The effects of the diterpenes isolated from the Brazilian brown algae Dictyota pfaffii and Dictyota menstrualis against the herpes simplex type-1 replicative cycle
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2010 |
| Outros Autores: | , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/25294 |
Resumo: | Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Laboratório de Estrutura e Regulação de Proteínas. Programa de Pós- Graduação em Química Biológica. Rio de Janeiro, RJ, Brasil. |
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Abrantes, Juliana L.Barbosa, JussaraCavalcanti, DianaPereira, Renato C.Fontes, Carlos L. FredericoTeixeira, Valeria L.Souza, Thiago Moreno L.Paixão, Izabel C. P.2018-03-13T17:49:15Z2018-03-13T17:49:15Z2010ABRANTES, Juliana L. et al. The Effects of the Diterpenes Isolated from the Brazilian Brown Algae Dictyota pfaffii and Dictyota menstrualis against the Herpes Simplex Type-1 Replicative Cycle. Planta Med., v.76, p.339–344, 2010.0032-0943https://www.arca.fiocruz.br/handle/icict/2529410.1055/s-0029-11861441439-0221engGeorg Thieme VerlagDiterpenosHerpes SimplesFeófitasBrasilAntiviraisHerpes simplexDiterpenesBrown algaeBrazilantiviralThe effects of the diterpenes isolated from the Brazilian brown algae Dictyota pfaffii and Dictyota menstrualis against the herpes simplex type-1 replicative cycleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Laboratório de Estrutura e Regulação de Proteínas. Programa de Pós- Graduação em Química Biológica. Rio de Janeiro, RJ, Brasil.Universidade Federal Fluminense. Instituto de Biologia. Departamento de Biologia Marinha. Niterói, RJ, Brasil.Universidade Federal Fluminense. Instituto de Biologia. Departamento de Biologia Marinha. Niterói, RJ, Brasil.Universidade Federal Fluminense. Instituto de Biologia. Departamento de Biologia Marinha. Niterói, RJ, Brasil.Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Laboratório de Estrutura e Regulação de Proteínas. Programa de Pós- Graduação em Química Biológica. Rio de Janeiro, RJ, Brasil.Universidade Federal Fluminense. Instituto de Biologia. Departamento de Biologia Marinha. Niterói, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Referência para Influenza e Viroses Exantemáticas. Laboratório de Vírus Respiratórios e do Sarampo. Rio de Janeiro, RJ. Brasil.Universidade Federal Fluminense. Instituto de Biologia. Departamento de Biologia Celular e Molecular. Laboratório de Virologia Molecular. Programa de Pós-Graduação em Neuroimunologia. Niterói, RJ, Brasil.We describe in this paper that the diterpenes 8,10,18-trihydroxy-2,6-dolabelladiene ( 1) and (6 R)-6-hydroxydichotoma-4,14-diene-1,17-dial ( 2), isolated from the marine algae DICTYOTA PFAFFII and D. MENSTRUALIS, respectively, inhibited HSV-1 infection in Vero cells. We initially observed that compounds 1 and 2 inhibited HSV-1 replication in a dose-dependent manner, resulting in EC (50) values of 5.10 and 5.90 microM, respectively, for a multiplicity of infection (MOI) of 5. Moreover, the concentration required to inhibit HSV-1 replication was not cytotoxic, resulting in good selective index (SI) values. Next, we found that compound 1 sustained its anti-herpetic activity even when added to HSV-1-infected cells at 6 h after infection, while compound 2 sustained its activity for up to 3 h after infection, suggesting that these compounds inhibit initial events during HSV-1 replication. We also observed that both compounds were incapable of impairing HSV-1 adsorption and penetration. In addition, the tested molecules could decrease the contents of some HSV-1 early proteins, such as UL-8, RL-1, UL-12, UL-30 and UL-9. Our results suggest that the structures of compounds 1 and 2, Brazilian brown algae diterpenes, might be promising for future antiviral design.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/25294/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALthiagom_souza_etal_IOC_2010.pdfthiagom_souza_etal_IOC_2010.pdfapplication/pdf178845https://www.arca.fiocruz.br/bitstream/icict/25294/2/thiagom_souza_etal_IOC_2010.pdf60743f003b4610167d2a20e780dfa185MD52TEXTthiagom_souza_etal_IOC_2010.pdf.txtthiagom_souza_etal_IOC_2010.pdf.txtExtracted texttext/plain33881https://www.arca.fiocruz.br/bitstream/icict/25294/3/thiagom_souza_etal_IOC_2010.pdf.txta1b0888013149c7eb65b39631feec22cMD53icict/252942020-07-17 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| dc.title.pt_BR.fl_str_mv |
The effects of the diterpenes isolated from the Brazilian brown algae Dictyota pfaffii and Dictyota menstrualis against the herpes simplex type-1 replicative cycle |
| title |
The effects of the diterpenes isolated from the Brazilian brown algae Dictyota pfaffii and Dictyota menstrualis against the herpes simplex type-1 replicative cycle |
| spellingShingle |
The effects of the diterpenes isolated from the Brazilian brown algae Dictyota pfaffii and Dictyota menstrualis against the herpes simplex type-1 replicative cycle Abrantes, Juliana L. Diterpenos Herpes Simples Feófitas Brasil Antivirais Herpes simplex Diterpenes Brown algae Brazil antiviral |
| title_short |
The effects of the diterpenes isolated from the Brazilian brown algae Dictyota pfaffii and Dictyota menstrualis against the herpes simplex type-1 replicative cycle |
| title_full |
The effects of the diterpenes isolated from the Brazilian brown algae Dictyota pfaffii and Dictyota menstrualis against the herpes simplex type-1 replicative cycle |
| title_fullStr |
The effects of the diterpenes isolated from the Brazilian brown algae Dictyota pfaffii and Dictyota menstrualis against the herpes simplex type-1 replicative cycle |
| title_full_unstemmed |
The effects of the diterpenes isolated from the Brazilian brown algae Dictyota pfaffii and Dictyota menstrualis against the herpes simplex type-1 replicative cycle |
| title_sort |
The effects of the diterpenes isolated from the Brazilian brown algae Dictyota pfaffii and Dictyota menstrualis against the herpes simplex type-1 replicative cycle |
| author |
Abrantes, Juliana L. |
| author_facet |
Abrantes, Juliana L. Barbosa, Jussara Cavalcanti, Diana Pereira, Renato C. Fontes, Carlos L. Frederico Teixeira, Valeria L. Souza, Thiago Moreno L. Paixão, Izabel C. P. |
| author_role |
author |
| author2 |
Barbosa, Jussara Cavalcanti, Diana Pereira, Renato C. Fontes, Carlos L. Frederico Teixeira, Valeria L. Souza, Thiago Moreno L. Paixão, Izabel C. P. |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Abrantes, Juliana L. Barbosa, Jussara Cavalcanti, Diana Pereira, Renato C. Fontes, Carlos L. Frederico Teixeira, Valeria L. Souza, Thiago Moreno L. Paixão, Izabel C. P. |
| dc.subject.other.pt_BR.fl_str_mv |
Diterpenos Herpes Simples Feófitas Brasil Antivirais |
| topic |
Diterpenos Herpes Simples Feófitas Brasil Antivirais Herpes simplex Diterpenes Brown algae Brazil antiviral |
| dc.subject.en.pt_BR.fl_str_mv |
Herpes simplex Diterpenes Brown algae Brazil antiviral |
| description |
Universidade Federal do Rio de Janeiro. Instituto de Bioquímica Médica Leopoldo de Meis. Laboratório de Estrutura e Regulação de Proteínas. Programa de Pós- Graduação em Química Biológica. Rio de Janeiro, RJ, Brasil. |
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2010 |
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2010 |
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2018-03-13T17:49:15Z |
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2018-03-13T17:49:15Z |
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info:eu-repo/semantics/article |
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ABRANTES, Juliana L. et al. The Effects of the Diterpenes Isolated from the Brazilian Brown Algae Dictyota pfaffii and Dictyota menstrualis against the Herpes Simplex Type-1 Replicative Cycle. Planta Med., v.76, p.339–344, 2010. |
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https://www.arca.fiocruz.br/handle/icict/25294 |
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0032-0943 |
| dc.identifier.doi.none.fl_str_mv |
10.1055/s-0029-1186144 |
| dc.identifier.eissn.none.fl_str_mv |
1439-0221 |
| identifier_str_mv |
ABRANTES, Juliana L. et al. The Effects of the Diterpenes Isolated from the Brazilian Brown Algae Dictyota pfaffii and Dictyota menstrualis against the Herpes Simplex Type-1 Replicative Cycle. Planta Med., v.76, p.339–344, 2010. 0032-0943 10.1055/s-0029-1186144 1439-0221 |
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Georg Thieme Verlag |
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Georg Thieme Verlag |
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