Trypanosoma cruzi: effect of phenothiazines on the parasite and its interaction with host cells

Detalhes bibliográficos
Autor(a) principal: Castro, Solange L. de
Data de Publicação: 1992
Outros Autores: Soeiro, Maria Nazaré C., Meirelles, Maria de Nazareth Leal de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/43479
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Ultraestrutura e Biologia Celular. Rio de Janeiro, RJ, Brasil.
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spelling Castro, Solange L. deSoeiro, Maria Nazaré C.Meirelles, Maria de Nazareth Leal de2020-09-19T17:43:39Z2020-09-19T17:43:39Z1992CASTRO, Solange L. de; SOEIRO, Maria Nazaré C.; MEIRELLES, Maria de Nazareth Leal de. Trypanosoma cruzi: effect of phenothiazines on the parasite and its interaction with host cells. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 87, n. 2, p. 209-215, Apr./June 1992.0074-0276https://www.arca.fiocruz.br/handle/icict/4347910.1590/S0074-027619920002000071678-8060engFundação Oswaldo Cruz. Instituto Oswaldo Cruz.Trypanosoma cruziFenotiazinasParasitasInteração da célula hospedeiraTrypanosoma cruziPhenothiazinesParasiteInteractionHost cellsTrypanosoma cruzi: effect of phenothiazines on the parasite and its interaction with host cellsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Ultraestrutura e Biologia Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Ultraestrutura e Biologia Celular. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Ultraestrutura e Biologia Celular. Rio de Janeiro, RJ, Brasil.Phenothiazines were observed to have a direct effect on Trypanosoma cruzi and on its in vitro interaction with host cells. They caused lysis of trypomastigotes (50 uM/24 h) and,to a lesser extent, epimastigote proliferation. Treatment of infected peritoneal macrophages with 12.5 uM chlorpromazine or triflupromazine inhibited the infection; this effect was found to be partially reversible if the drugs were removed after 24 h of treatment. At 60 uM, the drugs caused damage to amastigotes interiorized in heart muscle cells. However, the narrow margin of toxity between anti-trypanossomal activity and damage to host cells mitigates against in vivo investigation at the present time. Possible hypothesis for the mechanism of action of phenothiazines are discussed.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/43479/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALSolangeL_Castro_etl_IOC_1992.pdfSolangeL_Castro_etl_IOC_1992.pdfapplication/pdf439776https://www.arca.fiocruz.br/bitstream/icict/43479/2/SolangeL_Castro_etl_IOC_1992.pdf2ec6b3714a22ae40b92336faeac6d67eMD52TEXTSolangeL_Castro_etl_IOC_1992.pdf.txtSolangeL_Castro_etl_IOC_1992.pdf.txtExtracted texttext/plain7https://www.arca.fiocruz.br/bitstream/icict/43479/3/SolangeL_Castro_etl_IOC_1992.pdf.txt212b0306580d4f0044d18f9a3edcc832MD53icict/434792020-09-20 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dc.title.pt_BR.fl_str_mv Trypanosoma cruzi: effect of phenothiazines on the parasite and its interaction with host cells
title Trypanosoma cruzi: effect of phenothiazines on the parasite and its interaction with host cells
spellingShingle Trypanosoma cruzi: effect of phenothiazines on the parasite and its interaction with host cells
Castro, Solange L. de
Trypanosoma cruzi
Fenotiazinas
Parasitas
Interação da célula hospedeira
Trypanosoma cruzi
Phenothiazines
Parasite
Interaction
Host cells
title_short Trypanosoma cruzi: effect of phenothiazines on the parasite and its interaction with host cells
title_full Trypanosoma cruzi: effect of phenothiazines on the parasite and its interaction with host cells
title_fullStr Trypanosoma cruzi: effect of phenothiazines on the parasite and its interaction with host cells
title_full_unstemmed Trypanosoma cruzi: effect of phenothiazines on the parasite and its interaction with host cells
title_sort Trypanosoma cruzi: effect of phenothiazines on the parasite and its interaction with host cells
author Castro, Solange L. de
author_facet Castro, Solange L. de
Soeiro, Maria Nazaré C.
Meirelles, Maria de Nazareth Leal de
author_role author
author2 Soeiro, Maria Nazaré C.
Meirelles, Maria de Nazareth Leal de
author2_role author
author
dc.contributor.author.fl_str_mv Castro, Solange L. de
Soeiro, Maria Nazaré C.
Meirelles, Maria de Nazareth Leal de
dc.subject.other.pt_BR.fl_str_mv Trypanosoma cruzi
Fenotiazinas
Parasitas
Interação da célula hospedeira
topic Trypanosoma cruzi
Fenotiazinas
Parasitas
Interação da célula hospedeira
Trypanosoma cruzi
Phenothiazines
Parasite
Interaction
Host cells
dc.subject.en.pt_BR.fl_str_mv Trypanosoma cruzi
Phenothiazines
Parasite
Interaction
Host cells
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Ultraestrutura e Biologia Celular. Rio de Janeiro, RJ, Brasil.
publishDate 1992
dc.date.issued.fl_str_mv 1992
dc.date.accessioned.fl_str_mv 2020-09-19T17:43:39Z
dc.date.available.fl_str_mv 2020-09-19T17:43:39Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CASTRO, Solange L. de; SOEIRO, Maria Nazaré C.; MEIRELLES, Maria de Nazareth Leal de. Trypanosoma cruzi: effect of phenothiazines on the parasite and its interaction with host cells. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 87, n. 2, p. 209-215, Apr./June 1992.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/43479
dc.identifier.issn.pt_BR.fl_str_mv 0074-0276
dc.identifier.doi.none.fl_str_mv 10.1590/S0074-02761992000200007
dc.identifier.eissn.none.fl_str_mv 1678-8060
identifier_str_mv CASTRO, Solange L. de; SOEIRO, Maria Nazaré C.; MEIRELLES, Maria de Nazareth Leal de. Trypanosoma cruzi: effect of phenothiazines on the parasite and its interaction with host cells. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 87, n. 2, p. 209-215, Apr./June 1992.
0074-0276
10.1590/S0074-02761992000200007
1678-8060
url https://www.arca.fiocruz.br/handle/icict/43479
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
publisher.none.fl_str_mv Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
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