HIV-1 polymorphism: a challenge for vaccine development - a review

Detalhes bibliográficos
Autor(a) principal: Morgado, Mariza Gonçalves
Data de Publicação: 2002
Outros Autores: Guimarães, Monick Lindenmeyer, Castro Filho, Bernardo Galvão
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da FIOCRUZ (ARCA)
Texto Completo: https://www.arca.fiocruz.br/handle/icict/6254
Resumo: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil
id CRUZ_32117ef59439c1ec490b93fc0f89ed8a
oai_identifier_str oai:www.arca.fiocruz.br:icict/6254
network_acronym_str CRUZ
network_name_str Repositório Institucional da FIOCRUZ (ARCA)
repository_id_str 2135
spelling Morgado, Mariza GonçalvesGuimarães, Monick LindenmeyerCastro Filho, Bernardo Galvão2013-01-24T20:55:04Z2013-01-24T20:55:04Z2002MORGADO, M.G. et al. HIV-1 polymorphism: a challenge for vaccine development - a review. Memórias do Instituto Oswaldo Cruz, v. 97, n. 2, p. 143-150, mar. 2002.0074-0276https://www.arca.fiocruz.br/handle/icict/6254engHIV-1 polymorphism: a challenge for vaccine development - a reviewinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, BrasilFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório Avançado de Saúde Pública. Salvador, BA, BrasilThe perspective for the development of anti-HIV/AIDS vaccines became a target sought by several research groups and pharmaceutical companies. However, the complex virus biology in addition to a striking genetic variability and the limited understanding of the immunological correlates of protection have made this an enormous scientific challenge not overcome so far. In this review we presented an updating of HIV-1 subtypes and recombinant viruses circulating in South American countries, focusing mainly on Brazil, as one of the challenges for HIV vaccine development. Moreover, we discussed the importance of stimulating developing countries to participate in the process of vaccine evaluation, not only testing vaccines according to already defined protocols, but also working together with them, in order to take into consideration their local information on virus diversity and host genetic background relevant for the vaccine development and testing, as well as including local virus based reagents to evaluate the immunogenicity of the candidate vaccines.HIV-1 polymorphismHIV/AIDSVaccineVacinas contra AIDS/genéticaHIV-1/genéticaHIV-1/imunologiaPolimorfismo GenéticoVariação GenéticaDesenho de DrogasHumanosRevisãoinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZORIGINALMorgado, M.G. HIV-1 polimorphism....pdfMorgado, M.G. HIV-1 polimorphism....pdfapplication/pdf552704https://www.arca.fiocruz.br/bitstream/icict/6254/1/Morgado%2c%20M.G.%20HIV-1%20polimorphism....pdff7af88a25c28d7b4d90dfdcbe09d56ddMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81914https://www.arca.fiocruz.br/bitstream/icict/6254/2/license.txt7d48279ffeed55da8dfe2f8e81f3b81fMD52TEXTMorgado, M.G. HIV-1 polimorphism....pdf.txtMorgado, M.G. HIV-1 polimorphism....pdf.txtExtracted texttext/plain43609https://www.arca.fiocruz.br/bitstream/icict/6254/5/Morgado%2c%20M.G.%20HIV-1%20polimorphism....pdf.txt6de957f784a37ba1d500040a5133ff7bMD55THUMBNAILMorgado, M.G. HIV-1 polimorphism....pdf.jpgMorgado, M.G. HIV-1 polimorphism....pdf.jpgGenerated Thumbnailimage/jpeg2508https://www.arca.fiocruz.br/bitstream/icict/6254/4/Morgado%2c%20M.G.%20HIV-1%20polimorphism....pdf.jpgc26177e2d697aa4dd7a23535b8138434MD54icict/62542023-09-04 10:37:10.62oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-09-04T13:37:10Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.pt_BR.fl_str_mv HIV-1 polymorphism: a challenge for vaccine development - a review
title HIV-1 polymorphism: a challenge for vaccine development - a review
spellingShingle HIV-1 polymorphism: a challenge for vaccine development - a review
Morgado, Mariza Gonçalves
HIV-1 polymorphism
HIV/AIDS
Vaccine
Vacinas contra AIDS/genética
HIV-1/genética
HIV-1/imunologia
Polimorfismo Genético
Variação Genética
Desenho de Drogas
Humanos
Revisão
title_short HIV-1 polymorphism: a challenge for vaccine development - a review
title_full HIV-1 polymorphism: a challenge for vaccine development - a review
title_fullStr HIV-1 polymorphism: a challenge for vaccine development - a review
title_full_unstemmed HIV-1 polymorphism: a challenge for vaccine development - a review
title_sort HIV-1 polymorphism: a challenge for vaccine development - a review
author Morgado, Mariza Gonçalves
author_facet Morgado, Mariza Gonçalves
Guimarães, Monick Lindenmeyer
Castro Filho, Bernardo Galvão
author_role author
author2 Guimarães, Monick Lindenmeyer
Castro Filho, Bernardo Galvão
author2_role author
author
dc.contributor.author.fl_str_mv Morgado, Mariza Gonçalves
Guimarães, Monick Lindenmeyer
Castro Filho, Bernardo Galvão
dc.subject.en.pt_BR.fl_str_mv HIV-1 polymorphism
HIV/AIDS
Vaccine
topic HIV-1 polymorphism
HIV/AIDS
Vaccine
Vacinas contra AIDS/genética
HIV-1/genética
HIV-1/imunologia
Polimorfismo Genético
Variação Genética
Desenho de Drogas
Humanos
Revisão
dc.subject.decs.pt_BR.fl_str_mv Vacinas contra AIDS/genética
HIV-1/genética
HIV-1/imunologia
Polimorfismo Genético
Variação Genética
Desenho de Drogas
Humanos
Revisão
description Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil
publishDate 2002
dc.date.issued.fl_str_mv 2002
dc.date.accessioned.fl_str_mv 2013-01-24T20:55:04Z
dc.date.available.fl_str_mv 2013-01-24T20:55:04Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv MORGADO, M.G. et al. HIV-1 polymorphism: a challenge for vaccine development - a review. Memórias do Instituto Oswaldo Cruz, v. 97, n. 2, p. 143-150, mar. 2002.
dc.identifier.uri.fl_str_mv https://www.arca.fiocruz.br/handle/icict/6254
dc.identifier.issn.none.fl_str_mv 0074-0276
identifier_str_mv MORGADO, M.G. et al. HIV-1 polymorphism: a challenge for vaccine development - a review. Memórias do Instituto Oswaldo Cruz, v. 97, n. 2, p. 143-150, mar. 2002.
0074-0276
url https://www.arca.fiocruz.br/handle/icict/6254
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repositório Institucional da FIOCRUZ (ARCA)
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Repositório Institucional da FIOCRUZ (ARCA)
collection Repositório Institucional da FIOCRUZ (ARCA)
bitstream.url.fl_str_mv https://www.arca.fiocruz.br/bitstream/icict/6254/1/Morgado%2c%20M.G.%20HIV-1%20polimorphism....pdf
https://www.arca.fiocruz.br/bitstream/icict/6254/2/license.txt
https://www.arca.fiocruz.br/bitstream/icict/6254/5/Morgado%2c%20M.G.%20HIV-1%20polimorphism....pdf.txt
https://www.arca.fiocruz.br/bitstream/icict/6254/4/Morgado%2c%20M.G.%20HIV-1%20polimorphism....pdf.jpg
bitstream.checksum.fl_str_mv f7af88a25c28d7b4d90dfdcbe09d56dd
7d48279ffeed55da8dfe2f8e81f3b81f
6de957f784a37ba1d500040a5133ff7b
c26177e2d697aa4dd7a23535b8138434
bitstream.checksumAlgorithm.fl_str_mv MD5
MD5
MD5
MD5
repository.name.fl_str_mv Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv repositorio.arca@fiocruz.br
_version_ 1813009172425342976

Registros relacionados