Maternal immune response to ZIKV triggers high-inflammatory profile in congenital Zika syndrome
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2023 |
| Outros Autores: | , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/60825 |
Resumo: | Coordenação de Aperfeiçoamento de Pessoal do Ensino Superior - Brasil (CAPES). Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). Fundação de Amparo Pesquisa do Maranhão (FAPEMA). |
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Fialho, Eder M. S.Veras, Emanoel M.Jesus, Caroline M. deKhouri, RicardoSousa, Patrícia S.Ribeiro, Marizelia R. C.Costa, Luciana C.Gomes, Líllian N.Nascimento, Flávia R. F.Silva, Antônio A. M.Pereira, Paulo V. Soeiro2023-10-18T12:21:17Z2023-10-18T12:21:17Z2023FIALHO, Eder M. S. et al. Maternal immune response to ZIKV triggers high-inflammatory profile in congenital Zika syndrome. Viruses, v. 15, n. 220, p. 1-13, 2023.1999-4915https://www.arca.fiocruz.br/handle/icict/6082510.3390/v15010220Coordenação de Aperfeiçoamento de Pessoal do Ensino Superior - Brasil (CAPES). Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). Fundação de Amparo Pesquisa do Maranhão (FAPEMA).Universidade Federal do Maranhão. Programa de Pós-Graduação em Ciências da Saúde. São Luís, MA, Brasil.Universidade Federal do Maranhão. Escola de Medicina. São Luís, MA, Brasil.Universidade Federal do Maranhão. Programa de Pós-Graduação em Saúde e Tecnologia. São Luís, MA, Brasil.Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil.Secretaria Estadual de Saúde do Estado do Maranhão. Centro de Referência em Neurodesenvolvimento. Assistência e Reabilitação Infantil/NINAR. São Luís, MA, Brasil.Universidade Federal do Maranhão. Departamento de Medicina III. São Luís, MA, Brasil.Universidade Federal do Maranhão. Departamento de Saúde Pública. São Luís, MA, Brasil.Universidade de São Paulo. Departamento de Imunologia. São Paulo, SP, Brasil.Universidade Federal do Maranhão. Programa de Pós-Graduação em Ciências da Saúde. São Luís, MA, Brasil / Universidade Federal do Maranhão. Departamento de Patologia. São Luís, MA, Brasil.Universidade Federal do Maranhão. Departamento de Saúde Pública. São Luís, MA, Brasil.Universidade Federal do Maranhão. Programa de Pós-Graduação em Ciências da Saúde. São Luís, MA, Brasil / Universidade Federal do Maranhão. Departamento de Patologia. São Luís, MA, BrasilThe immunological mechanisms involved in the development of congenital Zika syndrome (CZS) have yet to be fully clarified. This study aims to assess the immuno-inflammatory profile of mothers and their children who have been diagnosed with CZS. Blood samples, which were confirmed clinically using the plaque reduction neutralization test (PRNT), were collected from children with CZS and their mothers (CZS+ group). Samples were also collected from children who did not develop CZS and had a negative PRNT result and from their mothers (CZS- group). The data demonstrated a correlation between the leukocyte profile of CZS+ children and their mothers, more evident in monocytes. Monocytes from mothers of CZS+ children showed low expression of HLA and elevated hydrogen peroxide production. CZS+ children presented standard HLA expression and a higher hydrogen peroxide concentration than CZS- children. Monocyte superoxide dismutase activity remained functional. Moreover, when assessing the monocyte polarization, it was observed that there was no difference in nitrite concentrations; however, there was a decrease in arginase activity in CZS+ children. These data suggest that ZIKV infection induces a maternal immunoinflammatory background related to the child’s inflammatory response after birth, possibly affecting the development and progression of congenital Zika syndrome.engMDPIEspécies que reagem ao oxigênioMicrocefaliaMonócitosInfecção pelo vírus ZikaReactive oxygen speciesMicrocephalyMonocytesZika virus infectionMicrocefaliaMonócitosInfecção pelo vírus ZikaMaternal immune response to ZIKV triggers high-inflammatory profile in congenital Zika syndromeinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/60825/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALFialho, Eder M. S. - Maternal Immune Response to ZIKV Triggers High-Inflammatory Profile in Congenital Zika Syndrome.pdfFialho, Eder M. S. - Maternal Immune Response to ZIKV Triggers High-Inflammatory Profile in Congenital Zika Syndrome.pdfapplication/pdf1216374https://www.arca.fiocruz.br/bitstream/icict/60825/2/Fialho%2c%20Eder%20M.%20S.%20-%20Maternal%20Immune%20Response%20to%20ZIKV%20Triggers%20High-Inflammatory%20Profile%20in%20Congenital%20Zika%20Syndrome.pdf7de3d82ea2fd841078c6cfbe2d224d19MD52icict/608252023-10-18 09:21:18.721oai:www.arca.fiocruz.br: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ório InstitucionalPUBhttps://www.arca.fiocruz.br/oai/requestrepositorio.arca@fiocruz.bropendoar:21352023-10-18T12:21:18Repositório Institucional da FIOCRUZ (ARCA) - Fundação Oswaldo Cruz (FIOCRUZ)false |
| dc.title.en_US.fl_str_mv |
Maternal immune response to ZIKV triggers high-inflammatory profile in congenital Zika syndrome |
| title |
Maternal immune response to ZIKV triggers high-inflammatory profile in congenital Zika syndrome |
| spellingShingle |
Maternal immune response to ZIKV triggers high-inflammatory profile in congenital Zika syndrome Fialho, Eder M. S. Espécies que reagem ao oxigênio Microcefalia Monócitos Infecção pelo vírus Zika Reactive oxygen species Microcephaly Monocytes Zika virus infection Microcefalia Monócitos Infecção pelo vírus Zika |
| title_short |
Maternal immune response to ZIKV triggers high-inflammatory profile in congenital Zika syndrome |
| title_full |
Maternal immune response to ZIKV triggers high-inflammatory profile in congenital Zika syndrome |
| title_fullStr |
Maternal immune response to ZIKV triggers high-inflammatory profile in congenital Zika syndrome |
| title_full_unstemmed |
Maternal immune response to ZIKV triggers high-inflammatory profile in congenital Zika syndrome |
| title_sort |
Maternal immune response to ZIKV triggers high-inflammatory profile in congenital Zika syndrome |
| author |
Fialho, Eder M. S. |
| author_facet |
Fialho, Eder M. S. Veras, Emanoel M. Jesus, Caroline M. de Khouri, Ricardo Sousa, Patrícia S. Ribeiro, Marizelia R. C. Costa, Luciana C. Gomes, Líllian N. Nascimento, Flávia R. F. Silva, Antônio A. M. Pereira, Paulo V. Soeiro |
| author_role |
author |
| author2 |
Veras, Emanoel M. Jesus, Caroline M. de Khouri, Ricardo Sousa, Patrícia S. Ribeiro, Marizelia R. C. Costa, Luciana C. Gomes, Líllian N. Nascimento, Flávia R. F. Silva, Antônio A. M. Pereira, Paulo V. Soeiro |
| author2_role |
author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Fialho, Eder M. S. Veras, Emanoel M. Jesus, Caroline M. de Khouri, Ricardo Sousa, Patrícia S. Ribeiro, Marizelia R. C. Costa, Luciana C. Gomes, Líllian N. Nascimento, Flávia R. F. Silva, Antônio A. M. Pereira, Paulo V. Soeiro |
| dc.subject.other.en_US.fl_str_mv |
Espécies que reagem ao oxigênio Microcefalia Monócitos Infecção pelo vírus Zika |
| topic |
Espécies que reagem ao oxigênio Microcefalia Monócitos Infecção pelo vírus Zika Reactive oxygen species Microcephaly Monocytes Zika virus infection Microcefalia Monócitos Infecção pelo vírus Zika |
| dc.subject.en.en_US.fl_str_mv |
Reactive oxygen species Microcephaly Monocytes Zika virus infection |
| dc.subject.decs.en_US.fl_str_mv |
Microcefalia Monócitos Infecção pelo vírus Zika |
| description |
Coordenação de Aperfeiçoamento de Pessoal do Ensino Superior - Brasil (CAPES). Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq). Fundação de Amparo Pesquisa do Maranhão (FAPEMA). |
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2023 |
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2023-10-18T12:21:17Z |
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2023-10-18T12:21:17Z |
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2023 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
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FIALHO, Eder M. S. et al. Maternal immune response to ZIKV triggers high-inflammatory profile in congenital Zika syndrome. Viruses, v. 15, n. 220, p. 1-13, 2023. |
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https://www.arca.fiocruz.br/handle/icict/60825 |
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1999-4915 |
| dc.identifier.doi.none.fl_str_mv |
10.3390/v15010220 |
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FIALHO, Eder M. S. et al. Maternal immune response to ZIKV triggers high-inflammatory profile in congenital Zika syndrome. Viruses, v. 15, n. 220, p. 1-13, 2023. 1999-4915 10.3390/v15010220 |
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