |
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2015-04-06T17:18:20Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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RODRIGUES-DA-SILVA, RODRIGO NUNES; et al. Alterations in cytokines and haematological parameters during the acute and convalescent phases of plasmodium falciparum and plasmodium vivax infections. Memórias do Instituto Oswaldo Cruz (Impresso), v.109, n.ahead, p. 154-162,2014. |
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https://www.arca.fiocruz.br/handle/icict/9889 |
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00740276 |
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DOI:10.1590/0074-0276140275 |
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RODRIGUES-DA-SILVA, RODRIGO NUNES; et al. Alterations in cytokines and haematological parameters during the acute and convalescent phases of plasmodium falciparum and plasmodium vivax infections. Memórias do Instituto Oswaldo Cruz (Impresso), v.109, n.ahead, p. 154-162,2014. 00740276 DOI:10.1590/0074-0276140275 |
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https://www.arca.fiocruz.br/handle/icict/9889 |
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eng |
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Fundação Oswaldo Cruz |
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Fundação Oswaldo Cruz |
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reponame:Repositório Institucional da FIOCRUZ (ARCA) instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
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