Potential mechanisms underlying the acute lung dysfunction and bacterial extrapulmonary dissemination during Burkholderia cenocepacia respiratory infection

Detalhes bibliográficos
Autor(a) principal: Cunha Jr, Luiz G.
Data de Publicação: 2010
Outros Autores: Assis, Maria Cristina, Machado, Gloria Beatriz, Assef, Ana Paula, Marques, Elizabeth A., Leão, Robson S., Saliba, Alessandra M., Plotkowski, Maria Cristina
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/30499
Resumo: Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Departamento de Microbiologia, Imunologia e Parasitologia. Rio de Janeiro, RJ, Brasil.
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spelling Cunha Jr, Luiz G.Assis, Maria CristinaMachado, Gloria BeatrizAssef, Ana PaulaMarques, Elizabeth A.Leão, Robson S.Saliba, Alessandra M.Plotkowski, Maria Cristina2018-12-11T10:34:43Z2018-12-11T10:34:43Z2010CUNHA JR., Luiz G. et al. Potential mechanisms underlying the acute lung dysfunction and bacterial extrapulmonary dissemination during Burkholderia cenocepacia respiratory infection. Respiratory Research, v.11, n.4, 9p, 2010.1465-9921https://www.arca.fiocruz.br/handle/icict/304991465-993XengBMCBurkholderia cenocepaciainfecção respiratóriadisfunção aguda pulmonardisseminação extrapulmonar bacterianaBurkholderia cenocepaciaacute lung dysfunctionbacterial extrapulmonary disseminationrespiratory infectionPotential mechanisms underlying the acute lung dysfunction and bacterial extrapulmonary dissemination during Burkholderia cenocepacia respiratory infectioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Departamento de Microbiologia, Imunologia e Parasitologia. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Departamento de Microbiologia, Imunologia e Parasitologia. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Departamento de Microbiologia, Imunologia e Parasitologia. Rio de Janeiro, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa em Infecção Hospitalar. Rio de Janeiro, RJ. Brasil.Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Departamento de Microbiologia, Imunologia e Parasitologia. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Departamento de Microbiologia, Imunologia e Parasitologia. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Departamento de Microbiologia, Imunologia e Parasitologia. Rio de Janeiro, RJ, Brasil.Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Departamento de Microbiologia, Imunologia e Parasitologia. Rio de Janeiro, RJ, Brasil.Background: Burkholderia cenocepacia, an opportunistic pathogen that causes lung infections in cystic fibrosis (CF) patients, is associated with rapid and usually fatal lung deterioration due to necrotizing pneumonia and sepsis, a condition known as cepacia syndrome. The key bacterial determinants associated with this poor clinical outcome in CF patients are not clear. In this study, the cytotoxicity and procoagulant activity of B. cenocepacia from the ET- 12 lineage, that has been linked to the cepacia syndrome, and four clinical isolates recovered from CF patients with mild clinical courses were analysed in both in vitro and in vivo assays.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/30499/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALanap_assef_etal_IOC_2010.pdfanap_assef_etal_IOC_2010.pdfapplication/pdf583026https://www.arca.fiocruz.br/bitstream/icict/30499/2/anap_assef_etal_IOC_2010.pdf16a5013ffa7a1a70d93b525057233801MD52TEXTanap_assef_etal_IOC_2010.pdf.txtanap_assef_etal_IOC_2010.pdf.txtExtracted 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dc.title.pt_BR.fl_str_mv Potential mechanisms underlying the acute lung dysfunction and bacterial extrapulmonary dissemination during Burkholderia cenocepacia respiratory infection
title Potential mechanisms underlying the acute lung dysfunction and bacterial extrapulmonary dissemination during Burkholderia cenocepacia respiratory infection
spellingShingle Potential mechanisms underlying the acute lung dysfunction and bacterial extrapulmonary dissemination during Burkholderia cenocepacia respiratory infection
Cunha Jr, Luiz G.
Burkholderia cenocepacia
infecção respiratória
disfunção aguda pulmonar
disseminação extrapulmonar bacteriana
Burkholderia cenocepacia
acute lung dysfunction
bacterial extrapulmonary dissemination
respiratory infection
title_short Potential mechanisms underlying the acute lung dysfunction and bacterial extrapulmonary dissemination during Burkholderia cenocepacia respiratory infection
title_full Potential mechanisms underlying the acute lung dysfunction and bacterial extrapulmonary dissemination during Burkholderia cenocepacia respiratory infection
title_fullStr Potential mechanisms underlying the acute lung dysfunction and bacterial extrapulmonary dissemination during Burkholderia cenocepacia respiratory infection
title_full_unstemmed Potential mechanisms underlying the acute lung dysfunction and bacterial extrapulmonary dissemination during Burkholderia cenocepacia respiratory infection
title_sort Potential mechanisms underlying the acute lung dysfunction and bacterial extrapulmonary dissemination during Burkholderia cenocepacia respiratory infection
author Cunha Jr, Luiz G.
author_facet Cunha Jr, Luiz G.
Assis, Maria Cristina
Machado, Gloria Beatriz
Assef, Ana Paula
Marques, Elizabeth A.
Leão, Robson S.
Saliba, Alessandra M.
Plotkowski, Maria Cristina
author_role author
author2 Assis, Maria Cristina
Machado, Gloria Beatriz
Assef, Ana Paula
Marques, Elizabeth A.
Leão, Robson S.
Saliba, Alessandra M.
Plotkowski, Maria Cristina
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Cunha Jr, Luiz G.
Assis, Maria Cristina
Machado, Gloria Beatriz
Assef, Ana Paula
Marques, Elizabeth A.
Leão, Robson S.
Saliba, Alessandra M.
Plotkowski, Maria Cristina
dc.subject.other.pt_BR.fl_str_mv Burkholderia cenocepacia
infecção respiratória
disfunção aguda pulmonar
disseminação extrapulmonar bacteriana
topic Burkholderia cenocepacia
infecção respiratória
disfunção aguda pulmonar
disseminação extrapulmonar bacteriana
Burkholderia cenocepacia
acute lung dysfunction
bacterial extrapulmonary dissemination
respiratory infection
dc.subject.en.pt_BR.fl_str_mv Burkholderia cenocepacia
acute lung dysfunction
bacterial extrapulmonary dissemination
respiratory infection
description Universidade do Estado do Rio de Janeiro. Faculdade de Ciências Médicas. Departamento de Microbiologia, Imunologia e Parasitologia. Rio de Janeiro, RJ, Brasil.
publishDate 2010
dc.date.issued.fl_str_mv 2010
dc.date.accessioned.fl_str_mv 2018-12-11T10:34:43Z
dc.date.available.fl_str_mv 2018-12-11T10:34:43Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv CUNHA JR., Luiz G. et al. Potential mechanisms underlying the acute lung dysfunction and bacterial extrapulmonary dissemination during Burkholderia cenocepacia respiratory infection. Respiratory Research, v.11, n.4, 9p, 2010.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/30499
dc.identifier.issn.pt_BR.fl_str_mv 1465-9921
dc.identifier.eissn.none.fl_str_mv 1465-993X
identifier_str_mv CUNHA JR., Luiz G. et al. Potential mechanisms underlying the acute lung dysfunction and bacterial extrapulmonary dissemination during Burkholderia cenocepacia respiratory infection. Respiratory Research, v.11, n.4, 9p, 2010.
1465-9921
1465-993X
url https://www.arca.fiocruz.br/handle/icict/30499
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv BMC
publisher.none.fl_str_mv BMC
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
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