Evaluation of the acute toxicity of dolabelladienotriol, a potential antiviral from the brown alga Dictyota pfaffii, in BALB/c mice
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2011 |
| Outros Autores: | , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da FIOCRUZ (ARCA) |
| Texto Completo: | https://www.arca.fiocruz.br/handle/icict/26468 |
Resumo: | Universidade Federal Fluminense. Instituto de Biologia. Departamento de Biologia Celular e Molecular. Laboratório de Virologia Molecular. Programa de Pós-Graduação em Neuroimunologia. Niterói, RJ, Brasil / Universidade Federal Fluminense. Instituto de Biologia. Departamento de Imunbiologia. Programa de Pós-Graduação em Neuroimunologia. Niterói, RJ, Brasil. |
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Garrido, ValériaTeixeira, Gerlinde A. P. B.Teixeira, Valéria L.Ocampo, PatríciaFerreira, Wilton J.Cavalcanti, Diana N.Campos, Sylvia M. N.Pedruzzi, Monique de M. B.Olaya, PatriciaSantos, Claudio C. C. dosGiongo, VivecaPaixão, Izabel C. P.2018-05-17T13:18:41Z2018-05-17T13:18:41Z2011GARRIDO, Valéria; et al. Evaluation of the acute toxicity of dolabelladienotriol, a potential antiviral from the brown alga Dictyota pfaffi i, in BALB/c mice. Brazilian Journal of Pharmacognosy, v.21, n.2, p.209-215, Mar./ Apr. 2011.0102-695Xhttps://www.arca.fiocruz.br/handle/icict/2646810.1590/S0102-695X2011005000053engSociedade Brasileira de Farmacognosiatoxicidade agudadolabelladienotriolantiviralditerpeneCamundongos Endogâmicos BALB CDictyota pfaffiidolabelladienotriolacute toxicityBALB/c micediterpeneantiviralEvaluation of the acute toxicity of dolabelladienotriol, a potential antiviral from the brown alga Dictyota pfaffii, in BALB/c miceinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleUniversidade Federal Fluminense. Instituto de Biologia. Departamento de Biologia Celular e Molecular. Laboratório de Virologia Molecular. Programa de Pós-Graduação em Neuroimunologia. Niterói, RJ, Brasil / Universidade Federal Fluminense. Instituto de Biologia. Departamento de Imunbiologia. Programa de Pós-Graduação em Neuroimunologia. Niterói, RJ, Brasil.Universidade Federal Fluminense. Instituto de Biologia. Departamento de Imunbiologia. Programa de Pós-Graduação em Neuroimunologia. Niterói, RJ, Brasil.Universidade Federal Fluminense. Instituto de Biologia. Departamento de Biologia Marinha. Niterói, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Imunologia Clínica. Rio de Janeiro, RJ. Brasil.Universidade Federal Fluminense. Instituto de Biologia. Departamento de Biologia Marinha. Niterói, RJ, Brasil.Universidade Federal Fluminense. Instituto de Biologia. Departamento de Biologia Marinha. Niterói, RJ, Brasil.Universidade Federal Fluminense. Instituto de Biologia. Departamento de Imunbiologia. Programa de Pós-Graduação em Neuroimunologia. Niterói, RJ, Brasil.Universidade Federal Fluminense. Instituto de Biologia. Departamento de Imunbiologia. Programa de Pós-Graduação em Neuroimunologia. Niterói, RJ, Brasil.Universidade Federal Fluminense. Instituto de Biologia. Departamento de Imunbiologia. Programa de Pós-Graduação em Neuroimunologia. Niterói, RJ, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Laboratório de Imunologia Clínica. Rio de Janeiro, RJ. Brasil.Universidade Federal Fluminense. Instituto de Biologia. Departamento de Biologia Celular e Molecular. Laboratório de Virologia Molecular. Programa de Pós-Graduação em Neuroimunologia. Niterói, RJ, BrasilUniversidade Federal Fluminense. Instituto de Biologia. Departamento de Biologia Celular e Molecular. Laboratório de Virologia Molecular. Programa de Pós-Graduação em Neuroimunologia. Niterói, RJ, BrasilDolabelladienotriol is a product extracted from the brown marine alga Dictyota pfaffii from Brazil that has been shown to have antiviral activity and low cytotoxicity. Our studies have evaluated the acute toxicity of dolabelladienotriol in BALB/c mice for ten days after administration of a single dose. Among the parameters considered were behavior, weight, biochemical and histological analyses of blood samples taken at three different times (Bs.0, Bs.1 and Bs.2) and optical microscopic examination of organs like liver, kidney, stomach and small intestine. Mice deaths were not observed at any dose during the ten day period. There were some changes in the biochemical analysis results for urea nitrogen (BUN) and alanine aminotransferase (ALT), but the changes were not significantly different from the reference levels of the animals before administration of the substance. Histological analyses of tissues were very similar for all animals. The alterations in liver and kidney tissues did not affect the animals´ behavior at any concentration, not even at 50 mg/kg, where the most significant changes in tissues were seen. This study indicates that dolabelladienotriol has low toxicity in administered dose range.info:eu-repo/semantics/openAccessreponame:Repositório Institucional da FIOCRUZ (ARCA)instname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZLICENSElicense.txtlicense.txttext/plain; charset=utf-82991https://www.arca.fiocruz.br/bitstream/icict/26468/1/license.txt5a560609d32a3863062d77ff32785d58MD51ORIGINALclaudioCC_santos_etal_IOC_2011.pdfclaudioCC_santos_etal_IOC_2011.pdfapplication/pdf1869318https://www.arca.fiocruz.br/bitstream/icict/26468/2/claudioCC_santos_etal_IOC_2011.pdf01ba5f546b0ec9ad910b686219c724a0MD52TEXTclaudioCC_santos_etal_IOC_2011.pdf.txtclaudioCC_santos_etal_IOC_2011.pdf.txtExtracted texttext/plain30947https://www.arca.fiocruz.br/bitstream/icict/26468/3/claudioCC_santos_etal_IOC_2011.pdf.txt11e8ed09424b5e188b5b9c6d8ff0f46eMD53icict/264682018-08-15 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| dc.title.pt_BR.fl_str_mv |
Evaluation of the acute toxicity of dolabelladienotriol, a potential antiviral from the brown alga Dictyota pfaffii, in BALB/c mice |
| title |
Evaluation of the acute toxicity of dolabelladienotriol, a potential antiviral from the brown alga Dictyota pfaffii, in BALB/c mice |
| spellingShingle |
Evaluation of the acute toxicity of dolabelladienotriol, a potential antiviral from the brown alga Dictyota pfaffii, in BALB/c mice Garrido, Valéria toxicidade aguda dolabelladienotriol antiviral diterpene Camundongos Endogâmicos BALB C Dictyota pfaffii dolabelladienotriol acute toxicity BALB/c mice diterpene antiviral |
| title_short |
Evaluation of the acute toxicity of dolabelladienotriol, a potential antiviral from the brown alga Dictyota pfaffii, in BALB/c mice |
| title_full |
Evaluation of the acute toxicity of dolabelladienotriol, a potential antiviral from the brown alga Dictyota pfaffii, in BALB/c mice |
| title_fullStr |
Evaluation of the acute toxicity of dolabelladienotriol, a potential antiviral from the brown alga Dictyota pfaffii, in BALB/c mice |
| title_full_unstemmed |
Evaluation of the acute toxicity of dolabelladienotriol, a potential antiviral from the brown alga Dictyota pfaffii, in BALB/c mice |
| title_sort |
Evaluation of the acute toxicity of dolabelladienotriol, a potential antiviral from the brown alga Dictyota pfaffii, in BALB/c mice |
| author |
Garrido, Valéria |
| author_facet |
Garrido, Valéria Teixeira, Gerlinde A. P. B. Teixeira, Valéria L. Ocampo, Patrícia Ferreira, Wilton J. Cavalcanti, Diana N. Campos, Sylvia M. N. Pedruzzi, Monique de M. B. Olaya, Patricia Santos, Claudio C. C. dos Giongo, Viveca Paixão, Izabel C. P. |
| author_role |
author |
| author2 |
Teixeira, Gerlinde A. P. B. Teixeira, Valéria L. Ocampo, Patrícia Ferreira, Wilton J. Cavalcanti, Diana N. Campos, Sylvia M. N. Pedruzzi, Monique de M. B. Olaya, Patricia Santos, Claudio C. C. dos Giongo, Viveca Paixão, Izabel C. P. |
| author2_role |
author author author author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Garrido, Valéria Teixeira, Gerlinde A. P. B. Teixeira, Valéria L. Ocampo, Patrícia Ferreira, Wilton J. Cavalcanti, Diana N. Campos, Sylvia M. N. Pedruzzi, Monique de M. B. Olaya, Patricia Santos, Claudio C. C. dos Giongo, Viveca Paixão, Izabel C. P. |
| dc.subject.other.pt_BR.fl_str_mv |
toxicidade aguda dolabelladienotriol antiviral diterpene Camundongos Endogâmicos BALB C |
| topic |
toxicidade aguda dolabelladienotriol antiviral diterpene Camundongos Endogâmicos BALB C Dictyota pfaffii dolabelladienotriol acute toxicity BALB/c mice diterpene antiviral |
| dc.subject.en.pt_BR.fl_str_mv |
Dictyota pfaffii dolabelladienotriol acute toxicity BALB/c mice diterpene antiviral |
| description |
Universidade Federal Fluminense. Instituto de Biologia. Departamento de Biologia Celular e Molecular. Laboratório de Virologia Molecular. Programa de Pós-Graduação em Neuroimunologia. Niterói, RJ, Brasil / Universidade Federal Fluminense. Instituto de Biologia. Departamento de Imunbiologia. Programa de Pós-Graduação em Neuroimunologia. Niterói, RJ, Brasil. |
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2011 |
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2011 |
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2018-05-17T13:18:41Z |
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2018-05-17T13:18:41Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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GARRIDO, Valéria; et al. Evaluation of the acute toxicity of dolabelladienotriol, a potential antiviral from the brown alga Dictyota pfaffi i, in BALB/c mice. Brazilian Journal of Pharmacognosy, v.21, n.2, p.209-215, Mar./ Apr. 2011. |
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https://www.arca.fiocruz.br/handle/icict/26468 |
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0102-695X |
| dc.identifier.doi.none.fl_str_mv |
10.1590/S0102-695X2011005000053 |
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GARRIDO, Valéria; et al. Evaluation of the acute toxicity of dolabelladienotriol, a potential antiviral from the brown alga Dictyota pfaffi i, in BALB/c mice. Brazilian Journal of Pharmacognosy, v.21, n.2, p.209-215, Mar./ Apr. 2011. 0102-695X 10.1590/S0102-695X2011005000053 |
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Sociedade Brasileira de Farmacognosia |
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Sociedade Brasileira de Farmacognosia |
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